... expression To verify that the constructs produce proteins of the expected masses, we attached the V5 epitope to the C terminus of the CRFR1 isoforms (Fig 1C) The predicted masses of the isoforms without/with ... First, we tested whether these messages are translatable In the second step, we characterized their coupling to different signaling pathways and their modulatory role on the CRFR1a activity Materials ... (Fig 2) The molecular mass (including tag) of these isoforms is listed in Table Thus, the mRNA from the alternatively spliced CRFR1 forms is translated into final protein products, which are the subject...
Ngày tải lên: 07/03/2014, 15:20
... calculated for each concentration of the inhibitor by nonlinear t of the data from the above negative controls; [I] is the concentration of the inhibitor, IC50 is the concentration of inhibitor that ... SPL1_HUMAN), the fth was a hypothetical protein from Homo sapiens (Q8N4S1), and the sixth (Q9VSK1) was a putative protein from Drosophila melanogaster In addition, the segment between the ultimate ... at 37 C, and the assay was considered positive if agglutination was apparent to the naked eye Results Protein isolation and sequence assignments The acidic extract prepared from the skin of a single...
Ngày tải lên: 30/03/2014, 13:20
Báo cáo Y học: Amphibian peptides that inhibit neuronal nitric oxide synthase The isolation of lesueurin from the skin secretion of the Australian Stony Creek Frog Litoria lesueuri docx
... called either Lesueur's Frog or the Stony Creek Frog, has varied dorsal colouration ranging from yellow to brown, with a black head stripe from the snout to the tympanum [35] The animal ranges from ... be addressed is what role these active peptides have in the amphibian integument? The glandular secretion of the animal is exuded onto the skin (and into the gut) when the animal is stressed, sick, ... Table lists the sequences of the natural peptides tested, both active and inactive towards nNOS The solubility of these peptides and the maximum tolerable amount of the peptide solvent in the nNOS...
Ngày tải lên: 31/03/2014, 15:20
Báo cáo y học: " Gunshot bullet embolus with pellet migration from the left brachiocephalic vein to the right ventricle: a case report Nicholas Greaves" pptx
... demonstrating the foreign body (pellet) artefact in the right atrium Note also the pellets in the left arm ventricular and valvular function with the pellet still in the right ventricle It showed there ... deviates from the path of penetration [6] Bullet emboli access the vascular system by direct propulsion or erosion into the vessel lumen 80% are arterial in nature with only 20% being venous, therefore ... projectile movement against the normal direction of blood flow [5,9] Second is paradoxical embolisation, defined as the passage of a foreign body from the venous to the arterial system by communication...
Ngày tải lên: 13/08/2014, 23:20
TIPS, TRICKS AND SECRETS FROM THE SKINCARE EXPERTS
... of our body's water is lost as those cells take hydration with them, which then evaporates. THE LAYERS OF THE SKIN. It's surprising how thin the layers of our skin actually are, considering the job the skin does. Of course if the skin ... time the skin changes color this is the result of an injury on the skin. Getting a tan from the sun is the same as burning your skin on an open flame or heating element. Skin ... components that are under the hood, just understanding a few things about what makes up the skin and why it is the way it is helps when trying to take care of it. THE MANY FUNCTIONS OF THE SKIN. Some functions of the skin are rather obvious; it ...
Ngày tải lên: 25/10/2016, 21:21
TIPS, TRICKS AND SECRETS FROM THE SKIN CARE EXPERTS
... much the same way Every time they look in the mirror, all they see is their acne regardless of what other features they may have They often assume that other people view them the same way they ... to the example they set and what they're providing for the household While teens may have their own money to buy their own lunches and snacks, they still learn their eating habits from what they ... both on the skin and internally These growths are not cancerous and often doctors not know what causes them or how to treat them, other than to have them removed Obviously any growths on the skin...
Ngày tải lên: 21/12/2016, 17:56
Báo cáo khoa học: "Prognostic factors for lymph node metastasis from advanced squamous cell carcinoma of the skin of the trunk and extremities" doc
... Carcinoma of the skin of the trunk and limbs: The incidence of metastases and their outcome Aust N Z J Surg 1992, 62:697-701 Ames FC, Hickey RC: Squamous cell carcinoma of the skin of the extremities ... node metastasis was the presence of previous lesions on the skin of 22 patients with lymph node metastasis over the time pre- The 24 cases of amputations (42.1%) also reflected the selection of ... collected from medical records Several clinical variables were examined These include age, gender, ethnicity, preceding chronic skin lesions(burns, scars, varicosae ulcers and others) at the site of the...
Ngày tải lên: 09/08/2014, 07:21
báo cáo khoa học: "Triple malignancy in a single patient including a cervical carcinoma, a basal cell carcinoma of the skin and a neuroendocrine carcinoma from an unknown primary site: A case report and review of the literature" ppt
... discussion; the first one concerns the relationship between the skin and cervical tumors, and the second one concerns the origin of the neuroendocrine metastatic disease Skin metastases from cervical ... In the case that we present, the histological type of the skin lesion as a basal cell carcinoma and the long survival after the local control of both tumors might exclude the hypothesis of skin ... the examination and biopsy confirmed the diagnosis of basal cell carcinoma of the skin Our patient refused the surgical excision of the nasal lesion, and so treatment consisted of radiation therapy;...
Ngày tải lên: 10/08/2014, 23:20
Báo cáo y học: "Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis" pps
... the ordinate *P < 0.05 as compared with the value in cells from healthy controls (c) The left panel shows the representative pattern of CD204 histogram The number of peaks was counted as in the ... collagen bundles in the skin of SSc patients (Figure 1) When the cell number in randomly selected areas (per 10,000 μm2) was counted, the number of CD68+, CD163+ or CD204+cells in the skin of SSc patients ... CD163+ and CD204+ in SSc skin, without changing the total number of macrophages To answer the question why the infiltration of activated macrophage is increased in SSc skin, we then examined PBMCs...
Ngày tải lên: 12/08/2014, 14:22
Báo cáo y học: "Mast cell tumours and other skin neoplasia in Danish dogs - data from the Danish Veterinary Cancer Registry" potx
... considered, the proportion of the malignant skin neoplasms was 21% in the current study, again equal to figures of the Norwegian registry (21.7%) [1] Comparative data from other countries were either ... was seen (M:F 2.58) [1,5] In other veterinary studies the majority of the skin neoplasms were benign as in the current study [1,2,4,10] In the Norwegian study [1], the most common malignant neoplasia ... used and treatment of skin neoplasms in dogs reported to the Danish Veterinary Cancer Registry (DVCR) Furthermore the possible correlation between the diagnostic modality and the treatment elected...
Ngày tải lên: 12/08/2014, 18:22
Migration to GPON practical considerations from the central office to the outside plant
... Splitters The ease of migration from earlier PON architectures to GPON will also be dependent on the design of the fiber distribution portion of the network – the link between customers and the central ... adequate bandwidth for the next generation of applications and services Migration to GPON - Practical Considerations from the Central Office to the Outside Plant Migration- Ready PONs There are several ... business and residential customers The pressure is on for providers to make their networks GPON-ready from the central office (CO) to the outside plant (OSP) The importance of future-proofing...
Ngày tải lên: 03/12/2015, 22:31
Cambridge.University.Press.Bioarchaeology.Interpreting.Behavior.from.the.Human.Skeleton.Feb.1999.pdf
... been the case with the Maghreb, the Levant or the northern shore of the Mediterranean The Great Eurasian Plain The low-lying land that stretches almost without interruption from Britain to the ... belt This is the belt that stretches from Iberia and the Maghreb in the west to the Himalayas in the east Any Eurasian population to the north must have dispersed from this area Its southerly position ... another Yet, there are many examples in the literature of the spread of populations and species, which is a part of the dynamics of the natural world It seems unlikely that, in the history of the...
Ngày tải lên: 21/09/2012, 10:46
Báo cáo y học: "ntravenous transplantation of allogeneic bone marrow mesenchymal stem cells and its directional migration to the necrotic femoral head"
... especially in the necrotic femoral heads, the mechanisms underlying the directional migration of MSCs should be further studied Besides, the efficacy of intravenous transplantation of MSCs in the treatment ... were placed on the platform, the background image was taken under the lights of an illuminator http://www.medsci.org Int J Med Sci 2011, Then, the illuminator was turned off, and the image of light ... feasible and safe Another concern of intravenous transplantation of MSCs is whether the MSCs can migrate into and proliferate in the target tissues, which is the basis of therapeutic effects of...
Ngày tải lên: 25/10/2012, 11:18
Báo cáo y học: " Self-reported sickness absence as a risk marker of future disability pension. Prospective findings from the DWECS/DREAM study 1990-2004"
... reduce the generalizability of the results, and the findings may therefore not apply to the general population The present study and the study by Gjesdal and Bratberg [10] are to our knowledge the ... for these analyses Methodological issues The DWECS/DREAM study provides data from a large representative sample of the Danish working population Further, selection bias is minimized from the ... disability pensioned, emigrated or died They were excluded from the study, as they were no longer under risk of disability pension in the follow-up period from 1994 through 2004 This left a total...
Ngày tải lên: 26/10/2012, 10:03
Báo cáo y học: " Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice
... action of CY in the stomach in this study was due to the activation of p53 and therefore leading to the suppression of the c-Myc/ODC pathway All these findings could explain the mechanism of ... restore their normal immune response (Fig 1) The present findings suggest that AP has immunostimulatory effect which can accelerate the recovery from leukopenia induced by CY and thereby shortens the ... drives the cell cycle from G0 to G1 [27] Furthermore, c-Myc is known to induce the transcriptional activity of ODC gene [29], which is involved in polyamine synthesis It is likely that the cell...
Ngày tải lên: 02/11/2012, 10:19
Báo cáo y học: "introduction to special issue on Eye and Zoonosis – from the guest editors"
... Coherence Tomography in ocular toxoplasmosis • Usefulness of vitrectomy in the treatment of ocular toxoplasmosis • Update on the treatment of ocular toxoplasmosis We hope that this special issue will ... provides researchers with timely update on various topics in this important field Conflict of Interest The authors have declared that no conflict of interest exists http://www.medsci.org ...
Ngày tải lên: 03/11/2012, 11:11
The Lady From The Sea
... (on the other side of the hedge) Good-morning Ballested (turning round) Hallo! Good-morning (Hoists up flag) That's it! Up goes the balloon (Fastens the ropes, and then busies himself about the ... Under the verandah a flagstaff In the garden an arbour, with table and chairs Hedge, with small gate at the back Beyond, a road along the seashore An avenue of trees along the road Between the ... Ballested She has wandered hither from the sea, and can't find her way out again And so, you see, she lies there dying in the brackish water Lyngstrand Ah, I see Ballested The mistress of this house...
Ngày tải lên: 06/11/2012, 14:13
A Call from the Dark
... from the other side of the counter It was a bitter, sour aroma, like the smell of my dad’s work jumpers in summer When I wash Dad’s work clothes I feel the sweat cling to me for the rest of the ... it’s way too expensive), but most of the time I just wolf down the cereal and slurp the milk from the bowl I quickly stuck on the same clothes I’d had on the night before I’ve got pretty simple ... have been outta here I returned the DVD discs to the shelf in the back of the store In Blockbuster all the DVDs were kept in their covers on the shelf Not at the Video Saloon We didn’t have any...
Ngày tải lên: 06/11/2012, 16:13
Flipside II: From the Plains of Metamor
... the sound of a strange, grating voice "Welcome to the Conquest! Before you lay the Valley of Mexico and the island/city of Tenochtitlan; the jewel of the New World!" Surprised by the voice, the ... wind currents down the side of the mountain When they reached the valley floor and neared the shoreline of the lake, a giant clamor caught his attention The water surrounding the city was literally ... continued their flight across the water The rhythms of drums, the blare of horns and conch shells, and the firing of musket and cannon intermingled to rake their senses But when they reached the city...
Ngày tải lên: 06/11/2012, 17:33
Notes from the Underground
... whether other people feel such enjoyment? I will explain; the enjoyment was just from the too intense consciousness of one's own degradation; it was from feeling oneself that one had reached the ... how to revenge themselves and to stand up for themselves in general, how is it done? Why, when they are possessed, let us suppose, by the feeling of revenge, then for the time there is nothing ... to the very act of revenge Apart from the one fundamental nastiness the luckless mouse succeeds in creating around it so many other nastinesses in the form of doubts and questions, adds to the...
Ngày tải lên: 07/11/2012, 09:09