3egfr family and src kinase activation in breast cancer

... with breast cancer in Chinese Int J Clin Exp Med 2015;8:10429–36 69 Breast Cancer Association C Commonly studied single-nucleotide polymorphisms and breast cancer: results from the breast Cancer ... patients and healthy women regarding menarche and menopausal age, parity and breastfeeding There was an increase in BMI in patients (p = 0.004) compared to controls, and an increase in the use ... factors and breast cancer risk Effect of age at diagnosis Ann Epidemiol 1995;5:315–20 32 Freund C, Mirabel L, Annane K, Mathelin C Allaitement maternel et cancer du sein [breastfeeding and breast cancer]

Ngày tải lên: 17/06/2020, 11:31

... patients with Luminal B breast cancer Conclusions: Cathepsin K induces platelet dysfunction and affects signaling in breast cancer cells Keywords: Cathepsin K, Platelets, Breast cancer, Protease ... potential in activating proteinases in tumor tissues, including breast, prostate, and colon cancer, and malignant melanomas, have been reported [11, 14] In addition, abnormalities in blood coagulation ... Oliva3 and Manoel J B C Girão1,4 Abstract Background: Breast cancer comprises clinically and molecularly distinct tumor subgroups that differ in cell histology and biology and show divergent clinical

Ngày tải lên: 21/09/2020, 02:04

... ADAM12-L and both miR-29b and miR-200c in breast invasive carcinomas Inhibition of the endogenous miR-29b and miR-200c with miRNA hairpin inhibitors increased the level of ADAM12-L mRNA in SUM149PT and ... washed and incubated in labeling media (9 parts DMEM without cysteine and methione: part complete DMEM), containing 80 μCi/ml EasyTag EXPRESS35S Protein labeling mix (PerkinElmer) After labeling ... pathways Cancer Res 2008;68:3645–54 Scheel C, Eaton EN, Li SH, Chaffer CL, Reinhardt F, Kah KJ, et al Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast

Ngày tải lên: 30/09/2020, 12:52

... of stained cells, and intensity were determined The evaluation of protein expression was determined as mean ± SEM from each individual case ER and PgR staining was assessed by Allred scoring, ... scores ranging from to [10] EGFR staining was considered positive if any cytoplasmic and/ or membrane staining was observed HER + (IHC) was defined as strong whole membrane staining in >30% of ... differentially distributed in breast cancer, while VEGF-A and HIF-1alpha mRNA have coincident distributions, and VEGF-A and HIF-1alpha proteins have uneven and opposing distributions to the miRNAs

Ngày tải lên: 14/10/2020, 15:39

... expression and clinicopathological significance of PTOV1 in breast cancer Methods: The mRNA and protein expression levels of PTOV1 were analyzed in 12 breast cancer cell lines and eight paired breast cancer ... PTOV1 in breast cancer cell lines and normal human mammary epithelial cell lines Expression of PTOV1 mRNA and protein in an immortalized “normal” breast epithelial cell line MCF-10A and breast cancer ... cell carcinoma, non-small cell lung cancer and breast cancer [13-16] Flotillin-1 promotes breast cancer carcinogenesis inducing entry into the S phase of the cell cycle and by upregulating the

Ngày tải lên: 14/10/2020, 17:23

... To gain new insights into the functional relationship linking MBP-1 and ERBB2 in breast cancer, we have investigated the effects of MBP-1 expression on endogenous ERBB2 transcript and protein levels, ... Histone Deacetylase, Breast cancer Background The ERBB2 (Her2/Neu) gene encodes a tyrosine kinase receptor whose abnormal activity is linked to oncogenesis in breast cancer In fact, ERBB2 gene ... functional link between MBP-1 and the ERBB2 gene in human breast carcinomas Page of 12 In the present study, we provide evidence that MBP-1 inhibits the expression of the ERBB2 gene in SKBr3 breast cancer

Ngày tải lên: 05/11/2020, 07:12

... and Alan Mackay, Ludwig Institute for Cancer Research, London, UK; SKBR3: breast cancer cell line overexpressing HER2; MDA MB-231: breast cancer cell line triple negative; and MCF-7: breast cancer ... p21WAF1/CIP1 and p27KIP1; growth factors, receptors and associated proteins as TGFβ, TGFβ receptors and insulin-like growth factor binding protein-3 (IGFBP-3) [26-31] In addition, gene expression profiling ... hand, clinical studies point to a clinical benefit for 1,25 (OH)2D3 (or analogues) alone or in combination with chemotherapy in the treatment of hormone refractory prostate cancer and breast cancer

Ngày tải lên: 05/11/2020, 07:23

... self-reported and objective PA (including sedentary behavior), HRF (including body composition), and disease outcomes in breast cancer survivors (including recurrence-free interval, breast cancer mortality, ... testing and 6–6.5 hours total over the morning and afternoon for single day testing Resting heart rate and blood pressure Using standardized procedures [30], after minutes of quiet sitting, resting ... Hannan PJ, Yee D: Safety and efficacy of weight training in recent breast cancer survivors to alter body composition, insulin, and insulin-like growth factor axis proteins Cancer Epidemiol Biomarkers

Ngày tải lên: 05/11/2020, 07:47

... MASTL targeting in breast cancer MASTL depletion induces cell death in breast cancer cells As MASTL inhibition reduces cell viability in various cancer cells [13–15] and targeting mitotic kinases ... Quantified staining intensity of MASTL in breast cancers (n = 55) and normal tissues (n = 24) Staining intensity was scored as follows: 0, no staining; + 1, weak; + 2, moderate; and + 3, strong ... avidin-biotin-peroxidase method in accordance with the manufacturer’s instructions (Invitrogen) The staining intensity was scored on a scale of 0–3: 0, no visible staining; 1+, faint staining;

Ngày tải lên: 24/07/2020, 01:45

... Breast cancer, Targeted-therapies and sphingosine kinase Background Clinically targeting oncogenic signaling pathways in breast cancer, such as those initiated by the estrogen receptor (ER) and ... targets in breast cancer Aleksandra M Ochnik1,2* and Robert C Baxter1 Abstract Background: Targeting the type insulin-like growth factor receptor (IGF1R) in breast cancer remains an ongoing clinical ... breast cancer formalin-fixed paraffin embedded (FFPE) tissue samples In addition we have undertaken pre-clinical in vitro studies using the dual IGF1R/insulin receptor (InsR) tyrosine kinase inhibitor,

Ngày tải lên: 06/08/2020, 03:26

... expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF-7 in vitro Qingming Jiang†, Hui Zhang* and Ping Zhang† Abstract Background: MTA1(metastasis ... MTA1, a cyclin-dependent kinase- activating kinase complex ring finger factor, and regulated estrogen receptor transactivation Mazumdar et al[16] studied that, MTA1 restrained CAK-induced ER alpha ... AH, Mishra SK, Mandal M, Balasenthil S, Mehta S, Sahin AA, Barnes CJ, Kumar R: MTA1 interacts with MTA1, a cyclin-dependent kinase- activating kinase complex ring finger factor, and regulates estrogen

Ngày tải lên: 10/08/2014, 10:21

... molecule) and TRIF (TIR- domain-containing adaptor protein i nducing IFNb), and can activate both NF B and IRF, inducing interferon synthesis. The importance of IL1/TLR signalling in atherosclerosis ... LPS INFLAMMASOME Flagellin Figure 2 The interaction between innate signalling, through TLRs, and inflammasome signalling in the transcription and translation of the pro-inflammatory cytokine ... selectin and CCL2, whilst IL1b and TNFa signalling remained unhindered [130]. Downstream of TLR4/ MD2/CD14, intracellular signalling in response to mmLDL stim ulation has been investigated and, in

Ngày tải lên: 11/08/2014, 03:20

... molecule) and TRIF (TIR- domain-containing adaptor protein i nducing IFNb), and can activate both NF B and IRF, inducing interferon synthesis. The importance of IL1/TLR signalling in atherosclerosis ... LPS INFLAMMASOME Flagellin Figure 2 The interaction between innate signalling, through TLRs, and inflammasome signalling in the transcription and translation of the pro-inflammatory cytokine ... selectin and CCL2, whilst IL1b and TNFa signalling remained unhindered [130]. Downstream of TLR4/ MD2/CD14, intracellular signalling in response to mmLDL stim ulation has been investigated and, in

Ngày tải lên: 11/08/2014, 06:22

... tumors and is associated with poor prognosis in several cancer types, including breast cancer The master regulator of the hypoxic response is the Hypoxia-inducible factor 1α (HIF‑1α) It is becoming ... hypoxia signature for breast and other cancers that will be useful for diagnosis and therapy In this review, we outline the existing markers of hypoxia and recently identified gene and miRNA expression ... Favaro et al Genome Medicine 2011, 3:55 http://genomemedicine.com/content/3/8/55 REVIEW Gene expression and hypoxia in breast cancer Elena Favaro†, Simon Lord†, Adrian L Harris and Francesca M Buffa*

Ngày tải lên: 11/08/2014, 12:21

... DNA-PKcs and telomere maintenance 16 1.5.2.3 PARP-1 and telomere maintenance 16 1.6 Dysfunctional telomere-induced genomic instability in cancer 17 1.7 Trends in breast cancer ... cells 41 3.1.3 Changes in cell cycle protein expressions in TQ-treated breast cancer cells 44 3.2 DNA damaging effects of TQ in normal and breast cancer cells 47 3.2.1 TQ induces significantly ... proteins in TQtreated breast cancer cells 45, 46 Figure 13 TQ induced greater amount of DNA damage in breast cancer cells 49 telomerase and Figure 14 TQ induced significant DNA double strand breaks

Ngày tải lên: 30/09/2015, 13:41

... carboxyl-terminal tail as illustrated in Figure 1.5C appears to be the docking site for at least two interacting sites including calmodulin (CAM) binding sites and region involved in microfilament-associated ... in levels of phospho-proteins and non-phospho proteins upon 4α-PDD stimulation for 15 mins and 16hrs in 4T07 cell line. 80 3.27 Changes in levels of phospho-proteins and non-phospho proteins upon ... a novel breast cancer metastasis-associated protein. TRPV4 was found to be upregulated in invasive breast cancer cell lines and tumor breast tissues. It has been shown that 4α-PDD induced activation

Ngày tải lên: 02/10/2015, 17:15

... rapamycin sensitivity in breast cancer cells." Clin Cancer Res 10(3): 1013-1023 O'Reilly, K E., F Rojo, et al (2006) "mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates ... dual inhibitor of mTOR and telomerase, sustained rapamycin treatment leading to Akt activation may play a role in resistance via telomerase activation in some breast cancers Altogether, the investigation ... telomerase 24 1.4 BREAST CANCER AS A MODEL OF STUDY .25 1.4.1 mTOR in breast cancer 25 1.4.2 Telomerase in breast cancer 26 1.4.3 Rapamycin in breast cancer .27

Ngày tải lên: 05/10/2015, 13:53

... trick the breast cancer cells into accepting it in place of estrogen Unlike estrogen, however, they not stimulate breast cancer cell growth Other SERMs being studied for breast cancer include toremifene ... proteins, thrombospondin-1, and collagen types I and IV 1.1.3 Overview of Combination Therapy in Cancer Treatment Sometimes, more than one type of treatment is used to treat breast cancer Combination ... nausea and vomiting that can be quite severe and require interrupting treatment A less frequent side effect is bone pain[47] Other rare side effects include vaginal bleeding, thrombophlebitis, and

Ngày tải lên: 09/10/2015, 11:24

... protein kinase C Adenosine triphosphate Basic helix-loop-helix Binding protein Bovine serum albumin Cyclin-dependent kinase inhibitor 2B Cytokeratin-19 Cytoplasmic lipid droplets 4’,6-diamidino- ... protein-29 (ERp29) is a chaperone protein that functions in the unfolding and escort of secretory proteins Like other reticuloplasmins, ERp29 is believed to be involved in carcinogenesis In breast ... N-terminal kinase Lethal giant larvae Mitogen-activated protein kinase Madin-Darby Canine Kidney Mesenchymal to epithelial transition Myosin light chain Phosphorylated myosin light chain Matrix

Ngày tải lên: 13/10/2015, 15:55

... patients with breast cancer Methods: One hundred and ten women hospitalized for breast cancer surgery were administered questionnaires assessing coping with cancer, defense mechanisms, and memories ... solving Daydreaming and engagement in self-comforting fantasies was previously found to be associated with a negative prognosis in breast cancer patients [50] High paternal overprotection and insecure ... Maternal reflective functioning, mother-infant affective communication, and infant attachment: exploring the link between mental states and observed caregiving behavior in the intergenerational transmission

Ngày tải lên: 10/01/2020, 13:42