3 phase ii studies of first salvage chemotherapy

... preparation 5T4-MVA vaccine was produced by homologous recombination of human 5T4 cDNA into deletion region III of MVA under the control of the modified H5 promoter, as previously described [12] Individual ... number of Tregs within four weeks of completing the first course of IL-2 (p = 0.006) and supports the notion that patients destined to respond to immunotherapy exhibit a decreased frequency of Tregs ... analysis, or interpretation of the data, or in the writing of the report They also had no access to the raw Page of 11 (page number not for citation purposes) Journal of Translational Medicine...

Ngày tải lên: 18/06/2014, 15:20

... disease of New York Heart Association Class III-IV Patients must have had no history of myocardial infarction within months of study entry and no history of deep venous thrombosis The requirement of ... A patients on day of cycles 2, 4, and as well as completion of treatment; for Arm B patients, on day 22 of cycle and day of cycles and and completion of treatment In the case of missing responses ... activity of this combination in limited studies We found a PSA response rate of 50%, progression free survival of 5.9 months, and overall survival of 19.4 months, consistent with clinical activity of...

Ngày tải lên: 18/06/2014, 16:20

... beyond weeks) rate of 20%, a null response rate of 5%, a type one error of 0.10, and a type two error of 0.10 As such, continuation to the second stage required one patient out of the first 12 recruited ... results of immune monitoring and clinical benefit in terms of tumor responses This lack of correlation of immune parameters and response may relate to the likely low sensitivity of the detection of ... autologous peptide-pulsed dendritic cells (DC) in firstline treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG Ann Oncol 2006, 17:563-570 12...

Ngày tải lên: 18/06/2014, 16:20

... one of the largest studies to date, the rate was 12% It is noteworthy that the findings from this study are comparable to studies using single-agent 5-FU [41] Overall, a number of phase II studies ... approved by the ethic committees of the Institute of Oncology, Ljubljana, Slovenia and of the Republic of Slovenia and was in agreement with the Declaration of Helsinki week for weeks The small ... presented with stage III disease The WHO performance status was in 12.3% of patients The median distance of the tumour from the anal verge was 5.5 cm (range 1-12 cm), and in 49.1% of patients the...

Ngày tải lên: 09/08/2014, 09:20

... UICC stage no (%) II III IV 59 (50) 49 (41.5) 10 (8.5) Tumor location no (%) Upper third of rectum Middle third of rectum Lower third of rectum 10 (8.5) 59 (50) 49 (41.5) Page of (page number not ... diarrhea Anal incontinence Number of patients (%) Grade III Grade IV (0.8) (2.5) (3.4) (2.5) (0.8) was 78%, 71% and 52% for UICC stage I, II and III, respectively A total of six local recurrences were ... and 70% after exclusion of UICC stage IV (Fig 1) OS was not statistically significant for UICC stages I to III: five-year OS was 81%, 74% and 59% for UICC stage I, II and III, respectively Five-year...

Ngày tải lên: 09/08/2014, 10:20

... days 1, and 15 of each cycle Response duration was defined as the interval between the dates of first documented CR, or study entry in the case of PR, and first documented sign of disease progression ... in arm A, 85% of patients received > 85% of docetaxel, while the remaining 15% received a cumulative dose of more than 70% of that planned In arm B, 74% of patients received > 85% of the planned ... perpendicular diameters of all measured lesions, with no appearance of new disease Progressive disease (PD) was an increase of more than 25% in the size of target lesions, or the appearance of an unequivocal...

Ngày tải lên: 18/06/2014, 15:20

... fairyland of Oberon, of Fallerina, of Alcina, of Armida, of Acrasia, the romance of the new world, had also turned into prose, prose of blood-stained filth The humanistic and rationalistic men of the ... "Morte d'Arthur" of the ladies and knights of Arthur's court; of the quest of the Grail by spotless knights who were bastards and fathers of bastards; of the intrigues of Tristram of Lyoness and ... result of a mixture with other epic cycles; of a gradual adaptation to a new state of civilization; and finally of their gradual separation from all kind of reality and real interests First of all,...

Ngày tải lên: 21/02/2014, 21:20

... MHC II (I-Au) receptor site are also reported in an effort to elucidate the role of the positively charged residue Arg78 and the effect of the reduction of cationicity of MBP in the triggering of ... from the side chain of Arg78 The side chain of Arg78 is less well defined, as in the case of aqueous solution, because of the absence of interactions with the side chains of Asp81 (in the agonist ... (Table 1) The evolution of the radius of gyration, which reflects the compactness of 3404 A G Tzakos et al (Eur J Biochem 271) Ó FEBS 2004 Fig Evolution of the radius of gyration of the MBP(74–85) and...

Ngày tải lên: 07/03/2014, 16:20

... including the gene encoding arginase II (ArgII) ArgII is the extrahepatic isoform of the arginase type enzymes, and ArgI is the hepatic-specific counterpart [16] The two isoforms possess the same enzymatic ... expression of a constitutively active form of IRF-3 This study shows for the first time that ArgII expression is up-regulated in the context of virus infection Previous studies reported the induction of ... line following inducible expression of the constitutively active form of IRF-3, IRF-3 5D [14] Up-regulation of ArgII gene expression was observed after treatment of the tetracycline inducible cell...

Ngày tải lên: 07/03/2014, 21:20

... Micro-Mechanics of composite materials, “Nauka Dumka”, Kiev, 1985 G.A Vanin, Nguyen Dinh Duc, The theory of spherofibre composite.1: The input relations, hypothesis and models, J Mechanics of composite ... + A55 ∂y A44 ∂x ∂x∂y   (3) 143 N.D Duc, D.K Minh / VNU Journal of Science, Mathematics - Physics 26 (2010) 141-145 The set of equation (3) is the basic set to determine the plate’s deflection ... (7) 144 N.D Duc, D.K Minh / VNU Journal of Science, Mathematics - Physics 26 (2010) 141-145 Experiment result In the experiment, the two shorter edges of the plate are clamped, while the two...

Ngày tải lên: 14/03/2014, 13:20

... mortality ii) the cost of reduced health care resource utilization (e.g., hospital care) iii) the value of avoided lost productive time (e.g., lost wages) iv) the value of increased quality of life ... are: i) complete elimination of anthropogenic ozone and particulate matter, ii) maintenance of current Ontario air pollution concentrations, iii) full implementation of Ontario’s Anti-Smog Action ... Background Levels of Ozone and Particulate Matter p K-6 Forecasts of Total Illnesses with the Maintenance of Current Levels of Anthropogenic Ozone and Particulate Matter p K-8 Forecasts of Total Economic...

Ngày tải lên: 15/03/2014, 16:20

... (73.8%) of the employees were full-time employees � Almost half (45.7%) of the employees were women � One-third (30.2%) of the employees were members of a racial/ethnic minority group  � 18.1% of ... recruitment package As Table indicates, many employers are offering a range of benefits to all of their employees Table 4: Profiles of Available Benefits % respondent organizations reporting ... Ph.D., is Co-Director of the Center on Aging & Work/Workplace Flexibility He is also the Dean of the Graduate School of Arts and Sciences and a Professor in the Department of Psychology at Boston...

Ngày tải lên: 23/03/2014, 02:20

... and the fraction of solid atoms in each layer [19] Computation of the interface temperature and regrowth velocity gives an indirect view of the congruent melting temperature of these heavily ... amorphous layer is determined to be of the order of several tens of nanometers at fluences up to two times above the melting threshold [24] Residual stress and amorphization of the silicon single crystal ... study of ultrafast laser heating For the purpose of allowing the motions of atoms at the surface, extra 480 empty unit cells and 120 empty unit cells, which are the empty space for the purpose of...

Ngày tải lên: 06/05/2014, 08:54

... Micro-Mechanics of composite materials, “Nauka Dumka”, Kiev, 1985 G.A Vanin, Nguyen Dinh Duc, The theory of spherofibre composite.1: The input relations, hypothesis and models, J Mechanics of composite ... + A55 ∂y A44 ∂x ∂x∂y   (3) 143 N.D Duc, D.K Minh / VNU Journal of Science, Mathematics - Physics 26 (2010) 141-145 The set of equation (3) is the basic set to determine the plate’s deflection ... (7) 144 N.D Duc, D.K Minh / VNU Journal of Science, Mathematics - Physics 26 (2010) 141-145 Experiment result In the experiment, the two shorter edges of the plate are clamped, while the two...

Ngày tải lên: 21/07/2014, 16:21

... immunohistochemistry (IHC) c) Quantification of extent of change in these biomarkers of response to chemotherapy one day and 21 days after first cycle of chemotherapy http://www.wjso.com/content/7/1/35 ... first cycle of chemotherapy (C1 biopsy) 30 100 Core biopsy 21 days after first cycle of chemotherapy (C2 biopsy) 26 86.6 At C0 biopsy 30 100 At C1 biopsy 28 93.3 At C2 biopsy 22 73.3 (84.3% of ... biopsy) after first cycle of chemotherapy Chemotherapy regimen was at discretion of the treating medical oncologist Serial core biopsies were obtained exclusively for the purpose of this study...

Ngày tải lên: 09/08/2014, 04:21

... determined by magnetic resonance imaging (MRI) of the pelvis of each patient Eligible patients had to have a histologically verified stage II or III adenocarcinoma of the rectum, the disease had be considered ... 60 months following the end of adjuvant chemotherapy Statistical analysis The primary endpoint of the study was pCR rate In the medical literature, phase II studies of capecitabine and RT suggest ... results of a randomised phase III study J Clin Oncol 2001, 19:2282-2292 Page of 11 Twelves C, Wong A, Nowacki MP, Abt M, Burris H, et al: Capecitabine as adjuvant treatment for stage III colon...

Ngày tải lên: 09/08/2014, 09:21

... expression ER expression 17 15 I-IIA 17 15 IIB-III 16 10 17 21 Positive” Ki67 Negative 22 15 Positive 14 10 CR+PR 15 11 SD+PD 21 14 13 23 18 21 18 15 I-IIA 17 16 IIB-III n.s Negative Positive 27 n.s ... 10% of the tumor cells (0); weak staining in part of the membrane in more than 10% of the tumor cells (1+); complete staining of the membrane with weak or moderate intensity in more than 10% of ... positive cells on the total number of tumor cells A value of 11% of positive cells, corresponding to the mean value of p53 expressing tumor cells, was used as cut-off to distinguish high and low...

Ngày tải lên: 10/08/2014, 10:21

... 6% of the melanoma patients, although 17% of melanoma patients and 14% of renal cell patients had stable disease at months or longer Pharmacodynamic studies of blood showed increased levels of ... are of interest Of the eleven drugs discussed, ten had clinical efficacy data available, and of these ten all showed, at the very least, some stable disease responders A number of phase II studies ... pairs of tumor biopsies Further analysis of survivin gene expression in these samples is planned Clinical response has so far been limited to stable disease in 10% of patients A phase II study of...

Ngày tải lên: 10/08/2014, 22:20

... in order to assess the opportunity of a larger phase III trial Making the hypothesis that the percentage of patients free of catecholamine at 10 days (end of study treatment) would be 60%, the ... would have allowed the detection of an absolute increase of 25% of this percentage of patients in a two-sided test performed with a type I error of 5% and a power of 80% Statistical analysis was ... potential interest of bolus administration, septic shock animal studies are first needed to test the efficacy of this approach as well as the mechanism of its action Page of 10 (page number not...

Ngày tải lên: 13/08/2014, 03:21