3 limitations of intraperitoneal antineoplastic drug delivery

... acquire most of the characteristic properties of sympathetic neurons Other salient responses to NGF include cessation of proliferation, generation of long neurites, acquisition of electrical ... for the entrapment and/or delivery of a variety of biological agents [8] Alginate is a co-polymer extracted from some types of brown algae and it is made up of two uronic acids: D-mannuronic acid ... a forest-like structure that could be exploited for the deposition of a polymeric thin film acting as drug delivery device For drug release kinetics investigation, bovine serum albumin (BSA, A3156...

Ngày tải lên: 22/06/2014, 00:20

... the implementation of time varying delivery of different therapeutics, which is essential for a more effective drug delivery system The direct delivery of DNA/portent based drugs into the metabolic ... Microneedles 2.1 Microneedles in Transdermal Drug Delivery Transdermal drug delivery is an alternative method for delivery of DNA/protein based drugs These drugs which have sophisticated compounds ... used for local delivery of other drugs, for example, drugs in anti-restenosis and anti-tumor therapies In transdermal drug delivery, microneedles are designed to painlessly deliver drugs into subcutaneous...

Ngày tải lên: 14/09/2015, 11:17

... the area under the curve of a plot of axis between Concentration of the drug vs the duration of exposure to the drug and is used here to provide consistency in the design of the control groups with ... matrix, control of the rate of polymer degradation can be achieved thereby changing rate of release of the drug Our study focuses on developing controlled releases implants in the form of discs for ... pressure quench and rapid solidification of drug- polymer melt This thesis presents a step-by-step approach in the analysis of the use of foams for controlled release of Paclitaxel as implants within...

Ngày tải lên: 05/10/2015, 21:33

... stability Chemical Aspects of Drug Delivery Systems Table Routes of administration and general classification of drug delivery systems ROUTES OF ADMINISTRATION DRUG DELIVERY CLASS ORAL SOLIDS ... imposed by the nature of the various routes of administration available for drug delivery ROUTES OF ADMINISTRATION AND CLASSIFICATION OF DRUG DELIVERY SYSTEMS The principal routes of administration ... for Drug Delivery and Targeting P York The Use of Bioadhesive Polymers as a Means of Improving Drug Delivery Slobodanka Tamburic and Duncan Q.M Craig Some Novel Aspects of Transdermal Drug Delivery...

Ngày tải lên: 28/03/2014, 10:20

... A4: series of multiple doses of a conventional drug delivery system B: ideal drug concentration profile PRODRUG What is a prodrug?  Prodrug is an inactive precursor of a drug  Prodrug reconversion ... and polymeric systems for drug delivery Dendrimers for drug delivery GENERALITIES OF DRUG DELIVERY DRUG DELIVERY SYSTEM Definition: A drug delivery system is a formulation or a device that safely ... MUCOSAL DRUG DELIVERY Advantages:  avoid the first-pass effect of drug cleareance ORAL MUCOSAL ROUTE Classification:  Sublingual delivery  Buccal delivery  Local delivery Sublingual delivery...

Ngày tải lên: 18/04/2014, 15:37

... construction of drug delivery systems in not too long a time The functionalization of CNTs used in the construction of drug delivery systems will be discussed in later sections In vivo behavior of functionalized ... application of CNTs as the molecular transporter in drug delivery Page 14 of 22 Drug delivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drug delivery systems ... schematic illustration of the strategy for the preparation of the CNT-based drug delivery systems Figure The modification of CNTs Schematic illustration of modification of CNTs with various molecules...

Ngày tải lên: 20/06/2014, 22:20

... molecule in general from a delivery are major factors that ultimately determine the success or failure of that vector when applied to targeted drug delivery One of the goals of this work was to demonstrate ... toxicity of CuCNPs upon reduction of Cu content water, which has a neutral to slightly acidic pH While this feature is promising in terms of the stability of solutions of CuCNPs over long periods of ... http://www.nanoscalereslett.com/content/6/1/445 capable of inducing oxidative stress, which is of great concern in terms of the nanotoxicology of particles being pursued for a variety of consumer products Furthermore,...

Ngày tải lên: 21/06/2014, 02:20

... the delivery of DCU via intravenous (IV) infusion route was explored Similar to oral delivery, IV delivery of DCU was limited by the poor aqueous solubility of DCU The poor aqueous solubility of ... [27] to estimate the amount of drug entering the small intestine as a function of time M = D e−Ke(t) where M is the mass of the drug remaining in the stomach, D is the drug dosed, Ke is the stomach ... SC drug depot should continuously provide a slow release of drug to the bloodstream providing a longer and sometimes steady drug supply Combined, both effects may result in a drug plasma profile...

Ngày tải lên: 21/06/2014, 03:20

... intravitreal drug levels Pharmacokinetic studies are important in the development of local ocular drug delivery Although a benefit of ocular drug delivery is the ability to achieve higher intraocular drug ... safety of the implant alone Studies showing compatibility of the drug delivery system should be performed There have been examples of toxicity resulting from the sterilization of drug delivery ... drug delivery A study arm with a low dose of drug in the delivery device may be accepted as an alternative control in some studies Drug Device Combination Products Combination products of a drug...

Ngày tải lên: 09/08/2014, 20:22

... process(es) Over the past couple of decades, the field of drug delivery has been revolutionized with the advent of nanoparticles, wherein these particles act as inert carriers for drugs and genes to target ... progression of the T cell-dependent chronic phase of the inflammatory response [20] Clearly, this warrants further evaluation and selective delivery of this class of compounds for treatment of CF lung ... [14,29-31] To test the efficacy of our novel therapeutic drug delivery vehicle we have tested the sustained release and delivery of FDA approved proteasome inhibitor drug, PS341 in murine lungs by...

Ngày tải lên: 11/08/2014, 00:22

... modification of the drug molecules may change the therapeutic properties of the drug, resulting in the dysfunction of drug Therefore, a better drug delivery strategy is required to transport a drug with ... antibiotic drugs to brain Drug delivery into the brain Since the BBB represents an insurmountable obstacle for a large number of drugs, including antibiotics, antineoplastic agents, and a variety of ... Nanoparticles in the brain drug delivery 27 4.1 Ideal properties of nanoparticles for brain drug delivery .28 4.2 Some successfully developed nanoparticles in brain drug delivery 29 4.2.1 PBCA...

Ngày tải lên: 11/09/2015, 09:10

... al., 1997; Lu and Low, 2002] Proof of concept of the folic acid-mediated targeting systems has been obtained with the delivery of drugs and liposomes to a variety of cancer cells [Leamon and Low, ... model drug in the development of targeting drug delivery platforms [Kalra and Campbell, 2006; Sun et al., 2006; Nasongkla et al., 2006] Figure 1-1 Chemical structure of doxorubicin 1.2 Targeted drug ... because of the lack of polarization of these cells Consequently, cancer cells with overexpressed FR are susceptible to folic acid-conjugated drug delivery systems circulating in the blood [Toffoli...

Ngày tải lên: 11/09/2015, 14:22

... surface of the polymer, resulting in a release rate that is proportional to the surface area of the drug delivery system (See Figure 2.5b) a Drug Drug Drug- loaded biodegradable particles b Drug Drug ... application of SBA-15 in the delivery of the small molecule model drug of ibuprofen (IBU), with emphasis on the influence of the different functional methods on the adsorption and release of IBU Chapter ... the rate of erosion exceeds the rate of water permeation into the bulk of the polymer This is often considered to be a desirable mechanism of erosion in drug delivery because the kinetics of erosion,...

Ngày tải lên: 13/09/2015, 19:46

... interaction of HP with DM β-CD The solubilization profile in Fig 3.2 is linear for all formulations indicating the formation of a 1:1 complex irrespective of the ionization of the drug (Loukas ... of increased solubility of the drug Synergistic effects can be achieved by adjusting the pH and concentration of RM β-CD to obtain improved solubility and therefore skin permeability of the drug ... Development of a Multilayered/ Multicomponent Fiber Mat for Improved Topical Delivery of Haloperidol 4.1 Introduction Biodegradable polymeric nanofibers have been used as carriers for drug delivery...

Ngày tải lên: 14/09/2015, 14:03

... topical drug delivery as this is the main focus of the present study I-B1 Advantages and limitations of topical drug delivery The principal advantage of topical drug delivery lies in targeting the drug ... topical drug delivery Transdermal drug delivery involves transport of drug through the skin into the systemic circulation for treatment of disorders remote from the site of application As the drug ... LIST OF FIGURES xiv LIST OF SYMBOLS xix LIST OF EQUATIONS xxiv I INTRODUCTION I-A The human skin I-B Transdermal and topical drug delivery I- B1 Advantages and limitations of topical drug delivery...

Ngày tải lên: 15/09/2015, 17:10

... ligands Of course, targeted colloidal carriers will be much more effective if they are also sterically stabilized 1.2.2 Samples of Drug Delivery Systems As far as the physical form of drug delivery ... for the delivery of drugs (lipophilic drugs, hydrophilic drugs provided with lipophilic moieties, or ionic drugs complexed with ionic lipids) to specific cell types, provided that these drugs: ... development of delivery systems which will allow the fate of drugs within the patient to be controlled by modifying these processes Although drug carriers usually act on the second process – drug distribution...

Ngày tải lên: 16/09/2015, 08:30

... further innovation of drug delivery systems Figure 1.1: Timeline of nanotechnology-based drug delivery Reproduced from [13] with permission The nanoscale feature of these drug delivery systems ... on drug delivery systems Drug delivery is defined as the system to dispense a pharmaceutically active compound in the body to attain a therapeutic effect In an extension of free drugs, drug delivery ... of liposomes changed the face of soft drug delivery systems, there are problems inundated with the use of liposomal drug delivery systems Firstly, the preparation of liposomes is a complex procedure...

Ngày tải lên: 30/09/2015, 06:07

... of standard The acceptable range for the variation of retention time was less than 5% 3.2.8 Calculation of the number of drug molecules (MacDiarmid et al., 2007b) The number of molecules of drug ... capable of being targeted to specific cells Because of the benefits of delivering chemotherapeutics drugs for cancer treatment, the practice of synthesizing and packagage of cytotoxic drug into ... therapy of cancer (Alexis et al., 2010) 2.1.3.2 Tumor-targeted drug delivery nanoparticles In recent years, the rapid advent of nanotechnology has stimulated the development of many novel drug delivery...

Ngày tải lên: 23/10/2015, 15:38

... mass of drug- loaded microgels Lref reference parameter Mt absolute cumulative amount of drug released at time t M∞ absolute cumulative amount of drug released at time t=∞ R mean radius of dry ... 4.3.3 Effect of effective crosslink density 51 - iii - Table of Contents 4.3.4 Effect of initial polymer volume fraction 54 Chapter Transient Model Development for Simulation of Drug Delivery from ... simulation of the swelling equilibrium of temperature-sensitive hydrogels with fixed charges 1.2.2 Microgel-based drug delivery system In development of bioengineering and biotechnology, one of studies...

Ngày tải lên: 26/11/2015, 12:31

... professional skills, capable of working at the typical position of trade expected by society in keeping with each period of socio-economic development The objective of professional training of ... to the increased education of the labor force Schultz’s (1963) method of measuring the contribution of education to economic growth (that is, in terms of the rate of return to human capital, ... improve the lives of individuals, their families and society as a whole The attainment of this objective requires the improvement of the educational and professional level of human resources,...

Ngày tải lên: 13/04/2013, 10:31