3  specifying the structure of the datafile

... also the reason why the determination of the spatial structure of the N-terminal domain containing the Cd(II)3-CysS9 cluster was thus precluded For a more detailed discussion of the dynamics of the ... just the result of the larger ionic radius of Cd(II) over Zn(II) and that the difference in amino acid sequence plays a role One of the most important aspects is the greater dynamics of the Cd(II)3-CysS9 ... structures of metallothioneins are not rigid and hence there is little selectivity concerning the size of the ion Thus, the affinity of the different metal ions in MTs is governed primarily by the thermodynamic...

Ngày tải lên: 16/02/2014, 15:20

... in the crystal, and a mixture of monomeric and dimeric forms in solution [18] Therefore, the available structural data suggest Fig Ribbon representation of the overall structure of hACMSD The ... as the amino acid numbers The alternative conformations of the Trp–Met couple can be observed; the arrows indicate the unidirectional movement of the two protein residues upon ligand binding The ... on the hACMSD crystals using the same beamline, clearly indicated the presence of a Zn metal ion bound to the enzyme Analysis of the diffraction data set allowed us to assign the crystal to the...

Ngày tải lên: 18/02/2014, 06:20

... ScPDC on the other hand involving the C-terminal part of the polypeptide chain (Fig 7) In the latter, differences in the conformation of the loop between Fig Stereo picture of the model of the a-carbanion/enamine ... in all of the tetrameric PDCs of known three-dimensional structure Binding of the cofactors ThDP and Mg2+ The homo-tetrameric IPDC binds four molecules of the cofactors ThDP and Mg2+ The ThDP ... catalytic residues The active site cavity in IPDC extends from the thiazolium ring of the cofactor to the surface of the protein The entrance of the active site cleft is covered by the C-terminal...

Ngày tải lên: 20/02/2014, 11:20

... for the N structure The G and TG structures were solved using the N structure as a search model, and the TG structure was used in phasing of the T structure The structures were refined using the ... typically increased the free R values by 0.1% Although the R and free R values of the four structures were in the range of the values of the published structures, those of the N and G structures were ... in the G and TG structures The electron density of l-glutamate became more pronounced upon the addition of Tris The location and orientation of l-glutamate were determined on the basis of the...

Ngày tải lên: 06/03/2014, 09:22

... a result, the structure of the complex is an average of the two half-sites Similarly, TL3 was bound in the active site of the 12X FIV PR with its C2 axis of symmetry coincident with the crystallographic ... K63I in the flap region, and L97T, I98P, Q99V, P100N, and L101I in the "90s loop" region The 2-fold axis of the 12X FIV protease dimer is vertical in the plane of the figure; the C2 axis of the bound ... regions of PR and the inhibitor However, there is an increase in packing contacts formed between the P1 phenyl group of TL-3 and residues in the "90s loop" of the chimeric PR which involve of the...

Ngày tải lên: 13/08/2014, 09:20

Ngày tải lên: 26/01/2015, 09:11

... in their homing position Each process blocked in the course of task execution relies on the other processes for removal of the barrier Essentially, the proof in question is a demonstration of the ... they are called the P-operation and the V-operation A process, "Q" say, that performs the operation " P (sem)" decreases the value of the semaphore called "sem" by If the resulting value of the ... the value of the semaphore called "sem" by If the resulting value of the semaphore concerned is positive, the V-operation in question has no further effect; if, however, the resulting value of...

Ngày tải lên: 12/09/2012, 15:05

... the deciduous effect of the respective parts of Z japonica The δ13C in the roots and rhizomes seems to be larger than the δ13C in the leaves and stems For the same species of seagrass, when the ... we think that the characteristics of the fatty acid structure in the leaves and stems differ from those of the roots and rhizomes because the content of the fatty acid 18:3n3 in the leaves and ... (LCFAs) These standards were used to obtain 56 kinds of fatty acids Therefore, the contents of each fatty acid were calculated based on the quantity of lipid, the content ratios of all the fatty...

Ngày tải lên: 05/09/2013, 10:17

... 1.6 Design of the Study The paper is designed in four chapters Chapter one: The introduction presents the rationale of the study, the aims of the study, scope of the study, methods of the study, ... most of the themes in the text belong to topical theme Of 33 clauses and clause complexes 27 have unmarked theme and have marked theme Using a proper noun at the beginning of the text, then the ... called Theme and Rheme The Theme served as the point of departure of the message (Halliday 1994:37), which in English coincides with the initial element(s) of the clause; and the Rheme is the remainder...

Ngày tải lên: 07/09/2013, 13:48

... n The n-period interest rate equals the average of the one-period interest rates expected to occur over the n-period life of the bond Expectations Theory • Explains why the term structure of ... over the life of the long-term bond • Buyers of bonds not prefer bonds of one maturity over another; they will not hold any quantity of a bond if its expected return is less than that of another ... Structure of Interest Rates • The risk structure of interest rates looks at bonds with the same term to maturity and different interest rates • The term structure of interest rates looks at the...

Ngày tải lên: 05/01/2014, 16:56

... for the operation of the Bank rests with a Board of Directors, which consists of fifteen members: • the governor (currently Mark Carney, who is the chief executive officer and chairman of the ... regulatory oversight of the national payments system, operated by the CPA • acts as the holder of deposit accounts of the federal government, the directly clearing members of the CPA, international ... the Board of Directors) • the senior deputy governor, • the deputy minister of finance, and • twelve outside directors Copyright  2011 15 - Formal Structure of the Bank of Canada II • The Board...

Ngày tải lên: 05/01/2014, 16:57

... system the precession of the orbit of Mercury and the bending of light by the Sun Over the ensuing decades theoretical analyses deepened the understanding of the theory and exhibited the richness ... radiation they emit in the last stages of their formation • The use of gravitational waves to probe the universe of complex astronomical phenomena by the decoding of the details of the gravitational ... EXPLORING THE STRUCTURE OF SPACE AND TIME of space and time The application of this new theory to predict the outcome of black hole evaporation and the nature of the big bang singularity • The continued...

Ngày tải lên: 12/02/2014, 16:20

... describing the state of being of the things under the observation of the astronauts in the new planet Most of the processes are in the simple past tense (25/36) They are used in the narrative portion The ... Subject The spaceship The planet They There The spaceship The two astronauts The woman It She We It Both of them They All plants and Animals They They Everything The man Nothing Something He I The ... What Table The Theme-Rheme Pattern of the Text Clause Textual Interpersonal Theme Topical Theme Theme Markedness of Theme I The spaceship unmarked II the planet unmarked III They unmarked There unmarked...

Ngày tải lên: 12/02/2014, 20:20

... (Leu104–Pro111) Indicative of the tightness of the fit, there are a large number (30) of atom-to-atom van der Waals’ contacts between the Tyr205 side chain and importin-a (Table 2) The numbers of contacts are ... competes for the importin-a binding site, reducing binding affinity for cargo proteins and helping to facilitate the release of the cargo within the nucleus [10,11] The removal of the autoinhibitory ... its location with the hydroxyl group reaching the importin-a main chain near the C-terminus of the ARM1 H3 helix Most of the hydrophobic contacts with importin-a residues lining the P4 pocket are...

Ngày tải lên: 14/02/2014, 19:20

... because the tertiary structure of ApeSOD has not been elucidated In the present study, for the first time, we describe the crystal structure of ApeSOD In particular, we focus on the coordination of the ... NE2 of His31, bound to the metal, in the company of a water oxygen, from the apical positions The manga˚ nese was only 0.06 A out of the equatorial plane (Table 3) The angles around the metal cofactor ... [26] These findings lead to the hypothesis that Fe-bound ApeSOD mimics the product-inhibited form and the shift of Tyr39 suppresses the release of the peroxide product This may be one of the reasons...

Ngày tải lên: 14/02/2014, 22:20

Ngày tải lên: 15/02/2014, 17:20

... take the use of the special structure of the Einstein equations one step further by deriving unexpected regularity properties of optical functions which are essential in the proof of the Main Theorem ... properties of the components of the Riemann curvature tensor Rαβγδ The remaining sections are occupied with the proof of the Asymptotics Theorem We give a detailed description of their content and the ... derivatives of the traceless part of χ A similar observation holds for another null component of the Hessian of the optical function, η The role of the Raychaudhuri equation is taken by the transport...

Ngày tải lên: 16/02/2014, 05:20

... molecules of the asymmetric unit of the wild-type structure Neither the mutation nor the different crystallization conditions evoked structural differences The crystal was grown in the presence of phytate, ... out of the catalytic pocket upon phytate binding Here, PhyK mimics the phytate-bound structure of AppA, even in the absence of sulfate ions The side chain of the corresponding Glu212 bends out of ... is the only direct contact between the protein backbone and the substrate The side chain of Thr292 is found to recognize the 2-phosphate in both the binding model of PhyK and the crystal structure...

Ngày tải lên: 16/02/2014, 09:20

... to the intensification of the sovereign debt crisis in the euro area The pricing of risk in the repo market has become more dependent on the geographic origin of both the counterparty and the ... Avenue avoids the problems of having to define ex ante the scope of activity to be separated or prohibited Against the backdrop of the ongoing financial crisis and the fragility of the financial ... entity by the funds of the deposit bank, and hence limit the liability of taxpayer and the deposit insurance system; 3) avoid the excessive allocation of lending from the deposit bank to other financial...

Ngày tải lên: 16/02/2014, 10:20

... mechanism of transphosphorylation, which implies the A Fig Stereo diagram of the active center of HtA (A) Superposition of the active-site residues of the 20 conformers of the solution structure of ... with the other charged groups In the NMR structures, this side ˚ chain of D40 is a short distance (£ A) from the side chains of H42 and R95 Finally, the aromatic ring of F126, placed close to the ... superposition of the active site of RNase T1, a-sarcin and HtA is shown in Fig 3B It is known that other side chains in the vicinity of these amino acids are also important for the activity Given the 3D structure...

Ngày tải lên: 18/02/2014, 08:20