3  coloring the scroll bar in ie

... FX, indicating that substrate subsites located in the vicinity of the active site and sensed by the peptidyl substrate are inuenced, in contrast to the remote exosites, e.g in the vicinity of the ... conned to the substrate binding cleft (the 170 loop) in the active site region and the S1 pocket, whereas the intramolecular connections, for instance between the TF-binding region and the active ... created by mutating the side chain in FVIIa taken from the FVIIaặTF structure [9] (Protein Data Bank accession number 1dan) using the mutation facility within the protein modeling module in Quanta...

Ngày tải lên: 18/02/2014, 08:20

... in the biosynthesis of natural polyamines (putrescine, spermidine and spermine) through conversion of l-arginine into l-ornithine [16] The latter is in turn used by ODC to produce putrescine, the ... stimulates the ArgII gene in an IFNindependent manner ArgII is a mitochondrial enzyme involved in the polyamine synthesis pathway through the catalysis of l-ornithine production from l-arginine Of the ... for converting l-arginine into l-ornithine and urea, a critical step in the polyamine biosynthesis pathway Subcellular localization of the two isoforms differs, with ArgI located in the cytoplasm...

Ngày tải lên: 07/03/2014, 21:20

... activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway Circ Res 85, 394–402 20 Subbaramaiah K, Lin DT, ... but not in other species is currently unknown, there is increasing evidence that they are physiologically distinct displaying differences in their basic mechanisms of intracellular signalling, modes ... largely independent of 15d-PGJ2 stimulation Examination of PPARc ⁄ RXRa interactions within the PPRE To further investigate the identity and specificity of the DNA ⁄ protein interactions within the...

Ngày tải lên: 07/03/2014, 21:20

... LBD Amino acids 3–36 in the NTD (AR3)36), including the 23 FxxLF27 motif, play a pivotal role in N/C interaction [15,20] Here we studied the function of the AR3)36 subdomain AR3)13 in N/C interaction ... and the role of individual amino acid residues in and flanking the 23 FQNLF27motif in AR16)36 in N/C interaction Yeast protein interaction assays indicated that AR3)13 contributed to the ligand-induced ... amino acids by arginine residues, resulting in GalAD-AR.NTD30/33RR These substitutions might cause steric hindrance in the interaction with the AR LBD surface, change the charge and disrupt the...

Ngày tải lên: 17/03/2014, 10:20

... arginine residues in proteins [18,19] when tested could not inactivate the enzyme indicting that this amino acid is not critically involved in the catalytic activity of EAC cell Gra3P DH Therefore, ... properties Therefore, in this paper we investigated the amino-acid residue(s) that are critically involved at the active site of the EAC cell enzyme and whether there is any difference between the ... to rapid loss of the enzyme activity of the control sample It was observed that for the EAC cell enzyme, the rate of inactivation was increased with the increase in pH of the incubation medium...

Ngày tải lên: 24/03/2014, 04:21

... often in these cases, the need to remove these sequences to obtain full activation is explained by the role of C-terminal determinants in allowing proper secretion, correct folding or targeting ... true inhibitory properties are solely ascribed to N-terminal domains, thus rendering intriguing the possibility that PC1 ⁄ CT-peptide might by itself possess intrinsic inhibiting properties Production ... been shown that the cysteine-rich domain of PC5 ⁄ 6A was responsible for membrane tethering, thus insuring cell-surface anchoring [37] In other cases, the CT-peptide contains integral transmembrane...

Ngày tải lên: 30/03/2014, 08:20

... proteins, including a 36 kDa protein (arrow), in the cytoskeletal fraction 11) Again these data support the view that complex formation is due to binding of a protein to the 3¢UTR implicated in ... and increasing amounts of unlabelled MW prior to cross-linking As shown in Fig 2(A), increasing amounts of unlabelled MW reduced the binding of RNA to the 36 kDa protein such that binding was reduced ... mRNA the localization signal lies in an 86-nucleotide region within the 3¢UTR and is abrogated by a mutation in a conserved AUUUA [11] The RNA-binding protein(s) involved in this retention of the...

Ngày tải lên: 30/03/2014, 15:20

... that during the contact time of 14 hours used in the study, the microorganisms have either incorporated the pharmaceuticals into the organic matter content of the soil or have degraded the pharmaceuticals ... tetracyclines from the dust found in an animal confinement shelter; however, the recoveries were not reported.3 Information on recoveries would have been interesting because the concentration in dust ... comparable to the recoveries obtained using PLE (78 to 79%) and MAE (81 to 82%) On the other hand, the recoveries of 4-nonylphenol and bisphenol A were disappointing and were lower than the recoveries...

Ngày tải lên: 18/06/2014, 16:20

... health at the district level in these districts [5] Increasing the proportion of healthcare providers who are PNS has the effect of increasing the cost of salaries and benefits (including their own ... productivity in West Java Province, Indonesia Unpublished] and the performance of the sector is inadequate [7] In addition, the quality of care in Indonesia is low [8-10] Merely increasing the total ... Methods The work was carried out in mid-2009 The methods were the same as used earlier and are described in detail in [1] and [2] The information was collected in each district where the primary...

Ngày tải lên: 18/06/2014, 17:20

... individual in 11 aspects of life mapped to domains and sub-domains of the ICF: mobility within the home, mobility outside the home, self-care, looking after belongings, looking after the home, looking ... and age for the remaining nine aspects of life Persistence was greater in women than men for four aspects of life (looking after the home, looking after belongings, interpersonal interaction, ... older ages combined with the age-related increase in the 3-year onset underlines the cumulative problem of participation restriction as people become older – exemplified by the declining likelihood...

Ngày tải lên: 18/06/2014, 19:20

Ngày tải lên: 01/07/2014, 20:20

... vegetable garden in the tropics Figure 7: Hoeing and spading 5.5 Preparing the beds The beds are the parts of the garden where the crops themselves are grown The division of the garden into beds makes ... these They are found in the soil as mineral salts and in humus The gardener must improve the soil in his or her garden by adding nutrient elements to replace the elements lost by harvesting the ... Work the compost into the soil in the same way as manure Composting has the advantage that plant and human diseases are killed by the high temperatures during the composting Agrodok describes in...

Ngày tải lên: 02/07/2014, 05:20

... they just briefly mention it as a note in their article when referring to a small area in one of the images The investigators focused in their work on the bulk structures and their reduction The ... using EDS in STEM mode Line scans were collected starting in the vacuum outside the edge of the crystal and then gradually moving in onto the bulkier parts of the material By using this technique, ... figure) the corresponding catalyst after ageing in an industrial reactor from the edge of the analysed crystal For the unused catalyst the Mo/Fe ratio is the highest at the edge, where the ratio...

Ngày tải lên: 11/07/2014, 18:09

... in D against the natural order, else according to the natural order ¯ All the remaining arcs orient in D in the same way as in D ¯ Note that relevant edges are oriented in the same way in both ... m odd the following: let n(xyz) be the number of arcs wxab , a ≤ y odd and z ≤ b ≤ (z + 1), oriented in D against the natural ¯ ordering If n(xyz) odd then we orient wxyz in D against the natural ... pairwise disjoint and for y = 2, , m − the curves representing the edges of Wxy intersect the curves representing the edges of Wx(y−1) and Wx(y+1) We again keep the rule that the interiors of the curves...

Ngày tải lên: 07/08/2014, 06:23

... far = Bearing in mind the importance of the relations studied and the excellent quality of the results obtained in this study, it would be interesting to continue the sampling and studies with ... in the coefficients of variation after the age of 12 months In older trees, the coefficients of variation remained relatively constant irrespective of the age of the clones, confirming that the ... at intervals of m, starting at the base of the tree Wood basic density determinations were carried out in the Department of Forest Science of Escola Superior de Agricultura de Lavras, using the...

Ngày tải lên: 08/08/2014, 19:21

... pinaster and P radiata coincides with the spring and lasts during the whole of end of (Vega, 1977) However, the availability of the seed for germination is not the same in all the species, either ... and more In this study, we intend to analyze the behaviour of species, Pinus pinaster, Pinus radiata and Pinus sylvestris, during germination, in relation to fire and to try to integrate the results ... that the pyrophyte character of these species is not due to the high temperatures directly favouring the germination of their seeds, but due to other circumstances such as the opening of the pinecones...

Ngày tải lên: 08/08/2014, 19:21

... expression can be induced by cytokines in human endothelial cells [13,14] The lung is the organ most frequently involved in WG, and in some cases it is the only organ affected [15] Given the potential ... issue the WG specimens have in common is the upregulation of PR-3 throughout the whole specimen The upregulation of PR-3 in the lung of WG patients may therefore reflect the selected organ injury, ... tubular epithelial cells and glomerular epithelial cells of the kidney [25] In vivo experiments in the kidney revealed a PR-3 expression in distal tubular epithelial cells and in the glomerulum The...

Ngày tải lên: 09/08/2014, 03:24

... ensured by the choice of the axial velocity of the co-moving frame Neglecting the torsion, the obtained flow is therefore similar to the one studied previously Indeed, the normal to the osculating plane ... constrain the motion to be horizontal The motion tends to be uniform in the vertical in the presence of rotation effects but not in the presence of stratification In some cases the shallowness of the ... its (negative) minimum In a rotating frame, Sipp and Jacquin [48] further extended the generalized Rayleigh criterion (2.4) for general closed streamlines by including rotation in the framework...

Ngày tải lên: 09/08/2014, 11:21

... it should rather be called an enquiry into the laws which determine the division of the produce of industry among the classes who concur in its formulation” (in Rothbard 1995b, 82) The difference ... restricted by the law of diminishing returns? Here again, history has not supported Malthus The law of diminishing returns only applies if we assume “all other things equal,” that technology and the quantity ... quantity of other resources are fixed But no input is fixed in the long run—neither land, nor labor, nor capital The economic importance of land has in fact dwindled in the modern world, due to intensive...

Ngày tải lên: 09/08/2014, 20:20

... public Point origin= new Point(); public Point ending = new Point(); } class lineApp { public static void Main() { Line line1 = new Line(); Line line2 = new Line(); // set line origin Line.origin.x ... from the Line class containing an origin point, only one origin point is shared by all instances of Line ANALYSIS Line 18 is the beginning of the Main routine Lines 20–21 declare two Line objects, ... instantiated Lines 37–44 print the origin point and the ending point for line1 and line2 Again, notice that the class name is used to print the origin values, not the object name Lines 47–48 change the...

Ngày tải lên: 13/08/2014, 08:20