... profiles Historically, inappropriate pharmacological properties have been one of the primary reasons for the failure of drug candidates in the later stages of drug development Thus tools for predicting ... summarizes the performance of several regression-based SLMs for predicting pharmaceutical agents of specific pharmacokinetic, pharmacodynamic or toxicological property The performances of these studies ... stages are desirable for fast elimination of agents with undesirable properties so that development efforts can be focused on the most promising candidates As part of the efforts for developing such...
Ngày tải lên: 14/09/2015, 12:43
... criteria Of course, a new strategy is required to prevent the progression of the disease The difficulty in predicting the prognosis of ALF is mainly attributable to incomplete elucidation of its ... recent reports of over-activation of macrophages in the liver, which is believed to cause hepatic hypoxia as a result of disturbance of the microcirculation [9-12] Although the importance of over-activation ... efficacy of the MELD score for ALF, the cut-off line was set between 30 and 35 As shown in Table 3, the MELD score from the first day data showed a high specificity of 88.24%, but a low sensitivity of...
Ngày tải lên: 13/08/2014, 13:20
(SPE78168MS) New Model for Predicting the Rate of Sand Production
... approach between predicting the onset of sanding and its severity once it occurs The following formulation has been used for the onset of sanding calculations; i.e the calculation of the critical ... a formation element next to a circular hole The hole could be the wellbore (for open hole completion) or a perforation (for cased hole completion) The orientation of the wellbore or the perforation ... Relation of Effective Formation Strength, U, to Measured Strength In the sanding models employed by BP, the collapse pressure of a so-called thick-walled cylinder test NEW MODEL FOR PREDICTING...
Ngày tải lên: 26/09/2016, 11:43
Tài liệu Environmental Technology Series-Part 2: Approaches for Consideration in Formualating Environmental Control Strategies pptx
Ngày tải lên: 12/02/2014, 15:20
Research Gaps and Measurement Challenges for Studying the Influence of New Media on Adolescent Sexual Health docx
... the same sort of efforts made offline Important aspects of new media that may alter the experience of social interaction and the distribution of information are that (1) its use affords psychological ... inadequate for understanding the effects of new media because they not capture the interactive and dynamic aspects of new media Our measures of new media use tend to provide a single snapshot of media ... Administration for Children and Families (ACF) and the Office of the Assistant Secretary for Planning and Evaluation (ASPE) within the U.S Department of Health and Human Services The goal of the task...
Ngày tải lên: 30/03/2014, 05:20
Working for independence The failure of New Deal politics in a rural industrial place
... Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited ... without permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited ... without permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited...
Ngày tải lên: 03/06/2014, 02:24
Báo cáo khoa học: "Equipment review: The success of early goal-directed therapy for septic shock prompts evaluation of current approaches for monitoring the adequacy of resuscitation" potx
... measurement of ScvO2 Whether measurements of ScvO2 are a reasonable surrogate for measurements of SvO2 is controversial Although the absolute values of ScvO2 are almost always higher than values for ... consequence of the stoichiometry of the reactions responsible for the substrate level phosphorylation of ADP to form ATP, anaerobiosis is inevitably associated with the net accumulation of protons ... critically ill patients Unfortunately, the notion of using tonometric estimates of gastrointestinal mucosal pH for monitoring perfusion is predicated on a number of assumptions, some of which may be partially...
Ngày tải lên: 12/08/2014, 22:22
An investigation into the usefulness of the techniques for guessing the meaning of new words through context for the 11th form students at Phuc Thanh High Schoo
... usefulness of the techniques for guessing the meaning of new words through context for 11th form students at Phuc Thanh High School 2 Aims and Objectives of the study Within a framework of a minor ... aimed at improving the proficiency of vocabulary and reading comprehension for the 11th form students through developing the students' techniques for guessing the meaning of new words through context ... purpose of this study was to investigate the usefulness of developing students' techniques for guessing the meaning of unknown words through context on improvement of their proficiency of vocabulary...
Ngày tải lên: 28/03/2015, 09:40
skkn SOME TECHNIQUES FOR GUESSING THE MEANING OF NEW WORDS
... for guessing the meaning of new words are put forward In order to help students have no difficulty in their reading comprehension, it is required that a teacher be aware of the significance of ... techniques for guessing the meaning of new words in an effective way Presented by Phan Van Hoa from Nguyen Dinh Chieu High School-Long Thanh District SOME TECHNIQUES FOR GUESSING THE MEANING OF NEW ... High School-Long Thanh District SOME TECHNIQUES FOR GUESSING THE MEANING OF NEW WORDS games and various forms of entertainment Tet is really a time of fun and festivals throughout the country Task...
Ngày tải lên: 14/08/2016, 02:32
(SPE 156394) A Numerical Model for Predicting the Rate of Sand Production in Injector Wells
... tension cut-off = initial yield tension cut-off = peak tension cut-off = residual tension cut-off = tension cut-off at HECS = tension cut-off at LECS T= square root of the second invariant of the ... Law of Conservation of Mass, the rate of the change of porosity is related to the rate of generated sand mass by the equation (Detournay et al., 2006): (6) where is the boundary surface area of ... cut-off is approximately constant both for the low and high effective confining stresses ( and ) Additional deformation after the peak results in the softening of the material and shrinkage of...
Ngày tải lên: 26/09/2016, 11:03
5 2 2 a day in the life of peter and eve
... Parsippany, New Jersey • New York, New York Sales Offices: Needham, Massachusetts • Duluth, Georgia • Glenview, Illinois Coppell, Texas • Ontario, California • Mesa, Arizona Every effort has been ... felt sorry for her Eve was too young to remember what life was like before the war It was a war that seemed to go on endlessly Last night, enemy bombers had flown right over the roof of their house ... transmission in any form by any means, electronic, mechanical, photocopying, recording, or likewise For information regarding permission(s), write to: Permissions Department, Scott Foresman, 1900...
Ngày tải lên: 11/02/2017, 08:54
5 2 2 a day in the life of peter and eve TG
... Possible response: The author’s purpose was to inform of the struggles of life in Nazi Germany left Germany; got a visa; disappeared; entered England a type of message or communication Answers will vary ... reader about life in Nazi Germany through the actions or words of that character RESPONSE OPTIONS WRITING Have students write a new ending to the story in which Peter presents the jar of apple butter ... purpose for writing—to persuade, inform, entertain, or express a mood or feeling Have students ask themselves: Why did the author write this story? (Possible response: to give an idea of what life...
Ngày tải lên: 11/02/2017, 09:20
5 2 2 a day in the life of peter and eve
... Parsippany, New Jersey • New York, New York Sales Offices: Needham, Massachusetts • Duluth, Georgia • Glenview, Illinois Coppell, Texas • Ontario, California • Mesa, Arizona Every effort has been ... felt sorry for her Eve was too young to remember what life was like before the war It was a war that seemed to go on endlessly Last night, enemy bombers had flown right over the roof of their house ... transmission in any form by any means, electronic, mechanical, photocopying, recording, or likewise For information regarding permission(s), write to: Permissions Department, Scott Foresman, 1900...
Ngày tải lên: 18/04/2017, 15:40
5 2 2 a day in the life of peter and eve TG
... Possible response: The author’s purpose was to inform of the struggles of life in Nazi Germany left Germany; got a visa; disappeared; entered England a type of message or communication Answers will vary ... reader about life in Nazi Germany through the actions or words of that character RESPONSE OPTIONS WRITING Have students write a new ending to the story in which Peter presents the jar of apple butter ... purpose for writing—to persuade, inform, entertain, or express a mood or feeling Have students ask themselves: Why did the author write this story? (Possible response: to give an idea of what life...
Ngày tải lên: 18/04/2017, 15:49
Báo cáo hóa học: " HPV vaccine: an overview of immune response, clinical protection, and new approaches for the future" pdf
... Authors information LM is in charge of HPV research at The Dept of Gynaecologic Oncology National Cancer Institute Regina Elena of Rome [Italy]; AV is the acting Chief of the Laboratory of Virology ... induction of the immune memory should be assessed by means of Page of evaluating immune responses to additional doses of vaccine administered at planned intervals following completion of the primary ... long-term impact of vaccines Indeed, papillomaviruses are an ideal model system for studying the DNA virus evolution From our understanding of phylogenetic studies, the root of the evolution of HPV types...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo hóa học: " Research Article A New General Iterative Method for a Finite Family of Nonexpansive Mappings in Hilbert Spaces Urailuk Singthong1 and Suthep Suantai1, 2" potx
... Kangtunyakarn and Suantai introduced a new mapping, called Kmapping, for finding a common fixed point of a finite family of nonexpansive mappings For a finite family of nonexpansive mappings {Ti }N1 and ... family of nonexpansive mappings with F : i n F Ti / ∅ There are many authors introduced iterative method for finding an element of F which is an optimal point for the minimization problem For n ... is identity mapping of H Lemma 1.7 see Let C be a nonempty closed convex subset of a strictly convex Banach space Let {Ti }N1 be a finite family of nonexpansive mappings of C into itself with...
Ngày tải lên: 21/06/2014, 11:20
Báo cáo toán học: "Combinatorial Approaches and Conjectures for 2-Divisibility Problems Concerning Domino Tilings of Polyominoes" pptx
... interchangeably For an arbitrary region R, we will use the notation # R for the number of domino tilings of R For example, # = We will use the notation #2 R for the parity of the number of domino tilings of ... removal of forced dominoes (for a definition and extensive discussion of Aztec diamonds see [3] ) If n is even we see that (14) reduces to the formula for the number of domino tilings of the Aztec ... combinatorial proofs for the formulas in Problem 1for n ≤ Unfortunately, the difficulty in establishing recurrences for N (n, m) combinatorially probably precludes the general applicability of the above...
Ngày tải lên: 07/08/2014, 06:22
DEVELOPMENT AND APPLICATION OF NEW APPROACHES FOR STUDIES OF INFLUENZA INDUCED INFLAMMATION AND DNA DAMAGE
... study forms a framework for future investigation of the clinical significance of DNA damage, not just for influenza infections, but also in the context of other acute infectious diseases, for which ... was performed based on previous publication [25] Plaque forming units (PFU) were normalized to protein concentration of lung homogenate estimated with a Bradford assay (for more details of plaque ... proteins at the site of DNA strand breaks [13, 14] Phosphorylation of H2AX histones at Ser-139 (cH2AX) is a well-studied example of chromatin modification that occurs following formation of DNA double-strand...
Ngày tải lên: 09/09/2015, 08:16
DEVELOPMENT AND APPLICATION OF NEW APPROACHES FOR STUDIES OF INFLUENZA INDUCED INFLAMMATION AND DNA DAMAGE
... to my supervisors Professor Bevin Engelward and Professor Vincent Chow, for offering me the opportunity to be a part of their labs, for their intellectual and moral support, for their inspiration ... change in the conformation of HA trimer, allowing HA2 (a subunit of HA) to facilitate fusion of the viral and endosomal membranes, leading to the formation of a pore which gives passage for vRNP complexes ... .42 Cell cultures .43 List of antibodies for western blot and immunofluorescence .44 List of antibodies for flow cytometry 45 Source of influenza viruses .45 pHLIP...
Ngày tải lên: 30/09/2015, 06:20