1824 1825 and the repeal of the bubble act
Tài liệu Báo cáo khoa học: Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR) doc
... much simpler ether strands These ether strands mimic the distance between the nucleobase and the diphospho-bridge, but on the other hand likely are involved in polar interactions with the cADPR receptor ... function of cADPR (ADPRC) and thereby induce the formation of cADPR (Fig 2) G-protein coupling and Tyr phosphorylation have been implicated in ADPRC activation [17,18] The enzymes responsible for the ... types and cADPR acts on the type and ⁄ or type RyR This interaction was initially demonstrated by the sensitivity of cADPR-mediated Ca2+ release to pharmacological inhibitors of RyR, such as ruthenium...
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Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx
... switch and alters the expression of the two nuclear genome coded isoforms of CytOX V [10,32] The regulation of genes CytOX5a and CytOX5b, coding for the two isofoms Va and Vb, parallels that of genes ... shows the effects of hypoxia on the steady state levels of nuclear genome encoded CytOX IV and Vb mRNAs There was no change in the levels of these mRNAs in macrophages at h of hypoxia, the time ... succinylacetone and CoCl2 are known inhibitors of heme biosynthesis, these agents also elicit nonspecific and toxic effects in animals To ascertain that the effects of these agents, on the catalytic activity...
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NATIONAL REPORT OF MALAYSIA ON THE FORMULATION OF A TRANSBOUNDARY DIAGNOSTIC ANALYSIS AND PRELIMINARY FRAMEWORK OF A STRATEGIC ACTION PROGRAMME FOR THE BAY OF BENGAL potx
... information on the use of, and threats to, the Malaysian coastal and marine resources off the Straits of Malacca and the adjacent waters of the Andaman Sea and the Indian Ocean In the process, an attempt ... TAI The Straits of Singapore The Straits of Singapore The Straits of Malacca The Straits of Singapore The Straits of Singapore The Straits of Malacca The South China Sea The South China Sea The ... trawlers and purse-seiners landed the most, about 79% of the total catch One of the main problems in the West Coast fishery is the encroachment of trawlers into the coastal fishing grounds of traditional...
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Báo cáo khoa học: Expression level and agonist-binding affect the turnover, ubiquitination and complex formation of peroxisome proliferator activated receptor b pptx
... Agonist and protein level influence the degree of high Mr complex formation To investigate the nature of the high Mr PPARb complexes, we analyzed the effects of PPARb protein concentration and binding ... reduction on the coprecipitation of PPARb by the FLAG-specific M2 antibody Quantitation of the data showed a coprecipitation of PPARb of 98% relative to FLAG-PPARb after transfection of lg of plasmid ... may be of particular importance in view of the fact that, unlike steroid hormone receptors, PPARs not require the interaction with a specific ligand for transcriptional activity [37,38] and figure...
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Báo cáo y học: "Influence of enrollment sequence effect on observed outcomes in the ADDRESS and PROWESS studies of drotrecogin alfa (activated) in patients with severe sepsis" pptx
... report the results of these analyses and additional exploratory analyses of both the PROWESS and ADDRESS databases We discuss the results of these analyses in the context of their implication on the ... the conception and design of the study, in the development and conduct of analyses, and in the clinical trials and data collection WLM, JJ, and DRN participated in the conception and design of ... Nevertheless, such findings not alter the overall conclusions of these studies The exact cause of the 'enrollment sequence' remains uncer- Table Potential recommendations to assist in the design of...
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DISTRIBUTION OF THE LASER INTENSITY AND THE FORCE ACTING ON DIELECTRIC NANO PARTICLE IN THE 3d OPTICAL TRAP USING COUNTER PROPAGATING PULSED LASER BEAMS
... w0 is the spot radius of the beam waist at the plane z = 0, ρ is the radial coordinate, x is the unit vector of the polarization along the x direction, k = 2π λ is the wave number, ω0 is the carrier ... distributed and depends on beam waist, firstly But, the magnitude of optical force and the stable region depend on many principle parameters as radius of particle, refractive index of particle and of ... = 3/2 Here n2 is the refractive index of the surrounding n2 cw0 (π) τ medium From the definition of the Pointing vector, we can readily obtain the intensity distribution for the left PGB as follows:...
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Cytophysiologic effects and molecular inhibition of a functional actin specific ADP ribosyltransferase CDT from clostridium difficile 5
... Biochemical characterization of the L-plastin-actin interaction shows a resemblance with that of alpha-actinin and allows a distinction to be made between the two actin-binding domains of the molecule ... selective activation of p38 MAP kinase isoforms Embo J 19, 1301-1311 Estes, J E., Selden, L A., and Gershman, L C (1981) Mechanism of action of phalloidin on the polymerization of muscle actin Biochemistry ... J Bacteriol 181, 6929-6936 Collier, R J (1967) Effect of diphtheria toxin on protein synthesis: inactivation of one of the transfer factors J Mol Biol 25, 83-98 Cooper, J A (1987) Effects of...
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Cytophysiologic effects and molecular inhibition of a functional actin specific ADP ribosyltransferase CDT from clostridium difficile 4
... with the AO1, NO1 and NO2 atoms of NAD phosphate and H-bond formation between the OE1 of Glu380 and NO2 of the ribose ring in order to form a highly folded compact ring-like conformation of the ... the F-actin-tropomyosin complex (Kabsch and Vandekerckhove, 1992) These contact sites outline two distinct parallel actin regions comprising the acto-tropomyosin interface in the activated and ... (S1) in the rigor state binds to the peripheral face of actin subdomain with a slight extension between the S1 interface and outer domain of the adjacent long-pitch monomer These interaction sites...
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Cytophysiologic effects and molecular inhibition of a functional actin specific ADP ribosyltransferase CDT from clostridium difficile 3
... NAD-binding cleft on the solvent exposed loop (connecting strand β13 and β14), where it could act in the deprotonation of actin Arg177 to increase its nucleophilicity for attach of the C1’ of the oxocarbenium ... Schematic illustration of the mechanism involved in ADP-ribosylation of actin showing the function of VIP2 residues Glu426 and Glu428, and the hydrophobic pocket composed of important residues ... green and TRITC labeling, denoting complementarity of G- plus F-actin levels to total actin However, the slightly higher total actin may be attributed to the presence of actin complexes with actin...
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Cytophysiologic effects and molecular inhibition of a functional actin specific ADP ribosyltransferase CDT from clostridium difficile 2
... numerically below the arrows they have been classified into four groups based on the type of substrate they act on The first group includes the diphtheria toxin (DT) of Corynebacterium diphtheriae (van ... cells, actin was classified into major groups namely: the skeletal muscle α-actin, cardiac muscle α-actin, smooth muscle and γ-actin, and cytoplasmic β- and γ-actin, which comprise the isoforms ... complement and thus move into the unbound fraction of the hybridization mixture The application of high temperature minimized capping and amplification of low Tm fragments A total of rounds of denaturation,...
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Cytophysiologic effects and molecular inhibition of a functional actin specific ADP ribosyltransferase CDT from clostridium difficile 1
... generated on the extent of actin interaction sites and different modes of inhibition of CDTa actions provided fresh evidences in support of the designation of actin interface domains with actin binding ... MAPK-ATF2 but not the MEK2-ERK1/2-AKTStat3 route In addition, activation of caspase-3 and inability of CDT to mediate phosphoinactivation of BAD (Bcl-activated death promoter) is suggestive of CDT’s commitment ... moiety onto Gactin to cause disruption of the microfilament structure and cell rounding Cytometric quantitation of G:F-actin ratio by binary CDT (CDTa and CDTb) with or without established actin modifiers...
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Cambridge.University.Press.Allegories.of.Union.in.Irish.and.English.Writing.1790-1870.Politics.History.and.the.Family.from.Edgeworth.to.Arnold.Oct.2000.pdf
... suspicious – not of the fact of conquest the poem describes, but of the sexualized and gendered binary it superimposes on the colonial relation, and of its attendant use of rape as a metaphor of imperial ... child of Union punishes its mother from within and threatens its father, too, ‘‘across the water’’ () The ‘‘legacy’’ () of force and violence, the poem suggests, is more of the same: the crossing ... allegorical lyric, ‘ Act of Union’’ (), the coupling of England and Ireland issues in the conception of ‘‘an obstinate fifth column,’’ ‘ the heaving province’’ of Ulster.¹ Identifying the masculine...
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Cambridge.University.Press.Gender.Race.and.the.Writing.of.Empire.Public.Discourse.and.the.Boer.War.Sep.1999.pdf
... the food stocks, and the mood of the garrison The tactics of the Daily Mail captured the attention of the nation; the newspaper dramatized the situation of the town by emphasizing the danger that ... examine both the role of the press in the formation of public opinion about imperialism and the role of the press in the formation of the concept of public opinion itself Mafeking Night marks the powerful ... powerful beginning of the New Journalism at the same time as it marks the beginning of the end of the New Imperialism The coincidence of these occasions arises from the nature of the South African...
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Cambridge.University.Press.Globalisation.and.the.Western.Legal.Tradition.Recurring.Patterns.of.Law.and.Authority.Mar.2008.pdf
... humanity, with the spread of the Gregorian calendar and the heliocentric idea of the world The ‘incipient phase’ began in the mid-eighteenth century and ended in the 1870s The concept of the unitary ... and the proper domain of the United Nations Many commentators write of the decline of the nation-state, in the face of the transference of national sovereignty to such structures as the UN, the ... the rise of the state 6.1 The birth of the state 6.2 Legal diversity and universality in the emerging European states 6.3 The decline of the Christian commonwealth 6.4 The arrival of the state...
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Cambridge.University.Press.The.Crisis.of.Literature.in.the.1790s.Print.Culture.and.the.Public.Sphere.Nov.1999.pdf
... conservative propaganda, and with the break up of the radical associations and the consequent erosion of the links between these organisations and other intellectual currents and circles, the conditions ... by enlightening the understanding, and uniting the sentiments and views of men and of nations, forms a concert of wills, and a concurrence of action too powerful for the armies of tyrants’ (2 ... about the role of literature and the status of the author; the second shifts its focus to the debates about working-class activists, radical women authors and the Orientalists and examines the...
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Cambridge.University.Press.The.Works.of.Archimedes.Volume.1.The.Two.Books.On.the.Sphere.and.the.Cylinder.Translation.and.Commentary.May.2004.pdf
... See the following note on purpose and practices of the critical edition of diagrams 2.3 Purpose and practices of the critical edition of diagrams The main purpose of the critical edition of diagrams ... the same base as the segment and an equal height.3 Later, theorems worthy of mention suggested themselves to us, and we took the trouble of preparing their proofs They are these: first, that the ... the center of the sphere, I call the figure internally contained by the surface of the cone, and by the surface of the sphere inside the cone, a “solid sector.” /6/ And when two cones having the...
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Cambridge.University.Press.War.and.the.Law.of.Nations.A.General.History.Sep.2005.pdf
... of individual, hand-to-hand combat Grand strategy, on the other hand, remained the preserve of Tiw.11 In India, too, much the same phenomenon was apparent in the role of Indra, the chief of the ... authors, the patience of readers and the economics of the publishing industry conspire to keep this account at the level of grand theme or contour rather than of exacting detail It is therefore ... testimony both to the warlike character of the Greeks and to their feeling of cultural unity, the cities of the Amphictyonic League of Delphi agreed that, in the event of war, the combatant states...
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Circuit theory of finance and the role of incentives in financial sector reform
... creating and advancing liquidity to producers; along the circuit, the financial system governs the supply and demand of funds and, at the end of the process, it determines the condition for the closure ... institutions and strengthen the complementarity between the formal and the informal sectors The poorest people of rural and urban societies live beyond the frontier of formal finance, or outside the formal ... firms negotiate with their bankers the terms and conditions of credit access, they and the bankers determine the total level of resource employment for the given technology of production Since...
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