12 stem cells in the lung

... remained in the circulation, showing a times enrichment of Lin- PCs in the pneumonia lungs Few of these Lin- PCs migrated into the airspaces (approximately 3.1% of all the cells remaining in the lung) , ... sequestered (2 hours) in the lung while the Lin- PCs were preferentially retained (24 hours) there during pneumococcal pneumonia Furthermore, these progenitor cells also remained in the lung tissues and ... damaged lung regions remain constant (as shown in the BM homing study by Szilvassy and colleagues [38]), increasing the number of infused progenitor cells will increase the number of these cells...

Ngày tải lên: 12/08/2014, 15:21

... T cells in vivo [38] The upregulation of IL-10 is in line with the induction of Tregs in vitro and in vivo in our study Moreover, in our experiments we did not find UC-MSCs in the joint of the ... proinflammatory cytokine IL-6 Interestingly, the UC-MSCs could downregulate the IL-6 production in the transwell but not the cell-to-cell contact system (Figure 3c) both in single time point and in dynamic ... separated in the transwell system or cocultured in the cell-to-cell contact system in 24-well plates After 72 hours, IL-6 in culture supernatants was determined IL-6 production was inhibited in the...

Ngày tải lên: 12/08/2014, 15:22

... into an oocyte or fused with an ES cell, the underlying mechanisms remain obscure Using the ES fusion system, Smith has found an unexpected role for the homeodomain-containing protein Nanog in ... by our inability to derive rat ES cells Shinohara hinted that he was making progress in applying his findings to the rat Finally, Tariq Enver (University of Oxford, UK) described a mathematical ... germ cells and ES cells is their epigenetic imprint status Shinohara reported that while the spermatagonial cells retain a stable androgenic imprint over long-term culture, the pluripotent cells...

Ngày tải lên: 14/08/2014, 16:21

... Rusch V, Sobin L, International Association for the Study of Lung Cancer International Staging Committee; Participating Institutions: The IASLC Lung Cancer Staging Project: Proposals for the revision ... Representative proteins up-regulated in LCNEC were AL1A1, AK1C1, AK1C3, brain-type fatty acid-binding protein (FABP) and b-enolase On the other hand, those in SCLC were brain acid soluble protein (BASP), ... those in SCLC in the region (y>3.84, z>3.84) on the y-z plane and those in LCC in the region (x>3.84, y>3.84) Nomura et al Journal of Clinical Bioinformatics 2011, 1:23 http://www.jclinbioinformatics.com/content/1/1/23...

Ngày tải lên: 10/08/2014, 09:22

... from a human pancreatic cell line in vitro and in vivo Mol Endocrinol 15, 476 - 483 Dzierzak, E et al (1998); Embryonic beginnings of definitive hematopoietic stem cells Ann N Y Acad Sci 872, 256 ... (1998); Embryonic stem cells lines derived from human blastocysts Science 282, 1145 - 1147 12 Raisman, G., (2001); Olfactory ensheathing cells - another miracle cure for spinal cord injury? Nat Rev ... circulating human embryonic blood stem cells Blood 96, 1740 - 1747 IItskovitz - Eldor, J and et al (2000).; Differentiation of human embryonic stem cells into embryoid bodies comprising the three...

Ngày tải lên: 02/04/2014, 22:20

... sections were incubated for 30 minutes at room temperature in streptavidin–peroxidase complex (1:500 in DPBS; Dako), rinsed in distilled water and incubated in fast-DAB (3,3'-diaminobenzidine) peroxidase ... stem cells, and although they stained poorly for STRO-1 and for LNGFR, the expression of these markers on bone marrow-derived stem cells is reported to decline with culture [22-25] In preliminary ... conditions therefore be possible that the IPFP cells isolated were derived from those staining with 3G5 in the tissue, but that in culture 3G5 was expressed on only few cells at any one time The IPFP cells...

Ngày tải lên: 09/08/2014, 10:20

... staining in the infrapatellar fat pad (IPFP) tissue vasculature 3G5 (a, b) staining predominantly the tunica adventitia consisting of supporting tissue in the vasculature, vWF (c, d) staining ... (endothelial cell marker) stained endothelial cells in the tunica intima (Figure 1c,d) and anti-αSMA (smooth muscle cell marker) stained cells in the tunica media, forming the muscular wall of the ... predominantly the tunica intima consisting of the endothelial layer and the basement membrane, and αSMA (e, f) staining predominantly the tunica media consisting of the muscular layer of the arteriole...

Ngày tải lên: 09/08/2014, 10:23

... from the blood into the brain parenchyma where they may then interact with microglia In addition to the presence of these inflammatory cytokines, other inflammatory mediators or ongoing inflammatory ... protein involved in the degradation of cytoplasmic proteins The function of α-synuclein is still not clear In the healthy brain, α-synuclein is present in the presynaptic terminals in the SN and locus ... contributing to the "sealing" of the tight junction (Amasheh et al., 2005) Both claudin-5 and occludin were found in the surrounding astrocytes, but not in the brain endothelium, after the BBB...

Ngày tải lên: 11/09/2015, 09:05

... 2001;Function and interactions of integrins Cell Tissue Res (3):285-298 41 Mould AP, Askari JA, Aota SI, et al 1997;Defining the topology of integrin alpha5beta1-fibronectin interactions using inhibitory ... differentiation Arthritis Res Ther (1):204 121 Owen M, Peck W 1985;Lineage of osteogenic cells and their relationship to the stromal system In ed Bone and MineralAmsterdam Elsevier pp :1-25 122 Owen M 1988;Marrow ... stromal stem cells J Cell Sci Suppl :63-76 123 Beresford JN 1989;Osteogenic stem cells and the stromal system of bone and marrow Clin Orthop Relat Res (240):270-280 124 Caplan AI 1991;Mesenchymal stem...

Ngày tải lên: 11/09/2015, 09:16

... domain to a new DNA-binding domain (Kim et al., 1996) The first DNA-binding domain used was a fruit fly homeobox domain, followed by zinc-finger DNA binding domain and yeast Gal4 DNA-binding ... modify the DNA-binding domain to bind specifically chosen target sequences, allowing an induced double strand break at a defined position Zinc finger modules are part of the DNA-binding domain of ... triplet targets changes the overall binding specificity of the zinc finger protein The naturally occurring fingers with known binding preference were disassembled to find fingers for all 64 different...

Ngày tải lên: 26/11/2015, 09:54

... larger in the core The heat is exchanged from the heating channels in the jacket, through the highly conductive jacket material, and into the core We can calculate the temperature profile by defining ... processor Finally, we will study the design of the bipolar plates and their influence on the ohmic losses in the fuel cell stack All of the models shown in the figures throughout the paper have ... heat being supplied to the system A combination of both reactions is obtained in the auto-thermal reactor, in which the reformation reaction gets its heat from the partial oxidation reaction The...

Ngày tải lên: 19/10/2013, 09:15

... Engineering in providing services to the government, the public, and the scientific and engineering communities The Council is administered jointly by both Academies and the Institute of Medicine ... called the trophoblast, and the cluster of cells inside the sphere is called the inner cell mass At this stage, there are about 70 trophoblast cells and about 30 cells in the inner cell mass The cells ... before they differentiate into their mature progeny One can envision two therapeutic approaches to stem cells In the first, stem cells themselves are implanted in a diseased or injured organ in the...

Ngày tải lên: 15/03/2014, 09:20

... which in turn is bound to maskin, which in turn is bound to eIF4E, the cap-binding factor The binding of maskin to eIF4E precludes the binding of eIF4G to eIF4E, thus inhibiting the formation of the ... cap structure at the 50 end of the mRNA, involved in 30 UTR processing, splicing, and mRNA transport into the cytoplasm, has yet another role in translation by binding the cap-binding complex (Fig ... role in initiating translation In fact, the mRNA is circularized, positioning the essential components of the translational machinery [eIF4G-eIF4E at the 50 end and poly(A)binding proteins at the...

Ngày tải lên: 22/03/2014, 20:21

... cells detected in patients with PTB in this study may therefore indicate the contribution of NK cells in the host immune response against MTB infection The immune response after MTB infection and ... response against MTB by increasing the infection inoculum (Vordermeier et al., 1996; Maglione et al., 2007) In addition the protection of mice against MTB infection by administration of intravenous ... the patients in this study Immunity against MTB comprises of a predominant cellular response and majority of researchers have dismissed the participation of B cells in defending against the infection...

Ngày tải lên: 29/03/2014, 03:20

... belching up gas now and thenor whether they result from the sound bouncing back and forth along the path between the source and the receiving instrument Schlindwein and her co-workers point out ... damage would be residents of the brain tissue, not interlopers from the blood Finally, they examined the brain region containing the remains of the aíected nerve cells Analyses of tissue from many ... live If the area is ịlled mainly with axons, the cells tend to become long and thin, in order to ịt between the cables If there is room to maneuver, as is the case in much of the brain, the cells...

Ngày tải lên: 12/05/2014, 15:02

... capsules of Stem- Kine in the morning and two in the evening for 14 days Phenotypic assessment of circulating stem cells Peripheral blood mononuclear cells (PBMC) were isolated by the Ficoll-Hypaque ... (p = 0.07) These data suggest Stem- Kine supplementation increases circulation of cells capable of giving rise to hematopoieticlineage cells in vitro Stem- Kine augments circulation of cells with ... a peak increase of approximately 53% in the number of CD34 expressing cells and and a 90% increase in CD133 cells in circulation Furthermore, a significant augmentation of cells possessing hematopoietic...

Ngày tải lên: 18/06/2014, 16:20

... putative stem cells The analysis confirmed the presence of round, SSEA-4 and SOX-2-positive primitive oocyte-like cells in the ovarian surface epithelium These cells resembled primitive oocytes in the ... VASA-positive cells (arrows) in the ovarian surface epithelium and cortex (A, B) Smaller cells with diameters of to μm in the epithelium (C-F) Bigger cells with diameters of 10 μm in the epithelium ... deeper into the ovarian cortex The nuclei of hypertrophic/necrotic cells consisted of degraded chromatin as revealed by DAPI staining (Figure 6C) This type of cells is usually not present in the...

Ngày tải lên: 20/06/2014, 08:20

... 1998), insulinimmunoreactive cells were found in the central regions of the principal pancreatic islets of both species in the present study Glucagon is synthesized in the A cells of the pancreas ... Somatostatin-immunoreactive cells were observed in the central regions, intermingled with insulin-immunoreactive cells (E and F) Bovine pancreatic polypeptide-immunoreactive cells were situated in the ... localization of endocrine cells in the principal pancreas of Silurus asotus and Siniperca scherzeri have not yet been reported In addition, the localization of these endocrine cells within the pancreatic...

Ngày tải lên: 07/08/2014, 14:23

... processes were intermingled with other IR cells especially with somatostatin-IR cells (Figs 2ac) In the pancreatic duct, spindle shaped insulin-IR cells were detected in the inter-epithelial cells of ... demonstrated in the mantle regions (a, b) In the pancreatic duct, they were located in the inter-epithelial cells or basal regions of epithelial lining (df) In addition, insulin-IR cells were also ... 5d) in there, the cytoplasmic process of insulin-, glucagon- and somatostatin-IR cells were intermingled with each other In the secondary islet regions, hPP-IR cells were mainly located in the...

Ngày tải lên: 07/08/2014, 15:20

... typed cells were restricted to the intestinal gland 90 Sae-kwang Ku et al Fig Serotonin-IR cells in the in the GI tract of ddY mice These IR cells were located in the epithelium and gastric or intestinal ... situated in the intestinal regions In this study, close typed cells were mainly located in the gastric or intestinal gland regions whereas most of open typed cells were found in the epithelial ... were found in the intestinal gland regions (Fig 2eg) Similar to that of the small intestine, open and close typed serotonin-IR cells were widely dispersed in the mucosa of the large intestine (Fig...

Ngày tải lên: 07/08/2014, 17:22