1 6 1 history the concept of stress
Báo cáo y học: "Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis" ppt
Ngày tải lên :
09/08/2014, 06:23
... region 61 Female 5.5 62 Female 6. 0 64 Male 8.4 66 Female 11 .5 67 Female 9 .6 68 Female 8.4 72 Female 9.0 maintain the concentration of approximately 6% When so indicated, recombinant human IL -1 (10 ... Rheum 2002, 46: 2 911 -2 9 16 Pfander D, Cramer T, Schipani E, Johnson RS: HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes J Cell Sci 2003, 11 6 :18 19 -18 26 Hall JL, Matter ... concentration of approximately to 11 % [13 ] Since O2 must enter from the cartilage surface, the concentration of oxygen is approximately 6% at the surface zone of the articular tissue and less than 1% in the...
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THE ROLE OF ANNEXIN 1 IN THE REGULATION OF INFLAMMATORY STRESS RESPONSE IN MACROPHAGES
Ngày tải lên :
01/10/2015, 17:27
... List of Tables List of Figures 10 List of Abbreviations 12 Chapter 1: Introduction 16 1. 1 Stress 16 1. 1 .1 Stress response and the heat stress response pathway 16 1. 1.2 HSPs and HSP70 19 1. 2 Inflammatory ... 29 1. 6 .1. 2 ANXA1 in cellular proliferation, differentiation and apoptosis 31 1 .6 .1. 3 ANXA1 in cancer 33 1. 6 .1. 4 ANXA1 in leukocyte migration 33 1. 6 .1. 5 ANXA1 in signaling 34 1. 6 .1. 6 ANXA1 and stress ... Inflammatory stress response involving HSP70 21 1.3 Toll like receptor signaling 22 1. 4 NFkB 25 1. 5 MAPK 26 1. 6 Introduction to Annexin -1 (ANXA1) 27 1. 6 .1 Functions of ANXA1 29 1. 6 .1. 1 ANXA1 in inflammation...
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Tài liệu Báo cáo Y học: Targeting of malate synthase 1 to the peroxisomes of Saccharomyces cerevisiae cells depends on growth on oleic acid medium pptx
Ngày tải lên :
22/02/2014, 04:20
... (1) GA1-8C Strain, plasmid, or oligonucleotide Strains (1) GA1-8C JD 11 (2) JR8 51 (3) JR 862 KM103 KM 113 (4) BJ19 91 (5) KM124 KM135 KM153 Plasmids pB10-WT pB10-WTDSKL YEp352-MLS1 YEp352-MLS1DSKL ... H1 61 H 162 H338 H339 H623 H625 Description Source or Reference MATa ura3-52 leu2 his3 trp1 -1 ctt1 -1 gal2 dal7D::HIS3 mls1D::LEU2 mls1D::LEU2 dal7D::HIS3 URA3, expressing Mls1pDSKL from the MLS1 ... locus URA3, expressing Mls1p from the MLS1 locus MATa leu2 ura3-52 trp1 pep4-3 prb1 -11 22 gal2 mls1D::LEU2 Expressing Mls1pDSKL from the MLS1 locus Over-expressing Mls1pDSKL from a multicopy vector...
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Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx
Ngày tải lên :
07/03/2014, 21:20
... a result of recombination processes; this signature is missing in DIDO1 and SPP1 The absence of the CXXC signature distinguishes SPP1 from the CGBP family (Figs 1, and S1); otherwise, the fungal ... Ash1, and Ash2 [12 ]; these latter are homologues of components of the yeast COMPASS ⁄ SET1 complex Some functional features have been reported [13 ,14 ] for the trithorax complex proteins in the ... et al 12 Shearn A (19 89) The ash -1, ash-2 and trithorax genes of Drosophila melanogaster are functionally related Genetics 12 1, 517 –525 13 Mazo AM, Huang DH, Mozer BA & Dawid IB (19 90) The trithorax...
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Báo cáo khoa học: End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair docx
Ngày tải lên :
23/03/2014, 11:20
... identification of these lesions as a strand break, verification of the nature of the 3¢ end, and identification of a satisfactory pathway for repair The XRCC1 component of the XRCC1–DNA ligase IIIa ... described [13 ] Furthermore, immunodepletion of PNK did not affect the amounts of XRCC1 and Pol b in the extract (Fig 5B) Using the same extract, we found efficient cross-linking of XRCC1 to the 3¢-OH ... the nicked DNA [18 ] Therefore, when repair enzymes are in excess over the amount of DNA SSBs, neither the cross-linking efficiency of XRCC1–DNA ligase IIIa heterodimer and Pol b nor the rate of...
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Báo cáo khoa học: Solution structure of long neurotoxin NTX-1 from the venom of Naja naja oxiana by 2D-NMR spectroscopy pot
Ngày tải lên :
23/03/2014, 13:20
... Saenger, W (19 91) The refined crystal structure of a-cobratoxin 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 ˚ from Naja naja siamensis at the 2.4 A resolution J Biol Chem 266 , 215 30– 215 36 Dewan, ... 0. 013 42.84 ± 7.32 380.78 ± 6. 84 )60 7.98 ± 6. 95 8.87 ± 1. 04 11 . 0 16 ± 1. 88 58.72 ± 3 .65 )20 71 ± 51. 29 )2220.2 ± 50.73 72 .6 24.7 2.4 0.3 1. 40 0.35 0.23 1. 96 0 .65 0 .62 the molecule, which is postulated ... 1 73 Residues 1 27, 38 68 b-sheets Heavy atom Residues 1 73 Residues 1 27, 38 68 b-sheets Value 540 252 39 283 19 11 33 19 35 0.027 ± 0.002 0. 51 ± 0 .15 0.003 ± 0.00 017 0.44 ± 0. 014 0. 36 ± 0. 013 ...
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Báo cáo hóa học: "Programmed cell death-1 (PD-1) at the heart of heterologous prime-boost vaccines and regulation of CD8+ T cell immunity" doc
Ngày tải lên :
18/06/2014, 16:20
... suggests a series of valuable criteria to guide the design of new immunization regimens Page of 11 10 11 12 13 14 15 16 17 18 19 20 Acknowledgements We acknowledge the contribution of our collaborators: ... Journal of Translational Medicine 2 010 , 8 :13 2 http://www.translational-medicine.com/content/8 /1/ 132 62 63 64 65 66 Page 11 of 11 primary, memory, and recall CD8+ T cells J Immunol 2003, 17 0 :18 22 -18 29 ... Klra, lectin subfamily A -2.27 -10 .89 Cd 160 1. 08 -2.34 Lag3 1. 41 3. 36 Ctla4 -1. 66 5.43 Pdcd1 (PD -1) 1. 88 7.82 Ptger2 1. 09 7. 06 Figure Differential co-expression of inhibitory receptors by CD8+...
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Chapter 1: Define the Art of Communication potx
Ngày tải lên :
31/07/2014, 17:20
... flexible in their communication style Overview of Text Chapter – Importance of versatility Chapter – Steps in the intelligence-gathering stage of negotiation Chapter – Development of goals ... Introduction to the topic • Why negotiation skills are integral to success • The importance of negotiations in developing partnerships Overview of the text chapters Ride the Ride Negotiations ... and the talk of negotiation Engagement connotes the active nature of negotiation begun with an invitation made by interdependent parties to grapple with shared concerns Characteristics of a...
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Báo cáo y học: " Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNF-induced MEK/ERK signalling" ppsx
Ngày tải lên :
09/08/2014, 01:22
... (predicted) [GenBank:NM_0 010 3 16 38] CD68 antigen 1. 01 1.80 1. 14 Cgref1, Cgr 11 [GenBank:NM _13 9087] Cell growth regulator with EF hand domain 1. 01 0. 61 0.83 Cyp4b1 [GenBank:NM_ 0 16 999] Cytochrome P450, ... receptor 0. 96 1. 97 1. 39 Spp1, OSP [GenBank:NM_ 012 8 81] Secreted phosphoprotein 0.97 4. 21 1.98 Vegfa [GenBank:NM_0 318 36] Vascular endothelial growth factor A 1. 11 1.80 1. 43 * ATPase activity Tap1, Cim, ... metalloproteinase domain 17 (TNF, alpha, converting enzyme) 0.93 1. 64 1. 41 Mmp13 [GenBank:XM_343345] Matrix metallopeptidase 13 0.33 6. 80 1. 10 Ctsc [GenBank:NM_ 017 097] Cathepsin C 1. 18 2.84 1. 72 Serpinb2,...
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Báo cáo y học: "The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration" pdf
Ngày tải lên :
09/08/2014, 06:22
... osteoarthritis [11 ,12 ] In this disease, the body of evidence points towards these being part of a more profound change in chondrocyte biosynthesis [13 ] driven by local production of IL -1 and tumour ... localization of IL -1 family proteins Immunohistochemistry was used to localize the two IL -1 agonists (IL -1 and IL -1 ) and their antagonist IL-1Ra together with the active receptor IL-1RI (IL -1 receptor, ... L5/S1 11 Surgical Female 36 Disc degeneration L5/S1 12 Surgical Male 39 Disc degeneration L4/5 13 Surgical Female 32 Disc degeneration L5/S1 14 Surgical Female 36 Disc degeneration L4/5 15 Surgical...
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Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc
Ngày tải lên :
09/08/2014, 07:20
... evidence that the dose of SN50 determines the specificity of the inhibitor [ 16 ] Therefore, it is likely that the doses of SN50 we used (10 0–200 µg/ml) can block both translocation of NF-κB and ... regulating the expression and activity of Cyp7b (Fig 6) , which strengthens the rationale for specific inhibition of these pathways in arthritis 12 13 14 Competing interests The author(s) declare that they ... noninvasive delivery of peptide carrying the nuclear localization sequence of NF-kappa B p50 J Immunol 19 98, 16 1 :60 84 -60 92 Boothby M: Specificity of sn50 for NF-kappa B? Nat Immunol 20 01, 2:4 71- 472 Wu Z,...
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Báo cáo y học: "The role of high-mobility group box-1 (HMGB-1) in the management of suspected acute appendicitis: useful diagnostic biomarker or just another blind alley?" docx
Ngày tải lên :
13/08/2014, 23:20
... 19 :28 http://www.sjtrem.com/content /19 /1/ 28 10 11 12 13 14 15 16 17 18 19 Page of Gaini S, Pedersen SS, Koldkjaer OG, Pedersen C, Moller HJ: High mobility group box -1 protein in patients with suspected ... J Invest Surg 2 010 , 23(4): 218 -223 Bealer JF, Colgin M: S100A8/A9: a potential new diagnostic aid for acute appendicitis Acad Emerg Med 2 010 , 17 (3):333-3 36 doi :10 .11 86 /17 57-72 41- 19-28 Cite this ... appendicitis Br J Surg 2 011 Sadr Azodi O, Andren-Sandberg A, Larsson H: Genetic and environmental influences on the risk of acute appendicitis in twins Br J Surg 2009, 96 (11 ) :13 36 -13 40 Andren-Sandberg...
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homomorphisms of the fundamental group of a surface into psu(1,1), and the action of the mapping class group
Ngày tải lên :
13/11/2014, 09:14
... is going to be crucial for the proof of the ergodicity of the mapping class group In section 6. 3 we state the main theorem of this paper To proceed the proof of the theorem we state and prove ... −→ −→ PSU (1, 1) −→ PSU (1, 1) 1 n 1 , inπ −→ (g, A) ±g As we said before, PSU (1, 1) acts on the unit circle and, therefore, PSU (1, 1) should act on the real line Given g ∈ PSU (1, 1) , ˜ R −→ ... denotes the projection from the conjugacy classes of PSU (1, 1) , to conjugacy classes of PSU (1, 1) The projection | tr | is the map PSU (1, 1) → R given by g → |trace(g)|, where g ∈ PSU (1, 1) The bifurcation...
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Role of poly (ADP ribose) polymerase 1 and copper homeostasis factor, antioxidant protein 1 in the maintenance of genomic integrity
Ngày tải lên :
11/09/2015, 10:18
... 1. 1.3 .1. 1 Role of PARP -1 at the telomeres 24 1. 1.4 Copper metabolism and disease 27 1. 1.4 .1 PARP -1 and Copper metabolism .29 1. 1.5 1. 2 1. 3 1. 4 Genomic Instability 1. 1 .1. 1 ... List of conference presentations .xvii Chapter 1: Introduction 1. 1 Review of Literature 1. 1 .1 1 .1. 2 Inducers of genomic instability 10 1. 1.2 .1 Oxidative stress ... 10 1. 1.2.2 Arsenic-induced oxidative stress .14 1. 1.2.3 Radiation 18 1. 1.3 Mechanisms for preventing genomic instability 20 1. 1.3 .1 Poly (ADP-ribose) polymerase (PARP -1) 21...
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Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia
Ngày tải lên :
16/10/2015, 15:38
... .7 1. 6 .1 Types and Location 10 1. 6. 2 Activation of SphKs 11 1. 6. 3 Functions of SphK1 and S1P 12 1. 6. 4 Clinical significances of sphingolipid pathways 15 1. 7 Aims ... and hypothesis of this study .18 1. 7 .1 Aims of this study .18 1. 7.2 Hypothesis .19 v Chapter 2: Materials and Methods 20 2 .1 Cell culture 21 2 .1. 1 Materials ... Chapter 1: Introduction .1 1 .1 The central nervous system 1. 2 Microglia: history and types .2 1. 3 Origins of microglia 1. 4 Functions of microglia .5 1. 5 Sphingolipids...
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Task 1 Explain the purpose of the following project document.
Ngày tải lên :
24/04/2016, 12:10
... It will provide an overview of the allocation of funds or the estimation of cost for the project (salaries, outsourcing costs, research fees, use of materials, hire of equipment and administrative ... reports are useful for explaining the status of the project as it currently stands and its future direction They also put the project’s progress into the context of where it stands compared to its ... because they holistically assess the overall project E) Project monitoring tool: Helps to maintain an overview of the project Monitoring tools will keep you up to date on the status of the project...
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Giải thích từ vựng_ IELTS Cambridge 11_Test 1 reducing the effects of climate change
Ngày tải lên :
12/05/2016, 16:49
... phân tán, truyền, lan truyền, xua tan) • The fog began to disperse • The crowd dispersed quickly • The seeds are dispersed by the wind 10 Eye-catching (a) 11 Replenish (v) / rɪˈplenɪʃ / = very attractive ... stratospheric (a) 13 Scrutinize (v) / ˈskruːtənaɪz / scrutiny (n) 14 Implement (v) / ˈɪmplɪment/ implementation (n) = the layer of the earth's atmosphere between about 10 and 50 kilometres above the surface ... will be implemented • the implementation of the new system /ɪmplɪmenˈteɪʃn/ 15 Cautious (a) / ˈkɔːʃəs / cautious about sb/sth 16 Precipitation (n) / prɪ.sɪpɪˈteɪʃn / 17 Scenario (n) / səˈnɑːriəʊ...
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