1— design of deep flexural member by the strut and tie model

... strut in a strut- and- tie model, taken perpendicular to the axis of the strut, in.2, Appendix A = area of that part of cross section between the flexural tension face and center of gravity of gross ... addresses the planning, design, and detailing of the slabs Background information on the design theories is followed by discussion of the soil support system, loadings, and types of slabs Design ... conservative than designs by the Strength Design Method of the Code The Alternate Design Method of the 1999 Code may be used in place of applicable sections of this Code Appendix A of the Code contains...

Ngày tải lên: 24/06/2015, 14:35

... PCR, the exon1 sense strand partially hybridizes with the exon2 antisense strand and the exon1 antisense strand with the exon2 sense strand Then "Amplification PCR" resulted in the accumulation of ... Thirdly, Tat synthesized in the RRL and the Tat/RRL mixture was added to either one of the viral Rluc RNAs and to the control Rluc RNA Under these conditions, increasing quantities of Tat/RRL were ... structures in the 5' UTR of Tat1 and Tat2 RNAs, which are not found in the 5' UTR of the genomic RNA [[55] and ref therein], are (i) an interaction between the PBS sequence and the 5' part of Tat exon...

Ngày tải lên: 12/08/2014, 23:22

... expression The activity of the intrinsic protease was inactivated by a D25A substitution of the catalytic aspartate The location of the Gag NC/p1 [53] and pl/p6 [54] sites and the Gag-Pro-Pol NC/ TF and ... in part, by the dimerization of the protease and RT domains We and others have shown that timed and ordered cleavage of the HIV-1 Gag precursors is highly regulated and is necessary for the production ... domains The other feature of the system we have used is the reliance of protease cleavages in trans Use of trans protease on the full length precursor allows for the clear evaluation of generation of...

Ngày tải lên: 13/08/2014, 09:21

... by the Creative Research Group of National Science Foundation of China (Grant no 50721003), the Foundation of the Ministry of Education of China for Returned Scholars (Grant no 2005383) and the ... image of SiC nanowires synthesized using the AAO template by thermal evaporation It reveals that large quantities of randomly distributed wire-like products have been obtained The nanowires are of ... about 3:2:2, which corresponds well to the standard SiC and SiO2 The small quantity of oxygen may come from the resident oxide layer The IR spectrum of the as-synthesized SiC nanowire samples (Fig...

Ngày tải lên: 16/03/2014, 15:21

... with x The change of the band-gap energy Eg with temperature is usually attributed to the effect of electrons or phonons The electron-hole pair is believed to soften the lattice vibration of the ... the vacancy site, thus softening the normal-mode frequencies of the lattice and reducing the zero-point energy of the oscillators An increase in the number of Mn atoms in the lattice seems to lead ... material and that the inhomogeneous broadening in Гinh may be accounted for implicitly and partly by the presence of various site symmetries of the Mn2+ ion in the lattice, the existence of stacking...

Ngày tải lên: 20/06/2014, 20:20

... Brief Description of SMint The ”objects” of study in the continuous version of the multi-WZ theory are expressions of the kind F (n, m, y, x)dx and identities between them In the above general ... calculations However, in both forms the evaluation of the right side of the integral is much faster (for specific m, n, and k) than the direct evaluation of the left side of our intergal Hence both forms ... specially designed to handle identities which invlove pure multiple integrals where the integrand is symmetric w.r.t the integration variables The detailed technical description of Mint and SMint...

Ngày tải lên: 07/08/2014, 06:22

... the solvent flux across the membrane and θ is the angle between the x axis r and the normal direction to the membrane n The first and second terms on the right hand side of each Eqs (2.15) and ... permeability properties of the cell membrane are functions of the aqueous environment and membrane stretching These areas are not central to the present work and hence beyond the scope of the thesis 1.5 ... However, the general accuracy of the method is limited to the first order 17 as it smears out the jumps of variables by using the discrete delta function In the case of different viscosities across the...

Ngày tải lên: 11/09/2015, 09:15

... element model is used only in the immediate vicinity of the delamination front and the remainder of the structure is modeled using shell elements The connection between the solid elements and the ... effective material properties of the damaged lamina 0 and E11 , E 22 and G12 are the material properties of the undamaged lamina The predicted damage progression patterns agreed with the experimental ... Coefficients of thermal expansion in material coordinate system E Elastic modulus of the rod A Cross-section area of the rod L One-third of the length of the rod Fint Internal nodal force of elements...

Ngày tải lên: 12/09/2015, 08:19

... Journal of Water and Environment Technology, Vol 7, No 4, 2009 Since the predomination of GAOs instead of PAOs leads to the deterioration of EBPR, it is essential to understand the mechanisms of the ... by these two species of bacteria seems to be similar within the initial pH range of to and the final pH range of around to The value of pH does not seem to be a major determining factor for these ... 2, and In all cases, acetate uptake and the release of phosphate were observed The pH range narrowed down to around and after the incubation, which originally ranged between and or The effect of...

Ngày tải lên: 05/09/2013, 09:38

Ngày tải lên: 24/12/2013, 14:39

... finally examined the effect of deletion of the components of the PDZ binding motif on the signaling properties of the receptor in Ca2+ imaging experiments Truncation of the receptor from the final eight ... significance of the observed interaction Further studies are necessary to shed light on the function of this interaction in the in vivo situation By influencing the duration of the Ca2+ signal of ORs in the ... source of olfactory signaling and the sites of expression of ORs are the ciliary structures of the OSNs Interestingly, we found MUPP1 to be predominantly expressed in the apical compartment of OSNs...

Ngày tải lên: 18/02/2014, 13:20

... Installing the game content To get all the content for the game that will be used over the course of the book, head to the Packt website and download the code file Unzip the file, and place the folder ... we will make our game dance and twirl They are the tools that change the position, rotation, and scale of the node the NodePath handles Each of these tools is made up of several methods, one to ... none of them are strictly necessary for this book since all of the content they create is provided with the book Nevertheless, we'll mention them here and provide tutorials on using some of them...

Ngày tải lên: 19/02/2014, 20:20

... from the slopes of the curves recorded during the first of the reaction and from the NADH concentrations using the value e340 ¼ 6.22 mM)1Æcm)1 Inhibition studies The inhibitory activities of ligands ... 4583 the T brucei and T cruzi proteins These Kd values actually represent the ligand affinities for a nonactive conformation of the enzyme in the absence of substrate and cofactor Molecular modelling ... positioning of the active residue Cys166 and the nicotinamide ring of the NAD+ cofactor during catalysis The average isotropic temperature factor values for the main chain and all atoms of the 359...

Ngày tải lên: 20/02/2014, 02:21

... identified the reverse products and shown that the CMP activation of the reverse of synthesis is by a different mechanism from base exchange [20] Further analysis of the products released from PtdIns by ... alignment on the same plot of the values found for de novo synthesis in the presence of 7.5 or 2.5 mM MnCl2 with various amounts of EDTA, or in the presence of MnCl2 only [11], as a function of the concentration ... extracted and the amount of labelled PtdIns was determined (Table 1) In the absence of CMP, the presence of AtPIS1 allows the incorporation of labelled inositol into PtdIns, according to the enzymatic...

Ngày tải lên: 22/02/2014, 04:20

... decrease in the affinity for GDP of Ga and the subsequent substitution of GDP by GTP [10] Such an agonist-dependent decrease in the affinity for GDP can be detected as the increase in binding of the nonhydrolysable ... identified the human Gao (accession no NM138736) as the most similar Ga in mammals The amino acid sequence of GOA-1 is 82.2% identical to that of Gao Although the similarity of the aA–aE region and the ... recognition are the a2 helix, the b6 ⁄ a5 loop, the a5 helix and the N- and C- extreme termini [31] In addition, the a4 helix and a4 ⁄ b6 loop region of Gai1 are important for specific recognition of receptors...

Ngày tải lên: 07/03/2014, 11:20

... to the syntheses of linear tetrapeptides of somatostatin [20] and of cyclic tetrapeptide and pentapeptide analogues of the RGD sequence [19] With the cyclic compounds it is uncertain whether the ... differences in biological activities between [Ala9]SP and [Gly9]SP on the one hand, and [b2-HAla9]SP and [HGly9]SP on the other hand Indeed, the higher pharmacological potency of [b2-HAla9]SP compared ... position of SP are tolerated by the NK-1 receptor, the substitution of the flexible Gly by the even more flexible HGly causes a 30- to 40-fold decrease in affinity and biological activity Substitution by...

Ngày tải lên: 08/03/2014, 08:20

... color, odor and flavor, and suppression of hemolysis and the bitter tastes of drugs [6,14,17] Taking into account the size of the hydrophobic pockets of CDs and the chemical structure of GA (Fig ... portion of GA should penetrate into the hydrophobic pocket of c-CD To determine the thermodynamic parameters, the area of each exothermic peak as observed in Fig 2B was integrated, and the heat of ... antisweet effect of GA is diminished by the addition of c-CD to the tongue The binding stoichiometry determined by ITC and NMR revealed that GA forms a complex with c-CD in the ratio of : The DLS results...

Ngày tải lên: 16/03/2014, 14:20

... providing the house dust mite kgt11 library, Fridolin van der Lecq and others for their quick and excellent work on the protein sequences (Sequentie centrum, Utrecht, the Netherlands), and Dr Maurits ... (Fig 6B) The 25-kDa mature band was recognized by rabbit antibodies against nDer p 1, con®rming the identity of the 25-kDa band as Der p (not shown) The 10-kDa fragment referred to as the propeptide ... the BCA method as described by the manufacturer (Pierce, Rockford, IL, USA) SDS/PAGE and immunoblotting Proteins were separated by SDS/PAGE (4±12%) (Novex) as described by the manufacturer, and...

Ngày tải lên: 17/03/2014, 11:20

... canstructure of theRS code parametersofto dimensionsUnit, This transmitterbythen sends silence for the voice At convert the LDU1 and LDU2 of the is done multiplying bits by encoding the See Figure for the ... the the this end oftothe thatData encoding ofThe terminating data unitterminating means Link thethe of the message voice oversimple air isfollow the may more data unit signify end frames the n and ... complexity of the P25 protocol suite, and especially given the reliance of upper layers such as the OTAR subsystem on the behavior of lower layers, such deficiencies make the security of the overall...

Ngày tải lên: 23/03/2014, 13:20

... downregulation of mRNA and protein levels of PAR-1 On the other hand, inhibition of PKA by its inhibitor H-89 prevented PAR-1 downregulation Similarly, the involvement of the PKA pathway and the lack of ... rate or the rate of internalization and degradation of PAR-1 protein As we and others [15–17,26,33] have shown the role of cAMP in the suppression of fibroblast function and promotion of the antifibrotic ... elements on the DNA and thereby regulates the transcription of genes, either positively or negatively Another pathway includes the direct activation of Epac (exchange protein directly activated by cAMP)...

Ngày tải lên: 30/03/2014, 04:20