1 regulation of immune responses
THE ROLE OF DMSO IN THE REGULATION OF IMMUNE RESPONSES BY DENDRITIC CELLS
Ngày tải lên :
16/10/2015, 11:59
... Master studies I TABLE OF CONTENTS Acknowledgements I Table of Contents II Summary VII List of Tables VIII List of Figures IX List of Abbreviations XI Chapter Introduction 1.1 The Immune System 1.2 ... occurrence of adverse immune response in autoimmune diseases, allergy and allograft rejection The antigen presenting cells (APCs) of innate immunity provide the activating signals through regulation of ... other important function of innate immunity is to process and present captured antigens for the stimulation of adaptive immune responses The innate immunity relies on a set of germ-line encoded receptors...
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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx
Ngày tải lên :
09/08/2014, 01:22
... analysis ofof upregulated genes in the functional category of immune response (a) Network 1, (b) Network 2, (c) Network 3, Network-based analysis upregulated genes in the functional category of immune ... expression profiles of immune response-related molecules in vivo Despite an additional proportion of granulocytes (mainly neutrophils), our results showed that there was an overexpression of several ... previous report of increased TNF levels in the serum of SLE patients [2], suggested that an abnormality in TNF signaling might exist Meanwhile, a cluster of MHC class II genes consisting of HLA-DRA,...
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Báo cáo y học: "A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses" pps
Ngày tải lên :
09/08/2014, 01:23
... the inhibition of APCs or pathogenic T cells, by maintenance of the TR cell population and/or by enhancement of their function (reviewed in [54]) Elucidation of the mechanism of TR cell suppression ... in mice by elimination of T cell subset I Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease J Exp ... in the control of immune responses Transplantation 2003, 75:8S-12S 50 Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F: An essential role for interleukin 10 in the function of regulatory T...
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Báo cáo y học: " Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" pptx
Ngày tải lên :
09/08/2014, 13:22
... analysis ofof upregulated genes in the functional category of immune response (a) Network 1, (b) Network 2, (c) Network 3, Network-based analysis upregulated genes in the functional category of immune ... expression profiles of immune response-related molecules in vivo Despite an additional proportion of granulocytes (mainly neutrophils), our results showed that there was an overexpression of several ... previous report of increased TNF levels in the serum of SLE patients [2], suggested that an abnormality in TNF signaling might exist Meanwhile, a cluster of MHC class II genes consisting of HLA-DRA,...
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Báo cáo y học: "Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV" pps
Ngày tải lên :
11/08/2014, 08:21
... pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV Journal of Immune Based Therapies and Vaccines 2011 9:2 Page of Submit your next manuscript ... Certainly the ability of Lm to direct immune responses to mucosal regions is an attractive feature of this vector [22] Thus, this technology should be considered a part of a heterologous prime-boost ... delivery of attenuated Lmdd-HIV-gag is immunogenic and can induce Gagspecific cellular immune responses, even in the presence of multiple prior Lmdd exposures Anti-vector and anti-HIV Gag antibody responses...
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Báo cáo khoa học: " Characterisation of immune responses and protective efficacy in mice after immunisation with Rift Valley Fever virus cDNA constructs" pot
Ngày tải lên :
12/08/2014, 04:21
... approved by The Animal Research Ethics Committee of Umeå University, Sweden Evaluation of immune response To evaluate and compare the immune responses after vaccination and infection, eight animals ... carbencillin to OD A600 of 0.7 Expression of the antigens was induced by the addition of isopropyl-beta-D-thiogalactopyranoside (IPTG) at a final concentration of 0.5 Page of 10 (page number not ... presentation of antigens [37], but interestingly, while the sera of immunised mice recognized the amino-terminal part (aa 1–100) of the Nprotein, sera of the infected animals did not The lack of reactivity...
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Báo cáo y học: "Antigen-presenting particle technology using inactivated surface-engineered viruses: induction of immune responses against infectious agents" pptx
Ngày tải lên :
13/08/2014, 09:21
... cell CD28 receptor, and fragment C of tetanus toxoid Implantation of these cells in mice resulted in successful in vivo induction of tetanus toxoid specific immune responses [25] Although successful, ... performed by the addition of 1.2 g of PEG (MW = 3,350) and 2.2 g of NaCl per 100 ml of culture supernatants, resulting in a 6% final concentration that would favor the recovery of particles relative ... PI values of 20 to 25 for B7 particles, compared to PI values of to 14 for B7+antiCD3 particles Concentrate and room temperature storage of surfaceengineered particles without loss of activity...
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Báo cáo y học: "Dynamic models of immune responses: what is the ideal level of detail" pptx
Ngày tải lên :
13/08/2014, 16:20
... tracking a larger number of immune components are often desirable when studying the progression of an infection or disease Given our need to study the dynamics of immune responses to infection ... can parameterize the continuous change of immune components as a function of time The model reveals specific parameters defining the dynamics of the host’s immune processes that are important in ... Cattadori, I M., Immune regulation of a chronic bacterial infection and consequences for pathogen transmission”, submitted] Since the immune responses involve interactions at the site of infection,...
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Mapping targets of immune responses in complete dengue viral genomes
Ngày tải lên :
10/11/2015, 12:27
... 13 2.1.2 Immune responses to dengue virus infection 13 2.1.3 Targets of immune responses in dengue viral genome 15 2.2 Antigenic diversity of targets of immune responses in ... capable of producing an immune response 14 2.1.3 Targets of immune responses in dengue viral genome The principal targets of cellular immune response to DENV are shown in Table 2.1 The T cell responses ... targets of immune responses in the proteome of dengue virus variants Mapping targets of immune response, using traditional experimental approaches is inefficient for large-scale screening of dengue...
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Báo cáo y học: "Negative regulation of cytokine signaling and immune responses by SOCS proteins" potx
Ngày tải lên :
09/08/2014, 06:23
... regulation of LPS responses Immunity 2002, 17:677-687 Gingras S, Parganas E, de Pauw A, Ihle JN, Murray PJ: Re-examination of the role of suppressor of cytokine signaling (SOCS1) in the regulation of ... weeks of age about 50% of the SOCS7-deficient mice died as a result of hydrocephalus that was characterized by cranial distortion, dilation of the ventricular system, reduced thickness of the ... the action of SOCS2 is in the regulation of the GH signaling pathway SOCS3 SOCS3 KO mice die by placental function defects during the embryonic stage of development [41,42] Deletion of SOCS3 causes...
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Báo cáo y học: " Phytol-based novel adjuvants in vaccine formulation: 1. assessment of safety and efficacy during stimulation of humoral and cell-mediated immune responses" doc
Ngày tải lên :
11/08/2014, 10:23
... Further, only small amounts of phytol and PHIS-01 are required to stimulate immune responses None of these two compounds stimulates reaginic immune responses, nor induces autoimmune lupus-like syndromes ... Acknowledgements The authors thank Professors William Brett and Jim Hughes of the Department of Life sciences and Tista Page of 11 (page number not for citation purposes) Journal of Immune Based Therapies ... (B) Effects of different doses of phytols on spleens: Spleen from mice injected with 100 μl of PBS Spleen from mice injected with 80 μg of Phytol Spleen from mice injected with 40 μg of Phytol...
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Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx
Ngày tải lên :
19/02/2014, 05:20
... measurement of heme content is useful for evaluation of heme dynamics in cultured cells Role of heme metabolism in cellular heme content Regulatory role of free heme in expression of HO-1 To evaluate ... expression levels of HO-1 and HO-2 and cellular heme content The cellular heme content represents the sum of free heme and bound heme of various hemoproteins for maintenance of cellular heme contents ... specific inhibitor of d-aminolevulinic acid dehydratase, the second enzyme of the heme biosynthetic pathway SnPP is a competitive inhibitor of HO activity [35] The heme content of all three cell...
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Control of Innate and Adaptive Immune Responses during Infectious Diseases ppt
Ngày tải lên :
05/03/2014, 23:20
... Control of Innate and Adaptive Immune Responses during Infectious Diseases Julio Aliberti Editor Control of Innate and Adaptive Immune Responses during Infectious Diseases ... severe in patients carrying higher loads of bacilli 2 Mechanisms of Host Protection and Pathogen Evasion of Immune Response… 2.4 2.4.1 31 Evasion of Immune Response Cell Wall Components Mycobacteria ... lines of evidence indicate that without innate immune responses, such as following NK-cell depletion, the initial IFN- -dependent control of parasite replication is compromised and, in the case of...
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Báo cáo khoa học: Alternative splicing: regulation of HIV-1 multiplication as a target for therapeutic action docx
Ngày tải lên :
06/03/2014, 09:22
... Action of SR proteins as positive regulators (B) Action of hnRNP proteins as negative regulators Fig Recognition of a weak 3¢ss of the HIV precursors The upper panel shows that the binding of U2 ... is the only case of an additional exon used in only one given HIV-1 strain (Fig 4A) [19,24–26] Binding of SR proteins downstream of a splice acceptor can increase the efficiency of U2AF binding ... utilization is repressed by inhibition of U2AF65 recognition of the 3¢ss A2 PPT through the binding of cellular hnRNP A ⁄ B proteins to ESSV [16,28] The maintenance of ESSV is necessary, not only for...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
Ngày tải lên :
08/03/2014, 08:20
... amounts of normalized messenger RNA were plotted as a function of time and the slope of this curve was used to calculate the interval period of time within which half of the original amount of mRNA ... indicate a prominent role of RhoA and p38 signaling in the activation of CREB via MSK1 Role of RhoA and p38 kinase in the activation of Cyr61/CCN1 promoter Fig Immunoblot analyses of RhoA activation ... the level of activity of a myriad of signaling cascades that leads to the activation of CREB kinases such as PKA, RSK, calmodulin kinase and MSK1/2 It was suggested that the group of genes that...
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Báo cáo Y học: Regulation of glypican-1, syndecan-1 and syndecan-4 mRNAs expression by follicle-stimulating hormone, cAMP increase and calcium influx during rat Sertoli cell development pptx
Ngày tải lên :
17/03/2014, 23:20
... PHOTOSHOPÒ software and the NIH IMAGE computer program (http:// rsb.info.nih.gov/nih-image) DNA quantification The DNA content of the cell layer at the end of incubation was quantified by the method of ... of intracellular cyclic AMP and calcium levels Effect of intracellular cAMP level increase The involvement of the cAMP pathway was evaluated using three approaches, all inducing high levels of ... cAMP but also inhibition of phosphodiesterase, activation of protein kinase, RNA and protein synthesis or mitotic activity present a peak of activity around 20 days of age which corresponds to...
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Báo cáo khoa học: Regulation of translational efficiency by different splice variants of the Disc large 1 oncosuppressor 5¢-UTR potx
Ngày tải lên :
22/03/2014, 16:20
... pGL3P-5¢-UTR reporter vectors The levels of SDH were analysed as a control of the amount of cDNA The levels of Renilla were analysed as an internal control for normalization of transfection efficiency (D) ... functional impact of these UTRs on the DLG1 mRNA transcripts, and their influence on the efficiency of translation of the subsequent ORF, we cloned each UTR immediately upstream of the firefly luciferase ... large includes exon A, exon B and part of exon C In the short version of 5¢-UTR DLG the exon B is absent Location of primers used for specific PCR amplification of each alternative DLG1 5¢-UTR (F3,...
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
Ngày tải lên :
23/03/2014, 07:20
... dominant nature of the disease suggests a toxic gain -of- function of the mutated protein that disrupts normal cellular functions and causes neuronal death [3] Loss -of- function of the wild-type ... translocation of AR to the nucleus Facilitation of nuclear transport of AR by HIP-1 depends on its C-terminal nuclear localization signal for HIP-1 In addition to that of AR, mediation of transcriptional ... Pro-caspase Activation of caspase that leads to activation of caspase either by extrinsic or intrinsic pathways Activation of caspase Entry of caspase to nucleus Entry of the HIP-1-HIPPI heterodimer...
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Báo cáo khoa học: Signalling and regulation of collagen I synthesis by ET-1 and TGF-b1 doc
Ngày tải lên :
23/03/2014, 11:20
... expression of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and inducing that of matrix metalloproteinase-2 (MMP-2) [7,16], which in turn degrades MMP-1 cleaved collagen I [17] Regulation of ... effects of combined ET-1 and TGF-b1 stimulation and of prolonged stimulation with respect to ET-receptor subtype expression and the induction of CTGF and TGF-b1 transcripts Results Expression of ET-receptor ... actions of TGF-b1 are mediated by the induction of connective tissue growth factor (CTGF) [2], which stimulates collagen production by fibroblasts [3] CTGF is coexpressed with TGF-b1 at sites of tissue...
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