1 molecular regulation of mandibular development
Báo cáo khoa học: B1–Proteases as Molecular Targets of Drug Development B1-001 DPP-IV structure and inhibitor design ppt
Ngày tải lên :
23/03/2014, 15:20
... Biotechnology Program of Department of Biology and Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong, PR China, 2Department of Biology, The Chinese University of Hong Kong, Hong ... Hlouchova and A Plechanovova Laboratory of Proteases, Department of Biochemistry, Institute of Organic Chemistry and Biochemistry of the Academy of Science of the Czech Republic, Prague, Czech Republic ... Department of Biochemistry, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic, 2Department of Biochemistry, Faculty of Natural...
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Molecular Regulation of Endocytosis Edited by Brian Ceresa pot
Ngày tải lên :
24/03/2014, 02:21
... inhibitory effect of l-EHD on dynamin-induced vesiculation in the constant presence of GTP after replacement of ATP with ATPγS (1 mM) D, Application of dynamin in the constant presence of GTPS induced ... elucidation 34 Molecular Regulation of Endocytosis Figure Current model of the Vid pathway Growth of yeast cells under glucose starvation conditions induces the synthesis of gluconeogenic enzymes ... uptake of cytosolic, peroxisomal and plasma membrane proteins by the yeast vacuole J Biol Chem 271: 9934-9941 38 Molecular Regulation of Endocytosis [40] Hoffman M, Chiang HL (1996) Isolation of...
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MOLECULAR REGULATION OF ENDOCYTOSIS pot
Ngày tải lên :
28/06/2014, 15:20
... inhibitory effect of l-EHD on dynamin-induced vesiculation in the constant presence of GTP after replacement of ATP with ATPγS (1 mM) D, Application of dynamin in the constant presence of GTPS induced ... elucidation 34 Molecular Regulation of Endocytosis Figure Current model of the Vid pathway Growth of yeast cells under glucose starvation conditions induces the synthesis of gluconeogenic enzymes ... uptake of cytosolic, peroxisomal and plasma membrane proteins by the yeast vacuole J Biol Chem 271: 9934-9941 38 Molecular Regulation of Endocytosis [40] Hoffman M, Chiang HL (1996) Isolation of...
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Báo cáo y học: "Transcriptional regulation of lung development: emergence of specificity" pdf
Ngày tải lên :
12/08/2014, 18:20
... Articles of particular interest have been highlighted as: • of special interest •• of outstanding interest Ten Have-Opbroek AAW: The development of the lung in mammals: an analysis of concepts ... implement the highly complex pattern of structural growth of the lungs and the differentiation of specialized epithelial cell types In deciphering the details of lung development, valuable insights ... expression of X-noggin, an inhibitor of BMP4, and a dominant-negative BMP4 receptor, Alk-6, both of which resulted in a proximalization of the lung akin to the functional deletion of Nkx2.1 [24,25]...
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Báo cáo Y học: Regulation of glypican-1, syndecan-1 and syndecan-4 mRNAs expression by follicle-stimulating hormone, cAMP increase and calcium influx during rat Sertoli cell development pptx
Ngày tải lên :
17/03/2014, 23:20
... the existence of a HSPG-specific regulation depending on the Sertoli cell developmental stage FSH induces the inhibition of the glypican-1 mRNA expression in all studied Sertoli cell developmental ... necessary to understand calcium regulation on glypican-1 and syndecans-1 and -4 in rat Sertoli cell development The physiological significance of the FSH regulation of glypican-1 and syndecans-1 ... proteoglycan, and down -regulation of glypican Biochem J 310, 73–81 12 Bansal, R., Kumar, R., Murray, K & Pfeiffer, S.E (1996) Developmental and FGF-2 mediated regulation of syndecans (1–4) and...
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
Ngày tải lên :
23/03/2014, 07:20
... nucleus Regulation of gene expression by HIPPI Caspase Nuclear pore complex HIP1 Fig Possible mechanisms of regulation of transcription and apoptosis by HIPPI and HIP-1 in HD Interaction of HIP-1 ... translocation of AR to the nucleus Facilitation of nuclear transport of AR by HIP-1 depends on its C-terminal nuclear localization signal for HIP-1 In addition to that of AR, mediation of transcriptional ... Pro-caspase Activation of caspase that leads to activation of caspase either by extrinsic or intrinsic pathways Activation of caspase Entry of caspase to nucleus Entry of the HIP-1-HIPPI heterodimer...
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Báo cáo y học: "Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies" ppsx
Ngày tải lên :
12/08/2014, 23:22
... reactivated in 60% of the patients tested (25 out of 42 patients) [302] These results constitute a proof -of- concept for the co-administration of (at least) two different categories of therapeutically ... termination of transcription from the weaker or from both promoters (d) enhancer trapping: an enhancer of one gene (the 5'LTR enhancer of HIV-1 in this case) is placed out of context near the promoter of ... general) in the maintenance of a reservoir of latently-infected CD4+ T cells [163], thereby questioning the relevance of immune activation therapy in the context of a purge of latentlyinfected reservoirs...
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Molecular function and regulation of the bax associating protein MOAP 1
Ngày tải lên :
14/09/2015, 12:54
... FUNCTION AND REGULATION OF THE BAX-ASSOCIATING PROTEIN MOAP-1 Fu Nai Yang INSTITUTE OF MOLECULAR AND CELL BIOLOGY NATIONAL UNIVERSITY OF SINGAPORE 2007 MOLECULAR FUNCTION AND REGULATION OF THE BAX-ASSOCIATING ... the Bcl-2 family genes 29 1.3.3 Regulation of mitochondrial outer membrane permeability by the Bcl-2 family 33 1.3.3.1 Regulation of MPT 33 1.3.3.2 Regulation of a putative VDAC-dependent protein-releasing ... 41 1.4.2 Regulation of Bax function 42 1.5 REGULATION OF MITOCHONDIA-DEPENDENT APOPTOSIS BY THE UBIQUITIN-PROTEASOME SYSTEM 47 1.5.1 The ubiquitin-proteasome system 47 1.5.2 Regulation of Bcl-2...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
Ngày tải lên :
16/02/2014, 09:20
... phosphorylation state of their proteins, thereby changing the amount and localization of Bcl-2 family members However, each type of cancer has its own way of disrupting the balance of the networks of signaling ... inhibition of Akt- and ERK1 ⁄ 2-dependent pathways eventually change the expression level of one or more of these Bcl-2 family members Bad Bad is one of the ‘death-promoting’ members of the Bcl-2 ... of EGFR kinase activity, blocks gefitinb-induced up -regulation of Bim and apoptosis [38] These experiments point to an important role for the induction of Bim in gefitinib-triggered apoptosis of...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
Ngày tải lên :
16/02/2014, 09:20
... genetic diseases [47] Most analyses of the regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene expression, have ... mouse development Analyses of AP-2a-null mice have demonstrated that AP-2a is a fundamental regulator of mammalian craniofacial development AP-2a knockout mice die perinatally with craniofacial ... increase in apoptosis [73] The authors of this study ascribe the regulation of outgrowth of limb buds and patterning of the digits to the chicken AP-2 The role of AP-2a was further studied in zebrafish...
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Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx
Ngày tải lên :
19/02/2014, 05:20
... measurement of heme content is useful for evaluation of heme dynamics in cultured cells Role of heme metabolism in cellular heme content Regulatory role of free heme in expression of HO-1 To evaluate ... siHO-2-mediated induction of HO-1 expression: increased stability of HO-1 mRNA and heme-dependent and heme-independent transcriptional regulation of the HO-1 gene These metabolic consequences of HO-2 knockdown ... resetting of HO-1 expression In contrast with HO-1 expression, expression of HO-2 mRNA and protein was not increased in several human cell lines examined [15,19,37] Such a mode of regulation of HO-2...
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MORPHOGENESIS THE CELLULAR AND MOLECULAR PROCESSES OF DEVELOPMENTAL ANATOMY pptx
Ngày tải lên :
05/03/2014, 11:21
... consequences of chromosome imbalance: principles, mechanisms, and models L Saxen Organogenesis of the kidney V Raghaven Developmental biology of fern gametophytes R Maksymowych Analysis of growth and development ... ignorance of genetic detail imposes on the study of morphogenesis is that the language of molecular biology cannot in general be used to explain the development of form; instead, we must use that of ... in wing development, the position of epithelial folding, the direction of spindle orientation and hence the direction of cell growth, the amount of sac contraction, and the symmetry of epithelial...
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Báo cáo khoa học: Alternative splicing: regulation of HIV-1 multiplication as a target for therapeutic action docx
Ngày tải lên :
06/03/2014, 09:22
... Action of SR proteins as positive regulators (B) Action of hnRNP proteins as negative regulators Fig Recognition of a weak 3¢ss of the HIV precursors The upper panel shows that the binding of U2 ... is the only case of an additional exon used in only one given HIV-1 strain (Fig 4A) [19,24–26] Binding of SR proteins downstream of a splice acceptor can increase the efficiency of U2AF binding ... alternative splicing regulation Fig Organization of HIV-1 genome and different mRNA splicing products The 5¢ss (D1–D4) and 3¢ss (A1–A7) are indicated ORFs of coding exons of each mRNA product...
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Báo cáo khoa học: Interactions of HIPPI, a molecular partner of Huntingtin interacting protein HIP1, with the specific motif present at the putative promoter sequence of the caspase-1, caspase-8 and caspase-10 genes pdf
Ngày tải lên :
07/03/2014, 10:20
... concentrations of NaCl, the fluor3888 escence intensities of GST–HIPPI increased, indicating a lesser extent of interactions of GST–HIPPI with AA AGACATG This result indicated that the interaction of GST–HIPPI ... Quenching of intrinsic fluorescence of GST–HIPPI (0.8 lM) at 340 nm (kexc ¼ 295 nm) in the presence of the bp putative motif sequence and six of its mutants Panel I Fluorescence quenching of GST–HIPPI ... in a Fluoromax spectrofluoremeter Panel II Study of any quenching of intrinsic fluorescence of GST– HIPPI due to addition of point-mutated sequences of the bp potent HIPPI-binding motif, namely:...
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Báo cáo khoa học: Structural and biological effects of a b2- or b3-amino acid insertion in a peptide Application to molecular recognition of substance P by the neurokinin-1 receptor ppt
Ngày tải lên :
08/03/2014, 08:20
... a-peptides (oligomers of a-amino acids) has recently been applied to the syntheses of linear tetrapeptides of somatostatin [20] and of cyclic tetrapeptide and pentapeptide analogues of the RGD sequence ... structures of the b-amino acids that best fit are shown in Fig They all correspond to gauche(+) values of the h angle The methyl group of b2-HAla occupies a position close to that of CH2b of Pro or ... response of these agonists could be explained by the number of receptors to be occupied by these agonists to get activation of the second messenger cascade as reported [40] Enzymatic degradation of...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
Ngày tải lên :
08/03/2014, 08:20
... amounts of normalized messenger RNA were plotted as a function of time and the slope of this curve was used to calculate the interval period of time within which half of the original amount of mRNA ... effects of S1P Transcriptional regulation of the Cyr61/CCN1 gene To determine whether S1P increased Cyr61/CCN1 mRNA accumulation by increasing the rate of its synthesis or decreasing that of its ... apparent regulation of Cyr61/CCN1 gene expression through RhoA and SAPK p38 cascades is associated with the actual activation of these pathways or merely a result of nonspecific side-effects of the...
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Báo cáo khoa học: Regulation of translational efficiency by different splice variants of the Disc large 1 oncosuppressor 5¢-UTR potx
Ngày tải lên :
22/03/2014, 16:20
... pGL3P-5¢-UTR reporter vectors The levels of SDH were analysed as a control of the amount of cDNA The levels of Renilla were analysed as an internal control for normalization of transfection efficiency (D) ... the 3¢-UTR can play a role in the regulation of translation, and that specific combinations of alternative 5¢- and 3¢-UTRs can specify the efficiency of translation of individual transcripts [31] ... mechanism by which the tumour suppressor activities of DLG1 may be regulated: downregulation of DLG1 by modulation of the relative expression of DLG1 5¢-UTRs Furthermore, having shown that these...
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Báo cáo khoa học: Signalling and regulation of collagen I synthesis by ET-1 and TGF-b1 doc
Ngày tải lên :
23/03/2014, 11:20
... expression of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and inducing that of matrix metalloproteinase-2 (MMP-2) [7,16], which in turn degrades MMP-1 cleaved collagen I [17] Regulation of ... effects of ET-1 on collagen I synthesis and breakdown clearly indicate an important role for ET-1 in the dynamic regulation of ECM and its dysregulation in disease [19] ET-1 and its isoforms ET-2 ... effects of combined ET-1 and TGF-b1 stimulation and of prolonged stimulation with respect to ET-receptor subtype expression and the induction of CTGF and TGF-b1 transcripts Results Expression of ET-receptor...
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Báo cáo khoa học: The C-terminal region of the proprotein convertase 1⁄ 3 (PC1⁄ 3) exerts a bimodal regulation of the enzyme activity in vitro pdf
Ngày tải lên :
30/03/2014, 08:20
... Bimodal regulation of proprotein convertase ⁄ N Rabah et al Furthermore, control of enzyme activity is accomplished through limited proteolysis of the zymogen molecule A role ... of the proregion in controlling activation of the enzyme, it appears that the CT-peptide might be implicated in regulating enzyme activity This adds an additional level of complexity to the regulation ... was obtained after analysis of the enhanced conversion of human prorenin into mature renin in cells devoid of secretory granules It has been reported that no conversion of prorenin into renin by...
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