1  compare the output of two commands

Investigation of the roles of two rac1 effectors phosphatidylinositol 5 kinase 1a and p21 activated kinase 1 in insulin secreting cells

Investigation of the roles of two rac1 effectors phosphatidylinositol 5 kinase 1a and p21 activated kinase 1 in insulin secreting cells

... represent the two major types of diabetes mellitus Although, from the epidemiological point of view, they are two distinct diseases, it is difficult to draw a line between them On the other hand, ... (279) Thus, the role of ERK in regulation of survival and death of cells varies by the cell types Taken together, the possible implication of p38 MAPK and ERK in the deleterious effect of chronic ... recruitment of granules from reserve pool to the plasma membrane The release of these granules corresponds to the second phase of insulin secretion However, according to the “signal-limited model”, the...

Ngày tải lên: 14/09/2015, 14:08

182 278 0
Tài liệu Đề tài " On the volume of the intersection of two Wiener sausages " ppt

Tài liệu Đề tài " On the volume of the intersection of two Wiener sausages " ppt

... (2.82) yields the claim in (2.80) This completes the proof of Lemma This completes the proof of Proposition and hence of Theorem Proof of Theorem In this section we indicate how the arguments ... second term on the right-hand side of the analogue of (2.93) Proof of Theorem In Sections 4–6 we prove Theorems 3–5 The proof follows the same line of reasoning as in [3, §5], but there are some ... generalization of the proof of Proposition in [3] We outline the main steps, while skipping the details Step One of the basic ingredients in the proof in [3] is to approximate the volume of the Wiener...

Ngày tải lên: 14/02/2014, 17:20

44 331 0
Tài liệu Báo cáo khoa học: Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation ppt

Tài liệu Báo cáo khoa học: Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation ppt

... fragments F and I The number at the right of each RT-PCR product represents the length of the product The scheme also shows the location of the reverse primer DN+89 used in another starting exon-specific ... numbers over the diagrams indicate the position of the corresponding nucleotides relative to the translation start site, and the numbers in parentheses below the diagram show the position of the corresponding ... is done from +1 of exon )11871 above the sequence indicates the 5¢-end of exon 1a The numbers in parentheses demonstrate the position of the corresponding nucleotides relative to the transcription...

Ngày tải lên: 19/02/2014, 06:20

12 610 0
Tài liệu Báo cáo Y học: Targeting of malate synthase 1 to the peroxisomes of Saccharomyces cerevisiae cells depends on growth on oleic acid medium pptx

Tài liệu Báo cáo Y học: Targeting of malate synthase 1 to the peroxisomes of Saccharomyces cerevisiae cells depends on growth on oleic acid medium pptx

... molecular mass of 62 000 in the lane with the wild-type extract that was absent from the lane corresponding to the mls1D mutant (arrow; Fig 1A), thereby con®rming the speci®city of the antibody ... 5A) The results demonstrated that the mls1D mutant failed to grow on ethanol or acetate However, expression of either of the two Mls1p constructs complemented the mls1D mutant phenotype on these ... constructed that was extended with the C-terminal 274 amino acids of Mls1p (out of a total of 554), including the terminal SKL Expression of this GFP-Mls1p was compared to that of a control GFP extended...

Ngày tải lên: 22/02/2014, 04:20

8 445 0
Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx

Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx

... predicted The other main group, obtained 97% of the time in 20 740 explored trees, contained the DIDO PHD sequences clustered with the PHF and the CGBP proteins As seen in the tree, two fungal PHD ... modifications of chromatin [9] Little is known, however, of the functional role of the remaining subclass members In this study, the yeast protein SPP1 (alias cps40), a member of the COMPASS complex ... constitute CGBP homologues The presence of a TFS2M domain is also indicative of a possible function for the DIDO1 long isoform (Figs and S2) It is the second domain of the elongation factor, TFSII...

Ngày tải lên: 07/03/2014, 21:20

7 658 0
Báo cáo khoa học: "Enriching the Output of a Parser Using Memory-Based Learning" potx

Báo cáo khoa học: "Enriching the Output of a Parser Using Memory-Based Learning" potx

... corpora For each of the steps 1, and we proceed as follows: compare the training corpus to the output of the parser on the strings of the corpus, after applying the transformations of the previous ... Example of (a) the Penn Treebank WSJ annotation, (b) the output of Charniak’s parser, and the results of the conversion to dependency structures of (c) the Penn tree and of (d) the parser’s output ... whether the word is the head of a finite verb cluster   We then trained TiMBL to predict the label of the missing dependency (or ‘none’), given an occurrence of a pattern and the features of all...

Ngày tải lên: 08/03/2014, 04:22

8 379 0
The Gentlemen and the Roughs: The Collision of Two Honor Codes in the American North

The Gentlemen and the Roughs: The Collision of Two Honor Codes in the American North

... higher than the beasts – and unworthy of the designation of honor, and, the title of man From the founding of the From the founding of the country, American leaders had argued that the strength ... and hard work The watchword of Northern honor, as it was for the English, was self-restraint This was the virtue that tied the others together; the man who had mastered himself had the discipline ... court-martialed for the use of profanity during the war, in violation of the 83rd Article of War requiring conduct appropriate to one’s status as an “officer and a gentleman.”) On the other hand, you...

Ngày tải lên: 14/03/2014, 09:31

14 365 0
Báo cáo khoa học: End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair docx

Báo cáo khoa học: End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair docx

... include identification of these lesions as a strand break, verification of the nature of the 3¢ end, and identification of a satisfactory pathway for repair The XRCC1 component of the XRCC1–DNA ligase ... period Approximately 80% of the repair of the substrate is achieved within at a point where the proteins are dissociating from the DNA Therefore, cross-linking of Pol b and the XRCC1–DNA ligase IIIa ... incubation for the times indicated, proteins involved in repair are cross-linked to the DNA and to each other by the addition of formaldehyde The beads are subsequently washed before reversal of the cross-links,...

Ngày tải lên: 23/03/2014, 11:20

11 299 0
Báo cáo khoa học: Solution structure of long neurotoxin NTX-1 from the venom of Naja naja oxiana by 2D-NMR spectroscopy pot

Báo cáo khoa học: Solution structure of long neurotoxin NTX-1 from the venom of Naja naja oxiana by 2D-NMR spectroscopy pot

... the length of loop I is longer in short neurotoxins The NMR structure of NTX-1 is closest to that of the a-cobratoxin crystal The superposition of these two ˚ structures shows an RMSD value of ... is similar They all show a conformational variability at the tip portion of loop II, with the difference being that the length of the b-strands in NTX-1 is longer than in the others These neurotoxins ... structure is not observed in other long neurotoxins On the other hand, the absence of any NOE between residues 69–73 and other regions of the peptide indicates that there is no structural involvement...

Ngày tải lên: 23/03/2014, 13:20

8 411 0
Báo cáo hóa học: "Programmed cell death-1 (PD-1) at the heart of heterologous prime-boost vaccines and regulation of CD8+ T cell immunity" doc

Báo cáo hóa học: "Programmed cell death-1 (PD-1) at the heart of heterologous prime-boost vaccines and regulation of CD8+ T cell immunity" doc

... understanding of the mechanism of action of DNA vaccination A key observation from many studies to date is that interchanging the order of vectors utilized in these regimens has a dramatic impact on the ... stimulation sheds light on the mechanism of action of DNA vaccines and their potency as priming agents in terms of: i) the importance of extended yet reduced levels of antigen exposure; and ii) ... treatment of diseases such as HIV, other microbes and cancer [11,22-37] In addition, such protocols offer a more Page of 11 practical alternative for active immunotherapy of cancer and other diseases...

Ngày tải lên: 18/06/2014, 16:20

11 506 0
Báo cáo hóa học: "Research Article The Solution of Two-Point Boundary Value Problem of a Class of Duffing-Type Systems with Non-C1 Perturbation Term" pdf

Báo cáo hóa học: "Research Article The Solution of Two-Point Boundary Value Problem of a Class of Duffing-Type Systems with Non-C1 Perturbation Term" pdf

... a solution of 2.11 if and only if u satisfies the operator equation ∇F u 2.25 The Main Theorems Now, we state and prove the following theorem concerning the solution of problem 2.11 Theorem 3.1 ... diagonalization matrix and μ1 λ1 ≤ μ2 B The proof of Lemma 2.2 is fulfilled λ2 ≤ · · · ≤ μn λn are the eigenvalues of Let ·, · denote the usual inner product on Rn and denote the corresponding norm 1/2 by ... v0 t ω t is exactly a unique solution of v0 t is just a unique solution of 2.12 and u0 t 2.11 The proof of Theorem 3.1 is completed Now, we assume that there exists a positive integer N such...

Ngày tải lên: 21/06/2014, 20:20

12 199 0
Báo cáo hóa học: " Research Article New Trace Bounds for the Product of Two Matrices and Their Applications in the Algebraic Riccati Equation" potx

Báo cáo hóa học: " Research Article New Trace Bounds for the Product of Two Matrices and Their Applications in the Algebraic Riccati Equation" potx

... Journal of Inequalities and Applications 11 Applications of the Results Wang et al in have obtained the following: let K be the positive semidefinite solution of the ARE 1.4 Then the trace of matrix ... including 3.1 Some of our results and 3.1 cannot contain each other Theorem 3.1 If 1/p and K is the positive semidefinite solution of the ARE 1.4 , then 1/q the trace of matrix K has the lower and ... Journal of Inequalities and Applications Therefore, considering the application of the trace bounds, many scholars pay much attention to estimate the trace bounds for the product of two matrices...

Ngày tải lên: 22/06/2014, 02:20

18 456 0
Báo cáo hóa học: "ON THE IDENTITY OF TWO q-DISCRETE PAINLEVÉ EQUATIONS AND THEIR GEOMETRICAL DERIVATION" docx

Báo cáo hóa học: "ON THE IDENTITY OF TWO q-DISCRETE PAINLEVÉ EQUATIONS AND THEIR GEOMETRICAL DERIVATION" docx

... pattern on the weight lattice of the affine Weyl group E(1) or one of its degenerations This proliferation of discrete Painlev´ equations raises the question of the indepene dence of the various ... have pointed out in [11], the geometry of the transformations of this equation is related to the affine Weyl group D(1) , just as in the case of (2.1) On the identity of two q-discrete Painlev´ equations ... In [6] the derivation of (2.1) was based on the analysis of discrete dynamical systems associated to extended affine Weyl groups of type A(1) × A(1) The derivation of (2.7), on m n the other hand,...

Ngày tải lên: 22/06/2014, 22:20

11 304 0
Chapter 1: Define the Art of Communication potx

Chapter 1: Define the Art of Communication potx

... flexible in their communication style Overview of Text  Chapter – Importance of versatility  Chapter – Steps in the intelligence-gathering stage of negotiation  Chapter – Development of goals ...  Introduction to the topic • Why negotiation skills are integral to success • The importance of negotiations in developing partnerships  Overview of the text chapters Ride the Ride  Negotiations ... and the talk of negotiation  Engagement connotes the active nature of negotiation begun with an invitation made by interdependent parties to grapple with shared concerns Characteristics of a...

Ngày tải lên: 31/07/2014, 17:20

10 355 0
Scientific report: "Application of PCR to detect the presence of two genes in the genome of rice AtAOS has been genetically modified" pdf

Scientific report: "Application of PCR to detect the presence of two genes in the genome of rice AtAOS has been genetically modified" pdf

... set of PCRs was carried out to detect the hygromycin resistance gene, CaMV35S promoter (the promoter located in front of the AtAOS2 gene), and the AtAOS2 gene in the transgenic rice genome The ... rice genome The results of PCRs would confirm the appearance of the AtAOS2 gene in the transgenic rice genome MATERIALS AND METHODS 2.1 Extraction of rice DNA The leaves of one-month-old wild-type ... thaliana AOS2 gene in the rice genome CONCLUSION From the above results, the hygromycin resistance gene, CaMV35S promoter (the promoter located in front of the AtAOS2 gene), and the AtAOS2 gene were...

Ngày tải lên: 06/08/2014, 18:21

8 406 0
Báo cáo y học: " Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNF-induced MEK/ERK signalling" ppsx

Báo cáo y học: " Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNF-induced MEK/ERK signalling" ppsx

... drafting and editing of the manuscript, and preparation of the figures SMB was involved with the design and coordination of the study AL was involved with the design and coordination of the study, drafting ... Mmp-12) Analysis of the TNF-regulated, MEK/ ERK-independent list of genes whose protein products were localized to the extracellular space determined that many of the protein products of these genes ... reduced the level of Sox9 activity and increased the level of NFB activity in chondrocytes (P < 0.01; Figure 4a, b) There was no significant effect, however, on the level of inhibition or the induction...

Ngày tải lên: 09/08/2014, 01:22

14 574 0
Báo cáo y học: "The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration" pdf

Báo cáo y học: "The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration" pdf

... increase in the gene expression of the aggrecanase ADAMTS4 in cells derived from degenerate NP In vivo, the NP contains the highest concentration of aggrecan in the IVD The response of cells derived ... immunopositivity was observed in the matrix of the IVDs or in blood vessels, with the exception of immunopositivity for ICE, which showed some staining in the matrix and blood vessels of the most degenerate ... characteristic of IVD degeneration, particularly in the NP, where degenerative changes first appear This study investigates two hypotheses: that in human IVD degeneration, there is local production of the...

Ngày tải lên: 09/08/2014, 06:22

14 404 0
Báo cáo y học: "Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis" ppt

Báo cáo y học: "Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis" ppt

... enter from the cartilage surface, the concentration of oxygen is approximately 6% at the surface zone of the articular tissue and less than 1% in the deep zone We histologically examined the oxygen ... during the progression of OA Our data show here for the first time a correlation between the levels of expression of HIF-1α and degeneration of articular cartilage in patients with OA To clarify the ... aspects of HIF-1 signaling should be also studied to further clarify the role of HIF-1 in the pathogenesis of OA References 10 11 12 13 Conclusion Taken together, our findings show for the first...

Ngày tải lên: 09/08/2014, 06:23

11 385 0
Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc

Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc

... chromatography The amount of 7α-OH-DHEA is expressed as the percentage [3H]-7α-OH-DHEA of the total amount of [3H]-label measured Results are expressed as the mean ± standard error of the mean of triplicate ... Biosystems (Nieuwerkerk a/d ijssel, The Netherlands) thermo cycler with an anneal temperature of 53°C Computer analysis of the Cyp7b promoter region The promoter sequence of the human Cyp7b gene was identified ... liquid chromatography The amount of 7α-OHDHEA is expressed as the percentage of 3H-labelled 7α-OHDHEA of the total amount of 3H-label measured Recoveries after extraction were in the range 85–95%,...

Ngày tải lên: 09/08/2014, 07:20

10 462 0
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