1 accessibility of code examples in documentation

... final purpose is using data in raster format.  3.1.1. Creating the map of origins  According  to  the  data  interpolation  in AccessMod, map of origins contain information  of population  in ... The result is showed in Fig. 2.  3.1.2. Creating the map of travel time  Travel  time  is  known  as  the  necessary  and  minimum  time  for  people  in order  to  move  from  origin  to  destination.  In ... 3.1.3. The distribution of destination  In the  study,  destinations  are  healthcare  facilities,  including  infirmaries  and  district  hospital.  There  are  two  important  attributes  in this  step: ...

Ngày tải lên: 14/03/2014, 15:20

... Zidovudine (AZT) synergistically inhibited HIV-1 replication in primary placental macrophages, possibly explaining why AZT can inhibit maternal fetal transmission in the absence of diminution of ... 33% of virus alone (VA, Table 1) In of the experiments summarized in Tables &2, virus levels in the presence of nM β-estradiol in combination with 50 nM D4T were higher than in the presence of ... HIV-1 replication in the presence of D4T to 74% (of VA, SE = 5.4), for a difference of 41% (of VA) To determine how the observed inhibition of drug efficacy translates into increased drug levels...

Ngày tải lên: 13/08/2014, 05:21

... deterioration in lung function The blood staining resolved following withdrawal of nebulised heparin Anticoagulant effects The mean APTT for each group following the final nebulisation, in order of increasing ... NA, Minter AJ, Chesterman CN: The effect of heparin and other glycosaminoglycans on levels of tissue plasminogen activator and plasminogen activator inhibitor in cultured human umbilical vein endothelial ... [19,20] In addition, in the setting of lung injury triggered by cardiac surgery, a preoperative heparin infusion reduced evidence of pulmonary microvascular thrombosis [21] We are unaware of previous...

Ngày tải lên: 13/08/2014, 11:22

... C-terminal tagging of IN resulted in 40% reduction in the virus titer in MAGI-5 cells and in integrase activity in vitro [15] In SupT1 cells, replication kinetics of NLXINB is delayed in comparison ... biotinylated tag at the C-terminus of the IN protein, which can be detected in virions, becomes inaccessible for streptavidin binding after entry into the cell Biotinylation and capture of IN- BAD ... of an HIV-based lentiviral vector containing a tagged integrase We tagged HIV-1 IN at its C-terminus by adding a 22 amino-acid Biotin Acceptor Domain (BAD) which can be biotinylated in vivo in...

Ngày tải lên: 12/08/2014, 23:23

... The inflammatory cytokines, TNF-alpha and certain interleukins play a key-role in initiating systemic inflammatory response syndrome (SIRS) and it is known that vitamin D may modulate the cytokine ... The effect of 1,25 vit-D or vehicle on chronic sepsis induced by single IP injection of LPS is shown in Int J Med Sci 2007, 192 table The LPS injection induced a septic condition in the rats ... 1,25-vit D was effective in protecting against DIC in experimental LPS-induced shock It has been argued that the experimental model of sepsis induced by infusion of LPS in high doses is unphysiological...

Ngày tải lên: 26/10/2012, 09:57

... vocabulary Using dialogues for practice Eliciting Checking understanding Using drills Getting students to speak freely Teaching listening Teaching writing Teaching reading Teaching speaking Using dictation ... Teaching listening Teaching speaking Teaching writing Grammar practice activities Using songs Testing comprehension Presenting new grammar Testing spoken English Practicing new vocabulary Teaching ... following topics for their use them regularly in their teaching: teaching: TOPICS Testing grammar Correcting students’ errors Testing vocabulary Eliciting Planning lessons Checking understanding...

Ngày tải lên: 07/11/2012, 14:41

... substrate binding process This provides strong evidence that N-glycans, in particular their terminal structures, are involved in regulating the GABA translocation of GAT1, but not in binding of GAT1 ... misfolding of this protein, resulting in its partial retention in the ER and its rapid digestion thereafter [16,19] Accordingly, our results indicate that the intracellular trafficking of N-glycosylation ... terminal structures of the N-glycans of GAT1, N-glycosylation processing of NNN was inhibited by 1-deoxymannojirimycin (dMM) Inhibition by dMM leads to the formation of NNN molecules containing...

Ngày tải lên: 19/02/2014, 17:20

... thermophilic proteins contain more arginines on the protein surface than mesophilic proteins [36–38] The effect of the large-scale increase in the number of arginines was tested experimentally in T reesei ... mimic the binding of the xylose ring in the active site The binding of glycerol to a single site may suggest that this site is the strongest binding subsite for the xylose subunits of xylan Structural ... several minor modifications that correlate with the increased thermostability Increase in the frequency of Arg is a known determinant in the thermostability, in the same way as the increase in the...

Ngày tải lên: 20/02/2014, 23:20

... transglutaminase autoantibodies as the best screening marker J Endocrinol Invest 2005; 28: 864-5 Hummel M, Bonifacio E, Stern M, et al Development of celiac disease-associated antibodies in offspring of ... prevalence of CD in Finnish healthy population *** The ratio was similar to prevalence of CD in diabetic Czech population (4.3%) and higher than in healthy population (0.69%) Prevalence of CD in T1DM ... were studied over a period of one year (2006-2007) None of the subjects had complaints related to the gastrointestinal tract or a suspicion of CD The control group included 103 children admitted...

Ngày tải lên: 05/03/2014, 12:20

... to elimination of perinatal transmission in the United States include the continued increase in HIV infection in women of childbearing age;12 absent or delayed prenatal care, particularly in women ... regarding use of lopinavir/ritonavir in neonates o Addition of new pharmacokinetic data on nevirapine in preterm infants • Initial Postnatal Management of the HIV-Exposed Neonate: o Because of the ... regarding PrEP in discordant couples who wish to conceive Discussion includes information on counseling, laboratory testing, and monitoring of individuals on PrEP and importance of reporting uninfected...

Ngày tải lên: 05/03/2014, 13:20

... Insertion of a new exon originating from the non-coding sequences of intron of the SAF-1/MAZ gene resulted in creation of a different C-terminus consisting of eight zinc finger domains in SAF-2 ... exon in human SAF-3 (exon 1A) encodes 12 amino acids, including the initiator methionine (Fig 2B) The nucleotide sequence around the initiation ATG codon in SAF-3 matches the translation initiation ... activity of SAF-3 could result from (a) a transactivating module present in the unique N-terminus, (b) binding of the N-terminus by ancillary factors, (c) the lack of a negatively functioning module...

Ngày tải lên: 07/03/2014, 02:20

... reduce postoperative insulin resistance Insulin resistance in type diabetes Tyrosine phosphorylation of the insulin receptor increased over the same concentration range of insulin in cells from patients ... maximal effects of insulin on the state of tyrosinephosphorylation of the insulin receptor or of IRS1, or of phosphorylation of ERK1 ⁄ 2, was not significantly different in either group of diabetics ... that mutations in the insulin receptor cannot explain the vast majority of cases of type diabetes Downstream defects in insulin receptor signalling to tyrosine phosphorylation of IRS1 has been...

Ngày tải lên: 07/03/2014, 16:20

... control of the inducible GAL1 promoter and the encoded proteins were expressed in S cerevisiae strain INVSc1 In induced cultures of cells harboring the cDNA of PuFAD12 accumulation of linoleic ... cDNA of Pun2 had a length of 1161 bp coding for a protein of 387 amino acids with a calculated molecular mass of 44.3 kDa The corresponding amino acid sequence showed higher identities against ... between linoleic acid and c-linolenic acid, yeast cells harboring PuFADX were grown in the presence of an equimolar mixture of linoleic acid, a-linolenic acid and c-linolenic acid The resulting fatty...

Ngày tải lên: 08/03/2014, 16:20

Ngày tải lên: 09/03/2014, 17:20

... concentrations of inhibitor The observed inhibition was, in each case, best described by competitive binding of coenzyme and adenine nucleotide Inhibition constants (KiEI) were obtained from nonlinear ts of ... constant level of Fru was not critical for determination of DKm (1.23 0.15) The KIE data in Table are instrumental in delineating the kinetic mechanism of AfM1PDH and AfM2DH, as described in the Discussion ... value of $ 3, indicates that NADH binds to the enzyme prior to binding of Fru6P The absence of a KIE on kcat Km for the substrate binding rst is a clear requirement of the strictly ordered kinetic...

Ngày tải lên: 14/03/2014, 23:20

... H, Canard B, Finet S & Longhi S (2005) The intrinsically disordered C-terminal domain of the measles virus nucleoprotein interacts with the C-terminal domain of the phosphoprotein via two 788 ... range of variation of 10–20% (Fig 7C) Although the high content of unordered Fig Intrinsic fluorescence of Core+1/S proteins UV fluorescence emission spectra of Core+1/S proteins were recorded in ... obtained substantial amount of native, highly pure, untagged proteins We detected antibodies against recombinant HCV-1b Core+1/S in the sera of HCVinfected patients, suggesting that the protein...

Ngày tải lên: 15/03/2014, 09:20

... explain differences in droplet formation between indium and gold, we will consider in the following the effects of different diffusion coefficients of gold and indium on silicon, the solubility of ... the UHV chamber in spite of the preceding HF-dip There are hints in the literature [11] that deposition of gold onto a thin layer of SiO2 on Si(1 1) favors the decomposition of SiO2, i.e that ... nanowires after flooding the chamber with diluted silane and explained the absence of nanowires by considering the surface tension of indium and the low solubility of silicon in indium Iacopi et...

Ngày tải lên: 16/03/2014, 15:17

... contains two DNA binding inhibitory domains flanking the Ets domain: the central 87 amino acid inhibitory domain is poorly conserved and virtually specific to ERM, and the C-terminal domain that ... footprinting with SK-N-SH cells (25) as well as site C which corresponds to an unknown binding protein Arrowheads indicate the position of DNase I hypersensitive sites observed in footprinting ... recognize specifically Ets motifs flanking the +1 site (A) The binding of nuclear factors is eliminated by mutations in Ets motifs The binding of nuclear factors present in SK-N-SH (K) or SH-SY5Y (H)...

Ngày tải lên: 16/03/2014, 18:20

... control in (C) the involvement of multiple domains of FPR in recognition of the agonist fMLF, including the first, second, and third extracellular loops The TMs in FPR are also implicated in contributing ... constructed by substituting the segments in FPR with following corresponding parts in FPRL1: the N-terminus and N-terminal half of the first TM (A: chimera C), the C-terminal half of the first TM through ... presented as chemotaxis index (CI) defining the fold increase of migrating cells in response to receptor agonists over cell migration in the absence of agonists *P < 0.01; significantly increased cell migration...

Ngày tải lên: 16/03/2014, 18:20

... analysis of cellular retinoid-binding proteins The bootstrap neighbor-joining phylogenetic tree was constructed using CLUSTALX [23] The zebrafish (Zf) intestinal type fatty acid-binding protein (I-FABP) ... retinoid-binding protein genes was performed using clustalx [53] A bootstrap neighbor-joining phylogenetic tree was constructed using the zebrafish intestinal-type fatty acid-binding protein sequence ... the brain, but not from any other tissues examined including the liver, ovary, skin, intestine, heart, muscle and testis crabp1b mRNA was detected by RT-PCR in the skin, intestine, brain and...

Ngày tải lên: 16/03/2014, 22:20