 that is not economically significant in its own country

... convert about 50% of adenosine residues into inosines, leading to the unwinding of the RNA duplex [11] Inosine-containing RNAs are not translated as they are retained in the nucleus [12] http://genomebiology.com/2005/6/6/R51 ... include any protein-coding region, which makes it unlikely that in this subgroup of COPs the antisense transcript plays a role in regulating the coding region of the sense gene Antisense transcripts ... processing [5] The bias for antisense transcripts to terminate close to the final intron-exon boundary remains a mystery One could assume that the termination of the antisense transcript near the final...

Ngày tải lên: 14/08/2014, 14:21

Ngày tải lên: 08/08/2012, 17:20

... to declines in income by reducing both spending and saving, thereby generating changes in spending that are smaller than the changes in income And the effects on income of some of the tax increases—for ... reduce fiscal restraint in 2013 but not eliminate it For example, the expiration of the extensions of the cut in CBO ECONOMIC EFFECTS OF REDUCING THE FISCAL RESTRAINT THAT IS SCHEDULED TO OCCUR IN ... challenges, such as economic downturns or international crises Growing debt also would increase the likelihood of a sudden fiscal crisis, during which investors would lose confidence in the government’s...

Ngày tải lên: 15/03/2014, 20:20

... composition of this phospholipid is quite distinctive in living organisms because, in comparison with other phospholipids, PI is by far the most saturated In bovine heart, bovine liver and rat ... among the proteins identified in proteomic studies of S cerevisiae mitochondria [31,32] Psi1p is involved in PI remodeling As noted in the Introduction, at least two models can explain the specific ... in vitro incorporation of stearic acid into lipids was the same with membranes containing Psi1p as it was in membranes devoid of this protein In other words, it appears that Psi1p is not a G3PAT...

Ngày tải lên: 29/03/2014, 22:21

... undergone extensive size reduction before being relocated to the mainland and it is surprising that the level of inbreeding is not higher In contrast, among the mainland Woodstock sheep, many different ... Australia/Merino/unknown 31 Hokonui I Tasmania/Merino/Saxon 12 Hokonui II Tasmania/Merino/Saxon 73 Herbert Tasmania/Merino/unknown 24 Mohaka Unknown/Merino/unknown 14 878 Domestic reference flocks Mainland ... 17 Arapawa Island II Australia/Merino/unknown 61 Chatham Island Australia/Merinos/Saxon 22 Pitt Island Australia/Merinos/Saxon 519 Campbell Island Australia/Merino × longwool 105 Mainland Woodstock...

Ngày tải lên: 14/08/2014, 13:21

... significant insight into the inner workings of Thai society and plays an important role in engaging its listeners (and producers) in producing and reproducing meanings and ideologies surrounding the ... number of high-ranking princes, including the Minister of the Interior, Prince Damrong, the Foreign Minister, Prince Thewawong and selected members of the aristocracy; however this soon became available ... “Other” is also often is used in reference to minority groups, such as the Southern Thais This process conditions the discursive use of music in the Thai films discussed in this paper and is central...

Ngày tải lên: 04/10/2015, 08:00

... thrombin and GPVI agonists is dependent on PKC ([7] and this study) In contrast, we found that a PKC inhibitor did not affect RAS activity in response to thrombin and convulxin This is consistent ... secretion induced by thrombin Interestingly, although inhibitors of PtdIns3K abolished this potentiation, the inhibitor of MEK had no or only a weak effect, suggesting that the MEK– ERK cascade is not ... observation that TPO, which is unable to induce activation of PKC, does not stimulate activation of ERK in platelets This result indicates that activation of RAS is not sufficient on its own to lead...

Ngày tải lên: 08/03/2014, 16:20

... explanations for this trend In all cases, we observe that near-record low global interest rates following the 2008 global financial crisis affected NRIRs  Using data up to May 2012, we find that for most ... nominal interest rate, , with one-year ahead inflation expectations,  , is now introduced: In this specification, the nominal long-term interest rate, , is equal to the short-term nominal interest ... financial indexation There is strong inertia due to the indexation of financial contracts to the overnight interest rate (World Bank, 2006) While this indexation has maintained financial intermediation...

Ngày tải lên: 15/03/2014, 14:20

... (selection) in women heterozygous for certain X-linked diseases,13,14 we have not observed clonal X-chromosome allelic expression in studies involving more than 200 healthy women, indicating this is a ... calculations that includes individuals who are informative for more than one marker; NS indicates not statistically significant *Age is not included Figure Linear regression analysis of the correlation ... solely to indicate this fact, this article is hereby marked ‘‘advertisement’’ in accordance with 18 USC section 1734 An Inside Blood analysis of this article appears at the front of this issue ©...

Ngày tải lên: 05/03/2014, 21:20

... the interaction between VBARP and Vpr is specific The input panel represents the amount of protein used in this assay indicating that an equal amount of protein was used in all our samples and that ... of interaction between VBARP and Nef is not due to the lack of input proteins To further confirm that a physical interaction exists between Vpr and VBARP in vivo, we tested this interaction in ... (data not shown) This result was in agreement with the structure prediction analysis that indicated that VBARP is a cytoplasmic protein Together, the transiently expressed VBARP exhibited a distinct...

Ngày tải lên: 07/03/2014, 21:20

... have proved the hypothesis that a region in the C-terminal half of stromal APX 2708 is involved in its susceptibility to hydrogen peroxide and indicated that this region is in a loop unique to chloroplastic ... spinach [5] These results indicated that an inserted loop region of stromal APX is involved in its hydrogen peroxide-mediated inactivation Discussion In this study, by using various chimeric APXs ... reasons that are unknown In conclusion, we have shown that a unique loop structure is involved in susceptibility of stromal APX to hydrogen peroxide However, the molecular mechanism of this inactivation...

Ngày tải lên: 16/03/2014, 14:20

... immuno-homologue of this kinase in pea (PsCCaMK) and in this study we show that PsCCaMK is involved in Ca2+/CaM-regulated stress signaling in plants PsCCaMK is tightly associated with its substrate, ... presence of its immunohomologues in a variety of other plants [21] including Arabidopsis (data not shown) We now show that the kinase homologue from pea is involved in stress signaling Conditions ... Biochem 269) binding with DNA [27,53–55] We have found that the binding of p40 is dependent on the dephosphorylation status of the protein and the binding is fully abolished once the protein is phosphorylated...

Ngày tải lên: 18/03/2014, 01:20

... they pointed to the empty frames; for they imagined that everyone else could see this exquisite piece of workmanship ‘How is this?’ said the Emperor to himself ‘I can see nothing! This is indeed ... and brown color from his face, threw off his dirty clothes, and stepped forth in his princely robes; he looked so noble that the Princess could not help bowing before him ‘I am come to despise ... times of King Hans, intended to go home, and malicious Fate managed matters so that his feet, instead of finding their way to his own galoshes, slipped into those of Fortune Thus caparisoned the...

Ngày tải lên: 24/03/2014, 00:20

... Characterisation of independent DNA and multiple Zn-binding domains at the N terminus of human DNA-(cytosine-5) methyltransferase: modulating the property of a DNA-binding domain by contiguous Zn-binding ... we indeed observed a protein that had retained the specificity and kinetic properties of a MTase [26] but had lost its topoisomerase activity, indicating the role of the N-terminal portion in ... obtained for the first 20 amino acids of p18 is GIPQKRKRFYLVAFLNQNIH This is in agreement with the C-terminal portion of M.MspI that would contain 166 amino acids The molecular mass for this fragment...

Ngày tải lên: 24/03/2014, 00:21

... edited with the 'visudo' command as root # # Please consider adding local content in /etc/sudoers.d/ instead of # directly modifying this file # # See the man page for details on how to write a sudoers ... Finished Sau đó: - Tại giao diện dòng lệnh, gõ: sudo cp /etc/sudoers /etc/sudoers.backup sudo nano /etc/sudoers - Và nhập đoạn mã vào file hiển thị: # # This file MUST be edited with the 'visudo' ... ALL=(ALL:ALL) ALL # Members of the admin group may gain root privileges %admin ALL=(ALL) ALL # Allow members of group sudo to execute any command %sudo ALL=(ALL:ALL) ALL #includedir /etc/sudoers.d - Nhấn...

Ngày tải lên: 30/03/2014, 00:20

... control substance in this context, because it is an inhibitor of P-glycoprotein rather than MPTP, and is devoid of calcineurin-inhibiting properties [23] We hypothesized that an increase in steady-state ... non-P-glycoprotein-containing cells and the same cells transfected in such a way that they 3008 express this protein We demonstrated that in cells that not contain P-glycoprotein, neither CsA, ... degree of increased ROS production in response to CsA and its analogs NIM811 and PSC833 The increased production was not of mitochondrial origin It is also unlikely that the calcineurininhibiting properties...

Ngày tải lên: 30/03/2014, 08:20

... animals Diabetes was induced with either intravenous or intraperitoneal injection of streptozotocin into male Wistar rats and insulin was subsequently administered intravenously into some of the ... cDNAs in the database (B) Human PPP1R3E cDNA and the encoded protein determined by PCR of human brain and testis cDNA libraries The PP1 binding motif is underlined, glycogen-targeting domain is ... glycogen-bound PP1 in skeletal muscle in humans and rodents The observation that R3E appeared to be predominantly expressed in insulin-sensitive tissues, led to investigation of whether this protein is regulated...

Ngày tải lên: 30/03/2014, 16:20

... resulting in an observed inhibition of the modification of Ras in vitro ExoS interacts with all isoforms of the 14-3-3 family ExoS interacts with 14-3-3 proteins in the C-terminal part and this interaction ... evidence that 14-3-3 proteins indeed interact with ExoS through amino acid residues 415–432, containing the DALDL sequence Fig E-son disrupts the binding between ExoS and 14-3-3 Recombinant 14-3-3 ... 14-3-3 interacting partners reveals five binding partners References are indicated in brackets after each interacting protein name and putative interaction amino acid residues are marked in bold E-son...

Ngày tải lên: 31/03/2014, 08:20

... There is also no need to explicitly maintain constraint (2), either, which states that a pair is either coreferent or not In the case that a pair cannot be set to (representing coreference), it is ... constraint—ought to spread over the whole candidate set, not just within in the window Transitivity without further constraints is pointless.6 What we really can gain from transitivity is consistency ... O0.5 (as indicated by the gold standard) set to Note that this is just another kind of constraints: the enforcement of coreference (this time extensionally given) The result was surprising: The...

Ngày tải lên: 31/03/2014, 20:20

... unable to interact with CD81 This region is conserved across genotypes, underlining its significance Finally, we have determined that the first putative CD81 binding region is not a CD81 binding region, ... implicating them as being directly involved in E2 binding to CD81 In conclusion, we have determined that the second and third putative CD81 binding regions are responsible for mediating E2 binding ... mutations in the putative CD81 binding region (Y474A, D481A, R483A, Y485A, W487A, H488A, Y489A, and R492A) suggesting that this region is not directly involved in binding CD81 (Fig 4A) The fact that...

Ngày tải lên: 20/06/2014, 01:20