— molecularly targeted therapies and new paradigms for clinical trials

... organizations and tens of thousands of individuals from across the country who work together in pursuit of three goals—increasing access to quality care and clinical trials for women with breast cancer and ... workforce; and ensuring adequate funding for clinical research In addition, the CRR has identified two translational blocks—from basic science into clinical practice and from the clinical identification ... include: • program costs for training efforts and committee discussion time; and • participation costs such as time for learning and ensuring that participant members can stand behind their views...

Ngày tải lên: 29/03/2014, 13:20

... contributions LM and AV conceived the study, and participated in its design and coordination and helped to draft the manuscript All authors read and approved the final manuscript 15 16 17 Authors information ... virological and clinical endpoints and implications for mass vaccination in cervical cancer prevention Gynecol Oncol 2008, 110:S18-S25 29 Joura E, Kjaer S, Wheeler C, Sigurdssond K, Iversen OE, Hernandez-Avila ... Importance of virological and clinical endpoints and implications for mass vaccination in cervical cancer prevention Gynecol Oncol 2008, 110:S18-S25 Campo MS, Grindlay GJ, ONeil BW, Chandrachud LM, McGarvie...

Ngày tải lên: 18/06/2014, 16:20

... Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward ... Fas Ligand Caspase-3 HIF1α Collagen I Collagen III Collagen IV Fibronectin Primer Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward Reversed Forward ... polymerase activation step and continued for 40 cycles at 95°C denaturation for 20 sec, annealing for 30 sec and elongation at 72°C for 30 sec with a final extension for at 72°C Annealing temperatures...

Ngày tải lên: 13/08/2014, 13:20

... lying first anteriorly and then above it Clinical features 1◊◊The greater width and more vertical course of the right bronchus accounts for the greater tendency for foreign bodies and aspirated material ... ◊◊Nerve supply, 288 The salivary glands, 289 ◊◊The parotid gland, 289 ◊◊The submandibular gland, 292 ◊◊The sublingual gland, 293 The major arteries of the head and neck, 294 ◊◊The common carotid ... incorporated into this new edition To Mrs Katherine Ellis go my grateful thanks for invaluable secretarial assistance New and revised illustrations were skilfully produced by Jane Fallows and new MR scans...

Ngày tải lên: 17/02/2014, 19:20

... Hauser, D Demner-Fushman, G Ford, and G Thoma 2004 PubMed on Tap: Discovering design principles for online information delivery to handheld computers In MEDINFO 2004 M Hearst and J Pedersen 1996 Reexaming ... evidencebased medicine exist (Mendonca and Cimino, ¸ 2001; Niu and Hirst, 2004), complete end–to– end clinical question answering systems are dif- standard non-parametric test for applications of this type ... judgments for the three experimental conditions For baseline PubMed, 20% of the examined drugs fell in the beneficial category; the values are 39% for the Cluster condition and 40% for the Oracle...

Ngày tải lên: 20/02/2014, 12:20

... Interviewing and Diagnostic Exercises for Clinical and Counseling Skills Building This page intentionally left blank Interviewing and Diagnostic Exercises for Clinical and Counseling Skills ... S., 1955­ Interviewing and diagnostic exercises for clinical and counseling skills building / Pearl S Berman, with Susan Shopland p cm Includes bibliographical references and index ISBN 0-8058-4640-9 ... situation and then ended with, "My boss is so demanding He never has any­ thing good to say." She then goes on to talk about her children and ends with, "My children seem to take and take and take and...

Ngày tải lên: 05/03/2014, 21:20

... research of information for the first edition of the book and in planning its organization and format I also want to thank Dr Sandoval Melin for his expertise in the area of exercise Sandoval has ... support, and your trustworthiness And to Ann Kafoury, L.P.C., I thank you for your skill, your grace and compassion, your trust in me and trustworthy ways, and your commitment to me and my own ... improved the feel and readability of each chapter Dr Elizabeth Newhall generously gave of her time and expertise as an obstetrician and gynecologist for the first edition If it were not for her generous...

Ngày tải lên: 22/03/2014, 20:21

... total sample for cabbage, and total fruits per total sample for water melon III Result and discussion 3.1.Supply chain mapping for cabbage and water melon After harvesting, cabbage and water melon ... requirement and consumer demand for higher food quality and safety: - Supply chain should be adequately simple, flexible, more direct, straightforward and well coordinated to meet the value and competitiveness ... harvest handbook and TOT/FFS training courses need to be taken place to upgrade knowledge of stakeholders A new approach for modern supply chain could be proposed to apply for cabbage and water...

Ngày tải lên: 21/06/2014, 04:20

... tools for PKM (Personal Knowledge management) are discussed Educational uses of wikis and blogs are outlined Blogs and wikis represent new repositories of information and knowledge for personal and ... networking processes and a community model to foster knowledge sharing and collaboration Blogs and wikis represent new repositories of information and knowledge for personal and organisational ... as a standalone version and can be seen as personal information managers An example of a Methodologies, Tools and New Developments for E-Learning personal wiki is Pimki (http://pimki.rubyforge.org),...

Ngày tải lên: 27/06/2014, 05:20

... long-span and high-rise building forms, materials transitioned from their pre-modern role of being subordinate to architectural needs into a means to expand functional performance and open up new formal ... and remove liability for performance failures For many uses, codes and standards often explicitly or implicitly identify acceptable materials, leaving the architect only to select between brands ... responsibility from the architect, and as such, it is less about informed choice and optimization and more about specification and standardization The result is information, not knowledge This general...

Ngày tải lên: 27/06/2014, 17:20

Ngày tải lên: 05/08/2014, 09:46

... mangrove forest Therefore, the project of planting mangroves and trees against sand [2] is the best way to prevent climate change in many respects, and two of the many benefits that energy and new ... so that people can live and income on these areas so that they stick with mangroves and sand The technological transformation of biomass into fuels and new materials for Vietnam's scientists ... change and sea level rise, the crops such as coconut water is very large role in keeping the land and improving the climate The use of coconut water has been known for quite some time and quite...

Ngày tải lên: 27/04/2015, 09:10

... (i.e., n = and n = 10) are studied For each scenario, 30 instances are randomly generated and solved by CPLEX and proposed GRASPs, respectively Both GRASP_1 and GRASP_2 are coded in Matlab and executed ... bound for the genuine integration model for the problem of quayside operations Meisel and Bierwirth (2009) devised a new model formulation to address the deciency of the study in Park and Kim ... in the Timespace Diagram For heuristics (Kim and Moon, 2003; Guan and Cheung, 2004; Wang and Lim, 2007) proposed for solving the continuous BAP, a fundamental procedure for the algorithms is to...

Ngày tải lên: 10/09/2015, 15:48

... independently read each clinical trial report and scored the reports for reporting quality and validity Disagreements were discussed and consensus achieved Trials were scored for quality using a ... three-item, 1- to 5-point scale [12], and at least two points, one each for randomisation and double blinding, were required for inclusion Trials were scored for validity using an eight-item, 16-point ... report forms, detailed statistical analyses, and protocol amendments Full clinical trial reports were not available for eight trials, but extensive clinical trial summaries were provided Information...

Ngày tải lên: 09/08/2014, 06:22

Ngày tải lên: 09/08/2014, 07:20

... PRISM and PRISM III scores, the AUCs were as follows: ≥0.7 for the PIM and PRISM III scores [15]; ≥0.8 for the PIM score, and ≥0.9 for the PRISM and PRISM III scores [16]; and between 0.83 and ... (PRISM)hoursPRISM and H24 for [1,2] for the length points for which the namely hours Index [1,2] for (a) the time points for which the scores were developed (1 hour [H1] for PIM, 24 hours [H24] for PRISM, and ... calibration for PIM from day until discharge, for PRISM between days and 15, and for PRISM III between days and 10 (Fig 1b) For both time periods, study of the length of stay showed that the AUC for...

Ngày tải lên: 12/08/2014, 20:20

... ENHANCE: further evidence for survival and safety and implications for early treatment Crit Care Med 2005, 33:2266-2277 Fleming TR, DeMets DL: Surrogate end points in clinical trials: are we being ... studies Based on the data and analysis presented in the report by Shorr and colleagues [1], what is the potential value of protein C as a surrogate end-point for treatment trials using DrotAA? The ... (up to 48 μg/kg per hour) and longer infusion times (up to days), and the efficacy of these infusions for normalization of protein C levels We agree that these are clinical scenarios in which...

Ngày tải lên: 13/08/2014, 10:20

... for participating physicians and nurses to want to change their traditional clinical practices and adopt the xxv newer approaches? Will the limited reimbursements for performing “e-visits,” for ... manually reviewed and corrected); for Performance Gaps, feature vector indexing by K-D Tree, and qualitative evaluation; and, for Usability Gaps, support for both query by composition and by interactive ... useful information/ knowledge over time, and ignoring irrelevant and/ or non-supportive information/knowledge As new information and knowledge become available, new nodes appear, replacing some existing...

Ngày tải lên: 14/03/2014, 21:20

... hopefully some of them represent interesting candidates for future clinical trials Two peptides and one peptide construct have reached advanced clinical trials in lupus patients The efficacy of the ... manifestations, both clinical and biological, management and endpoint determinations of clinical trials for SLE are complex In particular, a central question concerns the validity of biomarkers (and surrogate ... aimed at facilitating and better controlling clinical trials for SLE [65] Managing patients with SLE is challenging and new treatments are eagerly awaited Establishing a valuable and solid data monitoring...

Ngày tải lên: 09/08/2014, 14:21

... out CT and CBCT scans for clinical and systematic analyses; but the potential for systematic testing offered by gelatin blocks is far from having been fully exploited The present paper therefore ... shot and multi-slice CT scans were performed for each block (GE Medical Systems, Lightspeed, USA) at 120 kV and 200 mA Analysis The data obtained were stored in a digital format (DICOM) and transferred ... Sources of support and financial interest: none Authors’ contributions CS, MR, MS, CW, MRu, and NCG conceived of the work and participated in its design and coordination CS and MR made substantial...

Ngày tải lên: 11/08/2014, 20:21