``bottom up´´ approach physiologically based pharmacokinetic simulation

... next from a corpus based on the Cartesian product between two sentences defined using the following features: verbs (precedent relationships of verbs in the corpus); nouns (entity -based coherence ... Okazaki et al., 2004); and learning the natural order of sentences from large corpora not necessarily based on chronological information (Lapata, 2003; Barzilay and Lee, 2004) A newspaper usually disseminates ... We define the notation A B to show that segment A precedes segment B Let us consider a bottom-up approach in arranging sentences Starting with a set of segments initialized with a sentence for...

Ngày tải lên: 31/03/2014, 01:20

Ngày tải lên: 13/08/2014, 16:20

... Schmitt W: PK-Sim®: a physiologically based pharmacokinetic 'wholebody' model Biosilico 2003, 1:121-124 Mandema JW, Tuk B, van Steveninck AL, Breimer DD, Cohen AF, Danhof M: Pharmacokinetic- pharmacodynamic ... oral ITZ administration on the pharmacokinetics of intravenously administered MDZ using a mechanistic WB-PBPK simulation model WB-PBPK modeling allows for the simulation of the fate of xenobiotics ... UDP-glucuronosyltransferase Vmax Maximum velocity of an enzymatic reaction WB-PBPK Whole body physiologically- based pharmacokinetic Competing interests Figure 10 (b) lite OH-ITZ (a) and the simplified...

Ngày tải lên: 13/08/2014, 16:21

... Using Physiologically Based Modelling: A Retrospective Analysis of 26 Clinically Tested Drugs Drug Metab Dispos 2007:1766-1780 Björkman S: Reduction and lumping of physiologically based pharmacokinetic ... range of application is limited [5] In contrast, whole body physiologicallybased pharmacokinetic (WBPBPK) models for simulating human pharmacokinetics [6] enable the time-course of the tissue concentrations ... candidate selection and extrapolation of pharmacokinetics to man Basic Clin Pharmacol Toxicol 2005, 96:193-199 23 24 25 26 27 Reddy MB: Physiologically Based Pharmacokinetic Modeling: Science And...

Ngày tải lên: 13/08/2014, 16:21

... required to better characterize drug pharmacokinetics and pharmacodynamics Among pharmacokinetic modeling approaches, the physiologically based pharmacokinetic (PBPK) approach is now progressively used ... Nestorov I: Whole Body Pharmacokinetic Models Clin Pharmacokinet 2003, 42:883–908 Luttringer O, Theil F, Poulin P, Schmitt-Hoffmann A, Guentert T and Lave T: Physiologically Based Pharmacokinetic (PBPK) ... 38 39 40 41 42 43 44 45 Poulin P and Theil F: Prediction of Pharmacokinetics prior to in Vivo Studies II Generic Physiologically Based Pharmacokinetic Models of Drug Disposition J Pharm Sci 2002,...

Ngày tải lên: 13/08/2014, 16:21

... LITERATURE REVIEW 2.1 Phillips Curve -based Models 2.2 Univariate Models 2.3 Disaggregated Bottom-up Approach 11 2.4 Inflation Models for the ... 6.5% In this thesis, we focus on an econometric disaggregated bottom-up approach to model the inflation in Singapore The approach first analyzes price behaviors of the various categories of goods ... the history of Phillips curved -based models, followed by a discussion on the development of univariate benchmarks, and then introduce a practical disaggregated approach widely adopted by central...

Ngày tải lên: 26/11/2015, 12:38

Ngày tải lên: 01/12/2016, 23:48

... interpretation of simulation results Evidently, the relevance of simulation results is heavily dependent upon the model in use; whereas, the chosen simulation method determines the simulation results’ ... microscopic configurations, either by time averaging in MD simulations, or by ensemble averaging in MC simulations The optimal choice for the simulation method is strongly dependent 27 VJS | January ... tempering (24, 28), which use MD or MC simulations as their workhorse, to accelerate the sampling process C Simulation tools Since the first Molecular Dynamics simulation study by Alder and Wainwright...

Ngày tải lên: 20/06/2016, 23:17

Ngày tải lên: 21/08/2012, 15:21

Ngày tải lên: 21/08/2012, 15:28

Ngày tải lên: 27/04/2013, 11:20

... unit has one listening session These listening sessions are under the tendency of theme -based and task -based approaches The book provides different wide 21 rage of different listening texts and ... structure will be Task -based method: this method places stress on activities or tasks that learners in class in order to develop their communicative competence A task -based syllabus should be ... a single listening event the processes may flow one into the other, recycle and may be modified based on what occurred in prior or subsequent processes 8 Bang and Ngoc (2001, p38-39) divided...

Ngày tải lên: 07/09/2013, 13:48

Ngày tải lên: 14/12/2013, 13:15

Ngày tải lên: 14/12/2013, 13:15

... of MBOT To this end, we introduce a rule extraction and weight training method for LMBOT that is based on the corresponding procedures for STSG and STSSG However, general LMBOT can be too expressive ... Chiang (2005) and Graehl et al (2008) argue that STSG have sufficient expressive power for syntaxbased machine translation, but Zhang et al (2008a) show that the additional expressive power of ... Pietra, Fredrick Jelinek, John D Lafferty, Robert L Mercer, and Paul S Roossin 1990 A statistical approach to machine translation Computational Linguistics, 16(2):79–85 Peter F Brown, Stephen A...

Ngày tải lên: 17/03/2014, 00:20

... Network Security Layered security—using the OSI model as a security model Network security is often based on the familiar OSI model, which organizes networking into seven layers When information travels ... Physical Network Security Treat wireless with care Wireless is, by its very nature, unsecure A cable -based network requires access to a cable or a port to get into a network, but a wireless network ... paranoid In conclusion Physical network security is as important or more important than software -based security—a failure in physical security can quickly nullify all the work done on the software...

Ngày tải lên: 22/03/2014, 15:21

... criteria (based on qualitative assessment) If the medium stringent approach (Additionality scenario) is applied the CDM potential is more than double than that of the most stringent approach (Additionality ... efficient and cleaner technologies As opposed to transnational quantitative approaches, technology oriented approaches might be based on knowledge sharing and coordination, and extend to the sharing ... (Schmidt et al, 2005) More details on this approach are provided in Section 5.2.5, which explains how credits under a country -based sectoral crediting approach would be generated 5.2.3 International...

Ngày tải lên: 22/03/2014, 20:20

... Conclusion and Future Work Several parameters are relevant for the success of a seed -based bootstrapping approach to relation extraction One of these is the arity of the relation Another one ... type, i.e., persons These differences are relevant for any relation extraction approach The success of the bootstrapping approach crucially depends on the nature of the training data base One of the ... (Yangarber et al., 2000) We call our system DARE, standing for “Domain Adaptive Relation Extraction based on Seeds” DARE contains four major components: linguistic annotation, classifier, rule learning...

Ngày tải lên: 23/03/2014, 18:20

... devoted to operations on the processor structures (Kernel Functions), and, in the case of a feature -based system, in Ft, are all the functions devoted to the management of feature structures (Marino, ... Yl(cat0a),k) Such a rule scheduling allows an efficient realization of the immediate constituent analysis approach within a bottom-up parser by means of a partitioning of the roles in a Process Grammar ... proposing useless relations between constituents We terminate this Section pointing out that this same approach can be used in the dual case of this example, with a set P2 of productions like: P = {X...

Ngày tải lên: 31/03/2014, 18:20