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•KT 4» HỄ? ACKNOWLEDGMENTS would not have been able to finish this report Without the help of my supervisor, my family, and my friends would like to express my gratitude IO A/Prof Vo Truong Nhu Ngoc Vice Dean of School of Odonlo-Stomatology Hanoi Medical University, for his dedicated guidance, enthusiastic encouragement and precious advice he had for me Il is my honour to hav e him as a supervisor in my life Last but not least I would like to extend my thanks to my family and all my friends, who always accompany and support me in all of my decisions If Il were not for you I would not be where I am today Hanoi May 24’" 2021 DÍNH VIET HA •w.- -TíCa: