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Luận văn Thạc sĩ Hoá học: Phân tích cấu trúc của một số hợp chất Indenoisoquinoline chứa mạch nhánh Triazole

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Luận văn này tập trung phân tích cấu trúc của một số hợp chất indenoisoquinoline có chứa mạch nhánh triazole bằng các phương pháp hóa lý hiện đại như phổ hồng ngoại (IR), cộng hưởng từ hạt nhân (NMR) và phổ khối lượng (MS). Kết quả của luận văn sẽ là cơ sở khoa học giá trị cho việc nghiên cứu định tính và định lượng các dẫn xuất indenoisoquinoline chứa mạch nhánh triazole. Mời các bạn cùng tham khảo!

Ngày đăng: 09/07/2021, 11:05

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Tài liệu tham khảo Loại Chi tiết
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6. Brian M. Fox, Xiangshu Xiao, Smitha Antony, Glenda Kohlhagen, Yves Pommier, Bart L. Staker, Lance Stewart, và Mark Cushman, “Design, Synthesis, and Biological Evaluation of Cytotoxic 11- Alkenylindenoisoquinoline Topoisomerase I Inhibitors and Indenoisoquinoline – Camptothecin Hybrids”, Journal of Medicinal Chemistry, 2003, 46, 3275 – 3282 Sách, tạp chí
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7. Martin Conda-Sheridan, Eun-Jung Park, Daniel E. Beck, P. V. Narimha Reddy, Trung X. Nguyen, Bingjie Hu, Lian Chen, Jerry J. White, Richard B. van Breemen, John M. Pezzuto, và Mark Cushman,“Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Rexinoids with Chemopreventive Potential”, Journal of Medicinal Chemistry, 2013, 56, 2581 – 2605 Sách, tạp chí
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Tiêu đề: Alcohol-, Diol-, and Carbohydrate- Substituted Indeooisoquinolines as Topoisomerase I Inhibitors: Investigating the Relationships Involving Stereochemistry, Hydrogen Bonding, and Biological Activity”, "Journal of Medicinal Chemistry," 2011, "54
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Tiêu đề: Synthesis and biological evaluations of novel indenoisoquinolines as topoisomerase I inhibitors”, "Bioorganic & "Medicinal Chemistry Letters," 2012, "22
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Tiêu đề: On the mechanism of conversion of 4-carboxy-3,4-dihydro-3-phenyl-1(2H) isoquinolones to indeno[1,2-c]isoquinolines by thionyl chloride”, "Tetrahedron", 2006, "62
12. Maris A. Cinelli, P. V. Narasimha Reddy, Peng-Cheng Lv, Jian-Hua Liang, Lian Chen, Keli Agama, Yves Pommier, Richard B. van Breemen, and Mark Cushman, “Identification, Synthesis, and Biological Evaluation of Metabolites of the Experimental Cancer Treatment Drugs Indotecan (LMP400) and Indimitecan (LMP776) and Investigation of Isomerically Hydroxylated Indenoisoquinoline Analogues as Topoisomerase I Poisons”, Journal of Medicinal Chemistry, 2012, 55, 10844−10862 Sách, tạp chí
Tiêu đề: Identification, Synthesis, and Biological Evaluation of Metabolites of the Experimental Cancer Treatment Drugs Indotecan (LMP400) and Indimitecan (LMP776) and Investigation of Isomerically Hydroxylated Indenoisoquinoline Analogues as Topoisomerase I Poisons”, "Journal of Medicinal Chemistry", 2012, "55
13. Mark Cushman, Muthusamy Jayaraman, Jeffrey A. Vroman, Anna K. Fukunaga, Brian M. Fox, Glenda Kohlhagen, Dirk Strumberg, and Yves Pommier, “Synthesis of New Indeno[1,2-c]isoquinolines Sách, tạp chí
Tiêu đề: Synthesis of New Indeno[1,2-"c
14. Muthusamy Jayaraman, Brian M. Fox, Melinda Hollingshead, Glenda Kohlhagen, Yves Pommier, và Mark Cushman, “Synthesis of New Dihydroindeno[1-2]isoquinoline and Indenoisoquinolineium Chloride Topoisomerase I Inhibitors Having High in Vivo Anticancer Activity in the Hollow Fiber Animal Model”, Journal of Medicinal Chemistry, 2002, 45, 242- 249 Sách, tạp chí
Tiêu đề: Synthesis of New Dihydroindeno[1-2]isoquinoline and Indenoisoquinolineium Chloride Topoisomerase I Inhibitors Having High in Vivo Anticancer Activity in the Hollow Fiber Animal Model”, "Journal of Medicinal Chemistry", 2002, "45
15. Muthukaman Nagarajan, Andrew Morrell, Brian C. Fort, Marintha Rae Meckley, Smitha Antony, Glenda Kohlhagen, Yves Pommier, and Mark Cushman, “Synthesis and Anticancer Activity of Simplified Indenoisoquinoline Topoisomerase I Inhibitors Lacking Substituents on the Aromatic Rings”, Journal of Medicinal Chemistry, 2004, 47, 5651- 5661 Sách, tạp chí
Tiêu đề: Synthesis and Anticancer Activity of Simplified Indenoisoquinoline Topoisomerase I Inhibitors Lacking Substituents on the Aromatic Rings”, "Journal of Medicinal Chemistry", 2004, "47
16. Dirk strumberg, Yves Pommier, Kenneth Paull, Muthusamy Jayaraman, Pamela Nagafuji, and Mark Cushman, “Synthesis of Cytotoxic Indenoisoquinoline Topoisomerase I Poisons”, Journal of Medicinal Chemistry, 1999, 42, 446-457 Sách, tạp chí
Tiêu đề: Synthesis of Cytotoxic Indenoisoquinoline Topoisomerase I Poisons”, "Journal of Medicinal Chemistry", 1999, "42
17. Daulat Bikram Khadka, Won-Jea Cho, “3-Arylisoquinolines as novel topoisomerase I inhibitors”, Bioorganic & Medicinal Chemistry, 2011, 19, 724-734 Sách, tạp chí
Tiêu đề: 3-Arylisoquinolines as novel topoisomerase I inhibitors”, "Bioorganic & Medicinal Chemistry", 2011, "19
18. Daniel E. Beck, Keli Agama, Christophe Marchand, Adel Chergui, Yves Pommier, and Mark Cushman, Synthesis and Biological Evaluation of New Carbohydrate-Substituted Indenoisoquinoline Topoisomerase I Inhibitors and Improved Syntheses of the Experimental Anticancer Agents Indotecan (LMP400) and Indimitecan (LMP776), Journal of Medicinal Chemistry, 2014, 57, 1495−1512 Sách, tạp chí
Tiêu đề: Journal of Medicinal Chemistry", 2014, "57
19. Hue Thi My Van, Quynh Manh Le, Kwang Youl Lee, Eung-Seok Lee, Youngjoo Kwon, Tae Sung Kim, Thanh Nguyen Le, Suh-Hee Lee and Won-Jea Cho, “Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex”, Bioorganic & Medicinal Chemistry Letters, 2007, 17, 5763-5767 Sách, tạp chí
Tiêu đề: Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex”, "Bioorganic & Medicinal Chemistry Letters," 2007, "17
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Tiêu đề: Design, docking, and synthesis of novel indeno[1,2-c]isoquinolines for the development of antitumor agents as topoisomerase I inhibitors”, "Bioorganic & Medicinal Chemistry Letters", 2007, "17
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Tiêu đề: c"]isoquinolinone, "Journal of Medicinal Chemistry, "2005, "48
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Tiêu đề: Bioorganic & Medicinal Chemistry," 2011, "19
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Tiêu đề: Alternative synthetic approaches to biologically active indeno[1,2-c]isoquinoline-5,11-diones”, "15"th" international electronic conterence on synthetic organic chemistry
24. Trung Xuan Nguyen, Monica Abdelmalak, Christophe Marchand, Keli Agama, Yves Pommier, and Mark Cushman, “Synthesis and Biological Evaluation of Nitrated 7‑, 8‑, 9‑, and 10-Hydroxyindenoisoquinolines as Potential Dual Topoisomerase I (Top1)−Tyrosyl-DNA Phosphodiesterase I (TDP1) Inhibitors”, Journal of Medicinal Chemistry, 2015, 58, 3188−3208 Sách, tạp chí
Tiêu đề: Synthesis and Biological Evaluation of Nitrated 7‑, 8‑, 9‑, and 10-Hydroxyindenoisoquinolines as Potential Dual Topoisomerase I (Top1)−Tyrosyl-DNA Phosphodiesterase I (TDP1) Inhibitors”, "Journal of Medicinal Chemistry", 2015, "58

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