Front Matter
Copyright
Preface
Nomenclature
Greek Symbols
Subscript
Superscript
1.
Introduction
1.1.
Biological Cycle
1.2.
Green Chemistry
1.3.
Sustainability
1.4.
Biorefinery
1.5.
Biotechnology and Bioprocess Engineering
1.6.
Mathematics, Biology, and Engineering
1.7.
The Story of Penicillin: the Dawn of Bioprocess Engineering
1.8.
Bioprocesses: Regulatory Constraints
1.9.
The Pillars of Bioprocess Kinetics and Systems Engineering
1.10.
Summary
Further Reading
A.
Green Chemistry
B. Sustainability
C. Biorefinery
D. History of Penicillin
E. Regulatory Issues
Problems
2.1.
Cells and Organisms
2.1.3.
Viruses
2.1.6.
Eukaryotes
2.3.2.
Carbohydrates
Further Reading
3.2.
Chemical Reactions
3.3.
Reaction Rates
3.4.
Approximate Reactions
3.8.
Reaction Rates Near Equilibrium
3.10.
Classification of Multiple Reactions and Selectivity
3.12.
Reactor Mass Balances
3.15.
Ideal Reactors
3.16.
Bioprocess Systems Optimization
Further Reading
4.2.
Batch Reactor Sizing
Further Reading
5.
Ideal Flow Reactors
6.1.1.
Distribution Laws
6.2.
Collision Theory of Reaction Rates
6.4.
Unimolecular Reactions
Reading Materials
7.1.
Regression Models
7.4.
Correlation Coefficient
7.8.
Batch Kinetic Data Interpretation: Differential Regression Model
Further Reading
Problems
8.1.
How Enzymes Work
8.2.2.
Mechanistic Models for Simple Enzyme Kinetics
8.2.3.
Specific Activity
8.2.4.
Models for More Complex Enzyme Kinetics
8.2.6.
Insoluble Substrates
8.3.
Immobilized Enzyme Systems
8.5.
Large-Scale Production of Enzymes
8.7.3.
Modified Fast Equilibrium Approximation
Further Reading
Problems
9.1.
Adsorption and Desorption
9.1.2.2.
UniLan Isotherm
9.1.4.1.
Chemisorption, Physisorption and the BET Theory
9.1.4.2.
Multilayer Adsorption of Single Species
9.1.4.4.
Multispecies Multilayer Adsorption Isotherms
9.6.
Decline of Surface Activity: Catalyst Deactivation
Further Reading
Problems
10.1.
The Central Dogma
10.6.2.
Role of Cell Receptors in Metabolism and Cellular Differentiation
10.7.1.
Bioenergetics
10.8.
Overview of Biosynthesis
10.9.
Overview of Anaerobic Metabolism
Further Reading
11.1.1.
Cell Number Density
11.1.2.
Cell Mass Concentration
11.2.
Batch Growth Patterns
11.14.2.
Simple Growth Rate Model: Monod Equation
11.14.2.1.1.
Substrate Inhibition
11.14.2.1.2.
Product Inhibition
11.14.2.2.
Multiple Limiting Substrates
11.14.3.
Simplest Reaction Network or Simplest Metabolic Model
11.14.5.
Cybernetic Models
11.15.
Performance Analysis of Batch Culture
Reading Materials
12.3.
Wastewater Treatment Process
12.4.2.
Passive Immobilization: Biological Films
Further Reading
13.1.3.
Mass Balance on the Cell Biomass
13.6.
Examples of Fed-Batch Use in Industry
13.7.1.
Calorimetry
13.7.3.
Substrate Carbon and Nitrogen Source
13.7.4.
By-product concentration
13.7.6.
Respiratory Quotient
13.7.8.
Proton Production
13.9.
Summary
Further Reading
Problems
14.1.
Mutations
14.2.
Selection
14.3.
Natural Mechanisms for Gene Transfer and Rearrangement
14.4.
Techniques of Genetic Engineering
14.5.
Applications of Genetic Engineering
14.6.
The Product and Process Decisions
14.7.
Host?Vector System Selection
14.8.
Regulatory Constraints on Genetic Processes
14.9.
Metabolic Engineering
14.10.
Protein Engineering
14.11.
Summary
Further Reading
PROBLEMS
Further Reading
Further Reading
Further Reading
Further Reading
Index
A
B
C
D
E
F
G
H
I
K
L
M
N
O
P
Q
R
S
T
U
V
W
Y
Z