Danh sách thuốc bảo vệ thực vật sinh học

INTERVIEW 2020 Biologicals Special INTERVIEW INTERVIEW Getting your biorationals on the fast track to international market success All-round regulatory and scientific support for: MEET US • Biopesticides at ABIM 2020 in Basel • Basic and low-risk substances • Biostimulants and fertilisers – soil aids, soil conditioners or plant aids • Organic/precision farming and IPM Our knowledge is the key to your success 2020 Biologicals Special SCC Scientific Consulting Company Chemisch-Wissenschaftliche Beratung GmbH Am Grenzgraben 11 55545 Bad Kreuznach Germany info@scc-hq.de www.scc-gmbh.de 2020 Biologicals Special INTERVIEW 2020 Biologicals Special INTERVIEW 2020 Biologicals Special INTERVIEW CONTENTS INTERVIEW Advertiser Index Advanced Biological Marketing (ABM) P14 Agri Star P40 AgriThority P64 Azotic Technologies P32 Beijing Kingbo Biotech Co.,Ltd P48 Beijing Multigrass Formulation P4 BESTAR P3 Biolchim P8 Certis USA P44 Compliance Services International (CSI) P66 CropTrials GmbH P68 DOGAL P56 Eurofins Agroscience Services Group P15 Grupo Vigna Brasil P31 Hangzhou Pulan Biotechnology P63 Ingevity P28 INTERMAG Sp z o.o P36 IPL Biologicals Limited P2 Leili Marine BioIndustry INC P52 Kwizda Agro GmbH P34 LOMON CORPORATION P50 M2i Biocontrol P67 Plant Health Care P11 Scientific Consulting Company (SCC) P1 Seipasa P16 Shan Dong Peng Bo Bio Technology P20 Staphyt Inside Front Cover STK P24 Tradecorp P54 Verdesian Life Sciences U.S LLC P67 Opportunities or Challenges? - Changes in EU Registration Regulation in 2019 06 Biolchim: Adjust Strategy Under 2019-nCoV, Break Through the Encirclement and Lead Again 08 Plant Health Care: Focus on Plant Response Elicitors Technology, Boost Company's Rapid Development 11 Seipasa: Focus on the American Market, Develop Biotechnology Products 16 PRODUCT FOCUS New Registrations of Microbial Pesticides in US from 2015 to 2018 19 Botanical Pesticides Approved/Launched in Europe, US in Spring 2020 22 Regev™ – A Broad-spectrum Hybrid Fungicide for Plant Disease Control 24 Biorational Developments in Open Field Crops 27 Ingevity: Enhance the Efficiency of Micronutrients with Pine-based Kraft Lignin 28 Azotic’s Natural Nitrogen Fixing Technology Is A Must for Agriculture 32 Kwizda Agro: Driving Innovation in Biologicals 34 Complementary Approach to Biostimulation 36 How to Achieve Constant Quality in Horticulture 38 Agri Star is Positioned as the Leader in the Bio-Inputs Market in Argentina 40 VIEWPOINT Scan to Download It AGROPAGES TEL：+86-571-87240039 EMAIL：agropages@vip.163.com 2020 Biologicals Special Biopesticide in Latin America: The Market Is Changing, Where Are the Future Opportunities? 42 Viral Insecticides: Technological Innovation, A New Blue Ocean of Future Pesticides 46 Timing, One the Keys to Maximise Results When Using Biostimulants 54 RNAi Opens A New Vista for Pest Control 58 France: Reducing Chemical Pesticide Use And Developing Biological Control 60 Biopesticides – A Fast-growing Multibillion Market 62 COMPANY DIRECTORY 64 Disclaimer: If some advertisements and product profiles in this issue contain references to active ingredients still under patent protection in certain countries, such content are deemed inapplicable to those countries INTERVIEW INTERVIEW Opportunities or Challenges? - Changes in EU Registration Regulation in 2019 S CC – Scientific Consulting Company – was founded in 1989 by Dr Friedbert Pistel Since then, it has become one of Europe’s largest privately owned and independent regulatory consulting companies, supporting its global customers with all their registration needs for agrochemicals and biorationals, including biostimulants and fertilisers and other industries What kind of company is SCC? What has happened to the EU's registration policy for biopesticides and biostimulants in 2019? What are the points to note when registering biopesticides or biostimulants in the EU? Taking this opportunity, AgroPages interviewed Dr Lars Huber, Head of Biorationals, Fertilisers and IPM of SCC mean that we are not actively working in products Sale revenues for such products technical progress in regards to agrochemical registration projects also outside EU such often not justify the investments necessary practices such as Integrated Pest Management as in US, Australia or Southern American for a registration There are some support (IPM), Sustainability or Precision Farming or Asian countries Although, normally we schemes in place in certain countries but as well as testing methods to be used for cover all this work via our global network of they are still too few and they have to be study conduct Overall, requirements for cooperation partners, all of them having in- expanded But it’s not always the financial the registration of plant protection products depth knowledge of the national requirements investment itself that detain companies from become more and more complex but also and authorities Thus, we are already acting on the registration Often, the reasons are the more individualised, specifically considering a global scale with international registration uncertainties and the lack of harmonisation the characteristics of the individual active projects but of course we will expand further in regards to data requirements, requests substance and/or product This allows for if our clients require respective services for post-submissions during the registration General topics and trends are given by the very specific, substance-orientated approaches procedure or the timelines Thus, a regulatory in regards to requirements, studies and harmonisation and a fast track procedure, scientific justifications for study waivers for biorationals Thus, dossiers in general get more complex and scientifically demanding but, on the other hand, increased acceptance of scientific argumentation and use of public literature offers possibilities to reduce study requirements and thus registration costs at least for biorationals In the field of Agrochemicals and Biorationals, after more than 30 years of development, SCC has become a leading consulting company in this field What you think is the distinctive service of SCC compared with other companies? Why many companies choose to cooperate with SCC? types of natural substances under plant Asian customers as best as possible On the protection as well as fertiliser/biostimulant other hand this enables us to offer our other regulatory frameworks This includes not clients services in Asian countries and at least only the work in regards to registration partially use synergies, knowledge and data projects but also in R&D as well as academia produced for registrations in Europe or US research projects These different activities for example for registrations in Asia provide for in-depth knowledge, scientifically oriented testing and registration strategies for all types of biorationals and regulatory Lars: According to the feedback from our frameworks clients as well as cooperation partners, CROs have no own labs for example we are able always to choose the lab or CRO most suited to conduct a specific study in regards to its scientific experience as well as in regards What does a typical SCC global customer look like? Who are your target customers? What are your plans for future development and expansion into new markets / regions? At present, SCC has operations in overseas countries such as Japan and China Please summarize the global development of SCC, especially in the core market? to economic suitability or timing of studies and involves many different areas of the registration process On the one hand, there are the data requirements itself which clearly are not or only partially suitable for biopesticides, i.e natural substances and Lars: Due to SCCs mode of operation, at least in regards to the admissibility of an application, would be required Participation of EFSA in pre-submission meeting is a necessary first step to be welcomed but additional improvements in the regulatory registration process are also be necessary Regarding biostimulant registration, is there any change in EU biostimulant registration policy in 2019? In the biostimulant registration section, what services can SCC provide to help customers obtain registration quickly? especially microorganisms These have to be revised and adapted Respective scientific Lars: In 2019 the new EU regulation on work dates already back more than two fertilisers entered into force This regulation especially the already mentioned independent decades but has not been included in the also includes biostimulants and plant aids for character, there is no typical global customer regulatory process This implementation example This of course changed registration SCC cooperates, and is able to cooperate, is currently ongoing on authority level and, possibilities significantly as the regulation with the full scale of customers interested after a delay of many years, hopefully will introduces EU-harmonised rules Regrettably, in or in need of regulatory and scientific lead to significant improvements in the near applicability of the regulation will be in 2022 services for plant protection products, future On the other hand, the specifics of only as the respective guidelines and guidance according to the countries in which biostimulants, fertilisers and other related biopesticides have to be considered more have to be developed in the meantime Until registrations are envisaged e.g EU and US products Of course, in cooperation with detailed in the regulatory process For one, then, respective products still have to be Differences in regards to rules, regulatory our other departments, biocides or REACH the Modes of Action of many biopesticides registered on a national level if applicable frameworks and procedures as well as data projects for example can also be handled require not a curative but a preventive use National registrations can be a good basis for requirements between countries are one of Some of our clients conduct much of the Others not act directly on target organisms a subsequent registration as an EU-fertilising but have an indirect Mode of Action acting via product Thus, SCC can assist clients to Could you describe the status and some trends of the agrochemical consulting industry? What you think is the biggest challenge in the consulting industry? and authorities, one of the most distinctive features of SCC is our independence As we Lars: This is a very complex issue and regulatory, and synergies allow for the development of innovative and future- Regarding the registration of biopesticides, is there any change in the EU's biopesticide registration policy in 2019? How you think the EU's biopesticide registration policy should be changed to drive the rapid development of biopesticides? Lars: Status and challenges differ This feature also emphasises the quality and Lars: In the case of plant protection the biggest challenges Simultaneously, this relevant work themselves Other clients work neutrality of data monitored or provided by products and especially biorationals requests results in a quite different, country-specific with cooperation or distribution partners or the defence systems of plants This requires achieve national registrations in important SCC in dossiers in the eyes of evaluators and from clients from Asian countries for status quo in regards to active substance even split forces between active substances not only their IPM use in the agricultural target markets and evaluate the possible authorities Furthermore, this independence registrations in Europe increased in recent and product registrations One of the most and products Still, other clients require the practise but also the incorporation and registrability of individual products or acceptance of IPM in the regulatory process product portfolios according to the upcoming ensures high flexibility and enables us to offer years This is partly due to the changes recent examples is the establishment of a full SCC service from R&D issues, study all different types of projects according to the brought on by the new plant protection new legal and regulatory framework for monitoring, dossier writing, applications, In spite of the fact that IPM is mandatory EU rules Thus, SCC can support clients in needs of the client and sustainability goals, regulations and biostimulants in EU, clearly differentiating defence and follow-up Thus, there is no in EU since 2014 for all professional users, attaining national registrations and allow guidelines in EU SCC responded to these between biostimulants and biopesticides In typical SCC customer or even a target the regulatory process and the requirements for an early entry into core markets and for customer not reflect this This applies especially core products and prepare for the subsequent to active substances and products with a EU-wide registration of the products after very narrow range of applications and niche applicability of the EU harmonised rules Another important fact, especially in case of the quite new and constantly changing field increasing demands from Asian customers by other countries, such a strict differentiation of the registration of biorationals is the long- intensifying or establishing a SCC presence or definitions are missing or only under term experience of SCC with all different in certain Asian countries to be able to attend development 2020 Biologicals Special The fact that SCC has not established offices in additional countries does not 2020 Biologicals Special INTERVIEW INTERVIEW Biolchim: Adjust Strategy Under 2019-nCoV, Break Through the Encirclement and Lead Again B our bio-stimulants can play a crucial role, agronomic problems and needs So, growers support to our subsidiaries and continue to becoming year after year “standard practice” choose our products because they know develop products through the WIN platform for the farmers A history of success is that when we launch a product, we have with the help of local partners, distributors, our product (BLUPRINS) for improving tested it in situations, even in geographical universities, international research centres sprouting and uniformity in cherries in Chile, environments where their problem occurs We This is to position our products in the best which is today a consolidated solution which solve the problem close to the farmers, not in possible way and be close to the needs of many farmers apply to produce quality the laboratory farmers all over the world cherries even in areas with high temperatures Another example is the application of two of our star products like Folicist and Fylloton, iolchim is a leader in the production and commercialization of special fertilizers in Italy and in the world Biolchim today is a synonym for biostimulants: innovative products in all aspects, in the raw materials they contain as well as in the agronomic performances that characterize them Biolchim operates in more than 75 countries worldwide, and is a company where Research and Development represent the main which in Peru are widely used by blueberry producers to enhance the productivity of this crop of which the cultivated area is increasing year by year gear that drives the whole business activity Affected by the 2019-nCoV in 2020, most companies in the world will be affected to varying degrees in their construction and sales As a leader in the specialty fertilizer industry, how does the epidemic affect Biolchim? In this difficult environment, how does Biolchim break through itself and adjust the follow-up plan? Taking this opportunity, AGROPAGES interviewed Marco Civitareale, Product Manager of Biolchim What is the impact of the outbreak of 2019-nCoV in 2020 on Biolchim's overall business? In this particular situation, how did Biolchim carry out related work? technical support We expect this model to where there is the presence of nematodes that still be rewarded by the market even after the create an important stress on the plant crisis We all remain united and work in the same direction to get out of this situation and become stronger than we were before, when all this started Marco: The impact was very strong, in Kriss Bio is an organic product for increasing fruit size Therefore, in the second half of 2020 we At present, there are many types of special fertilizers on the market What you think is the biggest competitive advantage of special fertilizers from Biolchim? From the perspective of dealers or growers, how you think they should choose an excellent special fertilizer product?  Could you share with us the performance of Biolchim in new product development, product launch and sales performance in 2019? In terms of international market development, what level of Biolchim's international business is currently at? What plans does Biolchim have in the future for international market development? At present, special fertilizers are developing towards functional fertilizers Do you agree with this theory? In your opinion, if special fertilizers want to break through the bottleneck in the future, what aspects of attention and research should be paid attention to? Marco: In our opinion, special fertilizers, in particular biostimulants are much more than functional fertilizers, in the sense that Marco: In 2019 the important the part that is functional is only a feature of growth curve continued in national and the biostimulant Biostimulants have a root, international markets, and special products an application, that is much deeper and wider and biostimulants saw a relevant increase The peculiarity of marketing these products Biolchim's plan for the future is certainly is that they have to relate to the application linked to the very important activities of in the individual areas of use Biostimulants through the WIN platform which ensures the subsidiaries present at an international have to be developed, studied and applied the development close to where there are level, therefore we would strengthen the where they arrive on the market Marco: Our products are developed will continue to develop what was launched and planned in January the sense that we had to reorganize ourselves from the point of view of managing suppliers, supplies and sales activities very quickly The company has been and is strong, and therefore we managed to handle the impact fairly well, in terms of production, in the The first half of 2020 has passed For the second half of the year, what is Biolchim's plan to increase product sales? What are the new product launch plans? acquisition of raw materials, which obviously suffered enormous delays, and also from the Marco: In the second half of the year, Nowadays growers in Latin America are increasingly accepting biostimulants and specialty fertilizers Could you share with us some of Biolchim’s experience in developing the Latin American market? point of view of the sales We managed to not being sure of being able to work as before keep the connection alive with our customers, the crisis and travel we will continue with with our network, with our end users and online technical / marketing support activities also to maintain the connections within the and with online customer management We practices in several Latin-American Countries group in the various areas, in the various will be present in a different way but we’ll are today more focused to export markets departments This is due to the great sense be always effectively close to our customers Chile and Peru, for instance, as well as of responsibility, a great motivation, a great The product launch plan for us is always Brazil and Colombia nowadays are among desire to overcome this terrible crisis that we at the beginning of the year, so there will the biggest exporters of fruits to the US, and our collaborators have In this moment a consolidation of what was launched in Europe and Asian markets Farmers to keep of crisis, we continue to guarantee the three January, therefore the products Vhera, Vhera competitiveness need often to improve fruit fundamental characteristics that we have Life and Kriss Bio qualities, or to maintain a certain yield even always had as a group The focus on concrete Vhera and Vhera Life are part of the Marco: Yes, this is true Farming under stress conditions and/or to concentrate results, the great capacity for innovation strategy of supporting crop productivity even harvest to catch the proper time window and finally the ability to provide continuous in difficult environments, such as in soils for exporting In those particular conditions 2020 Biologicals Special 2020 Biologicals Special INTERVIEW INTERVIEW Plant Health Care: Focus on Plant Response Elicitors Technology, Boost Company's Rapid Development country Current distribution elsewhere is patchy, with sales building in countries such as Spain, UK, Turkey and S Africa, but with many other countries where we have limited or no presence   P We know that Plant Health Care’s R&D effort is now focusing on its next-generation plant response elicitor technology (PREtec) Could you tell us what is PREtec? Why should companies focus on this area? lant Health Care is a leading provider of proprietary biological products to global What are the products which Plant Health Care sells today? agricultural markets The company attaches technology – are peptides (short chains of amino acids) derived originally from great importance to product R&D and is famous Plant Health Care’s Commercial naturally occurring harpin proteins PREtec for its core Plant Response Elicitors technology business is driven by sales of Harpin αß, peptides act by initiating a complex defense (PREtec) a recombinant protein which acts as a mechanism in plants, analogous in some ways Why should the company focus on Plant powerful biostimulant, promoting the yield to a broad spectrum immune response in Response Elicitors research? What products and quality of crops Plant Health Care also animals This protective response makes the does the company currently have and how sells the proprietary soil treatment Myconate plant resistant to a wide range of fungal and does the specific market perform? What are the in selected countries Plant Health Care sells bacterial diseases during the growing season plans for the future? With these questions, we Harpin αß and Myconate through specialist In addition to protecting against various interviewed Christopher Richards, the CEO of distributors around the world In Mexico, diseases, PREtec peptides enhance tolerance Plant Health Care Plant Health Care also distributes third- to abiotic stress such as drought, leading party biological products in addition to our to enhanced plant growth and yield The Harpin αß business company has three distinct PREtec platforms, Could you share with us what kind of company Plant Health Care is? Plant Health Care® is a leading provider of proprietary agricultural biological products focused either on disease control, nematode Where is Plant Health Care active around the world with current sales? and technology solutions focused on improving crop performance We offer products to Plant Health Care has outstanding control, or biostimulants What you think are the significant advantages of plant immune proteins products? Where are the future market opportunities for plant immune proteins? improve the health, vigour and yield of major market access, through strong relationships field crops such as corn, soybeans, cotton and with well-established distributors in a rice, as well as speciality crops such as fruits range of countries; we are also seeking and vegetables We operate globally through additional distributors in some areas In subsidiaries, distributors and supply agreements the USA, we sell through two of the five with major industry partners largest ag input distributors, which gives pesticides, PREtec peptides are us outstanding market coverage In Brazil, environmentally friendly and not interact products help growers to protect their crops we are currently selling into sugar cane directly with disease pests Consequently, from stress and diseases, and to produce higher and seeking distributors for sales into other these pests are not expected to develop quality fruit and vegetables, with a favourable crops In Mexico, we sell a broad range resistance Because of their unique mode of environmental profile of products to retailers across the entire action, PREtec peptides complement and are Our innovative, patent-protected biological 10 2020 Biologicals Special PREtec – Plant Response Elicitors Unlike the action of most chemical 2020 Biologicals Special 11 INTERVIEW INTERVIEW compatible with existing chemical fungicides response and those that are known to have and can be deployed as part of an IPM formulation limitations, to cause a drag on strategy As concerns about the environmental crop yield, or to act via poorly understood footprint of large-scale agriculture continue mechanisms PREtec peptides have none of to grow, farmers and consumers will these shortcomings Rather, PREtec is based increasingly demand ‘greener’ products such on cutting-edge science built up over years Infuse Your Yield with ® the Power of EMPLOY as PREtec of research and development to develop a EMPLOY is the biochemical plant health promoter that offers reduction of cracking of cherries, improvement of coloring and fruit sizing of tree fruit, and increased overall yield of certain crops This is because it contains the 2nd generation of the Harpin protein, a naturally occurring compound produced by pathogenic bacteria that signals plants’ growth and pathogen pathways are under development and we are very • Improve fruit size for tree fruit • Improve fruit color • Improve yields for certain crops • Even fruit ripening • Rainfast in 30 minutes • Improves plant photosynthesis The opportunities for PREtec are very new class of products that are stable, can be broad: Plant Health Care is partnering with formulated as liquids or dry granules, and a number of companies globally exploring a deliver dependable results variety of PREtec product concepts in both specialty and row crops, through both foliar and seed treatment application, and as solo products and mix partners Solutions to some of the most pressing problems facing farmers optimistic about the ability of PREtec to bring Which market areas is Plant Health Care focusing on now? What are the future market development plans? Currently, Plant Health Care has commercial operations in the US, Mexico, are excited about the potential of our lead Brazil, Chile, Peru, Spain, UK, Italy, Greece, PREtec peptide, PHC279, as a seed treatment Morocco, Turkey, Portugal and South Africa for the management of Asian soybean rust Our plans are to expand into Argentina and in Brazil, as well as in the US to enhance Taiwan when we receive regulatory approvals the activity of foliar fungicides in corn, soy Plant Health Care products are focused and vegetable crops In the medium-term, into the specialty and row crops markets our PREtec peptide for nematode control is delivering yield and quality improvements to delivering impressive results from multi-state those crops which give the grower a greater field testing in soy and specialty crops and return for their crop is expected to be embraced by growers after Compared with other companies that plant immune proteins on the market, what you think is the biggest advantage of Plant Health Care? In terms of product line, does Plant Health Care plan to expand the existing product line? If so, could you share with us the company's existing product line and R & D pipeline? Absolutely Today we market and sell This is a great question There are very CEO of Plant Health Care   added value to growers. In the near-term, we receiving regulatory approval Christopher Richards Harpin ab and Myconate into the row crop few products currently on the market that and specialty crop markets We are excited claim to work via stimulating plants’ immune about the launch of our next generation technology we call PREtec Plant Health Care has filed for the first PREtec product registrations in the US and Brazil and we expect registrations in 2021 with first potential sales in 2022 Plant Health Care is finalizing the scale up of the manufacturing and will be looking to produce on a full-scale basis to meet the product launch dates In parallel, we are looking for complementary products to sell through our strong network of distribution relationships   What are Plant Health Care's requirements for partners in choosing a distribution partner? Does the company have plans to explore new markets such as Brazil and China? It is a great question Plant Health Care is a small biological company so when choosing our distribution partner first we are looking for leading distributors who have a strong presence in the row crop and specialty crop markets Next we are looking for partners who have strong technical and marketing skills with a presence in the market to reach the grower Lastly, we look for partners who want to add new technology to their portfolio and extract value from the market that is meaningful for both parties This alignment with large distributors is what sets us apart from other biological companies and gives us confidence in our growth plans for the business We are currently open to inquiries from distributors interested in exploring opportunities for Harpin αβ in crops where we have demonstrated compelling performance, such as soy, corn, cane, and citrus in Brazil, Contact your local Wilbur-Ellis retailer for the solution that is right for you actives.wilburellis.com 12 2020 Biologicals Special For information only Not a label Prior to use, always read and follow the product label directions WILBUR-ELLIS logo is a registered trademark of Wilbur-Ellis Company LLC Employ is a registered trademark of Plant Health Care, Inc K-93553 South Asia, China and East Asia 2020 Biologicals Special 13 INTERVIEW A Complete Line of Biological Seed Treatments for All Crops Contact Brad Custis to learn more at 011.419.232.2461 Ext 137 14 2020 Biologicals Special or bradcustis@ABM1st.com ABM1st.com | P.O Box 222 | Van Wert, OH 45891 INTERVIEW 2020 Biologicals Special 15 INTERVIEW INTERVIEW The latter is responsible for the launch of two new Seipasa products, Biocinnafol (natural plant-derived acaricides / fungicides for the prevention of mites and powdery mildew) and Biocrifol (insecticides containing natural pyrethrins, for the prevention of thorns) on the Mexican market Sucking pests).  In July 2017, Seipasa reached a longterm cooperative relationship with Israeli biopesticide company STK, which will jointly develop and exclusively distribute Seipasa's Seipasa: Focus on the American Market, Develop Biotechnology Products patented bacterial agent Bacillus subtilis in the United States This patented strain can quickly form a probiotic community around the plant roots and leaves, prevent pathogens Pedro Peleato, CEO of Seipasa from entering the plant through the roots and plant surface, and block the development of pathogens by plant induced SAR (system acquired resistance)  In order to better understand the T company's strategic intention to focus on he Americas region, especially Latin Seipasa is a pioneer in the development of In January 2020, Seipasa signs a the American market, we also took the natural plant protection products, biostimulants strategic cooperation agreement with French opportunity to interview the CEO of Seipasa most attractive regions for crop protection and nutrition products in Spain Over the past multinational company Suez, Suez will sell Pedro Peleato companies With more and more fruits and two decades, high-value solutions produced four products of Seipasa in Chile, including vegetables produced in the Americas imported and registered by the company have been Bryosei, Kynetic4, Seiland and Sweetsei into high-end markets such as Europe in used in most agricultural systems worldwide recent years, local requirements for pesticides Currently, Seipasa has carried out business in agreement with Ecuador distributor QSI- and fertilizers have also risen to a new level more than 20 countries Ecuador S.A, a company with 41 years America, has become one of the The demand for green, environmentally After sorting out the trajectory of Seipasa's In September 2019, Seipasa signed an of experience, providing various types of We have noticed that Seipasa has selected partners in the Americas, Mexico, Peru, Chile and other Americas Why does Seipasa set strategic markets in the Americas? friendly, residue-free biopesticides and development in the Americas in the past three solutions for different industrial sectors and biostimulant products in the Americas has years, it can be found that Seipasa's market agriculture increased significantly Focusing on the development in the Americas has selected American market has become an important strong local distributors for cooperation These distribution agreement with Peru’s Agritop The agri-food industry is a global market strategic layout for many European distributors may become potential partners of (a company specializing in plant nutrition) with numerous points of connection between companies The Seipasa company we domestic companies interested in exploring the Agritop is responsible for providing all countries and continents Seipasa is a fully analyzed for you today is one such company American market biological solutions that meet the current In July 2019, Seipasa signed a market requirements in Peru according to customer needs, that is, no residues and high efficiency for pests and diseases controlled products In May 2019, Seipasa signed an agreement with Summit Agro USA, which distributes Seican biological pesticides in the United States Seican has a dual action mode of insecticide and acaricide Seican is developed from a formula based on plantderived substances, with low dosage and high efficacy In September 2018, Seipasa signed a strategic cooperation agreement with Innovak Global, Mexico's leading biological solution development and sales company 16 2020 Biologicals Special   integrated actor in the agri-food production innovation and research applied to active chain and, as such, interacts with the main principles of botanical and microbiological players in the market from the point of view origin It is clear that the Latin American of regulation, production, distribution or market emulates all that is happening in consumption The market is calling out for Europe and that, furthermore, Europe is a Seipasa’s natural technology solutions and major importer of agri-food products grown the American continent is no different The in Latin America This strategic connection same widespread trend we see throughout and continuous exchange between both Europe for the consumption of healthy, markets is the reason why we are reinforcing residue-free fruit and vegetables has also our position in the American market grown strongly in Latin America.  To respond   to this demand, producers need solutions that can fight off pests and diseases and improve crop health from a sustainable, efficient and cost-effective point of view This is Seipasa’s goal in developing its natural technology model, backed by its strong commitment to Can you disclose which markets Seipasa will focus on in the next phase? Seipasa is commercially present in continents and in over 25 countries worldwide We currently have a catalogue of 45 products with phytosanitary registrations and our aim is to reinforce and broaden our presence in the USA and Latin America This process will come about via new phytosanitary registrations, once all the applications that are currently under way are approved Our international growth project also includes Africa where we already have a business unit in operation We are focusing on developing this market and are laying down the foundations for extremely strong growth in this area We are also currently carrying out an in-depth, strategic analysis of the Asian market to define the advantages and opportunities this region can offer us 2020 Biologicals Special 17 PRODUCT FOCUS PRODUCT FOCUS Agri Star is Positioned as the Leader in the Bio-Inputs Market in Argentina Agri Star is an Argentinian company founded in 2005 From its inception, it has demonstrated significant achievement in the development and distribution of environmentally friendly products, becoming one of the leaders in the field with significant short-term growth During the latest 10 years, Agri Star has been working on the incorporation of specialties to position itself within the bio-inputs market In 2014, the firm began to trade its first own organic insecticide “StarEco”, earning critical distribution and development agreements with foreign companies This was the beginning of exciting developments in the Agri Star portfolio “Signing distribution and development agreements open us to this market and to the interest of many leading bio-input companies looking for the right partner to introduce their products into the region Agri Star is a pioneer when it comes to biocrop protection and bio-fertilization, and we are sure that this is the future of the industry.” 40 2020 Biologicals Special Foreign Company Agreements Along with the development of these bioinputs, Agri Star has completed agreements with companies from the United States (Certis LLC, Plato Industries Ltd) and Portugal (CEV S.A.) for the exclusive distribution of their products in Argentina Regarding Plato Industries, the agreement relates to the pheromone system for the control of cotton boll weevil The agreement with Certis coordinates the distribution of CYD-X LC Carpovirus and Bacillus Thuringesis Ecotech in Argentina Most recently, the agreement signed with the CEV company in 2019 is for the exclusive distribution of a fungicide based on BLAD Problad Verde In recent weeks, Agri Star entered into a technology transfer agreement with a foreign University The objective of the agreement is not only the manufacture and distribution of a highly effective biological insecticide, but also the patent of the product and the knowledge of the manufacturing process “Currently, we have a complete portfolio of our own and third party products to satisfy the organic and low-residue market demand”, said Eng Ezequiel Nardini, Agri Star Manager, when asked about the importance of obtaining commercial agreements with foreign partners Next Steps All the work done in the recent years is due to the generation of multiple critical international commercial agreements Currently, there are advanced negotiations with a leading European company to create a joint venture where Agri Star will handle the bio-input products, as well as the national and regional agreements with local companies operating in Argentina and the region These milestones solidify Agri Star's position as the leader in bio-inputs in Argentina Eng Ezequiel Nardini Agri Star Manager 2020 Biologicals Special 41 VIEWPOINT VIEWPOINT Biopesticide in Latin America: The Market is Changing, Where Are the Future Opportunities? Matias Santipolo Gustavo Herrmann Gregorio M Katz Eduardo Perez Marketing Director of Rizobacter Commercial Director of Director of TENSAC Commercial Director of Biotrop Koppert Brazil biopesticide products tends to continue to grow, following the world trends where the biopesticide market grows at rates of 14% per year and the chemical market grows 4.5% Gustavo Herrmann: The demand is becoming more consistent, as the growers companies pay attention to and enter the South American biopesticide market Where you think the future market opportunities for South American biopesticides are? market was valued at USD 305.1 million in What has changed in the South American biopesticide market in the past few years? 2017 and is expected to register a CAGR of 16.4% during the forecast period (2018- Matias Santipolo: The South American crops Eduardo Perez: The main opportunity market is in the food production for export and economic sustainability The market a great opportunity for biopesticides because And in the next few years, it is expected to (specially the industry) is becoming more there are no launches of chemical active be an increase in extensive crops professional, as the requirements for quality ingredients in the coming years that will solve and high performance are increasing from all the problems that farmers currently have users The solutions will come by mixing old modes Gregorio M Katz: The trend in the report, the Latin America biopesticide lemon, fruit trees, grapevines, horticultural Matias Santipolo: The actual market is concept, in order to achieve environmental ccording to Mordor intelligence' in intensive regional productions; case of today in the South American biopesticide start to implement IPM as a mandatory A Gregorio M Katz: We think that the future opportunities for biopesticides are of action with new modes of action, applying of the first glyphosate resistant GM crop, it demand for bio-products is increasing, not more efficiently and using Biopesticides was what changed the agriculture model and only in South America, but in the world; this Biopesticides will help pesticides to increase allowed us today to have high production due to the constant restrictions of the allowed control, avoid resistance breakdown and levels, but in these more than 20 years is MRLs of the requesting countries; as well as increase crop yields becoming more frequent to find cases of to the global demand on the consumption of The biological compatibility and survival What you think are the biggest challenges in promoting and developing biopesticides in South America? Why? Matias Santipolo: Generally, the registrations of pesticide patents are preferred 2023) Brazil is the largest market share market is changing, we could not say that resistance to chemical molecules, making more sustainable products In addition, the of biopesticides are a determining factor for the ministry of agriculture than those of holder of biopesticides in Latin America with it is only for one factor but that it is a set of it difficult to control weeds, diseases and markets seek to have greater competitiveness since most microorganisms die in contact chemical pesticides, mainly when it comes the revenue USD 103.5 million in 2017 and is interrelated factors insects It is here where biopesticides along at the global level, so they aim to look for with chemicals or in environmental stresses to native microorganisms Apologies I not with chemicals help to fight these pests and productive alternatives to the conventional Companies that manage to industrialize have much knowledge of the regulatory area illnesses that are difficult to control one, for organic productions and to look biopesticide have excellent opportunities in Gustavo Herrmann: The biggest for niche markets, which grow more and expected to register a CAGR of 10.3% during forecast period (2018 - 2023) As in other parts of the world, society looks more and more closely at agriculture In Latin America, the biopesticides and calls for greener technologies This social the market Rizobacter has been working for challenge in broad acre crops is to combine market is witnessing a steady growth in the pressure is generating changes in the demand frontiers" such as the North Brazil region, the more, and which pay another price for the more than 40 years on the compatibility of biopesticides with the traditional ones, in past years As more and more companies enter for crop protection products, for instance, Chaco Paraguay / Bolivia region and western fruit (example: sugar, lemon, fruit trees, microorganisms with chemicals and resistance IPM programs that show more productivity the Latin American biopesticide market, what products with excellent agronomic efficiency, Argentina, carrying out agriculture is really vine, etc) Based on this, we think that the to abiotic factors and less impact for the environment And of changes have occurred in this market, and to regulate their use, even becoming banned challenging, the weather conditions are very markets are looking for BIO alternatives over what new opportunities and challenges have For example, in Argentina the chemicals that aggressive and the incorporation of beneficial conventional products; This generates an the biggest market, Brazil, the opportunities emerged? What types of biopesticide products can be used depending on their toxicity are microorganisms help to make agriculture expansion of a niche market, and we consider are larger in row crops, like soybean, are in strong demand in this market? I believe delimited by regions viable that the trend is in that sense corn, cotton, sugarcane and others At the number of small growers and keep the high these issues are of concern to every company Another factor influencing the growth Also in regions called "agricultural In this context of a society that demands Eduardo Perez: The improvement Gustavo Herrmann: When we look to course, at the same time not increase costs to the growers In the horti sector, to achieve a large same time, the challenges are as big as the level of quality within bioproducts can be that wants to enter the Latin American market of the biopesticide market is the constant agriculture with less environmental impact, of effectiveness of the biological products areas, because these segments are chemical very challenging, so logistics is key for any Therefore, we interviewed several companies increase in cases of resistance to chemical where we find increases in resistance to over the chemical products has been the intensive crops In other countries like Chile IPM program that performed well in the Latin American active ingredients Today in countries such as agrochemicals and the need to increase the main reason why the demand for biological and Colombia, for example, the focus of biopesticide market, they are Rizobacter, Argentina, Brazil, Uruguay and Paraguay, it surface in areas considered not optimal for products has increased in the past five years biologicals are more related to high value challenges lie in the regulations of the Koppert Brazil, TENSAC and Biotrop has been more than 20 years since the launch agriculture, the growth of the market for crops, like berries, tomatoes, flowers, etc different countries, in being able to register 42 2020 Biologicals Special More and more biopesticide Gregorio M Katz: The greatest 2020 Biologicals Special 43 VIEWPOINT VIEWPOINT them in the State institutions with often LEADING WITH YOU As the leading provider of biopesticides for conventional and organic producers, our mission is to drive the most effective solutions and product innovations for the industry exorbitant tariffs; This is because many times the requirements that a biopesticide has to pass at the time of registration, are the same as that of a conventional Partnering with industry leaders and growers to successfully commercialize biopesticides in several markets while innovating the industry with new technologies including the very first biological plant activator, LifeGard® BROAD PORTFOLIO Committed to providing a strong product portfolio to combat resistance, fight agronomic crop disease and pest challenges today and for the future RELIABILITY KNOWLEDGEABLE REPRESENTATIVES A passionate team comprised of over 20 technical, sales, and marketing professionals focused daily on leading biopesticides forward in the industry high temperatures, salinity and resistance to drought This new inoculant resists very relies in the ability to introduce these Beauveria Bassiana, Trichoderma Spp, stressful conditions, together with new products in extensive crops like corn, Paecilomyces fumosoroseus varieties of Soybeans will allow agriculture in There are products on the market with the improve their performance, but also as efficiency This difference in the efficiency of Challenger, the first bioinsecticide registered bioinsecticides and biofungicides the products is due to the artificial selection of for the control of ACP (Asian Citrus Psilid), microorganisms, it is also possible to see notable the vector of greening disease in citrus crops differences in the concentration, shelf time The product can be used in combination with and formulation between products of the same most of the recommended chemicals for microorganisms the pest, specially in flowering and harvest In terms of registration supervision, South American countries have special requirements for the registration of biological pesticides? Matias Santipolo: Generally, biopesticide patent registrations are Gustavo Herrmann: Most of the countries includes biologicals in the same regulation of chemical pesticides Gregorio M Katz: The BIO products that different in one country than the other, seasons, reducing the residues of pesticides are most in demand belong to the order of the in the end product (fruit or juice) This Biologicals (microorganisms) mainly product was developed in partnership with Eduardo Perez: Nowadays, biopesticides Fundecitrus (Citrus Industry Research Center) are mainly required in intensive crops but day by and ESALQ/USP (University of São Paulo) day are beginning to be used in extensive crops and it is now available for Brazil as well In the pipeline, we intend to launch a new Bacillus based product with nematicidal effect, EPNs (entomopathogenic nematodes) At present, what biopesticide products has your company launched in South America? What new products will enter the market in the future? There are some peculiarities that may be as bioinsecticides and new macro organisms, like Telenomus podisi , a parasitic wasp to control the soybean stink bug Gregorio M Katz: Those that TENSAC promotes are the Esten 80 and Esten 80 H Plus, Bioinsecticides The plan is to launch a Matias Santipolo: Currently Rizobacter bio Herbicide and a specific phyto regulator but in general everyone has to follow launched Rizoliq LLI, which is the only the PPP (plant protection products) liquid inoculant registered in Brazil based on registration path Bradyrhizobium spp, that can be in contact with that the ESTEN 80 product was nominated Gregorio M Katz: In some cases, to tobacco Referring to this question, we inform you agrochemicals in the seed for 60 days, currently for the Innovation Award “Bio-based Material the regulatory entities of each country most of the products on the market not resist of the Year 2020’’ at 13th International have some differential biopesticide contact with agrochemicals Rizoliq LLI is a Online-Conference of Bio-based Materials in treatment, what happens is that from great advantage for the seed treatment industry Cologne Germany, 12-13 May 2020 the point of view of technical analysis, and for the farmer who does not have to damage beyond physicists, chemists and his seed by re-treating with inoculants before company already launched biofertilizers, toxicologists, a lot of study or testing time planting PGPRs, inoculants and nematicides products is required (similar to a conventional one) In Argentina we launched a Rhamnolipids- Eduardo Perez: At present, our In the next few years, we will follow with requiring a lot of information, which is based Bio-surfactant, it was an innovative launch, the introduction of bioinsecticides and sometimes unnecessary and unjustifiable it is an adjuvant for tank mix use that replaces biofungicides problem in South America is that, in general, there is no specific legislation www.CertisUSA.com Gustavo Herrmann: We’ve launched same microorganism, but not all have the same Eduardo Perez: No The big Discover the biopesticide solutions you need, learn from our thought leadership & industry expertise, connect with our world-class field support team and access labels & certifications regions considered to be marginal of not only using them as PGPR to area Certis owns and operates three stateof-the-art production facilities, two of which are based in the United States for fermentation and a facility in India for plant extraction of neem-based products bacteria, we obtained an inoculant that resists spp, Bacillus Subtilis, Bacillus Thuringiensis, Eduardo Perez: The major challenge have much knowledge of the regulatory Our portfolio features sustainable alternatives for organic and conventional use including the broadest offering of over 30 OMRIListed Products, most of which are Residue Exempt and have short re-entry and pre-harvest intervals 44 2020 Biologicals Special Matias Santipolo: The main microorganisms native microorganisms Sorry I not MANUFACTURING EXPERTISE Dakar, an inoculant based on Bradyrhizobium spp, for inoculation in soybeans, which due to the artificial selection of resistant privileged, especially when it comes to Trusted to protect crops time and time again with the broadest line of biological products tested in 6,000+ field trials for over three decades Paraguay, Uruguay and Brazil will be Rizoliq used in South America are Bradyrhizobium product soybean and wheat with the purpose MARKET SHAPERS At present, what kind of biopesticides products in South America are in high demand? traditional adjuvants In Paraguay, Argentina and Bolivia we launched Rizoderma which is a fungal Bio- for biological products And this is an controller based on Trichodema , specifically important issue to be resolved in different developed for seed treatment countries The new launch in Argentina, Bolivia, 1–800–250–5024 2020 Biologicals Special 45 VIEWPOINT VIEWPOINT The combined use of insect viruses with chemical pesticides to increase mutual synergy reduces the use of chemical pesticides, and the resistance of insect pests to chemical pesticides Cheng Qingquan General Manager of Keyun Biotechnology such as pome fruit or citrus production, but PxGV and CPV, which are mainly used for insecticidal spectrum via recombination, since some years also in row crops such as control of plutella xylostella, beet armyworm, such that viral products can be accepted in cotton, sorghum or soybean We also should cotton bollworm and plusia agnata more market applications In the process of not forget that some insect viruses have been Viral Insecticides: Technological Innovation, A New Blue Ocean of Future Pesticides V iral Insecticides for Biological Control focuses on the basic as well as applied aspects of viral Could you give a briefing of the development status and major applications of viral insecticide? insecticides, which have the potential According to the outcome in the eighth viral recombination, not only the insecticidal very successfully applied to control important report of the International Committee on the spectrum is expanded, but also some viruses forest pests Taxonomy of Viruses in 2005, the recognized are found to have a synergistic effect against At present, more than 1,670 insect 5,000 virus species was split into 73 virus other viruses, which improves the lethality viruses have been discovered in more than families, of which 230 species are insect of products and achievement of a better 1,100 kinds of insects worldwide, which viruses (definitely pathogenic to insect), insecticidal effect involve hosts of 43 families in 11 classes being classified and included in the 18 virus On the other side, in order to improve the In China, 291 kinds of insect viruses have families, including rhabdoviridae , roniviridae , effect of control of insect virus on older larva, been discovered Although the research and biscistravirus, infectious PVA, ascoviridae , researches are made into recombination of development of viral insecticide started baculoviridae , birnaviridae , iridoviridae , insect viruses with some chemical pesticides quite late, it has moved forward rapidly in metaviridae , nimaviridae , nodamura In this aspect, a breakthrough has been viruses compared to the overall microbial recent years There have been more than 60 virus, orthomyxoviridae , parvoviridae , achieved The method is, during the field plant protection market is relatively low, kinds of viruses filed in various countries for multicomponent virus, polyviridae , spraying, to mix viral insecticidal products since the use of each product is restricted registration which are now in the process of pseudoviridae , reoviridae and tetravirus with some chemical pesticides for application to a single or relatively few numbers of field trial while more than 30 kinds of viruses Insect viruses commonly used in crop control as in a form of “combo” product It is target insects If we estimate a yearly annual have been registered, produced and applied are mainly NPV and GV of baculoviridae, found upon application that some chemical reliance on chemical pesticide insecticide around the world is mainly used for turnover of 70 m US$ for this product worldwide CPV of reoviridae Viral insecticide has pesticides have an obvious synergistic effect technology. Compared with traditional control of cotton bollworm, soybean worm, category, this represent only % of the global Chen Jiao: Since 1993 when HaNPV the superior properties of high safety, non- against insect viruses, which can speed pollution, non-residue and non-resistance, up the death of insect pests infected with having gradually attracted user’s attention viruses, causing a higher death rate of insect to significantly reduce the current Cheng Qingquan: At present, viral chemical insecticides, viral insecticides spodoptera frugiperda , codling moth, prodenia microbial plant protection market The market wettable powder, the first viral insecticide, are highly targeted, environmentally litura as well as the resistant beet armyworm can surely accept many more insect virus was granted registration in China, there have friendly, and have been rapidly and plutella xylostella Its market share has been products, as they are highly efficient, safe and been 74 viral biopesticide products being pests This has significantly increased user's developed in the past few years, growing constantly compatible with many production strategies granted registration by 2019, covering mother acceptance of this kind of product due to its The challenge lays in the high investment liquid and formulations There are 26 HaNPV especially in organic agriculture What is Kessler Philip: We are happy to recognize the current status of the development of a general increase of biological plant protection in registration for products to control single products, which accounts for the majority of viral pesticides, what new products and tools in agriculture, particularly of microbial pest species, as it is clearly disproportionate the registrations There are 12 insect virus technologies are there, and how will they biocontrol technologies Insect viruses, namely to its market potential As a consequence, varieties, eight of which are registered by Could you tell us about the status of research of viral insecticide (recombination of insect viruses or combined with small amount of chemical pesticide)? satisfactory control effect In fact, in terms of chemical pesticides, especially some patented chemical pesticide products, the combined use of insect viruses with chemical pesticides to increase mutual develop in the future To this end, we the baculoviruses, have been successfully applied there are very few virus species that have Chuqiang Biotechnology, a wholly-owned interviewed several leading companies for decades, as their high efficacy and safety become global success stories like the insect subsidiary of Wuhan Unioasis Biological in virus pesticides They are Cheng has been recognized from early on Several viruses against Cydia pomonella (CpGV) Technology So far, more than 20 virus Qingquan, General Manager of Keyun international biocontrol companies successfully and Helicoveropa armigera (HearNPV) insecticide products have been registered of recombination of viral insecticides The the resistance of insect pests to chemical first is the recombination between different pesticides, thus extending the product life Cheng Qingquan: There are two kinds synergy not only reduces the use of chemical pesticides, but also significantly reduces Biotechnology, Philip Kessler,Director develop and globally market products based on Insect viruses are used in organic crops and in the United States, France, Switzerland, International Market Development of baculoviruses There are also locally operating conventional IPM strategies to manage MRL Russia, Brazil, Spain, Japan, South Africa, insect viruses, including recombination cycle of chemical pesticides while pesticide Andermatt Biocontrol, Chen Jiao, Wuhan companies developing virus-based plant and resistance issues So far virus insecticides India and Australia The main insect viruses of two or more different kinds of insect residues are greatly reduced Unioasis Biological Technology Co Ltd production products However, the use of insect find their way in strategies in high value crops used for biological control include NPV, viruses The purpose is to broaden product’s 46 2020 Biologicals Special Chen Jiao: At present, there are two 2020 Biologicals Special 47 VIEWPOINT main virus mixture products on the market Mixture with Bacillus thuringiensis (B.t) VIEWPOINT The mixture of insect virus with Cheng Qingquan: The insect virus chemical pesticide below lethal dose can infection-purposed synergetic substance also effectively enhance insecticidal rate, the can destroy the normal physiological reason may be that chemical pesticide below state of insect pest, thus lowering the lethal dose cannot kill insect pest, but can immunocompetence of insect pest, increasing include EoNPV.Bt, SeNPV.Bt, AcNPV.Bt, greatly reduce the immunity of insect pest to the chance of infection via viral penetration, HaNPV.Bt, PrGV.Bt and Bt.DCPV, being increase the probability of infection, thus to and accelerating the extension of insect virus mostly the registrations of Wuhan Unioasis achieve synergistic effect inside the insect pest Hence, the lethality Mixture products available on the market Biological Technology Mixture with low toxic or common chemicals (or alternative use) Mixture products available on the market include beta-cypermethrin.PINPV SC, The purpose of mixture of insect virus is increased and death rate of insect pest is with high-efficient and low-toxic chemical increased In particular, the control effect on pesticide aims mainly to fix the fast-acting older insect pests is very obvious and long-lasting issue, reduce the amount of efficiency of insect virus, action can be the problem of pesticide residues taken on insect’s infection mechanism and immunologic mechanism in combination SC with the characteristics of virus itself Insect shows that the use of single agent is declining, formulation is speeding up, the market demand is growing strongly, NPV becomes dominant, especially the research of mixtures with AcNPV and PINPV, which are relatively more popular applications at present time How much you know about the insect virus infection-purposed synergetic substance? Can you share the knowledge and the major products on the insect virus infection-purposed synergetic substance? Philip Kessler Director International Market Development of Andermatt Biocontrol Chen Jiao: In order to increase the use of chemical pesticide, and gradually solve phoxim.HaNPV and chlorfluazuron.PINPV The development trend of viral insecticide So far virus insecticides find their way in strategies in high value crops such as pome fruit, and row crops such as cotton, sorghum or soybean viruses mainly infect larva insect midgut tissue, there is a membranous tissue called peritrophin in insect’s midgut The peritrophin is a reticular structure composed of chitin and protein, where the peritrophin including intestinal mucin and chitin binding protein, are tightly bound to the reticular structure, whilst polysaccharides are filled up in the interspace of the reticular structure to form spectrum Bacillus thuringiensis (B.t) can be mixed yellow The fluorescent whitening agent OB is synergistic on AcMNPV a semi-permeable membrane with certain with NPV Compared with insect virus, B.t pore size Some factors, which would affect has low cost and fast effect When being to researches, not only protects insect virus peritrophin, can increase the viral infectivity mixed with insect virus, the insecticidal effect from UV radiation but also enhances NPV of pathogenic microorganisms, especially is obviously much improved This kind of infection on hosts There are few studies made NPV to the insects via interference with synergism is represented by the registrations on the synergistic mechanism of fluorescent the normal formation of peritrophin or by of Wuhan Unioasis Biological Technology whitening agent on virus, the research is destructing its integrity In 1959, Tanada including EoNPV.B.t SC, HaNPV SC and mostly concentrated on insect midgut reported for the first time the synergism of AcNPV.B.t SC two kinds of mixed baculoviruses to infect the same host At present, the ways of synergism 2) Chemical synergists, such as the added food attractant, can stimulate food uptake, Chemical Synergistic factors include biological synergism and chemical synergism 1) Fluorescent whitening agent, according which increases the amount of ingested virus, thus enhancing the insecticidal activity Insect growth regulator: chitin synthesized inhibitors (chlorfluazuron, etc.) Biological Synergism can inhibit chitin synthesis after insect uptake, thus affecting the structure of peritrophin and The active substance of biological accelerating the viral infection on insects synergism is the virus enhancer, which UV protectant: folic acid, ascorbic acid, used to be called synergistic factor, viral 2-phenylbenzimidazole-5-sulfonic acid, enhancing factor or enhancing protein Today Congo red, brilliant yellow and acridine What you think to be the main advantages of viral insecticides? Why? Cheng Qingquan: The main advantages of viral insecticides are: (1) targeted insect it is given a unified name - enhancer, being the recombination of synergistic protein and enzyme as well as baculovirus There are totally 11 kinds of synergistic proteins, including kinds of EPV, kinds of GV, kinds of NPV and kinds of CPV (data as of 2005) What are included in documentation include baculovirus enhancin, poxvirus fusolin, baculovirus GP37 protein; the use of GV and NPV together is also synergistic GV enhancer, as a proteolytic enzyme which destructs peritrophin, can increase the pore size of peritrophin and the permeability into NPV Enzyme synergistic factors include chitinase which is hydrolytically specific to insect chitin and the cathepsin Baculovirus recombination is a genetic baculovirus recombination to expand its insecticidal 48 2020 Biologicals Special 2020 Biologicals Special 49 VIEWPOINT VIEWPOINT The issue of viral insecticide instability in the field can be solved via strengthening formulation development and having a prediction technique for the timing of applications Chen Jiao Vice Director in R&D Center of Wuhan University and UNIOASIS pest, acting only for control of target insect pest generations and result in a sustainable as years After death, dead and decayed pest, without hurt to non-target organism population reduction of the pest population insect bodies will release a large number of such as natural enemies, which is conducive Its unique mode of action has the further viruses in the field, which maintains the viral to maintaining an ecological balance and advantage to address resistance towards quantity in the field, hence the number of prevent repeated pest-outbreak; (2) insect other insecticides, or to manage resistance pesticide application is reduced, and the cost pest is not apt to be resistant, as insect virus prevention in pest control strategies The of application and labor is reduced, resulting is essentially a kind of microorganism of existing virus formulations are easy to use accordingly in a decreased comprehensive nucleic acid structure, which can co-evolve and can be sprayed as any other insecticide cost with insect pest while the latter has difficulty They are compatible with mostly all other in producing resistance Therefore, compared active ingredients We see therefore growing does not have cell structure and complete with chemical pesticides, viral insecticides potential to use insect viruses in combined enzyme system, the factors which act on would have more market potentials in respect strategies within integrated pest management metabolic pathways are not affected, and of resistance management; (3) being safe systems thus resistance will not occur easily So far, without residues, as the main components of there are has been no report of occurrence viral insecticide are natural organisms, and pesticides, viral insecticides have the of resistance to insect virus An example is there is no safety interval requirement on the following advantages: that the human body is not resistant to novel product Therefore, crops can be harvested on Specificity: the infection mechanism coronavirus and SARS, also without relevant the same day as applications are conducted of insect virus requires identification and immunity, and no specific medications are As for organic production and green combination of the cell surface receptor available agricultural production, which have residue glycoprotein of the host cell via the spike requirement, viral insecticides are regarded protein on the virus surface, only in this way as a green pest control product, which can be can the host be infected and only the target used at ease host is killed Kessler Philip: Thanks to their Higher safety: it is harmless to human specificity, the different baculovirus species and livestock, it does not kill natural enemies are harmless for non-target insects and and other beneficial insects, does not pollute arthropods This highly specific use of the environment, and is of great help to baculoviruses only controls the target pest protection of the ecological chain insects ensuring there is no effect on nontargets Therefore, protecting the existing beneficial fauna that can be important to Non-residue: a virus is a protein, without residue on crops Epidemic: virus can spread horizontally supress outbreaks of secondary pest species and vertically in pest population, being This significantly reduces the overall infectious We understand that the instability and poor lasting effect of viral insecticides have always been a problem which restricts the promotion of the use of viral insecticides What you think of the problem and how would you propose to solve the problem? Do you have any latest products and technologies that can make up for the situation? The production process is pollution- Cheng Qingquan: The instability pests Baculoviruses have a unique mode free and low energy consuming An insect is a and poor lasting effect are attributed to the of action The viruses infect and multiply virus synthesis factory reduced activity of the virion under the input of insecticides also against other within the insect larvae causing death, the virus can then be transferred to following 50 2020 Biologicals Special Chen Jiao: Compared with other Resistance will not occur easily: virus High efficient and long lasting: NPV can remain active in the soil for as long adverse environmental conditions such as ultraviolet irradiation and high temperature 2020 Biologicals Special 51 VIEWPOINT VIEWPOINT With regard to this situation, there are microorganisms and as an industry we have is not only the development of improved radiation; some adjuvants to increase adhesion can be added to protect the from the development of Cydia pomonella granulovirus (MADEX) solutions in two ways One way is to add learned to address these challenges Advanced product quality and formulations, but also long lasting effect of insect virus On the other hand, the retention of the and Adoxophyes orana granulovirus (CAPEX) to control codling protective agent such as UV protectant knowledge in the production and formulation the development of suitable and reasonable formulations in the field and the stomach toxicity may need to be increased moth and summer fruit tortrix respectively, two key pest insects to prevent ultraviolet irradiation, so as to of insect viruses has increased the resilience application strategies in the field that achieve Secondly, it can be mixed with B.t to solve the problem of unstable viral improve product performance and property of virus particles which results in increased the best results to gain customers satisfaction activity under different temperature conditions The viral products registered our portfolio of Cydia pomonella granulovirus products and The other way is to take measures accordingly stability and viability after application by the company are mainly mixtures with B.t pioneered the development of new products based on CpGV during the filed application such as the use of Therefore, as an R&D focused company, structure of insect virus, its tolerance to high insect sex attractant to determine the time of we not only concentrate on the development temperature and ultraviolet is poor, and it may of viral insecticide application, thus to solve farmer’s problem existing on the insect infestation, so as to accurately conduct of new active ingredients but also on the lose activity in the field However, the long timing of applications applications Moreover, pesticide application improvement of production processes and lasting effect is a major advantage of insect can be conducted to the greatest extent in development of stable formulations A further virus, which is not a problem for product where the concept of “pest control with decreased amount of pesticide” is become a standard tool in false codling moth control in Southern cloudy days or evening, such that viruses can key success is the understanding of host- promotion, especially after the continuous put forward, which is also an opportunity for viral insecticide products We Africa Furthermore, Andermatt Biocontrol Suisse and Sylvar play a better role in achieving its best control pathogen relationship, where we have learned use of insect virus, the population density of ought to change our business thinking to fully realize the series of problems Technologies produce nucleopolyhedroviruses against global pest effect how to adjust the application of insect viruses insect pest in the field are greatly reduced caused by chemical pesticide to the natural environment and the threat of insects such as Helicoverpa sp., Spodoptera exigua , Spodoptera littorals , Spodoptera frugiperda , Chrysodeixis includens Chen Jiao: Due to the simple biological To have a prediction and forecast technique to grasp the right timing First of all, from ecological perspective, the national policy is changing, in pome fruit production Over the years we significantly enlarged to control resistant codling moth population (MADEX PLUS, MADEX MAX, MADEX TOP) or to increase its efficacy against oriental fruit moth (MADEX TWIN) We produce and sell a Cryptophlebia leucotreta granulovirus (CRYPTEX) which has in the field to the biology and development of In the later period, the amount of use and pesticide residues to human health In the meantime, we need to realize that suppress population in the long term the host To maximise success, it is crucial to the number of applications will continue to the insect pest management is not just a random fight based on excessive and Trichoplusia ni (HELICOVEX SPEXIT, LITTOVIR, However, a reduced stability in the field has recognize optimal application timings and to decrease year by year use of pesticide to achieve immediate result for a moment’s comfort, which SPODOVIR, LOOPOVIR, LOOPEX) In addition, Sylvar has often been used as an argument against the avoid unsuitable conditions after application may cause abused use of chemical pesticide, leading to extermination and successfully engineered virus products to be used against the forest use of virus products It was perceived that This can seem quite complicated, so we extinction of insect pest pest insects such as balsam fir sawfly and gypsy moth (ABIETIV, the main challenge was the reduced viability invest much time with simple training tools of virus particles when exposed to UV that provide robust recommendations for radiation However, insect viruses are no less the farmers So in conclusion, the progress stable towards UV radiation than most other we have made in stability and sustainability Kessler Philip: Viruses can sustainably The issue of instability of viral insecticide in the field can be solved via two approaches: To strengthen the development of viral insecticide formulations First of all, an anti-UV adjuvant can be added to solve the problem of ultraviolet Secondly, in order to fix the issue of instability, the products need to be DISPARVIRUS) Our latest success story is TUTAVIR, a used in conjunction with the insect population forecast system (insect pest baculovirus to control Tuta absoluta , a globally significant forecast in advance), so as to grasp the right timing of application, which tomato pest insect This new product fills an important gap in will change farmer’s mistake of “applying pesticide when seeing pest" existing control strategies against Tuta absoluta , as many other Because of the special characteristics of viral insecticide, the best time to get available insecticides show reduced efficacy against this pest For pest infected is the peak time of egg hatching and instar - 2, when larvae the development of TUTAVIR, Andermatt Biocontrol has been are at low immunity, which is the period when insect pest is easily infected granted the Bernard Blum Award 2019 Our efforts will not only by virus Therefore, the application on the right time can improve the be focussing on the marketing of single species solutions, but also insecticidal stability on addressing the challenges of farmers with pest complexes in Finally, we will strengthen our research and development, and will various crops Mixture of viruses and the combination with other launch a series of full course solutions via multiple pilot schemes which will active ingredients can offer further flexibilities and options for constantly optimize our products Meanwhile, we will strengthen promotion farmers The use of insect virus products definitively contributes of correct use of viral insecticidal products to gradually narrow the gap to a healthier and sustainable food production between viral insecticide and the common chemical pesticide on the market in terms of pest control effect, especially to solve the problem of chemical Chen Jiao: At present, our company mainly produces the following products pesticide residues via the use of viral insecticide for pest control during crop Main products in UNIOASIS harvesting In this way, the benefit to ecology, environment and human health is achieved while pest is controlled No Name Formulation 01 EoNPV.Bt SC What are the main viral insecticides available from your company? 02 PrGV.Bt WP 03 SeNPV.Bt WP Cheng Qingquan: At present, we manufacture products in technical 04 AcNPV.Bt SC material and formulation which contain cotton bollworm nucleopolyhedrosis 05 HaNPV.B.t SC 06 PrGV.Bt SC virus, autographa californica nucleopolyhedrosis virus, cabbage moth 07 B.t DCPV WP nucleopolyhedrosis virus and plutella xylostella granulosis virus 08 HaNPV billion PIB WP 09 SeNPV 500 million PIB SC now used in a broad range of different crops worldwide Our subsidiaries 10 Beta-cypermethrin.PINPV SC Andermatt Biocontrol Suisse and Sylvar Technologies are manufacturing the 11 PfDNV Bait virus, beet armyworm nucleopolyhedrosis virus, prodenia litura nucleopolyhedrosis virus, spodoptera frugiperda nucleopolyhedrosis Kessler Philip: Andermatt Biocontrol is proud to develop and offer a large range of different insect viruses in the past 30 years Our products are virus products in Switzerland and in Canada respectively Initial growth came 52 2020 Biologicals Special 2020 Biologicals Special 53 VIEWPOINT VIEWPOINT Timing, One the Keys to Maximise Results When Using Biostimulants severe abiotic stress events Preventive management strategies, a combined abiotic both biostimulants and crop nutrition, when Biostimulants can be viewed as the stress management program that integrates both appropriately combined, bring maximum growers first line defence option that allow a preventive, and recovery strategy gives the benefit to crops crops to minimise or delay the disruption optimum result in terms of yield and quality to normal growth Another risk factor during the early phases of crop growth is excess vegetative growth, which can reduce root development Co-authored by Josué Castellanos, R&D specialist; Marcos Alajarín, R&D Specialist; Dr Cathal Daynes, Global Technical Manager at Tradecorp Recovery Biostimulant application - Use during or after the stress has occurred Biostimulants for specific growth stages of the crop This is a particular risk where basal doses of Nitrogen have been applied to the soil Specific Biostimulant products that promote balanced root and shoot development have an From the above it can be understood important role during this growth period, for abiotic stress situations, such as a long that certain Biostimulants have very specific example Ruter AA In this product, the key heatwave or cold spell, the crops demand roles in helping prevent and recover crops for this balanced root and shoot development for resources will alter away from yield from environmental and weather stresses A is the combination of amino acids with and quality production to focus on more different source of stress in crops is the stress nutrients favouring balanced early growth, essential basic growth and survival that occurs each time the crop passes through such as Phosphorus and Potassium, as well as functions This consequently reduces final a growth stage, for example changing from Molybdenum to enhance the plant metabolism harvest potential the germination stage to the vegetative stage, of the applied basal Nitrogen fertiliser During more severe or prolonged A s all growers know, weather conditions change across the How biostimulants work? season and this affects crop growth In fact, each year crops grow and develop in a constant interaction with the local weather and environmental conditions The final yield and quality of harvest Biostimulants have the capability to trigger the natural response therefore are the result of how well the crop could deal with, and functions of crops to combat abiotic stress In essence, with or without respond to, these environmental and weather conditions biostimulants, the crop will alter its metabolism to respond to abiotic stress Crops not alter their “normal” growth trajectory during small changes in environmental conditions However, if these changes are large enough that they require the crop to alter their “normal” growth However, the use of biostimulants on crops allows for a quicker, more effective and /or more efficient response There are a variety of biostimulants, and they differ in their origin and and metabolism, we speak about the crop suffering from abiotic / or their mode of action within the plant In general, biostimulants can be stress (Brown & Saa, 2015) allocated to one of seven groups: Humic / Fulvic Acids, protein hydrolysates The application of biostimulants can enhance crop yield and quality by improving their tolerance to abiotic stress In recent years, the use of biostimulants has been recognised as a good agricultural (e.g Amino Acids), seaweed extracts, chitosan, inorganic compounds, beneficial fungi and beneficial bacteria (du Jardin 2015) Knowledge about the mode of action of each biostimulant will enable practice, which may assist in making agriculture more sustainable growers to make the best decision about what biostimulant to apply, when and even more environmentally friendly and what dose to use The growers will also know what beneficial effect that is expected from that particular biostimulant application (Brown & Saa 2015), and this will benefit the grower’s decision making What is a biostimulant? A “biostimulant” in agriculture, according to the growth processes independently of the product’s nutritional content Biostimulation has the sole aim of improving one or more of the following characteristics of the plant or the plant rhizosphere (root zone): · nutrient use efficiency; · tolerance to abiotic stress; · quality traits; · availability of confined nutrients in soil or rhizosphere Biostimulation has been demonstrated to effectively reduce the impact of abiotic stress on crops when applied appropriately helping to achieve the crops full potential An important point about biostimulants is that they have no specific effect on pathogens or pests and to control these biotic challenges plant protection products are still needed What application timing is best when using biostimulants? Preventive biostimulant application - Use before the stress occurs Some biostimulants prepare or prime the response of the crop to enable it to better resist abiotic stress before the actual stress occurs These biostimulants generate a cascade of signals that "put the crop on alert" When a passing or temporary stress occurs, for example some hot, cold or cloudy days, the alert previously generated by the preventive biostimulant application allows the crop to respond quickly and effectively to the abiotic Biostimulants will benefit the crop, and changing from the vegetative stage to the flowering stage, etc Similar to preventive and recovery also the grower’s profitability Recovery Biostimulants, there are specific Biostimulants Biostimulants help the crop to return to that target, and help to reduce, each of these normal growth as quickly and efficiently specific crop growth stresses as possible, thus recovering some, but not all of the potentially lost yield and quality the go-to Biostimulants of choice As crops change from vegetative growth to flowering and then fruit set, a is produced, and stress is triggered, in the crop During these phases of growth, specific Humic and Fulvic Acids help in the recovery of the degraded structure of soils, in the retention and availability of nutrients in soil, Amino Acids as recovery biostimulants fruit set large biophysical and biochemical change Humic and fulvic acids for root growth In these recovery situations, solutions such as Tradecorp’s Amino Acid range are Biostimulants for enhanced flowering / targeted Biostimulants can have a very strong effect on flower number, fertility and fruit set Targeted biostimulants to benefit crop and facilitate improved soil moisture retention, growth during these critical growth phases among other functions Humic and Fulvic Acids, often have a seaweed or amino acid base, such as Humistar / Humifirst, have also been as both of these biostimulant classes have such as Oxygen, Hydrogen and Carbon, shown to have a direct Biostimulation effect beneficial effects on either flower number, that combine to make all matter that is on crops, in particular by triggering increased pollen vitality or pollination success present in the world A similar principle root growth that facilitates improved overall From a nutritional standpoint, Boron and operates in living organisms, like plants, crop performance (Szczepanek & Wilczewski Molybdenum are key nutrients demanded by which are composed of the “elements 2011) This Biostimulation effect is particularly the crop at this growth stage Therefore, it is of life” , the twenty or so foundation or beneficial in the early stages of growth, when logical to develop a product that combines elemental Amino Acids more root development is desired, such as one of the biostimulant raw materials with during the germination phase, during transplant, Boron and / or Molybdenum to produce growth, yield and quality In addition, they during vegetative growth phases and at the a combination biostimulant / nutritional are also key to help crops recover quickly breaking of root dormancy in perennial crops product, for example Florastart or Phylgreen These Amino Acids are essential for from abiotic stress and resume their Biostimulants can also be incorporated into B-Mo By taking this approach, it is easier for normal growth trajectory Application of formulations that contain specific nutrients, productive growth and metabolism recovery Biostimulants such as Amino such as the incorporation of Humic and Fulvic growers to ensure they are giving optimal Acids is thus in perfect harmony with Acids with the Phosphorus, Nitrogen and nutritional and biostimulation to their crop at Primactive effect - Preventive biostimulants the natural growth and recovery cycle of micronutrients needed for early and vigorous this key growth stage using a single product crops crop development, as in Tradecorp’s Turbo This avoids the need or confusion of having to Root In this example the synergy between mix and apply multiple different biostimulant and their preventive and recovery modes Biostimulants and specific crop nutrition and nutritional products that costs the grower of action has improved, it has become reduces transplant shock and promotes vigorous time and increases the risk of an adverse clear that, similar to pest and pathogen early growth demonstrating how knowledge of tankmix stress event This allows the crop to maintain or minimise disruption to One type of preventive alert effect is the unique “Primactive” effect of Tradecorp’s Phylgreen range of products that are based on Ascophyllum nodosum seaweed extract Preventive biostimulation, such as those with Primactive effect, can help during mild stresses or the early stages of more 54 2020 Biologicals Special of corrective, post-stress or recovery Nature consists of the basic elements, definition in the upcoming European Union fertiliser regulations, is a product that stimulates plant nutrition and In these situations, the application As knowledge about Biostimulants 2020 Biologicals Special 55 VIEWPOINT VIEWPOINT This scenario is a good example of the development of What next for biostimulants? the biostimulant market overall Whereas in the early days of biostimulant use it was more common to apply a pure biostimulant and then mix it with other nutritional products, it is In little under a decade, the use of biostimulants has grown from almost now usual to apply a single premixed product that contains both zero to become a multi-billion dollar industry Knowledge about the use and function of biostimulants has also increased at an exponential rate Biostimulants and better fruit fill First came the knowledge about which products had biostimulant effects, then came increasing knowledge about the mode of action and how During fruit fill the diversion of energy to fill the fruit and recommendations regarding timing and dosage of biostimulant applications Biostimulant with yet different modes of action are often and has led to more consistent results and greater returns on investment for beneficial during this stage, such as biostimulants that enhance the transport of sugars, like Amifol K, or solutions that promote growers The use of biostimulants in agronomic programs continues to expand fruit fill and quality thanks to added Calcium, like Phylgreen globally as this new knowledge is applied At the same time, a new generation Electra of biostimulants are currently under development, harnessing the knowledge Other options, promote fruit fill, while containing biostimulants that focus on reducing the negative effect of adverse temperature and reducing the effect of free radicals (also 56 2020 Biologicals Special biostimulants work inside the crop This has enabled increasingly precise produce viable seeds results in increased internal crop stress gained during the past decade and including new sources of raw materials, such as secondary metabolites of bacterial fermentation As a result, the use of biostimulants will continue to expand in this new known as Reactive Oxygen Species - ROS) Free radicals have decade gaining an increasing importance in assisting agriculture be more many negative effects on crops such as reducing amino acid and sustainable while at the same time helping to increase yield and quality to feed thus protein content the growing global population 2020 Biologicals Special 57 VIEWPOINT VIEWPOINT RNAi Opens A New Vista for Pest Control rootworm comes munching, the DvSnf7 technology to apply RNAi in a biopesticide Renaissance BioScience filed patent dsRNA disrupts a critical rootworm gene and against the Diamondback moth The funded application for RNA production kills the pest The western corn rootworm is project allows the Danforth Center to test a new known as the “billion dollar pest” as it causes delivery approach that would enable it to be massive damage to corn SmartStax Pro used on a wide variety of crops contains both Bt and dsRNA, which is a new tool for resistance management By Joyce Wang joyce@agropages.com R NA interference (RNAi) is a biological The most popular way to introduce of dsRNA uptake by target pests, the stability dsRNA into insects is through feeding This of dsRNA in the pest body, and dsRNA external-origin double-stranded RNA method is easy to implement, no special concentration in the pesticide These factors (dsRNA) inhibit gene expression or equipment is required, and it is convenient have an impact on the price of the product translation Such a process is common in to study RNAi using this approach It has natural organisms According to research, been successfully utilized to control many is in terms of RNA degradation RNA may scientists discovered RNAi in the 1990s, and species of pests, such as Nilaparvata lugen, be easily degraded after being sprayed in the since then, it has become evident that RNAi Reticulitermes flavipes, Rhodnius prolixus, field Therefore, its efficacy may not last long has enormous potential in the suppression Diabrotica virgifera, etc However, it might enough and frequent reapplication may be of target genes RNAi has been applied in provide slow-killing efficacy, and is invalid to required This might result in high costs for entomology research and the development pests at the egg or pupal stage since they feed growers of innovative pesticides in the past few on nothing process in which endogenesis or years, thanks to its high efficiency, species specificity and ease of application How does RNAi protect crops from insect pests? RNAi interferes with the insect’s gene expression, and prevents protein synthesis, A great challenge for many manufacturers Since the discovery of RNAi, scientists have made significant progress in the Advantages of RNAi applied for pest control 1) Due to the high specificity of dsRNA, improvement of technology A team from the University of Queensland developed a spray of nano-sized clay (BioClay) used to release dsRNA BioClay contains dsRNA and is such a technology has a small effect on non- broken down by a combination of water and target organisms CO2, leading to the slow release of dsRNA 2) As RNAi naturally occurs in over several weeks and high efficacy of RNA thus decreasing the insect’s adaptability the environment or organisms, and is to the environment or leading to its death biodegradable, the toxicity potential of RNA To make external-origin dsRNA work for pesticides is lower than that of chemical technologies have been overcoming crop protection, pest feeding on the dsRNA pesticides challenges through financing and R&D is the main way to start the RNAi process 3) RNA pesticides can be developed to to control pests Companies with leading edge collaboration All this facilitates the RNAi The dsRNA can be absorbed in the insect’s control all species of pests While comparing application on crop protection Examples midgut If the target gene is not in the midgut, such products to Bt technology, for example, below illustrate the progress that the industry the interference signal can be passed through scientists have found that Bt crops provide has made in the past few years cells and eventually reaches the gene to limited control on sucking insects as Bt toxins inhibit its expression have hardly any effect on them, whereas There are mainly five types of target genes that RNAi works on to control insects, namely lethal gene, resistance/immunityrelated gene (to decrease the resistance of insects to pesticides), growth/developmentrelated gene, oviposition-related gene, and the olfactory gene (to prevent insects from identifying crops) 58 2020 Biologicals Special US EPA approved first RNAi product RNAi may offer an alternative solution In June 2017, US EPA registered Challenges and breakthrough technologies in RNAi application The commercial potential of RNAi for pest control depends mainly on the efficiency Monsanto’s GM corn SmartStax® Pro to kill the western corn rootworm with RNAi It’s the first time that RNAi was being used as an insecticide The company encodes instructions for manufacturing DvSnf7 dsRNA in the DNA of the crop itself When a western corn patent application for a yeast platform participated in GreenLight Biosciences’ funding technology that produces and delivers round for collaborative research, leveraging RNA According to the company, yeast develop non-transgenic strategies to deliver GreenLight’s technology in advancing produced and delivered RNAi effectors dsRNA Their technologies are acceptable to biopesticides Brad Fabbri, Chief Science are protected from degradation in the field people who are against GMO produce Officer at TechAccel, said, “Until just a few Moreover, yeast is easy and inexpensive to years ago, RNA at the cheapest was maybe one produce, and is a safe and well-understood GreenLight Biosciences’ technology to US$10,000 per gram, which is too expensive microorganism reduces cost of RNA production to spray on a field, but GreenLight got it below a On the other hand, several companies Editor of AgroPages In 2019, TechAccel also announced that it Renaissance BioScience Corp announced the filing in 2019 of a PCT GreenWorX™ is the proprietary, cell- dollar a gram which makes it possible to actually Bayer has submitted RNAi-based use RNA as an ag chemical.” product to US EPA for registration free bioprocessing platform of GreenLight Biosciences that allows them and their AgroSpheres’ biomolecule encapsulation partners to produce high-quality, cost- improves product efficacy effective RNA products through biology Their RNA products are applied as a foliar BioDirect, based on dsRNA, was submitted by Bayer for registration in 2019 The product has been developed to In 2018, AgroSpheres signed partnerships control varroa, which is the most damaging spray on the leaves After the pest eats the with GreenLight Biosciences and TechAccel for pest to apiculture This is the first US EPA leaves, dsRNA enters the insect’s stomach dsRNA encapsulation These partnerships test submission for an exogenously applied and intercepts the RNA message, following AgroSpheres’ technology of dsRNA delivery dsRNA biopesticidal active ingredient in which the pest loses its appetite for leaves and to control the Colorado Potato Beatle and the industry starves to death Lepidopteran insects AgroSpheres provides a Mick Messman, chief commercial officer microscopic cell, AgriCell, that shields actives at GreenLight Biosciences, said, “Our system from harsh environmental conditions and accelerates the process of introducing a new enhances their stability in the field Prospect of RNAi products RNAi in crop protection can be product into the market As the timeline is achieved by transgenic technology, so much shorter than with a conventional sprayable dsRNA formulation, trunk chemical product, it is less expensive If the injection or root drenching Other genome of an insect is mapped, then it’s more approaches, such as seed coating or a matter of designing than discovering We powder/granule formulation, require essentially design a sequence to impact that further studies specific insect.” Key challenges and essential steps The company’s first product has been for RNAi-based pesticides include designed to control the Colorado potato identification of the right target genes and beetle, which feeds on potato leaves This improving the efficiency of product usage foliar spray product will be applied for Much progress has been made on their regulatory approval in 2020 The company application over the past few years expects complete registration in 2022 Until today, at least two regulatory agencies (Canadian Food Inspection TechAccel’s investment and collaboration Agency and US EPA) have approved RNAi-based pesticides RNAi technology TechAccel is an ag-tech and investment AgroSpheres’ AgriCell: A phospholipid is a new and innovative approach in the enterprise It awarded the first grant in 2017 membrane forms a natural shield that envelops crop protection market It may substitute under its “Path to Commercialization” actives and protects them from heat, UV light, or combine the use of chemical pesticides program at the Donald Danforth Plant Science enzymes, and microbes Actives encapsulated in and reduce the hazards from them This Center, one of the world’s largest independent the AgriCell degrade more slowly and remain technology opens a new vista for pest plant science institutes The grant was to effective against pests for a longer period of control and holds great promise for the fund a project to demonstrate a sprayable time (Source: AgroSpheres) future 2020 Biologicals Special 59 VIEWPOINT VIEWPOINT France: Reducing Chemical Pesticide Use And Developing Biological Control By Paul Zheng, Editor of AgroPages There is another advantage, being that the biological control products are benefiting from the accelerated process of approval of registration and marketing The review by inconsistencies between the rules for products for use in organic farming and traditional agricultural production To this end, it is predicted that in the future the EU will need to revise the ANSES of chemical pesticide products takes generally EU 91 / 414 Regulation to simplify the registration process of biopesticides, 12 months while for biological control products it takes especially product based on the natural substances, as well as to simplify the mutual only months However, this is not the case generally in recognition process among EU Member States Europe, where there is neither a standard definition yet of the biological control nor a favored approval process for registration and marketing of biopesticides T he development of the sector was placed at the top of the French political agenda at the sixth annual biocontrol meetings, which took place on 21 January in Paris That day, Agriculture Minister, Didier Guillaume, promised a roadmap to boost the sector, which will include support measures for the industry for the next five years According to the France Report of EURACTIV (EU’s official media), in the last few years France has endeavored to reduce the use of chemical pesticides while making effort to on development of biopesticides Meanwhile, France has been trying to promote enacting of more favorable laws and regulations in support of biopesticide development in EU European market grows stably while registration regulation remains as main obstacle Europe is the second largest biopesticide market in the world Biopesticides in Europe have development rapidly in the last few years Unfortunately, the development of biopesticides is facing some obstacles due to the complicated and chemical pheromones are subject to the same regulatory framework as chemical pesticides, and the requirements for and investment in Europe At present, the United States is a global leader in the January 2020: The neonicotinoid insecticides December 2019: ANSES announced the removal of 36 herbicides containing glyphosate, which accounted for / of the glyphosate used in 2018 research and development, registration and application of biopesticides EPA, the US pesticide registration and evaluation agency, has become the world leader in biopesticide regulation and supervision The United States accounted for 8% of the total pesticide market in 2018, having reached EUR170 has made great improvement to the testing methods of million Denis Longevial le, the secretary-general of the institution, said the proportion biopesticides, having lowered data requirement and reduced of biopesticide is expected to reach 10% by 2020, with the final goal of 30% by 2030 the time and cost e involved in registration of biopesticides As a whole, compared with other European countries, the biopesticide industry in France is relatively developing faster, but this rapid development is not accidental This has set a global precedent for simplification of biopesticide registration, which, as a result, has enabled Elisabeth Borne, the French ecology and sustainable development minister, farmers in the United States to use the large number of cost- of epoxiconazole, which is said to contain carcinogenic said that the sales of chemical pesticides in France increased sharply in 2018, which effective biopesticides instead of chemical pesticides, making substances while being also harmful to human reproductive appeared to be contradictive to the government’s goal of halving the use of chemical the United States a world leader in the use of biopesticides health, with a “worrisome danger” pesticides by 2025 This situation, in fact, also revealed that the agricultural model June 2019: ANSES announced prohibition of the sale November 2018: the French government publicly discussed the Ecophyto II + plan, targeting at reduction of the use of chemical pesticides by 50% by 2025 Bacillus firmus I-1582 Bacillus pumilus QST 2808 Bacillus thuringiensis subsp aizawai the biopesticides based on microorganism, biochemistry discourages the enthusiasm to file for this kind of registration flupyradifurone and sulfoxaflor banned in France Aureobasidium pullulans (strains DSM 14940 and DSM 14941) 414 Regulation is presently still in place in EU, under which, in the time and cost of registration of biopesticides, which According to the census of French IBMA, the French biopesticide market Ampelomyces quisqualis Bacillus subtilis str QST 713 for chemical pesticides This has led to a significant increase Rapid biopesticide development in France, fully supported by government Adoxophyes orana GV strain BV-0001 regulatory procedures in the EU It is understood that the 91 / registration of biological control products are the same as Key events in chemical pesticide prohibition and restriction in France in last three years Table 1: French L.253-5 and L.253-7 Biological Control Product List (microbiological product only) Bacillus thuringiensis subsp kurstaki Beauveria bassiana strain 147 Coniothyrium minitans Cydia pomonella granulosis virus Gliocladium catenulatum souche J1446 Helicoverpa armigera nucleopolyhedrovirus Isaria fumosorosea Apopka strain 97 Lecanicillium muscarium strain Ve6 Metarhizium anisopliae var anisopliae BIPESCO 5/F52 Phlebiopsis gigantea Pseudomonas chlororaphis MA342 Pythium oligandrum Streptomyces K61 (formerly S griseoviridis ) Trichoderma asperellum strains ICC012 T25 and TV1 Trichoderma asperellum T34 Trichoderma atroviride I-1237 To be frank, as aforesaid, the EU's regulatory process Trichoderma atroviride I-1238 based on the use of chemical pesticides seems to come to its end of life, whilst is still complicated Although some special provisions are made, the idea to put biopesticides, which are based on Trichoderma atroviride T11 et biological pesticides are embracing the best opportunity of development A better regulatory framework in favor of biopesticide development has promoted microorganism, biochemistry and chemical pheromones, Trichoderma asperellum T25 the rapid development of biopesticides in France Denis Longevial le said that France under same registration process as chemical pesticides Trichoderma gamsii ICC080 use of five new neonicotinoid insecticides (clothianidin, had focused on researches of biological control for the last decade In 2014, France is apparently unreasonable Knowing that the measures Trichoderma harzianum Rifai strains T-22 and ITEM-908 imidacloprid, thiamethoxam, thiacloprid, and acetamiprid), formulated a strategy which is being planned for implementation The main contents provided by legislation are intended to support the being the first EU country to prohibit neonicotinoid of the strategy are currently under review, to be properly implemented in the next 10 registration of "low-risk" products, but this does not insecticides so as to protect the honeybee population years serve the purpose in reality In addition, there are obvious In September 2018: France banned the sale and 60 2020 Biologicals Special Pepino mosaic virus, strain CH2, isolate 1906 Benign zucchini yellow mosaic virus 2020 Biologicals Special 61 VIEWPOINT VIEWPOINT Biopesticides regulation and licencing these products for have driven producers to increase their be quantified and proved, they require – A Fast-growing Multibillion Market already reaping the benefits of using non-toxic output and to find ever more efficient ways the biopesticide to pose minimal or zero alternatives to chemical pesticides In Spain’s of meeting demand Insecticides have done risk, toxicological and eco-toxicological notorious ‘Sea of Plastic’, the 30,000-hectare much to help meet those needs But they have evaluations, and other stringent tests corner of Almeria which produces most of done so at great cost to human health, to the These tests have been put in place for the fruits and vegetables that are consumed environment and to the long-term viability chemical pesticides, but they are perhaps not throughout Europe, sachets of miniscule of our soil Growers are also having to meet appropriate for biopesticides Meeting the T By Dr Minshad Ansari Founder and CEO of Bionema, UK consequences of food production and agricultural practices coming under increased scrutiny, and being reassessed and remodelled, biopesticides have come under the spotlight They are seen as filling a gap in the Some of Europe’s largest growers are current requirements can be prohibitively growing 3.5 times faster than the found within nature These biopesticides are, tomato and courgette plants, and attack the to those chemicals we have been using so expensive for biopesticide developers, conventional pesticide market and expected in many cases, already being developed or parasites that threaten these crops In fact, the liberally for years many of which are SME’s This can deter to grow from $3.8 billion in 2018 to used successfully, and others are well within use of insecticides in Almeria has, according almost $10 billion by 2025 at 17% CGAR our grasp In fact, I believe biopesticide can to local authorities, dropped by 40% since farmers, many of whom are in a holding products Therefore, the challenge for the (DunhanTrimmer 2019 ) Around 30% of plant fill gap in the market as well as increase 2007 pattern of disinfecting their land with regulator is to have an appropriate system protection tools now a vailable are biological, market share of 20% in next ten years We are fungicides, and using other chemical agents, in place for biopesticides that ensures their and more than 50% of new regulatory at a point in time where the public are more experienced a very interesting development simply because this is what they have always safety and consistency, but which does not applications are biological products aware of, or more vocal of, their expectations over the past few decades Our use of done, and because these chemicals are being inhibit commercialisation If this nettle can when it comes to the impact of the practices insecticides surged in the 1960s, at a time recommended and sold to them by companies be grasped, which I believe it can, then we biocontrol industry, there is an urgent need of industry upon our environment And public when, at least in the Western World, there they have dealt with over many years and can lift the primary drag upon progress in this to develop novel products, formulations scrutiny is a very powerful driver of the was a public awakening to the fact that our which they trust field and delivery systems to not only “fill the practices of the biopesticide industry chemical-laden environment was perhaps Despite significant growth in the pesticides being banned, but also to anticipate a watershed moment There is a growing future requirements as insects are developing acceptance among food producers that resistance to currently used insecticides. In practices need to be modernised There is addition, there is increasing consumer led a groundswell of public awareness that we retailer demand for growers to reduce the use cannot continue to lean upon traditional, of chemical pesticides in crop production and damaging pesticides, some of which we have to grow fruit and vegetables with reduced been using for many decades, to support detectable residues production The long-term negative effects Eco-friendly, nature-based alternatives of our land, and the threat this brings to our used for many decades to control pests and survival, is well documented Also, health diseases and increase yield are transforming experts and scientists have been flagging up diseases including Parkinson’s, Alzheimer’s, of conventional pesticides Dr biopesticides taking an increased share of the brain, prostate and kidney cancers, for many pesticide market – currently only 10% years (WHO) reports that pesticides are responsible and diseases and reduce the use of synthetic for up to five million cases of poisoning pesticides In fact, Bionema @Bionema is each year, of which 20,000 are lethal And, at the forefront of some of the most exciting it says, pesticides affect children and infants advances in technology being made in the disproportionately This is important because we are living 62 2020 Biologicals Special But the regulatory barriers are complex, The World Health Organization natural products to protect crops from pests biopesticide industry developers from commercialising their of using chemical pesticides on the fertility to the harsh, chemical pesticides we have Companies like ours develop eco-friendly The biopesticide movement has There is still work to be done to educate It is very clear that we have reached links between pesticide use and a host of unpicks this issue require the efficacy of a biopesticide to the man-made challenge of crop resistance new era of cleaner agronomy that could see developer Bionema, UK, and there are consistent challenges They mites are used, which are draped from pepper, the industry And they are ushering in a CEO of biopesticide technology However, global population pressures problems facing food production are to be market created by the removal Minshad Ansari, Founder and hostile to health and life he global biopesticide market is gaps” in the market due to a large amount of With the ecological the marketplace The evidence to support wholesale change is there, credible science is there, the in very crucial times for food production and will is there, and, to some extent, the funding land management Safe, responsible, and is increasingly there to ensure efficacious new sustainable food production is a cornerstone products to fill the gap in the market created of the continued survival of life, and some by the removal of pesticides The remaining of the most exciting solutions to the biggest hurdles are largely around the slow pace of 2020 Biologicals Special 63 COMPANY DIRECTORY SCC – Scientific Consulting Company COMPANY DIRECTORY Since its establishment in 1989, SCC (Scientific Consulting Company) has been supporting its international customers with cost-efficient tailored solutions for their scientific and regulatory needs within and outside the EU Our expertise extends over a broad range of areas, including agrochemicals, and biorationals, fertilisers, chemicals and biocides, feed and food additives, food contact materials, cosmetics and consumer products, medical devices, pharma preclinical and legal services In the field of biorationals, we offer fullscale services for: • Biopestides • Basic and low-risk substances • Biostimulants and fertilisers Biolchim Biolchim is leader in the production and commercialization of biostimulants and specialty fertilizers designed to optimize crop production and performance in every agronomic context With more than 40 years of experience and the close collaboration with universities and research centres, Biolchim has developed a complete product portfolio of the highest quality based on actual market requirements  Based in Italy, where the production lines and extraction units are located, Biolchim has seven global subsidiaries strategically located in Brazil, Germany, Hungary, Poland, New Zealand, Canada and China, and three representative offices in Russia, Turkey, and Colombia, • Organic/precision farming and IPM Biolchim operates through commercial headquarters in Bad Kreuznach and an office in Berlin, and runs SCC Japan K.K in Tokyo In 2019, SCC GmbH established SCC Legal, an independent company, to provide its customers with high quality legal services importers and distributors and improving the health of the soil, the novel technology to accelerate toward microbiome and the environment commercialization Our project scope extends from short Azotic is currently increasing sales of its natural nitrogen fixing technology to growers info@beevt.com agreements with start-up, mid-size and multi- across the USA and this will increase further http://www.beevt.com/ national organizations Or development with the launch of a foliar application strength in biological and synthetic chemistries spans across 29 crops in Latin Commercialisation of N-Fix® on rice is also on the agenda America, North America, EMEA and Asia By allowing plants to fix nitrogen from Pacific Add AgriThority to your team for the air, this technology increases yields and technical depth and business breadth Trust benefits the sustainability of agriculture our native guides to fuel your development and growth into unchartered territory Application on corn and soybean in the US saw yield increases of 5-13% on average Recent rice trials in Asia have shown that USA on average the N-Fix treated plots increased info@AgriThority.com yield by 17% (645 kg/ha) more than the www.AgriThority.com untreated UK allen@azotictechnologies.com Biobest is one of the world's leading Aminocore companies in the field of biological control of pests and diseases and natural pollination In 1987, Biobest was the first company to put bumblebees on the market Today, www.biolchim.it Biobest offers a complete selection of natural Aminocore is a leading Dutch/German based producer of amino acids and amino consortia management acid based products which meet today’s need solutions on all continents such as beneficial Bee Vectoring Technology (BVT) for high quality and environmentally friendly AgriThority www.scc-gmbh.de on vegetables, ornamentals, soft fruits, plant and safer than chemically hydrolysed amino Bee Vectoring Technology has pioneered contain the highest levels of easily absorbable a natural precision agriculture system that free amino acids in the market In fact, in replaces chemical pesticides and wasteful terms of plant nutrition, our products are at plant protection product spray applications by least twice as strong in L-amino acids versus delivering biological pesticide alternatives to conventional, chemically hydrolysed amino crops using commercially grown bees The acid alternatives And they are safer too system consists of the company’s innovative technical and strategic resource, we focus on We call this ‘plant efficient’ Want to know bee delivery system and proprietary exploring potential for innovation, expanding more what we can for you as a formulator, VECTORITE™ with CR-7 (Clonostachys market access, and evolving production for importer or distributor? rosea) biological fungicide Forward-thinking agriculture experts with deep scientific experience are the core of AgriThority® As an independent global greater food security and sustainability When your Research is ready for Development, turn to AgriThority® for scientific product, business and market biopesticides, monitoring and scouting growers with tailor-made advice We focus amino acid, our products are more effective acid products They are also organic, and they insects, mites, bumblebees, nematodes, products and pheromones Biobest provides solutions Using an exclusive-to-us natural info@scc-hq.de Biobest Group NV https://www.azotictechnologies.com/ products, chemicals and biocides as well as Germany Canada local programs to ongoing international CTuran@cifo.it We care for your success and yield results (by as much as 29%) over traditional chemical pesticides – Italy for chemical regulations of plant production blooms, providing improved crop protection Response™ Development Process to your the territory In more than 50 other countries, partnerships and capillary networks of Azotic Technologies Ltd We apply our disciplined Prescriptive with local distributors and provides continuous technical and sales support on SCC has offices in Germany – the between your great idea and a breakthrough through which it builds close partnerships • Soil conditioners, soil aids and plant aids expertise that can make the difference propagation, herbs and medicinal cannabis Belguim marketing.support@biobestgroup.com www.biobestgroup.com This award-winning technology is The Netherlands completely harmless to bees and allows info@aminocore.nl minute amounts of naturally-derived www.aminocore.nl biopesticides to be delivered directly to 2020 Biologicals Special 65 COMPANY DIRECTORY Certis USA COMPANY DIRECTORY DOGAL PESTICIDES AND CHEMICALS INDUSTRY TRADE S.A Certis USA is a pioneer in the and has become one of the world’s leading manufacturers and distributors of *Biological product development, from screening to formulation to field development *Manufacturing: fermentation and formulation *Global registrations for biological products *Global sales channels We export to more than 30 countries USA info@certisusa.com https://www.certisusa.com We are particularly well established in Agro a valued partner of the agricultural providing the growers or private gardeners sector and industry Kwizda Agro comprises with efficient solutions against more than 50 distinct business units: distribution (Crop), different pests to protect row crops, orchards, contract manufacturing (Tolling), pest vegetables, trees or stocked grains as well control (Biocides) and proprietary biological as row crops (corn) We provide dispensers focused on naturally occurring microorganism products (New Technologies) Within New that last in average for 100 days and can be based products & solution since 1994, Technologies, Kwizda Agro develops strongly stored 2,5 years at normal temperature thanks and improving soil health, crop yield & needed products based on natural extracts, to our microencapsulation technology This quality while managing crop resistance and minerals or micro-organisms for conventional unique formulation patent allows regular and residue. IPL developed its products through and organic use in field crops, specialty crops linear pheromone release for better efficacy in its proprietary discovery and development and forestry fields; it also makes possible to commercialize IPL BIOLOGICALS LTD is totally development of biological pesticides biopesticides We specialize in: portfolio and advisor offerings make Kwizda IPL BIOLOGICALS LTD Dogal Inc has been manufacturing and exporting plant protection products since the day it was established (1989) Dogal Inc is one of Turkey’s leading manufacturers of innovative crop protection products, that are technologically advanced and scientifically proven Our firm has a high capacity R&D laboratory and quality systems such as ISO 9001 and ISO 14001 Main Services • Formulator, Manufacturer and process IPL is offering its effective products In research & development, KWIZDA for soil health conditioning, plant nutrition & collaborates with a tight network of scientific health, and managing pests and plant diseases.  communities, companies and agricultural practitioners India the European Business Award for the www.iplbiologicals.com  c.bardewyk@kwizda-agro.at European Commission in 2016 / 2017, and kwizda.at/en/agro/ were recognized in 2019 as one of the 50 the biggest manufacturers of fertilizers and biostimulants, and actively participates in the sector of animal health products INTERMAG GLOBAL AGRO Co., Ltd antimicrobial/biocide, fertilizer, and consumer / ecotoxicology / chemistry consulting / agricultural economic analysis / litigation / scientific support USA Info@complianceservices.com http://www.complianceservices.com 66 2020 Biologicals Special has expanded its operations in Europe, Asia, Africa, North, and South America Poland demanding agricultural systems in the world Seipasa is established in more than 25 countries worldwide Spain contact@seipasa.com www.seipasa.com Verdesian Life Sciences U.S LLC At Verdesian Life Sciences, we enable a Founded in 2012, M2i is a French more sustainable, profitable future for farmers industrial group of 165 people with expertise through nutrient use efficiency We firmly in developing, formulating and manufacturing believe that sustainability and profitability complex molecules Through our strong R&D facilities and our GMP plant based in France, Plant Health Care are not mutually exclusive, and our NUE technologies are designed to protect the we are able to meet customer needs in plant environment while helping farmers outdo biocontrol We are currently the N1 in Europe what they’ve always done Everything we for pheromones production Pheromones are substances secreted by insects which enable at Verdesian has the best, long-term interest of Plant Health Care is a leading provider the grower in mind Our portfolio of products them to interact with others of the same of proprietary biological products to global and technologies enhance nutrient uptake, species in order to gather together, mate or agricultural markets.Plant Health Care’s reduce nutrient losses to the environment and flee By reproducing them in a laboratory Commercial business is driven by sales of biological solution provider based on improve yield potential We are committed using biomimicry and developing innovative Harpin αß, a recombinant protein which acts professional R&D capabilities to helping farmers maintain and improve and patented release methods, M2i has as a powerful biostimulant, promoting the water quality and soil health, and are adamant created a way of fighting pests by drawing yield and quality of crops The Group sells in our belief that we can this together them in and trapping them, or by disrupting the proprietary soil treatment Myconate in Sustainability is a global movement, but big them so as to prevent their reproduction and selected countries The Group sells Harpin αß changes start with small actions One practice, spread and Myconate through specialist distributors one tool or one new agronomic opportunity around the world In Mexico, the Group also can improve nutrient efficiency, increase yield distributes third-party biological products and dial up profits products Our services include International / endocrine disruptor support / toxicology value solutions that are applied in the most INTERMAG is a company founded consulting services for product registration placement and monitoring / data development formulated and registered high technological www.m2i-lifeciences.com in Poland in 1988 From the beginning, specializes in global regulatory and scientific modeling and spatial analysis / study nutrition For over 20 years the company has www.dogaltrm.com Compliance Services International (CSI) / environmental fate and modeling / exposure johann.fournil@m2i-lifesciences.com M2i Biocontrol agriculture Currently the company is one of assessment / endangered species assessment France INTERMAG and production of modern preparations for and Asia pertaining to ecological risk for natural crop protection, biostimulation and newspaper Les Echos its activity focused on the development regulatory affairs in the USA, EU, Canada, Seipasa is a pioneering company in the formulation and development of treatments most promising French companies by the • Sales and Marketing (PPP) info@dogaltrm.com (biopesticides/biologicals/biostimulants), Environment award for Innovation from Austria Turkey and risk assessment for crop protection We won in 2015, the Business and the French Ministry of Environment, and • R&D (Develop improved products Compliance Services International (CSI) sprayed in fields ashish.sharma@iplbiologicals.com Distributor Company formulation and innovative products) flowable pheromone formulation that can be Seipasa intermag@intermag.eu GLOBAL AGRO is the innovative https://intermag.eu/ As one of market leaders in biological business sector of Korea, we are dedicated to safe and smart agriculture by providing KWIZDA AGRO GmbH creative agricultural solutions With 19 patents in years, M2i focuses Korea on innovation and advanced technology www.globalagro.co.kr to promote“made in Europe” solutions as dlkim7@dongoh.co.kr Kwizda Agro is part of the Kwizda Group and a leading provider of crop protection products High quality standards, a broad an alternative to traditional pesticides Our USA USA pheromone products protect efficiently the mturner@planthealthcare.com augusto.meneses@VLSci.com crops and orchards in more than 25 countries www.planthealthcare.com www.VLSci.com 2020 Biologicals Special 67 PRODUCT FOCUS FIRST CLASS TRIAL SERVICES GmbH SUPPORTING YOUR MARKET ACCESS! 68 2020 Biologicals Special