Survival in overweight patients with advanced pancreatic carcinoma: A multicentre cohort study

Obesity is a risk factor for developing pancreatic cancer. We investigated the impact of obesity on survival in patients diagnosed with locally advanced or metastatic pancreatic cancer. Methods: In a multicentre, retrospective study, we included all patients with advanced or metastatic pancreatic cancer treated at four Swiss hospitals between 1994 and 2004.

Kasenda et al BMC Cancer 2014, 14:728 http://www.biomedcentral.com/1471-2407/14/728 RESEARCH ARTICLE Open Access Survival in overweight patients with advanced pancreatic carcinoma: a multicentre cohort study Benjamin Kasenda1,2†, Annatina Bass1†, Dieter Koeberle3, Bernhard Pestalozzi4, Markus Borner5, Richard Herrmann1, Lorenz Jost6, Andreas Lohri6 and Viviane Hess1* Abstract Background: Obesity is a risk factor for developing pancreatic cancer We investigated the impact of obesity on survival in patients diagnosed with locally advanced or metastatic pancreatic cancer Methods: In a multicentre, retrospective study, we included all patients with advanced or metastatic pancreatic cancer treated at four Swiss hospitals between 1994 and 2004 We categorized patients into four body mass index (BMI) groups ( =2) Diabetes (yes versus no) Stage (stage III versus stage IV) Sex (male versus female) CA 19-9 (continuously on log scale) Univariable Multivariable HR 95% CI P-value HR 95% CI P-value 1.25 1.10 - 1.42