Previous population-based studies have demonstrated an association between metformin use and improved survival among diabetic patients with cancer. We sought to analyze the effects of diabetes and its treatment in terms of the survival of patients with lung cancer.
Arrieta et al BMC Cancer (2016) 16:633 DOI 10.1186/s12885-016-2658-6 RESEARCH ARTICLE Open Access Metformin use and its effect on survival in diabetic patients with advanced non-small cell lung cancer Oscar Arrieta1*, Edgar Varela-Santoyo1, Enrique Soto-Perez-de-Celis2, Roberto Sánchez-Reyes1, Martha De la Torre-Vallejo1, Sắ Miz-Hernández1 and Andrés F Cardona3,4 Abstract Background: Previous population-based studies have demonstrated an association between metformin use and improved survival among diabetic patients with cancer We sought to analyze the effects of diabetes and its treatment in terms of the survival of patients with lung cancer Methods: Overall, 1106 patients with non-small cell lung cancer (94.3 % with stage IV disease) were included The outcomes were compared between the patients with (n = 186) and without diabetes (n = 920) The characteristics associated with antidiabetic treatment and proper glycemic control (defined as a mean plasma glucose