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The optimized patch containing FEL-TEA and 10% Azone had significantly higher skin permeation amount (P Furthermore, the in vitro skin permeation results of FEL-TEA patch was found to have a good correlation with the in vivo absorption results in rabbit. These findings indicated that a combination of ion-pair and chemical enhancer strategy could be useful in developing a novel transdermal patch of FEL.
AAPS PharmSciTech, Vol 17, No 2, April 2016 ( # 2015) DOI: 10.1208/s12249-015-0342-9 Research Article Design and Evaluation of a Novel Felbinac Transdermal Patch: Combining Ion-Pair and Chemical Enhancer Strategy Nannan Liu,1 Wenting Song,1 Tian Song,1 and Liang Fang1,2 Received 14 February 2015; accepted 23 May 2015; published online 13 June 2015 Abstract The aim of this study was to design a novel felbinac (FEL) patch with significantly higher (P