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The aim of this study was to determine the body weight changes and gross pathological alterations induced by glyphosate exposure in male albino Wistar rats and its amelioration with Ascorbic Acid. Forty eight (48) adult male albino Wistar rats were used for this study.
Int.J.Curr.Microbiol.App.Sci (2019) 8(10): 1486-1493 International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume Number 10 (2019) Journal homepage: http://www.ijcmas.com Original Research Article https://doi.org/10.20546/ijcmas.2019.810.174 Effect of Glyphosate (GLP) Induced Toxicity on Body Weights and Gross Pathology: Ameliorative Effect of Ascorbic Acid (AA) in Wistar Rats M Lakshmi Namratha1, M Lakshman1*, M Jeevanalatha2 and B Anil Kumar3 Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad-500030, India Department of Veterinary Pathology, College of Veterinary Science, Mamnoor-506166, India Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad-500030, India *Corresponding author ABSTRACT Keywords Glyphosate, Albino Wistar rats, Body weights Ascorbic Acid and oral gavage Article Info Accepted: 12 September 2019 Available Online: 10 October 2019 The aim of this study was to determine the body weight changes and gross pathological alterations induced by glyphosate exposure in male albino Wistar rats and its amelioration with Ascorbic Acid Forty eight (48) adult male albino Wistar rats were used for this study The experiment was carried out for 21 days The animals were randomized into groups with twelve (12) animals in each Group - control, group - GLP (@500 mg/kg b.wt), group - AA (@250 mg/kg b.wt) and group - GLP+AA (@500 mg/kg b.wt + 250mg/kg b.wt) The treatment regimens were administered by oral gavage once daily for three weeks Individual body weights of all the rats were recorded soon after arrival and subsequently on 7th, 14th and 21st day of experiment to study the body weight gains A significant (P