(BQ) Part 1 book Hematology, immunology and infectious disease expert consult presents the following contents: Updated information on stem cells for the neonatologist; current issues in the pathogenesis, diagnosis, and treatment of neonatal thrombocytopenia; nonhematopoietic effects of erythropoietin,... Invite you to consult.
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Log in at expertconsult.com REGISTER Scratch off your Activation Code below s #LICKh2EGISTER.OWvATEXPERTCONSULTCOM Enter it into the “Add a Title” box s &ILLINYOURUSERINFORMATIONANDCLICKh#ONTINUEv Click “Activate Now” ACTIVATE YOUR BOOK Click the title under “My Titles” s 3CRATCHOFFYOUR!CTIVATION#ODEBELOW s %NTERITINTOTHEh%NTER!CTIVATION#ODEvBOX s #LICKh!CTIVATE.OWv s #LICKTHETITLEUNDERh-Y4ITLESv For technical assistance: email online.help@elsevier.com call 800-401-9962 (inside the US) call +1-314-995-3200 (outside the US) Activation Code HEMATOLOGY, IMMUNOLOGY AND INFECTIOUS DISEASE Neonatology Questions and Controversies HEMATOLOGY, IMMUNOLOGY AND INFECTIOUS DISEASE Neonatology Questions and Controversies Series Editor Richard A Polin, MD Professor of Pediatrics College of Physicians and Surgeons Columbia University Vice Chairman for Clinical and Academic Affairs, Department of Pediatrics Director, Division of Neonatology Morgan Stanley Children’s Hospital of NewYork-Presbyterian Columbia University Medical Center New York, New York Other Volumes in the Neonatology Questions and Controversies Series GASTROENTEROLOGY AND NUTRITION HEMODYNAMICS AND CARDIOLOGY NEPHROLOGY AND FLUID/ELECTROLYTE PHYSIOLOGY NEUROLOGY THE NEWBORN LUNG HEMATOLOGY, IMMUNOLOGY AND INFECTIOUS DISEASE Neonatology Questions and Controversies Robin K Ohls, MD Professor of Pediatrics University of New Mexico Associate Director, Pediatrics Clinical Translational Science Center University of New Mexico Health Sciences Albuquerque, New Mexico Akhil Maheshwari, MD Associate Professor of Pediatrics and Pharmacology Chief, Division of Neonatology Director, Neonatology Fellowship Program Director, Center for Neonatology and Pediatric Gastrointestinal Disease University of Illinois at Chicago; Medical Director, Neonatology Intensive Care Unit and Intermediate Care Nursery Children’s Hospital of University of Illinois Chicago, Illinois Consulting Editor Richard A Polin, MD Professor of Pediatrics College of Physicians and Surgeons Columbia University Vice Chairman for Clinical and Academic Affairs, Department of Pediatrics Director, Division of Neonatology Morgan Stanley Children’s Hospital of NewYork-Presbyterian Columbia University Medical Center New York, New York SECOND EDITION 1600 John F Kennedy Blvd Ste 1800 Philadelphia, PA 19103-2899 HEMATOLOGY, IMMUNOLOGY AND INFECTIOUS DISEASE: NEONATOLOGY QUESTIONS AND CONTROVERSIES Copyright © 2012, 2008 by Saunders, an imprint of Elsevier Inc ISBN: 978-1-4377-2662-6 No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the Publisher Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein) Notices Knowledge and best practice in this field are constantly changing As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein In using such information or methods, they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered to verify the recommended dose or formula, the method and duration of administration, and contraindications It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein Library of Congress Cataloging-in-Publication Data Hematology, immunology, and infectious disease : neonatology questions and controversies / [edited by Robin K Ohls] — 2nd ed p. cm — (Neonatology questions and controversies series) Includes bibliographical references and index ISBN 978-1-4377-2662-6 (alk paper) 1. Neonatal hematology. 2. Newborn infants—Immunology. 3. Communicable diseases in newborn infants. I. Ohls, Robin K RJ269.5.H52 2012 618.92′01—dc23 2011053382 Senior Content Strategist: Stefanie Jewell-Thomas Content Development Specialist: Lisa Barnes Publishing Services Manager: Anne Altepeter Team Manager: Hemamalini Rajendrababu Project Manager: Siva Raman Krishnamoorthy Design Direction: Ellen Zanolle Printed in The United States of America Last digit is the print number: 9 8 7 6 5 4 3 2 Working together to grow libraries in developing countries www.elsevier.com | www.bookaid.org | www.sabre.org Contributors Jennifer L Armstrong-Wells, MD Catalin S Buhimschi, MD Director Perinatal and Hemorrhagic Stroke Programs Department of Pediatrics Section of Neurology Hemophilia and Thrombosis Center; Assistant Professor Pediatric Neurology University of Colorado Aurora, Colorado; Assistant Adjunct Professor Neurology University of California, San Francisco San Francisco, California Hematology and Immunology: Coagulation Disorders Associate Professor, Director Perinatal Research Interim Division Director Maternal Fetal Medicine Obstetrics, Gynecology, and Reproductive Sciences Yale University School of Medicine; Interim Chief of Obstetrics Obstetrics, Gynecology, and Reproductive Sciences Yale New Haven Hospital New Haven, Connecticut Chorioamnionitis and Its Effects on the Fetus/Neonate: Emerging Issues and Controversies Nader Bishara, MD Associate Professor Obstetrics, Gynecology, and Reproductive Sciences Yale University School of Medicine New Haven, Connecticuit Chorioamnionitis and Its Effects on the Fetus/Neonate: Emerging Issues and Controversies Attending Neonatologist Pediatrix Medical Group Huntington Memorial Hospital Pasadena, California The Use of Biomarkers for Detection of Early- and Late-Onset Neonatal Sepsis L Vandy Black, MD Instructor, Division of Pediatric Hematology The Johns Hopkins University Baltimore, Maryland A Practical Approach to the Neutropenic Neonate Suresh B Boppana, MD Professor, Pediatrics and Microbiology University of Alabama at Birmingham Birmingham, Alabama CMV: Diagnosis, Treatment, and Considerations on Vaccine-Mediated Prevention Irina A Buhimschi, MD, MMS Robert D Christensen, MD Director of Research Women and Newborns Intermountain Healthcare Salt Lake City, Utah The Role of Recombinant Leukocyte Colony-Stimulating Factors in the Neonatal Intensive Care Unit Misti Ellsworth, DO Pediatric Infectious Disease San Antonio, Texas Neonatal Fungal Infections v vi Contributors Björn Fischler, MD, PhD Akhil Maheshwari, MD Associate Professor Pediatrics CLINTEC Karolinska Institutet; Senior Consultant Pediatric Hepatology Pediatrics Karolinska University Hospital Stockholm, Sweden Breast Milk and Viral Infection Associate Professor of Pediatrics and Pharmacology Chief, Division of Neonatology Director, Neonatology Fellowship Program Director, Center for Neonatology and Pediatric Gastrointestinal Disease University of Illinois at Chicago; Medical Director, Neonatology Intensive Care Unit and Intermediate Care Nursery Children’s Hospital of University of Illinois Chicago, Illinois A Practical Approach to the Neutropenic Neonate Marianne Forsgren, MD, PhD Associate Professor of Virology Department of Clinical Microbiology Karolinska University Hospital, Huddinge Stockholm, Sweden Breast Milk and Viral Infection Peta L Grigsby, PhD Assistant Scientist Division of Reproductive Sciences Oregon National Primate Research Center; Assistant Research Professor Department of Obstetrics and Gynecology Oregon Health and Science University Portland, Oregon The Ureaplasma Conundrum: Should We Look or Ignore? Sandra E Juul, MD, PhD Professor, Pediatrics University of Washington; Professor, Pediatrics Seattle Children’s Hospital Seattle, Washington Nonhematopoietic Effects of Erythropoietin David B Lewis, MD Professor and Chief, Division of Immunology and Allergy Department of Pediatrics Stanford University School of Medicine Stanford, California; Attending Physician in Immunology and Infectious Diseases Department of Pediatrics Lucile Packard Children’s Hospital Palo Alto, California Neonatal T Cell Immunity and Its Regulation by Innate Immunity and Dendritic Cells Marilyn J Manco-Johnson, MD Professor, Pediatrics Hemophilia and Thrombosis Center University of Colorado and Children’s Hospital Aurora, Colorado Hematology and Immunology: Coagulation Disorders Cynthia T McEvoy, MD Associate Professor of Pediatrics Division of Neonatology Oregon Health and Science University Portland, Oregon The Ureaplasma Conundrum: Should We Look or Ignore? Neelufar Mozaffarian, MD, PhD Medical Director Immunology Development Global Pharmaceutical Research and Development Abbott Abbott Park, Illinois Maternally Mediated Neonatal Autoimmunity Lars Navér, MD, PhD Senior Consultant in Pediatrics and Neonatology Departments of Pediatrics and Neonatology Karolinska University Hospital Stockholm, Sweden Breast Milk and Viral Infection Contributors Robin K Ohls, MD Simon Pirie, MBBS, MRCPCH Professor of Pediatrics University of New Mexico Associate Director, Pediatrics Clinical Translational Science Center University of New Mexico Health Sciences Albuquerque, New Mexico Why, When, and How Should We Provide Red Cell Transfusions and Erythropoiesis-Stimulating Agents to Support Red Cell Mass in Neonates? Consultant Neonatologist Neonatal Unit Gloucestershire Hospital National Health Service Foundation Trust Gloucester, England Probiotics for the Prevention of Necrotizing Enterocolitis in Preterm Neonates David A Osborn, MBBS, MMed (Clin Epi), FRACP, PhD Clinical Associate Professor Central Clinical School University of Sydney; Senior Neonatalogist and Director Neonatal Intensive Care Unit Royal Prince Alfred Newborn Care Royal Prince Alfred Hospital Sydney, Austrailia What Evidence Supports Dietary Interventions to Prevent Infant Food Hypersensitivity and Allergy? Luis Ostrosky-Zeichner, MD, FACP, FIDSA Associate Professor of Medicine and Epidemiology Division of Infectious Diseases University of Texas Medical School at Houston Houston, Texas Neonatal Fungal Infections Shrena Patel, MD Assistant Professor Department of Pediatrics Division of Neonatology University of Utah Salt Lake City, Utah Diagnosis and Treatment of ImmuneMediated and Non–Immune-Mediated Hemolytic Disease of the Newborn Sanjay Patole, MD, DCH, FRACP, MSc, DrPH Clinical Associate Professor Department of Neonatal Paediatrics King Edward Memorial Hospital for Women Subiaco, Australia; University of Western Australia Perth, Australia Probiotics for the Prevention of Necrotizing Enterocolitis in Preterm Neonates vii Nutan Prasain, PhD Postdoctoral Fellow Pediatrics Herman B Well Center for Pediatric Research Indiana University School of Medicine Indianapolis, Indiana Updated Information on Stem Cells for the Neonatologist Victoria H.J Roberts, PhD Staff Scientist II Oregon National Primate Research Center Oregon Health and Science University Portland, Oregon The Ureaplasma Conundrum: Should We Look or Ignore? Shannon A Ross, MD, MSPH Assistant Professor Pediatrics University of Alabama School of Medicine Birmingham, Alabama CMV: Diagnosis, Treatment, and Considerations on Vaccine-Mediated Prevention Matthew A Saxonhouse, MD Attending Neonatologist, Pediatrics Pediatrix Medical Group; Attending Neonatologist, Pediatrics Jeff Gordon Children’s Hospital Concord, North Carolina Current Issues in the Pathogenesis, Diagnosis, and Treatment of Neonatal Thrombocytopenia Robert L Schelonka, MD Associate Professor and Chief Division of Neonatology Pediatrics Department of Oregon Health and Science University Portland, Oregon The Ureaplasma Conundrum: Should We Look or Ignore? viii Contributors Elizabeth A Shaw, DO Anne M Stevens, MD, PhD Acting Assistant Professor of Pediatrics Division of Pediatric Rheumatology Seattle Children’s Hospital University of Washington Seattle, Washington Maternally Mediated Neonatal Autoimmunity Associate Professor Pediatrics University of Washington Center for Immunity and Immunotherapies Seattle Children’s Research Institute Seattle, Washington Maternally Mediated Neonatal Autoimmunity Charles R Sims, MD Division of Infectious Diseases The University of Texas Health Science Center at Houston Laboratory of Mycology Research Houston, Texas Neonatal Fungal Infections John K.H Sinn, MBBS, FRACP, MMed (Clin Epi) Assistant Professor Neonatology and Pediatric and Child Health University of Sydney; Assistant Professor Neonatology Royal North Shore Hospital; Assistant Professor Pediatric and Child Health The Children’s Hospital at Westmead Sydney, Australia What Evidence Supports Dietary Interventions to Prevent Infant Food Hypersensitivity and Allergy? Martha C Sola-Visner, MD Assistant Professor of Pediatrics Department of Medicine Division of Newborn Medicine Children’s Hospital Boston; Harvard Medical School Boston, Massachusetts Current Issues in the Pathogenesis, Diagnosis, and Treatment of Neonatal Thrombocytopenia Philip Toltzis, MD Professor of Pediatrics Pediatrics Rainbow Babies and Children’s Hospital Cleveland, Ohio Control of Antibiotic-Resistant Bacteria in the Neonatal Intensive Care Unit Christopher Traudt, MD Acting Assistant Professor of Pediatrics University of Washington Seattle, Washington Nonhematopoietic Effects of Erythropoietin Mervin C Yoder, Jr., MD Richard and Pauline Klingler Professor of Pediatrics Professor of Biochemistry and Molecular Biology Professor of Cellular and Integrative Physiology Director, Herman B Wells Center for Pediatric Research Indiana Universitiy School of Medicine Indianapolis, Indiana Updated Information on Stem Cells for the Neonatologist ... 800-4 01- 9962 (inside the US) call +1- 314 -995-3200 (outside the US) Activation Code HEMATOLOGY, IMMUNOLOGY AND INFECTIOUS DISEASE Neonatology Questions and Controversies HEMATOLOGY, IMMUNOLOGY AND INFECTIOUS. .. SECOND EDITION 16 00 John F Kennedy Blvd Ste 18 00 Philadelphia, PA 19 103-2899 HEMATOLOGY, IMMUNOLOGY AND INFECTIOUS DISEASE: NEONATOLOGY QUESTIONS AND CONTROVERSIES Copyright © 2 012 , 2008 by Saunders,... 2002; 18 5 :11 7 -12 5 16 Fraser ST, Ogawa M, Nishikawa S Embryonic stem cell differentiation as a model to study hematopoietic and endothelial cell development Methods Mol Biol 2002 ;18 5: 71- 81 17 Li