(BQ) Part 1 book Manual of neonatal care has contents: Fetal assessment and prenatal diagnosis, diabetes mellitus, thyroid disorders, preeclampsia and related conditions, resuscitation in the delivery room, birth trauma, care of the well newborn, multiple births,... and other contents.
000i-0xxii_Cloherty_FM.indd i 11/02/11 2:01 PM MANUAL OF NEONATAL CARE Seventh Edition Editors John P Cloherty, MD Associate Clinical Professor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Associate Neonatologist Neonatology Program at Harvard Brigham and Women’s Hospital Beth Israel Deaconess Medical Center Children’s Hospital Boston Boston, Massachusetts Eric C Eichenwald, MD Associate Professor Department of Pediatrics Chief, Division of Neonatology Vice-Chair, Department of Pediatrics University of Texas Health Science Center Children’s Memorial Hermann Hospital Houston, Texas Anne R Hansen, MD, MPH Assistant Professor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Medical Director, Neonatal Intensive Care Unit Children’s Hospital Boston Boston, Massachusetts Ann R Stark, MD Professor Department of Pediatrics - Neonatology Baylor College of Medicine Houston, Texas 000i-0xxii_Cloherty_FM.indd i 11/02/11 2:01 PM Acquisitions Editor: Sonya Seigafuse Product Manager: Nicole Walz Vendor Manager: Bridgett Dougherty Senior Manufacturing Manager: Benjamin Rivera Marketing Manager: Lisa Lawrence Design Coordinator: Doug Smock Production Service: Absolute Service, Inc./Maryland Composition © 2012 by LIPPINCOTT WILLIAMS & WILKINS, a WOLTERS KLUWER business © 2008 and 2004 by Lippincott Williams & Wilkins Two Commerce Square 2001 Market Street Philadelphia, PA 19103 USA LWW.com All rights reserved This book is protected by copyright No part of this book may be reproduced in any form by any means, including photocopying, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews Materials appearing in this book prepared by individuals as part of their official duties as U.S government employees are not covered by the above-mentioned copyright Printed in China Library of Congress Cataloging-in-Publication Data Manual of neonatal care / editors, John P Cloherty [et al.] — 7th ed p ; cm Includes bibliographical references and index ISBN 978-1-60831-777-6 (pbk.) Neonatology—Handbooks, manuals, etc I Cloherty, John P [DNLM: Infant, Newborn, Diseases—Handbooks Intensive Care, Neonatal—Handbooks Neonatology—methods—Handbooks WS 39] RJ251.M26 2012 618.92'.01—dc23 2011021093 Care has been taken to confirm the accuracy of the information presented and to describe generally accepted practices However, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the contents of the publication Application of the information in a particular situation remains the professional responsibility of the practitioner The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accordance with current recommendations and practice at the time of publication However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions This is particularly important when the recommended agent is a new or infrequently employed drug Some drugs and medical devices presented in the publication have Food and Drug Administration (FDA) clearance for limited use in restricted research settings It is the responsibility of the health care providers to ascertain the FDA status of each drug or device planned for use in their clinical practice To purchase additional copies of this book, call our customer service department at (800) 638-3030 or fax orders to (301) 223-2320 International customers should call (301) 223-2300 Visit Lippincott Williams & Wilkins on the Internet at LWW.com Lippincott Williams & Wilkins customer service representatives are available from 8:30 am to pm, EST 10 000i-0xxii_Cloherty_FM.indd ii 11/02/11 2:01 PM We dedicate this edition to our spouses: Ann, Caryn, Jonathan, and Peter to our children: Maryann, David, Joan, Neil, Danny, Monica, Tom, Victoria, Anne, Tim, Zachary, Taylor, Connor, Laura, Jonah, Gregory, Oliver, Julian, and Nathalie to our grandchildren: Chrissy, Elizabeth, Daniel, Patrick, John, Tom, Ryan, Catherine, Sophie, Jack, Eva, Jane, Peter, Nora, Sheila, and James and to the many babies and parents we have cared for 000i-0xxii_Cloherty_FM.indd iii 11/02/11 2:01 PM 000i-0xxii_Cloherty_FM.indd iv 11/02/11 2:01 PM Contributors Elisa Abdulhayoglu, MD Diane M Anderson, PhD, RD Instructor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Neonatologist Department of Neonatology Newton-Wellesley Hospital Newton, Massachusetts Associate Professor Department of Pediatrics Baylor College of Medicine Houston, Texas; Neonatal Nutritionist Department of Pediatrics Texas Children’s Hospital Houston, Texas Steven A Abrams, MD Theresa M Andrews, RN, CCRN Professor Department of Pediatrics Baylor College of Medicine Houston, Texas; Attending Physician Department of Pediatrics Texas Children’s Hospital Houston, Texas James M Adams, MD Professor Department of Pediatrics Baylor College of Medicine Houston, Texas; Attending Physician Neonatology Texas Children’s Hospital Houston, Texas Pankaj B Agrawal, MD, DM, MMSc Instructor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Neonatologist Children’s Hospital Boston Boston, Massachusetts Katherine W Altshul, MD Instructor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Pediatric/NICU Hospitalist Division of Newborn Medicine Brigham and Women’s Hospital Boston, Massachusetts Staff Nurse III Neonatal Intensive Care Unit Children’s Hospital Boston Boston, Massachusetts John H Arnold, MD Associate Professor Department of Anesthesia Harvard Medical School Boston, Massachusetts; Senior Associate Anesthesia & Critical Care Children’s Hospital Boston Boston, Massachusetts David J Askenazi, MD, MsPH Assistant Professor Department of Pediatrics University of Alabama at Birmingham Birmingham, Alabama; Attending Physician Division of Nephrology and Transplantation Children’s Hospital of Alabama Birmingham, Alabama Muhammad Aslam, MD Instructor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Neonatologist Division of Newborn Medicine Children’s Hospital Boston Boston, Massachusetts v 000i-0xxii_Cloherty_FM.indd v 11/02/11 2:01 PM vi CONTRIBUTORS Carlos A Bacino, MD Sandra K Burchett, MD, MSc Associate Professor Department of Molecular and Human Genetics Baylor College of Medicine Houston, Texas; Director Genetics Clinic Texas Children’s Hospital Houston, Texas Associate Professor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Clinical Director, Division of Infectious Diseases Associate Physician in Medicine Children’s Hospital Boston Boston, Massachusetts Mandy Brown Belfort, MD, MPH Heather H Burris, MD, PhD Instructor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Attending Neonatologist Division of Newborn Medicine Children’s Hospital Boston Boston, Massachusetts Ann M Bergin, MB, SCM Assistant Professor Neurology Harvard Medical School Boston, Massachusetts; Staff Physician Neurology Children’s Hospital Boston Boston, Massachusetts Kushal Y Bhakta, MD Assistant Professor Department of Pediatrics - Neonatology University of California Irvine, California; Attending Neonatologist Neonatology Children’s Hospital of Orange Country Orange, California Rosalind S Brown, MD Associate Professor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Director, Clinical Trials Research Division of Endocrinology Medicine Children’s Hospital Boston Boston, Massachusetts 000i-0xxii_Cloherty_FM.indd vi Instructor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Neonatologist Department of Neonatology Beth Israel Deaconess Medical Center Boston, Massachusetts Carol Spruill Turnage, MSN, RN, CNS Neonatal Clinical Nurse Specialist Nursing-Neonatal Intensive Care Texas Children’s Hospital Houston, Texas Kimberlee Chatson, MD Instructor Newborn Medicine Harvard Medical School Boston, Massachusetts; Associate Medical Director Special Care Nursery Winchester Hospital Winchester, Massachusetts Chaitanya Chavda, MD Clinical Fellow Harvard Program in Newborn Medicine Boston, Massachusetts Helen A Christou, MD Assistant Professor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Neonatologist Division of Newborn Medicine Brigham and Women’s Hospital, Children’s Hospital Boston, Massachusetts 11/02/11 2:01 PM Contributors John P Cloherty, MD Stephanie Dukhovny, MD Associate Clinical Professor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Associate Neonatologist Neonatology Program at Harvard Brigham and Women’s Hospital Beth Israel Deaconess Medical Center Children’s Hospital Boston Boston, Massachusetts Clinical Fellow Maternal Fetal Medicine/Genetics Boston University School of Medicine Boston, Massachusetts; Division of Maternal-Fetal Medicine Brigham and Women’s Hospital Boston, Massachusetts William D Cochran, MD Associate Clinical Professor (emeritus) Department of Pediatrics Harvard Medical School Boston, Massachusetts; Senior Associate in Medicine (emeritus) Newborn Intensive Care Unit Beth Israel Deaconess Medical Center Boston, Massachusetts Elizabeth G Doherty, MD Instructor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Neonatologist Division of Newborn Medicine Children’s Hospital Boston and Winchester Hospital Winchester, Massachusetts Caryn E Douma, MS, RN Project Manager for the Chief Nursing Officer Administration Children’s Memorial Hermann Hospital Houston, Texas Dmitry Dukhovny, MD, MPH Instructor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Neonatologist Department of Neonatology Beth Israel Deaconess Medical Center Boston, Massachusetts 000i-0xxii_Cloherty_FM.indd vii vii Eric C Eichenwald, MD Associate Professor Department of Pediatrics Chief, Division of Neonatology Vice-Chair, Department of Pediatrics University of Texas Health Science Center Children’s Memorial Hermann Hospital Houston, Texas Ayman W El-Hattab, MBBS Medical Biochemical Genetics Fellow Department of Molecular and Human Genetics Baylor College of Medicine Houston, Texas; Medical Biochemical Genetics Fellow Genetics Texas Children’s Hospital Houston, Texas Deirdre M Ellard, MS, RD, LDN, CNSD Neonatal Dietitian Department of Nutrition Brigham and Women’s Hospital Boston, Massachusetts Caraciolo J Fernandes, MD Associate Professor Department of Pediatrics - Neonatology Baylor College of Medicine Houston, Texas; Medical Director, Transport Section of Neonatology Texas Children’s Hospital Houston, Texas 11/02/11 2:01 PM viii CONTRIBUTORS Jennifer Schonen Gardner, PharmD Anne R Hansen, MD, MPH Neonatal Clinical Pharmacy Specialist Department of Pharmacy Texas Children’s Hospital Houston, Texas Assistant Professor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Medical Director, Neonatal Intensive Care Unit Children’s Hospital Boston Boston, Massachusetts Stuart L Goldstein, MS Professor Department of Pediatrics University of Cincinnati College of Medicine Cincinnati, Ohio; Director Center for Acute Care Nephrology Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio James E Gray, MD, MS Assistant Professor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Attending Neonatologist Department of Neonatology Beth Israel Deaconess Medical Center Boston, Massachusetts Mary Lucia P Gregory, MD, MMSc Instructor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Attending Neonatologist Department of Neonatology Beth Israel Deaconess Medical Center Boston, Massachusetts Munish Gupta, MD, MMSc Instructor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Associate Director, Neonatal Intensive Care Unit Department of Neonatology Beth Israel Deaconess Medical Center Boston, Massachusetts 000i-0xxii_Cloherty_FM.indd viii Linda J Heffner, MD, PhD Professor and Chair Obstetrics and Gynecology Boston University School of Medicine Boston, Massachusetts; Chief Obstetrics and Gynecology Boston Medical Center Boston, Massachusetts Nancy Hurst Assistant Professor Department of Pediatrics Baylor College of Medicine Houston, Texas; Director Women’s Support Services Texas Children’s Hospital Houston, Texas Ruth A Hynes Staff Nurse III Neonatal Intensive Care Unit Children’s Hospital Boston Boston, Massachusetts Lise Johnson, MD Instructor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Medical Director, Well New Born Nurseries Division of Newborn Medicine Brigham and Women’s Hospital Boston, Massachusetts 11/02/11 2:01 PM Contributors Yvette R Johnson, MD, MPH Michelle A LaBrecque, MSN Assistant Professor Department of Pediatrics Baylor College of Medicine Houston, Texas; Medical Director of the Perinatal Outcomes Database Section of Neonatology Texas Children’s Hospital Houston, Texas Clinical Nurse Specialist Neonatal Intensive Care Unit Children’s Hospital Boston Boston, Massachusetts Marsha R Joselow Social Worker Pediatric Advanced Care Team Children’s Hospital Boston and Dana-Farber Cancer Institute Boston, Massachusetts James R Kasser, MD Catharina Ormandy Professor of Orthopaedic Surgery Harvard Medical School Boston, Massachusetts; Orthopaedic Surgeon-in-Chief Department of Orthopaedic Surgery Children’s Hospital Boston Boston, Massachusetts Kirsten A Kienstra, MD Assistant Professor Department of Pediatrics - Neonatology Baylor College of Medicine Houston, Texas; Attending Physician Neonatology Texas Children’s Hospital Houston, Texas Aimee Knorr, MD Instructor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Staff Physician Newborn Medicine Director of Newborn Hearing Screening at Winchester Hospital Winchester, Massachusetts 000i-0xxii_Cloherty_FM.indd ix ix Aviva Lee-Parritz, MD Associate Professor Obstetrics and Gynecology Boston University, School of Medicine Boston, Massachusetts; Vice-Chair Obstetrics and Gynecology Boston Medical Center Boston, Massachusetts Joseph R Madsen, MD Associate Professor Department of Surgery Harvard Medical School Boston, Massachusetts; Director, Neurodynamics Laboratory Director, Epilepsy Surgery Program Neurosurgery Children’s Hospital Boston Boston, Massachusetts Lucila Marquez, MD Clinical Fellow Department of Pediatrics, Section of Infectious Diseases Baylor College of Medicine Houston, Texas Camilia R Martin, MD, MS Associate Professor Department of Pediatrics Harvard Medical School Boston, Massachusetts; Associate Director Neonatal Intensive Care Unit Beth Israel Deaconess Medical Center Boston, Massachusetts Thomas F McElrath, MD, PhD Associate Professor Department of Obstetrics and Gynecology Harvard Medical School Boston, Massachusetts; Division of Maternal-Fetal Medicine Brigham and Women’s Hospital Boston, Massachusetts 11/02/11 2:01 PM ... 000i-0xxii_Cloherty_FM.indd xv 11 /02 /11 2: 01 PM xvi CONTENTS General Newborn Condition 10 Common Genetic Problems in the Newborn 11 1 Carlos A Bacino 11 Multiple Births 12 4 Yvette R Johnson 12 Maternal Drug... have cared for 000i-0xxii_Cloherty_FM.indd iii 11 /02 /11 2: 01 PM 000i-0xxii_Cloherty_FM.indd iv 11 /02 /11 2: 01 PM Contributors Elisa Abdulhayoglu, MD Diane M Anderson, PhD, RD Instructor Department... Diseases—Handbooks Intensive Care, Neonatal Handbooks Neonatology—methods—Handbooks WS 39] RJ2 51. M26 2 012 618 .92'. 01 dc23 2 011 0 210 93 Care has been taken to confirm the accuracy of the information presented