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Objectives: To investigate the relationship between plasma dopamine level and clinical features in patients with bipolar disorder, manic episode. Subjects and methods: The study included 62 inpatients with bipolar disorder, manic episode, who were received treatment at National Psychiatric Hospital No 1, from July 2015 to December 2017.
7.38 n = 12 21.50 ± 6.09 p < 0.001 Unstalbe mood n = 10 32.42 ± 6.76 n=1 19.13 ± 0.00 p > 0.05 Explosive mood n = 21 35.30 ± 8.84 n=2 24.71 ± 2.65 p > 0.05 Tensive mood n = 30 32.75 ± 7.32 n=3 21.60 ± 5.71 p < 0.05 (1: t1 - t2 = 9.8928 and p = 0.0000; 2: t1 - t2 = 13.29 and p = 0.094; 3.: t1 - t2 = 10.5855 and p = 0.113; 4: t1 - t2 = 11.1473 and p = 0.016) 168 Journal of military pharmaco-medicine n06-2018 Plasma dopamine levels in surveys of increasing mood were statistically significant differences with p < 0.001 Plasma dopamine levels in surveys of tensive mood had statistically significant differences with p < 0.05 Table 4: Relationship between plasma dopamine levels and activity Plasma dopamine levels (ng/L) Statistical index Test time (t1) Disorder of activity Test time (t2) p1 = p2 n = 62 ( X ± SD) n = 62 ( X = SD) Hyperactivity n = 57 31.08 ± 7.00 n=9 22.43 ± 6.42 p < 0.01 Interfering in everything n = 34 31.90 ± 7.88 n=4 22.92 ± 6.32 p < 0.05 Do not cooperate on medical examination n =13 34.45 ± 7.24 n=1 31.87 ± 0.00 p > 0.05 Agitated activity n = 31 33.88 ± 7.93 n=1 22.84 ± 0.00 p < 0.05 Waste of money n = 12 32.26 ± 6.23 n=1 26.59 ± 0.00 p > 0.05 (1: t1 - t2 = 8.6597 and p = 0.001; 2: t1 - t2 = 8.9810 and p = 0.035; 3: t1 - t2 = 2.5769 and p = 0.738; 4: t1 - t2 = 11.0361 and p = 0.0181; 5: t1 - t2 = 5.6708 and p = 0.408) Plasma dopamine levels in surveys of hyperactivity were statistically significant differenct with p < 0.01 Plasma dopamine levels in surveys of interfering in everything and hysterical activity were statistically significant differences (p < 0.05) Table 5: Relationship between plasma dopamine levels and delusions Plasma dopamine levels (ng/L) Statistical index Test time (t1) Kind of delusion Test time (t2) p1 = p2 n = 62 ( X ± SD) n = 62 ( X = SD) Delusion of persecution n = 19 37.41 ± 7.12 n=0 0 Grandiose delusions n = 42 33.95 ± 7.01 n=4 14.60 ± 1.10 p < 0.001 Delusion of jealousy n=4 35.39 ± 8.20 n=0 0 (1: t1 - t2 = and p = 0; 2: t1 - t2 = 19.3457 and p = 0.0000; 3: t1 - t2 = and p = 0) Plasma dopamine levels in surveys of grandiose delusions were statistically significant differences with p < 0.001) DISCUSSION The first time test: n = 62; X = 34.40 ng/L; SD = 7.38 ng/L; SE = 0.94; CI = 29.52 33.27 The second time test: n = 62; X = 17.66 ng/L; SD = 5.95 ng/L; SE = 0.75; CI = 16.15 - 19.18 The two surveys of test dopamine were statistically significant difference with p < 0.001 Ambade V et al (2011) found that mean ± standard deviation of plasma dopamine in healthy was 21.8 ± 9.5 ng/L 169 Journal of military pharmaco-medicine n06-2018 Cousins D.A et al (2009) found that dopamine plays a very important role in the pathogenesis of bipolar mood disorders, mania The authors suggested that dopamine levels increase and dopaminergic activity increase in the brain - Plasma dopamine levels in surveys of F31.1 and F31.2 were statistically significant different with p < 0.001 Sadock B.J (2015) supposes that symptoms of manic episodes without psychosis and psychosis are similar - Plasma dopamine levels statistically significantly decreased in patients with increasing mood, emotional tension, hyperactivity, agitated activity and grandiose delusions According to Kristina R (2012), dopamine is a catecholamine that plays a significant role in bipolar disorders Excess dopamine activity facilitates mania and delusional symptoms John Cookson (2013) found that drugs with more specific dopamine-receptor blocking actions have antimanic properties although these drugs are less sedative, without blocking actions at histamine or noradrenaline receptors He supposes drug treatment (with olanzapine, quetiapine and presumably the other antipsychotics) improved the whole range of symptoms (including elation, flight of ideas, grandiosity, sexual interest, irritability, aggression, general appearance and insight, as well as the items most sensitive to sedation: insomnia, overactivity and pressure of speech) 170 CONCLUSION After a period of treatment: - Mean plasma dopamine levels in patients decreased significantly p < 0.001 (from 31.40 ± 7.38ng/L in the first time to 17.66 ± 5.95ng/L in the second time) - Plasma dopamine levels were statistically significantly decreased in patients with diagnostic groups F31.1 and F31.2 - Plasma dopamine levels were statistically significantly decreased in patients with increasing mood, emotional tension, hyperactivity, agitated activity and grandiose delusions REFERENCES Ambade V, Brig M.M A, Col P S et al Adrenaline, noradrenaline and dopamine level estimation in depression: Does it help? MJAFI 2009, 65, pp.216-220 Cousins D.A, Butts K, Young A.H The role of dopamine in bipolar disorder Bipolar Disord: 11, pp.787-806 The Authors Journal Compilation John Wiley & Sons A ⁄S John C Dopamine hypothesis of Mania Journal of Mood Disorders (Suppl 1), S1-S3 2013 Kristina R.S, Bertalan D Bipolar disorder: Diagnosis, neuroanatomical and biochemical background Clinical research and treatment approaches to affective disorders Edited by Dr Mario Juruena Published in print edition 2012, February Sadock B.J, Sadock V.A Mood disorders Synopsis of Psychyatry Eleventh edition 2015, pp.457-486 ... in the pathogenesis of bipolar mood disorders, mania The authors suggested that dopamine levels increase and dopaminergic activity increase in the brain - Plasma dopamine levels in surveys of. .. 5.6708 and p = 0.408) Plasma dopamine levels in surveys of hyperactivity were statistically significant differenct with p < 0.01 Plasma dopamine levels in surveys of interfering in everything and. .. differences (p < 0.05) Table 5: Relationship between plasma dopamine levels and delusions Plasma dopamine levels (ng/L) Statistical index Test time (t1) Kind of delusion Test time (t2) p1 = p2