Gender-specific associations between low skeletal muscle mass and albuminuria in the middle-aged and elderly population

Data from the Korea National Health and Nutrition Examination Survey 2011 were employed. The study consisted of 1,087 subjects (≥50 years old). Skeletal muscle index (SMI) was defined as the weight-adjusted appendicular skeletal muscle mass.

Int J Med Sci 2017, Vol 14 Ivyspring International Publisher 1054 International Journal of Medical Sciences 2017; 14(11): 1054-1064 doi: 10.7150/ijms.20286 Research Paper Gender-Specific Associations between Low Skeletal Muscle Mass and Albuminuria in the Middle-Aged and Elderly Population Hye Eun Yoon1, 2, Yunju Nam1, 2, Eunjin Kang1, 2, Hyeon Seok Hwang1, 3, Seok Joon Shin1, 2, Yeon Sik Hong2, and Kwi Young Kang 2, 4 Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea; Department of Internal Medicine, Incheon St Mary’s Hospital; Department of Internal Medicine, Daejeon St Mary’s Hospital; Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea  Corresponding author: Kwi Young Kang MD, PhD, Division of Rheumatology, Department of Internal Medicine, The Catholic University of Korea, Incheon St Mary’s Hospital, 56 Dongsu-ro, Bupyeong-gu, Incheon, 21431, South Korea E-mail: kykang@catholic.ac.kr © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/) See http://ivyspring.com/terms for full terms and conditions Received: 2017.03.27; Accepted: 2017.07.24; Published: 2017.09.03 Abstract Objective This study assessed gender-specific associations between low muscle mass (LMM) and albuminuria Methods Data from the Korea National Health and Nutrition Examination Survey 2011 were employed The study consisted of 1,087 subjects (≥50 years old) Skeletal muscle index (SMI) was defined as the weight-adjusted appendicular skeletal muscle mass Mild LMM and severe LMM were defined as SMI that were 1–2 and >2 standard deviations below the sex-specific mean appendicular skeletal muscle mass of young adults, respectively Increased albuminuria was defined as albumin-to-creatinine ratio ≥30mg/g Results Men with mild and severe LMM were significantly more likely to have increased albuminuria (15.2% and 45.45%, respectively) than men with normal SMI (9.86%, P