To investigate the effects of inferior alveolar nerve on new bone formation in rabbit mandibular distraction osteogenesis. The inferior alveolar nerve of one side was resected under the surgical microscope, with the inferior alveolar vascular intact.
Int J Med Sci 2019, Vol 16 Ivyspring International Publisher 831 International Journal of Medical Sciences 2019; 16(6): 831-837 doi: 10.7150/ijms.31883 Research Paper Sensory Nerves Affect Bone Regeneration in Rabbit Mandibular Distraction Osteogenesis Jian Cao1,3,6,#, Shijian Zhang2,3,#, Anand Gupta4, Zhaojie Du5, Delin Lei5, Lei Wang2,3, Xudong Wang1,3 Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai JiaoTong University School of Medicine, Shanghai, China Department of Oral and Maxillofacial-Head & Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai JiaoTong University School of Medicine, Shanghai, China National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China Government Medical College Hospital, Chandigarh, India Department of Oral and Maxillofacial Surgery, Fourth Military Medical University, School of Stomatology, Xi’an, China Department of Oral and Maxillofacial Surgery, the General Hospital of Lanzhou Command, Lanzhou, China #, contributed equally to the article Corresponding authors: Dr Xudong Wang, Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai JiaoTong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology; Shanghai, China; Tel: +86 21 53315159; Email: xudongwang70@hotmail.com and Dr Lei Wang, Department of Oral and Maxillofacial-Head & Neck Oncology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai JiaoTong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology; Shanghai, China; Tel: +86 15921941601; Email: wangleizyh@aliyun.com © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/) See http://ivyspring.com/terms for full terms and conditions Received: 2018.11.29; Accepted: 2019.04.11; Published: 2019.06.02 Abstract Objectives: To investigate the effects of inferior alveolar nerve on new bone formation in rabbit mandibular distraction osteogenesis Methods: 20 New Zealand White rabbits underwent bilateral distraction osteogenesis with a rate of mm/day The inferior alveolar nerve of one side was resected under the surgical microscope, with the inferior alveolar vascular intact The contralateral side received sham operation The rabbits were sacrificed at consolidation time of 28 days The regenerate callus underwent radiograph examination, dual-energy X-ray absorptiometry, haematoxylin and eosin staining and histomorphometric analysis A paired t-test was performed using SPSS 16.0 software package Results: The BMD of the new bone in the distraction gap on the denervation side of mandibular was significantly lower (P0.05) in regenerated bone dimensions was observed between the both sides of mandibles http://www.medsci.org Int J Med Sci 2019, Vol 16 835 BMD of the new bone in the distraction gap on the experimental side was 0.46±0.07g/cm2, which is significantly lower (P