Changes of articular cartilage and subchondral bone after extracorporeal shockwave therapy in osteoarthritis of the knee

We assessed the pathological changes of articular cartilage and subchondral bone on different locations of the knee after extracorporeal shockwave therapy (ESWT) in early osteoarthritis (OA). Rat knees under OA model by anterior cruciate ligament transaction (ACLT) and medial meniscectomy (MM) to induce OA changes.

Int J Med Sci 2017, Vol 14 Ivyspring International Publisher 213 International Journal of Medical Sciences 2017; 14(3): 213-223 doi: 10.7150/ijms.17469 Research Paper Changes of articular cartilage and subchondral bone after extracorporeal shockwave therapy in osteoarthritis of the knee Ching-Jen Wang1,2*, Jai-Hong Cheng1*, Wen-Yi Chou2, Shan-Ling Hsu1,2, Jen-Hung Chen2 and Chien-Yiu Huang1,2 Center for Shockwave Medicine and Tissue Engineering; Department of Orthopedic Surgery, Section of Sports Medicine; Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan *Equal contribution  Corresponding author: w281211@adm.cgmh.org.tw; Tel.: 886-7-733-5279; Fax: 886-7-733-5515 © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/) See http://ivyspring.com/terms for full terms and conditions Received: 2016.09.05; Accepted: 2016.12.21; Published: 2017.02.23 Abstract We assessed the pathological changes of articular cartilage and subchondral bone on different locations of the knee after extracorporeal shockwave therapy (ESWT) in early osteoarthritis (OA) Rat knees under OA model by anterior cruciate ligament transaction (ACLT) and medial meniscectomy (MM) to induce OA changes Among ESWT groups, ESWT were applied to medial (M) femur (F) and tibia (T) condyles was better than medial tibia condyle, medial femur condyle as well as medial and lateral (L) tibia condyles in gross osteoarthritic areas (p