Handbook of Cardiac Anatomy, Physiology, and Devices 2e

Handbook of Cardiac Anatomy, Physiology, and Devices Paul A Iaizzo Editor Handbook of Cardiac Anatomy, Physiology, and Devices Second Edition Foreword by Timothy G Laske 13 Editor Paul A Iaizzo University of Minnesota Department of Surgery B172 Mayo, MMC 195 420 Delaware St SE., Minneapolis, MN 55455 USA iaizz001@umn.edu ISBN 978-1-60327-371-8 e-ISBN 978-1-60327-372-5 DOI 10.1007/978-1-60327-372-5 Library of Congress Control Number: 2009920269 # Springer ScienceỵBusiness Media, LLC 2009 All rights reserved This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer ScienceỵBusiness Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made The publisher makes no warranty, express or implied, with respect to the material contained herein Printed on acid-free paper Springer is part of Springer ScienceỵBusiness Media (www.springer.com) Foreword A revolution began in my professional career and education in 1997 In that year, I visited the University of Minnesota to discuss collaborative opportunities in cardiac anatomy, physiology, and medical device testing The meeting was with a faculty member of the Department of Anesthesiology, Professor Paul Iaizzo I didn’t know what to expect but, as always, I remained open minded and optimistic Little did I know that my life would never be the same During the mid to late 1990s, Paul Iaizzo and his team were performing anesthesia research on isolated guinea pig hearts We found the work appealing, but it was unclear how this research might apply to our interest in tools to aid in the design of implantable devices for the cardiovascular system As discussions progressed, we noted that we would be far more interested in reanimation of large mammalian hearts, in particular, human hearts Paul was confident this could be accomplished on large hearts, but thought that it would be unlikely that we would ever have access to human hearts for this application We shook hands and the collaboration was born in 1997 In the same year, Paul and the research team at the University of Minnesota (including Bill Gallagher and Charles Soule) reanimated several swine hearts Unlike the previous work on guinea pig hearts which were reanimated in Langendorff mode, the intention of this research was to produce a fully functional working heart model for device testing and cardiac research Such a model would allow engineers and scientists easy access to the epicardium and the chambers through transmural ports It took numerous attempts to achieve the correct osmotic balance and an adequately oxygenated perfusate, and to avoid poisoning the preparation with bacteria (which we found were happy to lurk anywhere and everywhere in the plumbing of the apparatus) This project required a combination of art, science, and dogged persistence In addition to the breakthrough achieved in the successful animation of numerous swine hearts, bigger and better things were in store Serendipitously, when faced with a need to see inside the heart, the research team found a fiberoptic scope on an upper shelf in the laboratory The scope was inserted into the heart and a whole new world was observed Due to the clear nature of the perfusate, we immediately saw the flashing of the tricuspid valve upon insertion of the scope We were in awe as we viewed the first images ever recorded inside of a working heart This is the moment when my personal revolution began The years that have followed have included numerous achievements which I attribute to the vision and persistence of Paul and the team The human hearts that Paul initially considered impossible to access and reanimate were soon functioning in the apparatus due to a collaboration with LifeSource Indeed, the team’s ‘‘never say never’’ attitude is at the heart of their pursuit of excellence in education and research v vi Foreword The Visible Heart Laboratory has evolved into a dream for engineers, educators, and cardiac physiologists as scientific equipment has been added (echocardiography, electrical mapping systems, hemodynamic monitors, etc.) and endoscopic video capabilities have improved (the lab is currently using video endoscopes with media quality recording equipment) The lab produces educational images, conducts a wide spectrum of cardiac research, and evaluates current and future medical device concepts each week Hundreds of engineers and students have worked and studied in the lab, countless physicians have assisted with procedures, and thousands of educational CDs/DVDs have been distributed (free of charge) Eleven years after the beginning of our collaborative effort, the Visible Heart Laboratory remains the only place in the world where a human heart can be reanimated outside of the body and made to work for an extended period of time This is a tribute to the efforts of Paul and his team in managing the difficulty it takes to make this happen Interestingly, the team currently works in the laboratory in which Lillehei and Bakken first tested the battery-powered pacemaker; the ‘‘good karma’’ lives on This book is a result of Paul’s passion for excellence in teaching and for innovation in the medical device field I am confident that the reader will find this book an invaluable resource It is a testament to Paul’s dedication to both education, collaboration, and the ongoing development of his current and past students By the way The personal revolution I referred to, fueled by my collaboration with Paul, has included numerous patents, countless device concepts accepted and/or rejected, several scientific articles, a PhD in Biomedical Engineering, and a collaboration in black bear hibernation physiology None of this would have happened had I not met Paul that day in 1997, and benefited from his friendship and mentoring over the years I can only imagine what the future will bring, but you can be rest assured that success is sure to come to those that associate themselves with Paul Iaizzo Minneapolis, MN Timothy G Laske, Ph D Preface Worldwide, the medical device industry continues to grow at an incredibly rapid pace Our overall understanding of the molecular basis of disease continues to increase, in addition to the number of available therapies to treat specific health problems This remains particularly true in the field of cardiovascular care Hence, with this rapid growth rate, the biomedical engineer has been challenged to both retool and continue to seek out sources of concise information The major impetus for the second edition of this text was to update this resource textbook for interested students, residents, and/or practicing biomedical engineers A secondary motivation was to promote the expertise, past and present, in the area of cardiovascular sciences at the University of Minnesota As Director of Education for The Lillehei Heart Institute and the Associate Director for Education of the Institute for Engineering in Medicine at the University of Minnesota, I feel that this book also represents a unique outreach opportunity to carry on the legacies of C Walton Lillehei and Earl Bakken through the 21st century Interestingly, the completion of the textbook also coincides with two important anniversaries in cardiovascular medicine and engineering at the University of Minnesota First, it was 50 years ago, in 1958, that the first wearable, battery-powered pacemaker, built by Earl Bakken (and Medtronic) at the request of Dr Lillehei, was first used on a patient Second, 30 years ago, in 1978, the first human heart transplantation was performed at the University of Minnesota For the past 10 years, the University of Minnesota has presented the week-long short course, Advanced Cardiac Physiology and Anatomy, which was designed specifically for the biomedical engineer working in industry; this is the course textbook As this course has evolved, there was a need to update the textbook For example, six new chapters were added to this second edition, and all other chapters were either carefully updated and/or greatly expanded One last historical note that I feel is interesting to mention is that my current laboratory, where isolated heart studies are performed weekly (the Visible Heart1 laboratory), is the same laboratory in which C Walton Lillehei and his many esteemed colleagues conducted a majority of their cardiovascular research studies in the late 1950s and early 1960s As with the first edition of this book, I have included electronic files on the companion DVD that will enhance this textbook’s utility Part of the companion DVD, the ‘‘The Visible Heart1 Viewer,’’ was developed as a joint venture between my laboratory at the University of Minnesota and the Cardiac Rhythm Management Division at Medtronic, Inc Importantly, this electronic textbook also includes functional images of human hearts These images were obtained from hearts made available via LifeSource, more specifically through the generosity of families and individuals who made the final gift of organ donation (these hearts were not deemed viable for transplantation) Furthermore, the companion vii viii Preface DVD contains various additional color images and movies that were provided by the various authors to supplement their chapters Since the first printing of this textbook, my laboratory has also developed the free-access website, ‘‘The Atlas of Human Cardiac Anatomy,’’ that readers of this text should also find valuable as a complementary resource (http://www.vhlab.umn.edu/atlas) I would especially like to acknowledge the exceptional efforts of our lab coordinator, Monica Mahre, who for a second time: (1) assisted me in coordinating the efforts of the contributing authors; (2) skillfully incorporated my editorial changes; (3) verified the readability and formatting of each chapter; (4) pursued requested additions or missing materials for each chapter; (5) contributed as a co-author; and (6) kept a positive outlook throughout I would also like to thank Gary Williams for his computer expertise and assistance with numerous figures; William Gallagher and Charles Soule who made sure the laboratory kept running smoothly while many of us were busy writing or editing; Dick Bianco for his support of our lab and this book project; the chairman of the Department of Surgery, Dr Selwyn Vickers, for his support and encouragement; and the Institute for Engineering in Medicine at the University of Minnesota, headed by Dr Jeffrey McCullough, who supported this project by funding the Cardiovascular Physiology Interest Group (many group members contributed chapters) I would like to thank Medtronic, Inc for their continued support of the Visible Heart1 Laboratory for the past 12 years, and I especially acknowledge the commitments, partnerships, and friendships of Drs Tim Laske, Alex Hill, and Nick Skadsberg for making our collaborative research possible In addition, I would like to thank Jilean Welch and Mike Leners for their creative efforts in producing many of the movie and animation clips that are on the DVD It is also my pleasure to thank the past and present graduate students or residents who have worked in my laboratory and who were contributors to this second edition, including Sara Anderson, James Coles, Anthony Dupre, Michael Eggen, Kevin Fitzgerald, Alexander Hill, Jason Johnson, Ryan Lahm, Timothy Laske, Anna Legreid Dopp, Michael Loushin, Jason Quill, Maneesh Shrivastav, Daniel Sigg, Eric Richardson, Nicholas Skadsberg, and Sarah Vieau I feel extremely fortunate to have the opportunity to work with such a talented group of scientists and engineers, and I have learned a great deal from each of them Finally, I would like to thank my family and friends for their continued support of my career and their assistance over the years Specifically, I would like to thank my wife, Marge, my three daughters, Maria, Jenna, and Hanna, my mom Irene, and siblings Mike, Chris, Mark, and Susan for always being there for me On a personal note, some of my inspiration for working on this project comes from the memory of my father, Anthony, who succumbed to a sudden cardiac event, and from the memory of my Uncle Tom Halicki, who passed away years after a heart transplantation Minneapolis, MN Paul A Iaizzo Contents Introduction General Features of the Cardiovascular System Paul A Iaizzo Anatomy 13 Attitudinally Correct Cardiac Anatomy Alexander J Hill 15 Cardiac Development Brad J Martinsen and Jamie L Lohr 23 Anatomy of the Thoracic Wall, Pulmonary Cavities, and Mediastinum Mark S Cook, Kenneth P Roberts, and Anthony J Weinhaus 33 Anatomy of the Human Heart Anthony J Weinhaus and Kenneth P Roberts 59 Comparative Cardiac Anatomy Alexander J Hill and Paul A Iaizzo 87 The Coronary Vascular System and Associated Medical Devices Sara E Anderson, Ryan Lahm, and Paul A Iaizzo 109 The Pericardium Eric S Richardson, Alexander J Hill, Nicholas D Skadsberg, Michael Ujhelyi, Yong-Fu Xiao and Paul A Iaizzo 125 Congenital Defects of the Human Heart: Nomenclature and Anatomy James D St Louis 137 Physiology and Assessment 145 10 Cellular Myocytes Vincent A Barnett 147 11 The Cardiac Conduction System Timothy G Laske, Maneesh Shrivastav, and Paul A Iaizzo 159 12 Autonomic Nervous System Kevin Fitzgerald, Robert F Wilson, and Paul A Iaizzo 177 Part I Part II Part III ix x Contents 13 Cardiac and Vascular Receptors and Signal Transduction Daniel C Sigg and Ayala Hezi-Yamit 14 Reversible and Irreversible Damage of the Myocardium: New Ischemic Syndromes, Ischemia/Reperfusion Injury, and Cardioprotection James A Coles, Daniel C Sigg, and Paul A Iaizzo 191 219 15 The Effects of Anesthetic Agents on Cardiac Function Jason S Johnson and Michael K Loushin 231 16 Blood Pressure, Heart Tones, and Diagnoses George Bojanov 243 17 Basic ECG Theory, 12-Lead Recordings and Their Interpretation Anthony Dupre, Sarah Vieau, and Paul A Iaizzo 257 18 Mechanical Aspects of Cardiac Performance Michael K Loushin, Jason L Quill, and Paul A Iaizzo 271 19 Energy Metabolism in the Normal and Diseased Heart Arthur H.L From and Robert J Bache 297 20 Introduction to Echocardiography Jamie L Lohr and Shanthi Sivanandam 319 21 Monitoring and Managing the Critically Ill Patient in the Intensive Care Unit Greg J Beilman 22 Cardiovascular Magnetic Resonance Imaging Michael D Eggen and Cory M Swingen 341 Devices and Therapies 363 A Historical Perspective of Cardiovascular Devices and Techniques Associated with the University of Minnesota Paul A Iaizzo and Monica A Mahre 365 Part IV 23 331 24 Pharmacotherapy for Cardiac Diseases Anna Legreid Dopp and J Jason Sims 383 25 Animal Models for Cardiac Research Richard W Bianco, Robert P Gallegos, Andrew L Rivard, Jessica Voight, and Agustin P Dalmasso 393 26 Catheter Ablation of Cardiac Arrhythmias Xiao-Huan Li and Fei Luă 411 27 Pacing and Defibrillation Timothy G Laske, Anna Legreid Dopp, and Paul A Iaizzo 443 28 Cardiac Resynchronization Therapy Fei Luă 475 29 Cardiac Mapping Technology Nicholas D Skadsberg, Bin He, Timothy G Laske, and Paul A Iaizzo 499 30 Cardiopulmonary Bypass and Cardioplegia J Ernesto Molina 511 31 Heart Valve Disease Ranjit John and Kenneth K Liao 527 .. .Handbook of 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