CARDIAC DRUGS CARDIAC DRUGS Editors Kanu Chatterjee MBBS FRCP (London) FRCP (Edin) FCCP FACC MACP Clinical Professor of Medicine Division of Cardiology The Carver College of Medicine University of Iowa Iowa City, Iowa, USA Emeritus Professor of Medicine University of California San Francisco, California, USA Eric J Topol MD FACC Director, Scripps Translational Science Institute Chief Academic Officer, Scripps Health Vice Chairman, West Wireless Health Institute The Gary and Mary West Chair of Innovative Medicine Professor of Translational Genomics The Scripps Research Institute La Jolla, California, USA JAYPEE BROTHERS MEDICAL PUBLISHERS (P) LTD New Delhi ● Panama City ● London ● Dhaka ● Kathmandu Jaypee Brothers Medical Publishers (P) Ltd Headquarters Jaypee Brothers Medical Publishers (P) Ltd 4838/24, Ansari Road, Daryaganj New Delhi 110 002, India Phone: +91-11-43574357 Fax: +91-11-43574314 Email: jaypee@jaypeebrothers.com Overseas Offices J.P Medical Ltd 83 Victoria Street London Jaypee-Highlights Medical Publishers Inc SW1H 0HW (UK) City of Knowledge, Bld 237, Clayton Phone: +44-2031708910 Panama City, Panama Fax: +02-03-0086180 Phone: +507-317-0160 Email: info@jpmedpub.com Fax: +507-301-0499 Email: cservice@jphmedical.com Jaypee Brothers Medical Publishers (P) Ltd 17/1-B Babar Road, Block-B, Shaymali Jaypee Brothers Medical Publishers (P) Ltd Mohammadpur, Dhaka-1207 Shorakhute, Kathmandu Bangladesh Nepal Mobile: +08801912003485 Phone: +00977-9841528578 Email: jaypeedhaka@gmail.com Email: jaypee.nepal@gmail.com Website: www.jaypeebrothers.com Website: www.jaypeedigital.com © 2013, Jaypee Brothers Medical Publishers All rights reserved No part of this book may be reproduced in any form or by any means without the prior permission of the publisher Inquiries for bulk sales may be solicited at: jaypee@jaypeebrothers.com This book has been published in good faith that the contents provided by the contributors contained herein are original, and is intended for educational purposes only While every effort is made to ensure the accuracy of information, the publisher and the editors specifically disclaim any damage, liability, or loss incurred, directly or indirectly, from the use or application of any of the contents of this work If not specifically stated, all figures and tables are courtesy of the contributors Where appropriate, the readers should consult with a specialist or contact the manufacturer of the drug or device Cardiac Drugs/Editors Kanu Chatterjee, Eric J Topol First Edition: 2013 ISBN 978-93-5025-879-8 Printed at: Dedicated to Our wives Docey Chatterjee and Susan Topol CONTENTS Contributors ix Preface xi Acknowledgments xiii CHAPTER Angiotensin, Aldosterone, and Renin Inhibition in Cardiovascular Disease Abdallah Kamouh, Gary S Francis, Kanu Chatterjee CHAPTER Positive Inotropic Drugs: A Limited but Important Role 34 Carl V Leier, Garrie J Haas, Philip F Binkley CHAPTER Antihypertensive Drugs 72 William J Lawton, Kanu Chatterjee CHAPTER Diuretics 158 Michael E Ernst CHAPTER Drugs for Dyslipidemias 184 Byron Vandenberg CHAPTER Drugs for Diabetes and Cardiodysmetabolic Syndrome 242 Prakash Deedwania, Sundararajan Srikanth CHAPTER Drugs for Acute Coronary Syndromes 267 Stephen W Waldo, Yerem Yeghiazarians, Kanu Chatterjee CHAPTER Drugs for Dysrhythmia 326 Rakesh Gopinathannair, Brian Olshansky vii CARDIAC DRUGS CHAPTER Drugs for Heart Failure 389 Kanu Chatterjee CHAPTER 10 Drugs for Stable Angina 424 Kanu Chatterjee, Wassef Karrowni CHAPTER 11 Drugs for Pulmonary Hypertension 454 Ravinder Kumar, Sif Hansdottir CHAPTER 12 Cardiac Drugs in Pregnancy and Lactation 485 Wassef Karrowni, Kanu Chatterjee CHAPTER 13 Future Directions: Role of Genetics in Drug Therapy 506 Eric J Topol Index 509 viii CONTRIBUTORS EDITORS Kanu Chatterjee MBBS FRCP (London) FRCP (Edin) FCCP FACC MACP Clinical Professor of Medicine Division of Cardiology The Carver College of Medicine University of Iowa Iowa City, Iowa, USA Emeritus Professor of Medicine University of California, San Francisco, California, USA Eric J Topol MD FACC Director, Scripps Translational Science Institute Chief Academic Officer, Scripps Health Vice-Chairman, West Wireless Health Institute The Gary and Mary West Chair of Innovative Medicine Professor of Translational Genomics The Scripps Research Institute La Jolla, California, USA CONTRIBUTING AUTHORS Philip F Binkley MD MPH Wilson Professor of Medicine College of Medicine, The Ohio State University Professor of Epidemiology College of Public Health, The Ohio State University Vice Chairman for Academic Affairs Department of Internal Medicine, The Ohio State University Director, Center for FAME Associate Dean for Faculty Affairs College of Medicine, The Ohio State University Columbus, Ohio, USA Michael E Ernst Pharm D Professor (Clinical) Department of Pharmacy Practice and Science College of Pharmacy Department of Family Medicine Carver College of Medicine The University of Iowa Iowa City, Iowa, USA Prakash Deedwania MD FACC Rakesh Gopinathannair MD MA Director Cardiac Electrophysiology University of Louisville Hospital Assistant Professor of Medicine Division of Cardiology University of Louisville Louisville, Kentucky, USA FACP FAHA Chief of Cardiology Division VACCHCS/UMC, UCSF Program at Fresno, Fresno, California, USA Professor of Medicine UCSF School of Medicine San Francisco, California, USA Gary S Francis MD Professor of Medicine Cardiovascular Division University of Minnesota Minneapolis, Minnesota, USA ix ... Kanu Chatterjee CHAPTER Drugs for Dysrhythmia 326 Rakesh Gopinathannair, Brian Olshansky vii CARDIAC DRUGS CHAPTER Drugs for Heart Failure 389 Kanu Chatterjee CHAPTER 10 Drugs for Stable Angina.. .CARDIAC DRUGS CARDIAC DRUGS Editors Kanu Chatterjee MBBS FRCP (London) FRCP (Edin) FCCP FACC MACP Clinical... Michael E Ernst CHAPTER Drugs for Dyslipidemias 184 Byron Vandenberg CHAPTER Drugs for Diabetes and Cardiodysmetabolic Syndrome 242 Prakash Deedwania, Sundararajan Srikanth CHAPTER Drugs for Acute Coronary