AHA radial artery in CABG 2004

Should Radial Arteries Be Used Routinely for Coronary Artery Bypass Grafting? Subodh Verma, Paul E Szmitko, Richard D Weisel, Daniel Bonneau, David Latter, Lee Errett, Yves LeClerc and Stephen E Fremes Circulation 2004;110:e40-e46 doi: 10.1161/01.CIR.0000136998.39371.FF Circulation is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Copyright © 2004 American Heart Association, Inc All rights reserved Print ISSN: 0009-7322 Online ISSN: 1524-4539 The online version of this article, along with updated information and services, is located on the World Wide Web at: http://circ.ahajournals.org/content/110/5/e40 Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published in Circulation can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services Further information about this process is available in the Permissions and Rights Question and Answer document Reprints: Information about reprints can be found online at: http://www.lww.com/reprints Subscriptions: Information about subscribing to Circulation is online at: http://circ.ahajournals.org//subscriptions/ Downloaded from http://circ.ahajournals.org/ by guest on February 26, 2013 CLINICIAN UPDATE Should Radial Arteries Be Used Routinely for Coronary Artery Bypass Grafting? Subodh Verma, MD, PhD; Paul E Szmitko, BSc; Richard D Weisel, MD; Daniel Bonneau, MD; David Latter, MD; Lee Errett, MD; Yves LeClerc, MD; Stephen E Fremes, MD C ase Presentation: Mr P is a 57-year-old construction worker who has had Canadian Cardiovascular Society class III angina for the past months He has multiple cardiovascular risk factors including smoking, hypertension, dyslipidemia, and diabetes He is obese and has had a previous laparotomy for a perforated bowel Coronary angiography revealed triple vessel disease involving the left anterior descending artery (LAD), the first obtuse marginal branch, and the right coronary artery (RCA), and an akinetic inferior wall with an estimated ejection fraction of 40% The patient was referred for consideration of coronary artery bypass graft (CABG) surgery Is Mr P a candidate for CABG and, if so, which vascular conduits should be used? CABG is the standard surgical procedure for the treatment of advanced coronary artery disease Since the first successful results reported by Favaloro,1 CABG surgery has been demonstrated to improve symptoms and, in specific subgroups of patients, to prolong life.2 Despite its success, the long-term outcome of coronary bypass surgery is strongly influenced by the fate of the vascular conduits used Five to years after surgery, patients are at increased risk of suffering from ischemic complications coincident with graft failure.2 Furthermore, as patients undergoing CABG surgery become older with more preoperative risk factors, and treated patients are living longer and therefore requiring reoperation, the optimal selection of vascular grafts for bypass is essential Conduits Used in Bypass Surgery Conventional CABG surgery utilizes a combination of arterial and venous grafts Saphenous vein (SV) grafts, the first vascular conduits used in CABG, are still widely utilized, primarily to bypass vessels other than the LAD Despite being readily accessible, of adequate length to access every vessel on the heart, and the correct diameter to facilitate coronary and aortic anastomoses, SV grafts are limited by poor long-term patency Because of a combination of intimal hyperplasia and accelerated atherosclerosis, up to 15% of SV grafts are occluded within year,3 and by 10 years postoperatively, at least 50% demonstrate significant disease.4,5 To bypass the LAD, most centers use the left internal thoracic (mammary) artery (LITA or LIMA) In contrast to SV grafts, the LITA displays excellent long-term patency, up to 90% after 10 years, which is associated with improved survival.5–9 The excellent results obtained with the LITA anastomosed to the LAD have added strength to the concept of complete arterial revascularization to improve clinical outcomes Recently, a prospective randomized trial demonstrated that total arterial revascularization with composite grafts improved patient outcome in terms of freedom from cardiac events, angina recurrence, and the need for percutaneous transluminal coronary angioplasty reintervention when compared with conventional arterial and venous grafting.10 Additional arterial grafts are being increasingly used in place of the SV to avoid the late complications of vein graft atherosclerosis and restenosis The use of arterial conduits has expanded beyond the LITA to include the right internal thoracic artery (RITA), the right gastroepiploic artery (RGEA), the inferior epigastric artery (IEA), and the radial artery (RA) Bi- From the Division of Cardiac Surgery, Toronto General Hospital (S.V., P.E.S., R.D.W.), St Michael’s Hospital (D.B., D.L., L.E., Y.L.), and Sunnybrook and Women’s College Health Sciences Centre (S.E.F.), University of Toronto, Toronto, Canada Correspondence to Subodh Verma, MD, PhD, Division of Cardiac Surgery, Toronto General Hospital, 14 EN-215, 200 Elizabeth St, Toronto, ON, M5G 2C4, Canada E-mail subodh.verma@sympatico.ca (Circulation 2004;110:e40-e46.) © 2004 American Heart Association, Inc Circulation is available at http://www.circulationaha.org DOI: 10.1161/01.CIR.0000136998.39371.FF e40 Downloaded from http://circ.ahajournals.org/ by guest on February 26, 2013 Verma et al lateral ITAs, using the RITA as a pedicled or free graft, have been demonstrated to have long-term patency exceeding SV grafts and result in improved patient survival.11–14 However, no randomized trials have been done The use of bilateral ITAs is commonly avoided in elderly, obese, or diabetic patients, characteristics common to CABG patients, because of higher rates of sternal infection, dehiscence, and mediastinitis.15 The RGEA, primarily used as an in situ graft to bypass the RCA and its branches, has shown reasonable long-term patency that exceeds 90% up to years postoperatively.16,17 Its use, however, has been limited because of the fragile quality of the artery, the small diameter of the vessel at the site of distal anastomosis, concerns regarding vessel twisting, increased operative time, and incisional discomfort with associated ileus The IEAs, used in composite arterial conduits or as free grafts,18 –20 are limited primarily by their short usable length, only making them suitable as grafts to diagonal or intermediate branches The principle adverse events associated with IEA harvesting are related to wound complications such as abdominal wall hematoma or infection, and relative contraindications to their use include obesity, lower abdominal surgery, or coexisting illness potentially requiring abdominal surgery Thus, despite improved graft patency, multiple arterial conduits have not gained wider acceptance for myocardial revascularization because of increased operative time, limited access to distal coronary sites because of graft length, and patient factors that preclude their use The final arterial conduit used, the radial artery, which is the focus of this review, overcomes many of these disadvantages Radial Arteries for CABG: Historical Perspective The RA was first used for coronary revascularization by Carpentier and colleagues in 1971.21 However, years later, its use was abandoned because of Radial Arteries for CABG Surgery an occlusion rate that was greater than that observed in SV grafts A combination of graft spasm and severe intimal hyperplasia,22,23 likely the result of endothelial denudation from mechanical dilation and trauma on skeletonized harvesting, was thought to contribute to the initial poor results obtained with RA grafting The discovery of a patent RA graft 15 years postoperatively, which was initially thought to be occluded, prompted the revitalization of the RA as a bypass conduit.24 In 1992, Acar and colleagues24 reported the results from 104 patients who received a RA graft as a bypass conduit since 1989 The study showed that the RA is a reasonable alternative to other types of conduits to complement the LITA Notably, in contrast to initial attempts, early RA patency was 100% in this modern experience, likely because of modifications that reduced endothelial damage and graft spasm e41 Three major modifications are now used to minimize RA spasm, the primary cause of early graft failure First, the RA is harvested as a pedicle, including satellite veins and the surrounding fatty tissue, using an atraumatic “no-touch” technique similar to that used in the harvest of other arterial conduits for coronary surgery (see the Figure).25,26 During harvesting, direct handling of the RA is avoided Second, mechanical dilation of the graft has been replaced by pharmacological dilation with papaverine, a phosphodiesterase III inhibitor that enhances the nitric oxide pathway, minimizing endothelial damage and dysfunction Third, in hopes of minimizing postoperative RA spasm, vasodilator therapy, most commonly with calcium channel blockers or nitrates, has been adopted, despite limited clinical outcome data to support this practice The RA, harvested as a pedicle, is dissected through a skin incision starting cm distal to the elbow crease lateral to the biceps tendon, stopping cm before the proximal crease at the wrist level, centered over the radial pulsation, between the flexor carpi radialis and the radial tubercle Care is taken to avoid damaging the lateral antebrachial cutaneous nerve (sensory), which crosses obliquely from medial to lateral After incision of the skin and fatty tissue, the RA can be seen in the distal third of the forearm beneath the fascial layer and is completely exposed by lateral mobilization of the brachioradialis All side branches are ligated and the artery is irrigated topically with dilute papaverine solution during the dissection Compared with the LITA, the RA has a much thicker muscular media that likely contributes to its increased propensity to go into spasm The RA may be proximally anastomosed to the LITA, forming a composite graft, or to the ascending aorta to bypass all coronary territories Illustrated is the use of a free RA graft anastomosed proximally to the ascending aorta to bypass a lesion in the right coronary artery, the LITA anastomosed to the LAD, and a SV graft to the first obtuse marginal branch This operation is representative of those included in the RAPS OM indicates first obtuse marginal branch Downloaded from http://circ.ahajournals.org/ by guest on February 26, 2013 e42 Circulation August 3, 2004 Potential Advantages of Radial Artery Use The RA possesses several anatomical features that make it an excellent candidate for use in coronary revascularization.27 The average length of the RA, Ͼ20 cm, makes it suitable to bypass all coronary artery territories, and its inner diameter, which is between to mm, closely matches that of the coronary arteries Both coronary and aortic anastomoses are technically less demanding to construct with the RA when compared with other arterial conduits because of its thick muscular wall On a practical basis, harvesting of the RA may occur concurrently with harvesting of all other conduits, reducing the duration of the surgical procedure.26 When compared with other vascular conduits, the RA provides additional benefits According to observational studies, relative to SV grafts, RAs can be harvested without interfering with ambulation and their use has been shown to be protective against both early and late mortality and morbidity,28 resulting in enhanced late survival.29 Also, unlike SV grafts, RA grafts are adapted to higher arterial pressures and have a homogeneous caliber free from internal valves, characteristics possibly contributing to the RA’s superior results Compared with other arterial grafts, contraindications such as obesity, diabetes mellitus, or previous laparotomy not apply to RA harvesting, allowing this conduit to be harvested in a majority of patients TABLE When comparing the RITA to the RA as a second arterial graft, patients receiving a RA have a lower incidence of sternal wound infection and decreased transfusion requirement, though there is no difference in perioperative or intermediate-term cardiac morbidity or mortality rates.30 Furthermore, RA use is safe in patients with moderate to severe left ventricular dysfunction31 and in patients over the age of 6532 (see Table 1) Potential Disadvantages of Radial Artery Use Before harvesting the RA, it is mandatory to assess the adequacy of the ulnar collateral circulation to the hand to avoid ischemia Methods to detect adequate forearm collateral flow include the Allen test, static and dynamic Doppler testing, direct digit pressure measurement during RA compression, and oxymetric plethysmography, together with the computation of a perfusion index.33 If concerns with the adequacy of the forearm collateral circulation are raised by the preoperative testing method, RA harvesting is contraindicated Other contraindications to RA harvesting include a radial artery plaque on ultrasound, damage to the RA due to trauma or previous cannulation, the presence of an arteriovenous fistula for hemodialysis, vasculitis, or Raynaud’s disease.26,34 If there are no contraindications before harvesting, removal of the RA does not result in any symptoms of hand ische- The Advantages and Disadvantages of Using the RA as a Bypass Conduit Advantages Disadvantages Anatomical Length (‫ف‬20 cm) Luminal diameter (2 to mm) Thick muscular wall/easy to work with Clinical Excellent short-, mid-, and long-term patency Obesity, diabetes, and previous laparotomy are not contraindications Decreased transfusion requirement Lower rate of sternal wound infection Practical Decreased operating time since harvested concurrently with other grafts Increased propensity to spasm Contraindications include poor forearm collateral circulation, plaque on ultrasound, damage due to trauma or previous cannulation, presence of an arterio-venous fistula for hemodialysis, vasculitis, or Raynaud’s disease Risk of hand sensory or motor dysfunction mia or motor dysfunction.35 Although rare, complications after RA harvesting may occur The most common complications noted, occurring in 2.6% to 15.2% of patients, are sensory abnormalities, especially cutaneous paresthesias in the radial distribution of the lateral antebrachial cutaneous nerve or superficial branch of the radial nerve, likely secondary to nerve injury from direct trauma, edema, or carpal tunnel hematoma.35,36 Other disadvantages of the RA include a slightly higher degree of atherosclerosis as compared with the LITA and its increased chance of being subject to previous iatrogenic vascular trauma.33,37 However, the inability to use the RA because of severe calcification or chronic dissection from prior cannulation is relatively rare, occurring in less than 2% of candidates for RA harvest34 (see Table 1) The major disadvantage, which may affect long-term performance, is the propensity of the RA to go into spasm RA graft spasm is more intense and more difficult to reverse compared with spasm of the internal thoracic artery.38 Basic science investigations have elucidated the mechanism by which RA spasm is mediated Although nonreceptor-mediated spasm in response to surgical trauma and local tissue acidity is important, it is the receptor-mediated response to catecholamines and platelet-derived factors, induced by endothelial damage and platelet aggregation, which should be abrogated in the setting of a coronary bypass graft Endothelial function of the RA, in terms of the release of endothelium-derived relaxing factors such as nitric oxide, is similar to that of other arteries, as is its sensitivity to vasoconstricting agents.38 Thus, the propensity for the RA to go into spasm is likely due to the higher density of muscle cells in the media of this vessel that are organized into multiple tight layers, whereas the internal thoracic, gastroepiploic, and epigastric arteries have fewer muscle cells that are less organized.27 Because of the more muscular nature of the RA, a significantly Downloaded from http://circ.ahajournals.org/ by guest on February 26, 2013 Verma et al TABLE Radial Arteries for CABG Surgery e43 Relative Patency Rates of Radial Artery Grafts Study Timing RA LITA RITA FITA early 56/56 (100%) 48/48 (100%) 11/11 (100%) 16/18 (89.9%) early 26/26 (100%) 43/43 (100%) 35/35 (100%) ⅐⅐⅐ Calafiore et al20 early 75/76 (98.7%) ⅐⅐⅐ ⅐⅐⅐ Chen et al48 early 90/94 (95.7%) ⅐⅐⅐ 62/62 (100%) da Costa et al49 early 59/61 (96.7%) 31/32 (96.8%) ⅐⅐⅐ 12/13 (92.3%) ⅐⅐⅐ 50 ⅐⅐⅐ 27/27 (100%) Acar et al24/p Calafiore et al 47 ⅐⅐⅐ RGEA ⅐⅐⅐ 5/5 (100%) ⅐⅐⅐ 13/14 (92.8%) ⅐⅐⅐ 48/50 (96.0%) ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ 34/38 (89.5%) ⅐⅐⅐ ⅐⅐⅐ 86/90 (95.5%) 137/139 (98.6%) ⅐⅐⅐ 99/100 (99%) Acar et al24 mid 29/31 (93.5%) 28/28 (100%) 9/9 (100%) Calafiore et al47 mid 16/17 (94.1%) 31/31 (100%) 22/23 (95.6%) ⅐⅐⅐ ⅐⅐⅐ 2/2 (100%) Calafiore et al20 mid 33/35 (99.3%) Manasse et al52 mid 43/49 (87.8%) ⅐⅐⅐ 45/47 (95.8%) ⅐⅐⅐ 1/2 (50%) ⅐⅐⅐ 2/4 (50%) ⅐⅐⅐ 5/5 (100%) Tatoulis et al34 mid 21/22 (95.7%) 16/16 (100%) ⅐⅐⅐ 1/1 (100%) Bhan et al53 mid 60/62 (96.8%) 56/57 (98.2%) Amano et al51 mid 213/229 (93.0%) 142/149 (95.3%) ⅐⅐⅐ 27/27 (100%) Acar et al24 late 54/64 (84.4%) 44/47 (93.6%) Possati et al55 late 57/61 (91.9%) 58/60 (96.7%) ⅐⅐⅐ 3/4 (75%) Buxton et al45 group late 38/39 (95%) ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ 29/29 (100%) Buxton et al45 group late 21/24 (86%) ⅐⅐⅐ Possati et al56 late ⅐⅐⅐ 79/82 (96.3%) Totals: early 529/542 (97.6%) 283/285 (99.3%) mid 415/445 (93.3%) 318/328 (97.0%) late 244/272 (89.7%) 181/189 (95.8%) 74/84 (88%) ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ early ⅐⅐⅐ ⅐⅐⅐ 67/70 (95.7%) ⅐⅐⅐ early ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ 1/1 (100%) Brodman et al ⅐⅐⅐ 11/13 (84.6%) SVG 8/9 (88%) ⅐⅐⅐ 24/26 (92.3%) Amano et al51 ⅐⅐⅐ IEA ⅐⅐⅐ 25/25 (100%) ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ 35/46 (76.1%) ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ 75/82 (91.4%) ⅐⅐⅐ ⅐⅐⅐ 71/79 (89.8%) ⅐⅐⅐ ⅐⅐⅐ 9/10 (90%) ⅐⅐⅐ ⅐⅐⅐ 43/58 (74.1%) ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ 21/22 (95%) ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ 39/73 (53.4%) ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ ⅐⅐⅐ Early inidcates a mean follow-up of Ͻ6 months; mid, a mean follow-up of to 36 months; late, a mean follow-up exceeding 36 months; and SVG, saphenous vein graft higher maximal contractile force can result in response to vasoconstricting agents, such as norepinephrine, serotonin, endothelin I, and angiotensin II, generated in response to endothelial damage and dysfunction.33,38 Thus, use of the RA as a bypass conduit in patients at high risk of needing postoperative vasopressor support should be avoided Currently, the propensity of the RA to spasm has been greatly reduced by minimal touch harvesting, pharmacological dilation, and the use of both topical and systemic vasodilators, including calcium channel blockers,24,30 papaverine,24 the phosphodiesterase inhibitor milrinone,34 intravenous nitroglycerin,39 and ␣-adrenergic receptor blockers.40 Finally, studies suggest that the RA should be limited to grafting native vessels with a high degree of stenosis (Ͼ70%) because of graft sensitivity to competitive flow and its increased propensity to spasm.41 Patency Rates of Radial Artery Conduits The long-term success of CABG depends largely on graft patency Based on the perceived advantages from arterial revascularization, the RA was increasingly used in the 1990s, either as a separate graft or in composite grafts.20,24,34,42–56 Several angiographic observational studies have shown that the RA achieves excellent short-, mid-, and long-term patency when used as a conduit for revascularization (see Table 2) Patency rates exceed that of SV grafts at all time points and are comparable to those observed for other arterial conduits Similarly, the use of the RA in composite grafts, as T or Y grafts to the LITA, displays favorable short- and long-term patency.42– 44 Recently, Possati and colleagues56 described the long-term (105Ϯ9 months) angiographic patency of RA grafts in a series of 90 consecutive CABG pa- tients They found that the long-term patency rate of the RA, which was grafted to either an obtuse marginal or posterior descending branch, was 88% This was less than that of the LITA (96.3%), but was significantly better than the patency rate for saphenous vein grafts (53.4%) Thus, the long-term patency of the RA appears to be superior to that of the SV, supporting its proposed role as a complementary arterial conduit for myocardial revascularization Although these results are encouraging, there are few long-term studies assessing the patency rates of RA grafts in symptom-free patients in a randomized, controlled setting To address this concern, there are ongoing randomized trials to compare angiographic patency of RA grafts versus other vascular conduits These are the Radial Artery Patency and Clinical Outcome (RAPCO) study,45 the Radial Artery Patency Study (RAPS),46 and the VA Compara- Downloaded from http://circ.ahajournals.org/ by guest on February 26, 2013 e44 Circulation August 3, 2004 tive Study (Dr Steven Goldman, personal communication, 2004) The RAPCO study was undertaken to compare elective angiographic patency and cardiac event-free survival of the RA graft with that of the free RITA or SV during a 10-year period after primary CABG surgery The RA was compared with the free RITA in a younger patient group (nϭ285, age Ͻ70 years) and with the SV in an older patient group (nϭ153, age Ն75 years) Patients were randomly assigned to receive either the RA, RITA, or SV grafted to the largest available coronary artery other than the LAD The 5-year interim results of this prospective, randomized, single-center trial were recently reported.45 Buxton and colleagues45 report that in the first years after surgery, there were no differences in the angiographic failure rates and major clinical outcomes, namely survival and cardiac event-free survival, of the RA compared with the RITA or SV However, these results were based on only a small proportion of the expected angiographic results Furthermore, in their study,45 SV graft patency rates were much better than those previously recorded or the nonstudy SVs Also, the 5-year time point may be too short to assess the true difference in patency as SV grafts begin to display accelerated graft atherosclerosis and increasing rates of graft failure between and 10 years postoperatively Thus, the final results obtained after 10 years of follow-up should help clarify the long-term RA patency rates and whether the use of this graft in CABG is superior to the RITA or SV The results of the second trial, RAPS,46 were reported at the 2003 American Heart Association Scientific Sessions.57 RAPS was a prospective, multicenter, randomized clinical trial comparing RA patency with that of the SV when randomly allocated as the graft to the right or circumflex coronary arteries The primary objective of the study was to determine the 8- to 12-month angiographic patency of the RA relative to the SV, with each pa- tient serving as his or her own control The long-term patency (5 to 10 years) of the RA relative to SV grafts will be assessed in follow-up studies A total of 561 patients were enrolled, of whom 440 underwent follow-up angiography Graft patency was greater in RA grafts (91.8%) than in SV grafts (86.4%, Pϭ0.01; graft occlusion odds ratio ϭ0.53, 95% confidence interval 0.31 to 0.85) Perfect graft patency, defined as grafts with Thrombolysis In Myocardial Infarction (TIMI) flow, was similar (87.7% versus 85.7%, Pϭ0.37) Perfect patency of the radial artery was highly dependent on the severity of the proximal native coronary artery stenosis (70% to 89% coronary stenosis: 81.7%; Ն 90% coronary stenosis: 91.5%) Patency of the RA graft was similar in the RCA and circumflex territories The Future of the Radial Artery as a Vascular Conduit The RA is becoming increasingly popular as a third arterial conduit in association with the LITA and RITA, or as the second in patients with contraindications to bilateral ITA harvesting With the movement toward complete arterial revascularization and more frequent off-pump surgery to avoid aortic manipulation, the use of the RA to form composite arterial grafts to the LITA will become more common.58,59 Techniques simplifying the construction of anastomoses between vessels and the aorta, by use of aortic connectors, may be extended to RA grafts.60 New pharmacological agents or gene therapy strategies61 will be developed to further decrease the potential for RA spasm, which remains a problem that may be most relevant in patients who require postoperative vasopressor support Furthermore, minimally invasive approaches for the harvesting of the RA are being developed, providing desirable clinical and cosmetic outcomes.62 Finally, as more patients require reoperation, the RA will be one of the few conduits still available for use Mr P was deemed eligible for CABG Because of his age, the use of arterial grafts was preferred However, his obesity, diabetes, and previous laparotomy prompted the surgeons to avoid harvesting the RITA, IEA, and RGEA His right Allen test was sluggish; however, it was normal on the left Therefore, Mr P underwent CABG with a LITA to the LAD, a left radial artery graft to the distal RCA, and a SV graft to the first obtuse marginal branch, similar to the procedure illustrated in the Figure His perioperative course was unremarkable and he was discharged from hospital days after surgery Note Added in Proof During the review process, an important article on radial arteries was published by Zacharias et al.63 The authors evaluated 6-year outcomes in propensity-matched CABG-LITALAD patients (925 each) divided into those with one radial graft and those with vein-only grafting Perioperative outcomes, including death, were similar, although cumulative survival was better for patients receiving the radial artery graft Angiography data in restudied symptomatic patients showed a trend for greater radial artery graft patency Furthermore, the extent of vein graft failure was significantly worse than that of radial graft falure These data would support the use of radial arteries as a second arterial conduit in CABG-LITA-LAD as opposed to vein grafting References Favaloro RG Saphenous vein autograft replacement of severe segmental coronary artery occlusion: operative technique Ann Thorac Surg 1968;5:334 –339 Kirklin JW, Akins CW, Blackstone EH, et al ACC/AHA Task Force report: guidelines and indications for coronary artery bypass graft surgery J Am Coll Cardiol 1991;17: 543–589 Fremes SE, Levinton C, Naylor CD, et al Optimal antithrombotic therapy following aortocoronary bypass: a metaanalysis Eur J Cardiothorac Surg 1993;7:169 –180 Bourassa MG, Fisher LD, Campeau L, et al Long-term fate of bypass grafts: the Coronary Artery Surgery Study (CASS) and Downloaded from http://circ.ahajournals.org/ by guest on February 26, 2013 Verma et al 10 11 12 13 14 15 16 17 18 19 Montreal Heart Institute experiences Circulation 1985;72(Suppl V):V71–V78 Lytle BW, Loop FD, 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Improved survival with radial artery versus vein conduits in coronary bypass surgery with left internal thoracic artery to left anterior descending artery grafting Circulation 2004; 109:1489 –1496... expanded beyond the LITA to include the right internal thoracic artery (RITA), the right gastroepiploic artery (RGEA), the inferior epigastric artery (IEA), and the radial artery (RA) Bi- From the... maximal contractile force can result in response to vasoconstricting agents, such as norepinephrine, serotonin, endothelin I, and angiotensin II, generated in response to endothelial damage and