Cognitive Dysfunction in Bipolar Disorder A Guide for Clinicians This page intentionally left blank Cognitive Dysfunction in Bipolar Disorder A Guide for Clinicians Edited by Joseph F Goldberg, M.D Katherine E Burdick, Ph.D Washington, DC London, England Note: The authors have worked to ensure that all information in this book is accurate at the time of publication and consistent with general psychiatric and medical standards, and that information concerning drug dosages, schedules, and routes of administration is accurate at the time of publication and consistent with standards set by the U.S Food and Drug Administration and the general medical community As medical research and practice continue to advance, however, therapeutic standards may change Moreover, specific situations may require a specific therapeutic response not included in this book For these reasons and because human and mechanical errors sometimes occur, we recommend that readers follow the advice of physicians directly involved in their care or the care of a member of their family Books published by American Psychiatric Publishing, Inc., represent the views and opinions of the individual authors and not necessarily represent the policies and opinions of APPI or the American Psychiatric Association If you would like to buy between 25 and 99 copies of this or any other APPI title, you are eligible for a 20% discount; please contact APPI Customer Service at appi@psych.org or 800-368-5777 If you wish to buy 100 or more copies of the same title, please e-mail us at bulksales@psych.org for a price quote Copyright © 2008 American Psychiatric Publishing, Inc ALL RIGHTS RESERVED Manufactured in the United States of America on acid-free paper 12 11 10 09 08 First Edition Typeset in Adobe Galliard and Optima American Psychiatric Publishing, Inc 1000 Wilson Boulevard Arlington, VA 22209-3901 www.appi.org Library of Congress Cataloging-in-Publication Data Cognitive dysfunction in bipolar disorder : a guide for clinicians / edited by Joseph F Goldberg, Katherine E Burdick.—1st ed p ; cm Includes bibliographical references and index ISBN 978-1-58562-258-0 (alk paper) Manic-depressive illness Cognition disorders I Goldberg, Joseph F., 1963– II Burdick, Katherine E., 1972– [DNLM: Bipolar Disorder—complications Bipolar Disorder—physiopathology Cognition—physiology Cognition Disorders—etiology WM 207 C6756 2008] RC516.C62 2008 616.89’5—dc22 British Library Cataloguing in Publication Data A CIP record is available from the British Library 2008014109 For my wife and partner, Carrie L Ernst, M.D., my children, Joshua and Brian Goldberg, for their inspiration and energy, and my parents, Daniel and Ethel Goldberg J.F.G To my husband and colleague, Raphael J Braga, M.D., and my father, Henry, and late mother, Bonnie, for their lifelong encouragement toward the pursuit of knowledge K.E.B This page intentionally left blank Contents Contributors ix Foreword xv Frederick K Goodwin, M.D Preface xix Joseph F Goldberg, M.D., and Katherine E Burdick, Ph.D Overview and Introduction: Dimensions of Cognition and Measures of Cognitive Function Katherine E Burdick, Ph.D., and Terry E Goldberg, Ph.D Attentional and Executive Functioning in Bipolar Disorder 23 Luke Clark, D.Phil., and Guy Goodwin, M.D Memory Deficits Associated With Bipolar Disorder 49 Safa Elgamal, M.D., M.Sc., Ph.D., Marta Sokolowska, Ph.D., and Glenda MacQueen, M.D., Ph.D The Endophenotype Concept: Examples From Neuropsychological and Neuroimaging Studies of Bipolar Disorder 69 David C Glahn, Ph.D., Katherine E Burdick, Ph.D., and Carrie E Bearden, Ph.D Impact of Mood, Anxiety, and Psychotic Symptoms on Cognition in Patients With Bipolar Disorder 89 Gin S Malhi, M.B.Ch.B., B.Sc (Hons), F.R.C.Psych., F.R.A.N.Z.C.P., M.D., Catherine M Cahill, M.Sc., M.Psychol., and Philip Mitchell, M.B., B.S., M.D., F.R.A.N.Z.C.P., F.R.C.Psych Improving Psychotherapy Practice and Technique for Bipolar Disorder: Lessons From Cognitive Neuroscience 113 Joseph F Goldberg, M.D., Cory F Newman, Ph.D., Gin S Malhi, M.B.Ch.B., B.Sc (Hons), F.R.C.Psych., F.R.A.N.Z.C.P., M.D., and David J Miklowitz, Ph.D Adverse Cognitive Effects of Psychotropic Medications 137 Joseph F Goldberg, M.D Pharmacologic Strategies to Enhance Neurocognitive Function 159 Joseph F Goldberg, M.D., and L Trevor Young, M.D., Ph.D Cognitive Dysfunction in Children and Adolescents With Bipolar Disorder: Relative Contributions of Bipolar Disorder and Attention-Deficit/Hyperactivity Disorder 195 Paula K Shear, Ph.D., and Melissa P DelBello, M.D 10 Cognition and Functional Outcome in Bipolar Disorder 217 Ivan J Torres, PhD., Colin M DeFreitas, M.A., and Lakshmi N Yatham, M.B.B.S., F.R.C.P.C., M.R.C.Psych 11 Cognition Across the Life Span: Clinical Implications for Older Adults With Bipolar Disorder 235 Eduard Vieta, M.D., Ph.D., Anabel Martinez-Aran, Ph.D., and Joseph F Goldberg, M.D 12 Summary and Assessment Recommendations for Practitioners 257 Joseph F Goldberg, M.D., and Katherine E Burdick, Ph.D Index 273 Contributors Carrie E Bearden, Ph.D Assistant Professor in Residence, Jane & Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences and Department of Psychology, University of California, Los Angeles, California Katherine E Burdick, Ph.D Assistant Professor of Psychiatry, Albert Einstein College of Medicine, the Bronx, New York; Director, Neurocognitive Assessment Unit, Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York Catherine M Cahill, M.Sc., M.Psychol Clinical Psychologist, University of Sydney, Northern Clinical School, Royal North Shore Hospital; Clinical Psychologist, Traumatic Stress Clinic, Westmead Hospital, Sydney, Australia Luke Clark, D.Phil University Lecturer, Department of Experimental Psychology, University of Cambridge, Cambridge, England Colin M DeFreitas, M.A Graduate Student, Department of Psychology, Simon Fraser University, Burnaby, British Columbia Melissa P DelBello, M.D Vice-Chair for Clinical Research and Associate Professor of Psychiatry and Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio Safa Elgamal, M.D., M.Sc., Ph.D Schlegel Research Chair in Aging and Assistant Professor of Cognitive Neuroscience, University of Waterloo, Waterloo, Ontario, Canada ix .. .Cognitive Dysfunction in Bipolar Disorder A Guide for Clinicians This page intentionally left blank Cognitive Dysfunction in Bipolar Disorder A Guide for Clinicians Edited by Joseph F... premature—likely some of both, inasmuch as clinical research specific to neurocognitive function in bipolar disorder is in its relative infancy Interest in cognitive function in bipolar disorder represents... disorder Br J Psychiatry 175:246–251, 1999 44 Cognitive Dysfunction in Bipolar Disorder Frangou S, Donaldson S, Hadjulis M, et al: The Maudsley Bipolar Disorder Project: executive dysfunction in bipolar