Polymeric drugs and drug delivery systems 2001 ottenbrite

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Polymeric drugs and drug delivery systems 2001   ottenbrite

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... clinical studies There are 22 chapters in the book and they cover the most important aspects of polymers as drugs, prodrugs, drug delivery systems, and in situ prostheses The major features promulgated... Anticancer Drugs Conclusions References THERMORESPONSIVE POLYMERIC MICELLES FOR DOUBLE TARGETED DRUG DELIVERY J E CHUNG and TERUO OKANO Introduction Preparation of Thermoresponsive Polymeric Micelles... OF PEPTIDE AND PROTEIN DRUGS EMO CHIELLINI, ELISABETTA E CHIELLINI, FEDERICA CHIELLINI, and ROBERTO SOLARO Introduction Experimental Results and Discussion Conclusions References DRUG RELEASE

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Mục lục

  • tx69566_fm

    • Polymeric Drugs and Drug Delivery Systems

      • Table of Contents

      • Preface

      • TX69566_01

        • Polymeric Drugs and Drug Delivery Systems

          • Table of Contents

          • Chapter 1: Semitelechelic Poly [N-(2-hydroxypropyl)-methacrylamide] for Biomedical Applications

            • INTRODUCTION

            • SYNTHESIS OF SEMITELECHELIC HPMA POLYMERS

            • CHARACTERIZATION OF SEMITELECHELIC HPMA POLYMERS

            • MODIFICATION OF PROTEINS WITH SEMITELECHELIC HPMA POLYMERS

            • MODIFICATION OF BIOMEDICAL SURFACES WITH SEMITELECHELIC HPMA POLYMERS

            • CONJUGATION WITH HYDROPHOBIC ANTICANCER DRUGS

            • CONCLUSIONS

            • REFERENCES

            • TX69566_02

              • Polymeric Drugs and Drug Delivery Systems

                • Table of Contents

                • Chapter 2: Thermoresponsive Polymeric Micelles for Double Targeted Drug Deli ery

                  • INTRODUCTION

                  • PREPARATION OF THERMORESPONSIVE POLYMERIC MICELLES (SCHEME 3)

                    • SYNTHESIS OF A-B BLOCK COPOLYMERS OF PIPAAm WITH VARIOUS HYDROPHOBIC SEGMENTS

                    • MICELLE FORMATION FROM PIPAAm BLOCK COPOLYMERS

                    • THERMORESPONSIVE STRUCTURAL CHANGES OF POLYMERIC MICELLES

                      • Core-Shell Micellar Structure Formation

                      • Reversible Structural Change Responding to Temperature Change

                      • ON –OFF SWITCHABLE DRUG RELEASE FROM THERMORESPONSIVE POLYMERIC MICELLES

                        • ADRIAMYCIN (ADR)INCORPORATION INTO PIPAAm-PBMA MICELLES

                        • THERMORESPONSIVE ADR RELEASE FORM POLYMERIC MICELLES

                        • CYTOTOXICITY OF POLYMERIC MICELLES MODULATED BY TEMPERATURE CHANGES

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