DSpace at VNU: Biomedical and environmental applications of magnetic nanoparticles

Home Search Collections Journals About Contact us My IOPscience Biomedical and environmental applications of magnetic nanoparticles This content has been downloaded from IOPscience Please scroll down to see the full text 2010 Adv Nat Sci: Nanosci Nanotechnol 045013 (http://iopscience.iop.org/2043-6262/1/4/045013) View the table of contents for this issue, or go to the journal homepage for more Download details: IP Address: 134.129.120.3 This content was downloaded on 18/05/2015 at 07:12 Please note that terms and conditions apply IOP PUBLISHING ADVANCES IN NATURAL SCIENCES: NANOSCIENCE AND NANOTECHNOLOGY Adv Nat Sci.: Nanosci Nanotechnol (2010) 045013 (5pp) doi:10.1088/2043-6262/1/4/045013 Biomedical and environmental applications of magnetic nanoparticles Dai Lam Tran1 , Van Hong Le1 , Hoai Linh Pham1 , Thi My Nhung Hoang2 , Thi Quy Nguyen2 , Thien Tai Luong3 , Phuong Thu Ha1 and Xuan Phuc Nguyen1 Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Hanoi, Vietnam Faculty of Biology, Hanoi University of Science, Vietnam National University, 334 Nguyen Trai, Hanoi, Vietnam Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy, Hanoi, Vietnam E-mail: lamtd@ims.vast.ac.vn Received 20 October 2010 Accepted for publication 25 December 2010 Published 25 January 2011 Online at stacks.iop.org/ANSN/1/045013 Abstract This paper presents an overview of syntheses and applications of magnetic nanoparticles (MNPs) at the Institute of Materials Science, Vietnam Academy of Science and Technology Three families of oxide MNPs, magnetite, manganite and spinel ferrite materials, were prepared in various ways: coprecipitation, sol–gel and high energy mechanical milling Basic properties of MNPs were characterized by Vibrating Sample Magnetometer (VSM) and Physical Properties Measurement Systems (PPMS) As for biomedical application, the aim was to design a novel multifunctional, nanosized magnetofluorescent water-dispersible Fe3 O4 -curcumin conjugate, and its ability to label, target and treat tumor cells was described The conjugate possesses a magnetic nano Fe3 O4 core, chitosan (CS) or Oleic acid (OL) as an outer shell and entrapped curcumin (Cur), serving the dual function of naturally autofluorescent dye as well as antitumor model drug Fe3 O4 -Cur conjugate exhibited a high loading cellular uptake with the help of a macrophage, which was clearly visualized dually by Fluorescence Microscope and Laser Scanning Confocal Microscope (LSCM), as well as by magnetization measurement (PPMS) A preliminary magnetic resonance imaging (MRI) study also showed a clear contrast enhancement by using the conjugate As for the environmental aspect, the use of magnetite MNPs for the removal of heavy toxic metals, such as Arsenic (As) and Lead (Pb), from contaminated water was studied Keywords: magnetic nanoparticles, magnetic heating, hyperthermia, heavy ion removal Classification numbers: 2.04, 2.05, 4.02 have been studied for hyperthermia and considered as the novel environmental treatment [5] The adsorbability of MNPs, applying for toxic metals (Arsenic and Lead) in contaminated water, has also been demonstrated However, naked MNPs still have disadvantages It is most important to stabilize the MNPs, preventing agglomeration, which reduces the surface area of the materials, and to keep naked MNPs from being oxidized, which destroys their magnetism Thus, it is crucial to chemically stabilize the morphology and magnetism of MNPs, during and after tsynthesis with non-toxic biocompatible protecting layers [6–8] Introduction Magnetic nanoparticles (MNPs) are attractive to many researchers because of their wide-ranging applications of data storage, magnetic fluids, catalysis, biotechnology, biomedicine and environmental remediation [1–4] Several methods have been developed for synthesizing MNPs with different compositions MNPs with appropriate modified surfaces have been widely applied in biomedical applications, such as diagnostic (magnetic resonance imaging and magnetic enhanced enzyme-linked immunoassay) and therapeutic (drug delivery and hyperthermia) applications The magnetites 2043-6262/10/045013+05$30.00 © 2010 Vietnam Academy of Science & Technology Adv Nat Sci.: Nanosci Nanotechnol (2010) 045013 D L Tran et al In our studies, chitosan (CS), an excellent biocompatible and biodegradable polymer with a high content of amino groups (–NH2 ), making it possible to form metal complexes to enhance the surface for drug delivery; oleic acid (OL), a common natural substance that is nontoxic and able to treat chronic diseases; and curcumin (Cur), which supplies us with a multi-functional method of fluorescent and magnetic imaging as well as a cancer treatment, were chosen Our aims were (i) to study the magnetic heating effect (MH) of different MNPs and (ii) to fabricate CS- or OL-coating Fe3 O4 -Cur conjugates with a diameter of