1. Trang chủ
  2. Ngoại Ngữ

A study on open chromatin based on pair end sequencing data

101 204 0
A study on open chromatin based on pair end sequencing data

Đang tải... (xem toàn văn)

Tài liệu hạn chế xem trước, để xem đầy đủ mời bạn chọn Tải xuống

Thông tin tài liệu

. A STUDY ON OPEN CHROMATIN BASED ON PAIR- END SEQUENCING DATA YANG RUIJIE NATIONAL UNIVERSITY OF SINGAPORE 2015 A STUDY ON OPEN CHROMATIN BASED ON PAIR- END SEQUENCING DATA YANG RUIJIE (B.Eng.,. and ATAC (Assay for Transposase-Accessible Chromatin) are three assays to isolate and identify open- chromatin regions of a given genome. As it is commonly known, open- chromatin regions are unpacked and. gene-regulation mechanisms. However, this relies heavily on the analysis of open- chromatin data. In this thesis, we conduct a study on pair- end ATAC-seq data. The study consists of two parts. In

Ngày đăng: 26/09/2015, 10:34

Xem thêm: A study on open chromatin based on pair end sequencing data

Từ khóa liên quan

Mục lục

  • Introduction

    • Motivation

    • Contributions

    • Organization of the Thesis

    • Biological Background

      • The Pipeline of Biological Research

        • Sequence Data Storage

        • Peak Calling

        • Downstream Analysis

        • Assays on Open Chromatin

          • DNase Digestion

          • FAIRE(Formaldehyde Assisted Isolation of Regulatory Elements)

          • ATAC(Assay for Transposase-Accessible Chromatin)

          • Gene Regulation

          • Literature Review

            • Peak-Calling Methods

              • Sliding-Window Approaches

              • Kernel-Density-Estimation Approaches

              • Summary on Peak-Calling Methods

              • Studies on Open Chromatin

                • Open Chromatin vs. Protein

                • Open Chromatin vs. Gene Expression

                • Summary on Studies of Open Chromatin

                • OpenEM: Peak Calling For Open Chromatin Based on EM

                  • Introduction

                  • Observations

                    • Data Preprocessing

                    • Observations on Tag Count

                    • Observations on Distribution of Fragment Length

Tài liệu cùng người dùng

Tài liệu liên quan