RESEARCHING TO SYNTHESIZE NANO DENDRITIC POLYMER

RESEARCHING TO SYNTHESIZE NANO DENDRITIC POLYMER Laboratory of organic and polymer chemistry, Institute of Chemical Technology, VAST 1 Mac Dinh Chi, Dist.1, Ho Chi Minh City Email: hoangthikimdung@gmail.com Ha Noi - 2009 INTRODUCTION DENDRITIC POLYMER Dendritic architecture class dendrons and dendrimers dendrigraft or dendronized polymers randomly hyperbranched polymers and star polymers DENDRIMERS • most size-controlled macromolecules • geometrically restricted structures • well-defined and highly branched structure with a high degree of control over their size and shape in three dimensions • very low polydispersities • a wide variety of functionalization on their multiple functional groups on the exterior as well as interior. Structure of Dendrimers Figure 1. Structure of a dendrimer includes core, branched interior layers known as ‘generation’ and periphery (surface group) Characteristic features of dendrimers • isolated as a monodisperse single compound • the properties of dendrimers (e.g., solubility, chemical reactivity, glass transition temperature) are dominated by the nature of the end groups • dendritic growth is mathematically limited linear polymer growth that theoretically can continue ad infinitum • Viscosity: decrease in dependence with increase in dendrimer generation after a maxima is reached APPLICATION OF DENDRIMERS Dendrimers are application in many fields such as catalysis, materials, biological (delivery devices)… Figure 2. Dendrimer as drug carrier agent Drug molecules can be loaded both in the interior of the dendrimers as well as attached to the surface groups by covalently or non-covalently bounds. OUR LAB’S RESULTS 1. Synthesis PAMAM (polyamidoamine) PAMAM: a popular dendrimer By using ethylenediamine (EDA) and amonia as cores, we synthesized 2 kind of PAMAM.  PAMAM using ethylenediamine (EDA) core: up to G(3,0) Figure 3. Structure and TEM image of PAMAM G(2,0) core EDA Figure 4: Structure and TEM image of PAMAM G(2,5) core EDA [...]... benzoyl chloride, propionyl chloride, stearic acid • Researching about influence of dendrimer on vitamine C preserve The initial result shown that polyester can make to increase the time of vitamine C preserve about 10% Figure 8 TEM images of benzoyl-modified hyperbranched polymer Figure 9 TEM images of vitamine C in stearate-modified hyperbranched polymer THANK YOU FOR YOUR ATTENTION! ... that the silver nanoparticles could remain stable at least 3 month  Forthcoming plan PEG-PAMAM as 5flourouracil carrier agent synthesize PAMAM - cis-platin complex Test biological activities 2 Hyperbranched polyester  their properties are similar to those of dendrimers  synthesized via one-step reactions Hyperbranched polyester: 2-ethyl-2-(hydroxymethyl)-1,3-propanediol (TMP) as a core, interior... G(4,0)  Initial applied research: making silver nanoparticle in dendrimer: G(1,0) G(2,0) G(3,0) Figure 6 TEM images of Ag-PAMAM generations (EDA core) Figure 7 UV-vis spectrum of Ag-PAMAM The absorption spectra of the obtained silver particles system were measured at different shelf time so as to investigate its stability The result shown that the silver nanoparticles could remain stable at least 3 month . RESEARCHING TO SYNTHESIZE NANO DENDRITIC POLYMER Laboratory of organic and polymer chemistry, Institute of Chemical Technology, VAST. Noi - 2009 INTRODUCTION DENDRITIC POLYMER Dendritic architecture class dendrons and dendrimers dendrigraft or dendronized polymers randomly hyperbranched polymers and star polymers DENDRIMERS • . different shelf time so as to investigate its stability. The result shown that the silver nanoparticles could remain stable at least 3 month.  Forthcoming plan synthesize PEG-PAMAM as 5- flourouracil