Báo cáo y học: "Comprehensive characterization of the cis-regulatory code responsible for the spatio-temporal expression of olSix3.2 in the developing medaka forebrain" potx
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Cấu trúc
Abstract
Background
Results
Conclusion
Background
Results
Isolation, characterization, and expression of olSix3.2
The cis-regulatory elements responsible for olSix3.2 expression are contained in a 4.5 kb genomic region ending with a distal 'silencer'
Early expression of olSix3.2 in the anterior neural structures depends on one enhancer, whereas that in the lens placode requires the additional activity of four cis-regulatory modules
During organogenesis, appropriate expression of olSix3.2 requires the combined activity of two silencers, one enhancer, and two putative 'silencer blockers'
Identification and characterization of conserved regions among vertebrate
Discussion
Conclusion
Materials and methods
Microinjection and establishment of transgenic lines