diabetic ketoacidosis

Diabetic Ketoacidosis Diabetic Ketoacidosis (DKA) (DKA) DKA - Definition DKA - Definition  Clinical – Acute state of severe Clinical – Acute state of severe uncontrolled diabetes that requires uncontrolled diabetes that requires emergency treatment with insulin emergency treatment with insulin and intravenous fluids and intravenous fluids  Biochemical – Triad of hyperglycemia Biochemical – Triad of hyperglycemia (blood glucose > 250 mg/dl), (blood glucose > 250 mg/dl), ketonemia (serum ketones > 5 ketonemia (serum ketones > 5 mEq/L) and acidemia (blood pH < mEq/L) and acidemia (blood pH < 7.3) 7.3) Kitabchi, AE etal., Management of hyperglycemic crisis in patients with diabetes, Diabetes Care, 24:1, Jan. 2001, 132. Why DKA? Why DKA?  Medical Illnesses – Alcohol abuse, Medical Illnesses – Alcohol abuse, trauma, pulmonary embolism, trauma, pulmonary embolism, myocardial infarction myocardial infarction  Drugs Drugs – Induce insulin resistance Induce insulin resistance  Corticosteroids Corticosteroids – Decrease insulin secretion Decrease insulin secretion  B-Blockers B-Blockers  Diuretics Diuretics  Dilantin Dilantin [...]... Adolf Kussmaul (1822-1902) " Since I have seen three diabetics in the course of a year die, with remarkably similar symptoms in which there was a peculiar comatose condition preceded and accompanied by dyspnoea, I believe that it…has to do with a form of . Diabetic Ketoacidosis Diabetic Ketoacidosis (DKA) (DKA) DKA - Definition DKA - Definition  Clinical. secretion  B-Blockers B-Blockers  Diuretics Diuretics  Dilantin Dilantin " Since I have seen three diabetics in the course of a year die, with remarkably similar symptoms in which there was a peculiar