Textbook of Interventional Cardiovascular Pharmacology - part 1 doc

[...]... Cangrelor - Erythromycin breath test- 12 Gg 1 AA-Induced Platelet Aggregation - LTA(PRP) - TEG (Whole Blood) 2 TxB2 Metabolite - Plasma - PRP (AA-Induced) TxA2 - Urine Receptor 3 Verify Now (AA-induced) 4 Flow Cytometry AA-induced G P-selectin, PAC -1 P PI 1 LTA- ADP and Collagen- Induced 2 PFA -1 0 0 P2Y 11 P2Y12 ion ”Autocrine and Paracrine Effect” TP CD40L P-selectin Peptidomimetics Figure 1. 3 COX -1 Non-Specific... Change AA X COX -1 TxA2 lat Ib/ ele III tAaA cti gg v re at ga io tio n, n X G12 Granule Secretion ASA P2Y12 Gi Ca++ Mobilization – Pl3K Adenylyl Cyclase cAMP ? RAP-1b Akt VASP-P P-selectin and CD40L Expression, Platelet-Leukocyte Aggregation 3 ADP-Induced Platelet Aggregation - LTA (PRP) - TEG (Whole Blood) 4 P2Y12 Reactivity Ratio - Flow cytometry VASP-P levels 5 P-selectin, activated PAC -1 expression... trials.(See p 309.) Figure 25 .10 Inhibition of restenosis by paclitaxel inhibits in a porcine coronary model (See p 309.) Intimal area (mm2) 1. 5 1. 0 ** * 0.5 0.0 0 10 20 30 40 50 60 Days after stenting Uncoated stent Poly(lactide-co-Σ-caprolactone)-coated stent Poly(lactide-co-Σ-caprolactone)-coated paclitaxel-releasing stent Figure 25 .11 Relative Extent of Response Relative Extent of Response Sustained reduction... Number of cells migrated (% of control) 11 80 FM 15 0 10 0 * ## * 50 * 0 10 0 nM Insulin 0. 01 ng/ml SRL 0 .1 ng/ml SRL 1 ng/ml SRL + – – – + + – – + – + – + – – + – – – + + – – – + + – – + – + – + – – + – – – + (B) Normal glucose SRL High glucose SRL 15 0 Normal glucose PTXL High glucose PTXL 10 0 *p . class="bi x0 y0 w1 h0" alt="" Textbook of Interventional Cardiovascular Pharmacology 11 80 FM 3 /15 /07 6:57 PM Page i 11 80 FM 3 /15 /07 6:57 PM Page ii Textbook of Interventional Cardiovascular Pharmacology Nicholas. Federation Foreword 11 80 FM 3 /15 /07 6:57 PM Page xvii 11 80 FM 3 /15 /07 6:57 PM Page xviii The Textbook of Interventional Cardiovascular Pharmacology is an excellent up-to-date text that focuses on agents, interventional. Hospital Hyogo-ken Japan Luis G. Melo PhD Associate Professor of Physiology Department of Physiology College of Medicine Queen’s University Kingston, Ontario Canada xii List of contributors 11 80 FM 3 /15 /07