Basics of Blood Management - part 1 ppsx

[...]... modifies FCD and capillary blood flow is the metabolic requirement of the 12 Chapter 2 10 0 90 Oxygen saturation (%) 80 70 60 pH decrease CO2 increase 2,3-DPG increase temperature increase 50 40 30 20 10 P50 0 0 10 20 30 40 50 60 70 80 90 10 0 11 0 12 0 13 0 14 0 15 0 Partial pressure of oxygen (mm Hg) tissue Demand increases blood flow and excess of oxygen decreases blood flow This mechanism is partially mediated by... Gynecol, 19 99 18 0(6, Pt 1) : p 14 91 14 98 15 Stover, E.P., et al Institutional variability in red blood cell conservation practices for coronary artery bypass graft surgery Institutions of the MultiCenter Study of Perioperative Ischemia Research Group J Cardiothorac Vasc Anesth, 2000 14 (2): p 17 1 17 6 2 Physiology of anemia and oxygen transport Tolerance of anemia while it is being treated is one of the... Cook County Hospital (blood preservation) JAMA, 19 37 10 9: p 12 8 13 2 12 Allen, J Serum hepatitis from transfusion of blood JAMA, 19 62 18 0: p 10 79 10 85 13 Vernon, S and G.M Pfeifer Are you ready for bloodless surgery? Am J Nurs, 19 97 97(9): p 40–46; quiz 47 14 deCastro, R.M Bloodless surgery: establishment of a program for the special medical needs of the Jehovah’s Witness community—the gynecologic surgery... gradient Science, 19 97 276(53 21) : p 2034–2037 10 Longmuir, I.S The effect of hypothermia on the affinity of tissues for oxygen Life Sci, 19 62 1: p 297–300 11 Wittenberg, B.A and J.B Wittenberg Transport of oxygen in muscle Annu Rev Physiol, 19 89 51: p 857–878 12 Clay, A.S., M Behnia, and K.K Brown Mitochondrial disease: a pulmonary and critical-care medicine perspective Chest, 20 01 120: p 634–648 13 Intaglietta,... will eventually define future blood management by a new generation of physicians Blood management as a program The organized approach to blood management is a program These programs are named according to the emphasis each one puts on different facets of blood management, such as bloodless programs, transfusion-free programs, blood conservation programs, or global blood management programs No matter... York, 19 80 9 Spence, R Blood substitutes In L.D., Petz, S., Kleinman, S.N., Swisher, and R.K., Spence (eds.) Clinical Practice of Transfusion Medicine Churchill-Livingstone, New York, 19 96 p 967–984 10 Bull, W On the intravenous injection of saline solutions as a substitution for transfusion of blood Med Rec, 18 84 25: p 6–8 11 Fantus, B Therapy of the Cook County Hospital (blood preservation) JAMA, 19 37... 11 78 11 90 3 Pries, A.R., T.W Secomb, and P Gaehtgens Biophysical aspects of blood flow in the microvasculature Cardiovasc Res, 19 96 32(4): p 654–667 4 Tuman, K.J Tissue oxygen delivery: the physiology of anemia ACNA, 19 90 8: p 4 51 469 5 Farhaeus, R and T Lindqvist The viscosity of the blood in narrow capillary tubes Am J Physiol, 19 31 96: p 562–568 6 Langenfeld, J.E., et al Correlation between red blood. .. reason for blood conservation; History and Organization of Blood Management the incremental increase of blood products is another and lastly, sporadic but serious blood shortages are all good reasons to consider effective blood management Blood management today and tomorrow Currently, there are more than 10 0 organized bloodless programs in the United States Many are transitioning to become blood management. .. Anaesth, 19 98 81( Suppl 1) : p 10 15 21 Morgan, T.J., et al Siggaard-Andersen algorithm-derived p50 parameters: perturbation by abnormal hemoglobin-oxygen affinity and acid-base disturbances J Lab Clin Med, 19 95 12 6(4): p 365–372 22 Borgstrom, L., H Johannsson, and B.K Siesjo The influence of acute normovolemic anemia on cerebral blood flow and oxygen consumption of anesthetized rats Acta Physiol Scand, 19 75 93(4):... 505– 514 23 Van der Linden, P., et al Influence of hematocrit on tissue O2 extraction capabilities during acute hemorrhage Am J Physiol, 19 93 264(6, Pt 2): p H1942–H1947 24 Habler, O., et al Hyperoxia in extreme hemodilution Eur Surg Res, 2002 34 (1 2): p 18 1 18 7 25 Deem, S., et al Mechanisms of improvement in pulmonary gas exchange during isovolemic hemodilution J Appl Physiol, 19 99 87 (1) : p 13 2 14 1 26 . w0 h0" alt="" BLUKO82-Seeber March 19 , 2007 10 :12 Basics of Blood Management i BLUKO82-Seeber March 19 , 2007 10 :12 Basics of Blood Management Petra Seeber MD Department of Anesthesiology Critical. chemistry of hemostasis, 77 8 Recombinant blood products, 96 9 Artificial blood components, 11 0 10 Oxygen therapy, 12 5 11 Preparation of the patient for surgery, 13 9 12 Iatrogenic blood loss, 16 0 13 . 16 0 13 The physics of hemostasis, 17 2 14 Anesthesia—more than sleeping, 19 1 15 The use of autologous blood, 200 16 Cell salvage, 211 17 Blood banking, 227 18 Transfusions. Part I: cellular components