Mayo Clinic Antimicrobial Therapy quick guide - part 8 pps

Infectious Syndromes Special Circumstances • HIV coinfection 1) rifampin-based regimens generally not recommended with most protease inhibitors or nonnucleoside reverse transcriptase inhibitorsf 2) rifabutin causes less hepatic cytochrome P-450 induction than rifampin and may be used in place of rifampin (with dosing adjustments); information about rifamycin and select antiretroviral drug dosing can be found on the Web site of the Centers for Disease Control and Prevention* 3) The once-weekly isoniazid plus rifapentine continuation phase is contraindicated for HIVpositive patients because of an unacceptably high rate of relapse or failure (often with rifamycin-resistant organisms) 4) Twice-weekly treatment, as part of either an initial phase or a continuation phase, is not recommended for HIV-positive patients with a CD4 count