International University Biotechnology Biochemistry ppt

International University Biotechnology Biochemistry Lecturer: Msc. Le Hong Phu Topic 9: Detailed Mechanism of Enzyme Catalyst • Group Members: 1. Do Ngoc Anh Huy 2. Tran Van Kha 3. Doan Luong Huy 4. Dang Duong 5. Nguyen Quang Toan 6. Nguyen Thi Huong Giang 7. Pham Vinh Phuoc Group leader Content: • Definition and basic process: 1. Induced fit 2. Mechanisms of transition state stabilization • Detailed in example to make you understand more about mechanism of enzyme catalyst: Chymotripsin Lock-key theory • A Specific active site for a specific substrate How can make the key to be fixed to the locker??? Induced fit theory • The initial reaction between E and S is weak, but it rapidly induce by conformational changes in the enzyme. The transition state • When a chemical reaction occurs, the energy content of the reacting molecule or atom increases. • This is why most chemical reactions, whether they release heat or absorb heat. • The high-energy state of the reactants is called the transition state. . International University Biotechnology Biochemistry Lecturer: Msc. Le Hong Phu Topic 9: Detailed Mechanism of Enzyme