Complex Systems Science in Biomedicine doc

[...]... 843 846 Index 849 Part I INTRODUCTION INTEGRATIVE SYSTEMS VIEW OF LIFE: PERSPECTIVES FROM GENERAL SYSTEMS THINKING J Yasha Kresh Departments of Cardiothoracic Surgery and Medicine, Drexel University College of Medicine, Philadelphia The application of systems thinking and the principles of general systems science to problems in the life sciences is not a new endeavor In the 1960s systems. .. confined to a single plane As regards the relations among levels in the vast hierarchy-heterarchy of living order, researchers have expressed interest in simulating biological systems, i.e., bottom–up, commencing with single genes and protein molecules, or top–down, starting with large-scale physiological behavior (devoid of gene and protein–protein interactions) Notable modelers (see chapter 3.2 by Winslow,... Part I: Introduction INTEGRATIVE SYSTEMS VIEW OF LIFE: PERSPECTIVES FROM GENERAL SYSTEMS THINKING J Yasha Kresh 1 2 3 4 5 6 7 Introduction General System Theory: The Laws of Integrated Wholes Systemic Principles of Cybernetics Biological Systematics: Understanding Whole Systems Systems Biology and Mathematical Modeling Emergence: Complex Adaptive Systems. .. robustness and fragility The defining aims of systems thinking: — The Believing: why do I see what I see? — The Being: why do things stay the same? — The Becoming: why do things change? The notion of a system comprised of interdependent elements has been the subject of human concern and inquiry for centuries Man has explored the solar system and the constellations since the beginning of recorded time We,... array of interconnected elements that control our internal and external world The more formal understanding of a system, offered by systems science, as a complex of components and their interactions has not changed dramatically through the years An inkling of systems science was anticipated by the Gestalten in physics, a natural worldview proposed in the 1920s According to the great leader in the field... to note that the average Figure 4 Types of systems with respect to methods of study and complexity ranking, as given by Weinberg (11) Conceptual representation and generalized systems view of "organized complexity." Note the ranking and association between uncertainty and complexity (11) and their mutual interaction in defining ranges of systems (from machines to random aggregates) 12 J Y KRESH person... 265 266 268 277 Section III.2: The Cell as a Complex System Chapter 2.1 TENSEGRITY, DYNAMIC NETWORKS, AND COMPLEX SYSTEMS BIOLOGY: EMERGENCE IN STRUCTURAL AND INFORMATION NETWORKS WITHIN LIVING CELLS 283 Sui Huang, Cornel Sultan, and Donald E Ingber 1 2 3 4 5 Introduction: Molecular Biology and Complex System Sciences Complexity in Living Systems Model: Networks as the General... Emergence: Complex Adaptive Systems The Complex Systems in Systems Biology 3 4 5 6 9 17 21 26 Part II: Complex Systems Science: The Basics Chapter 1 METHODS AND TECHNIQUES OF COMPLEX SYSTEMS SCIENCE: AN OVERVIEW Cosma Rohilla Shalizi 1 2 3 4 5 6 7 8 9 Introduction Statistical Learning and Data-Mining Time-Series Analysis Cellular Automata... Evaluating Models of Complex Systems Information Theory Complexity Measures Guide to Further Reading 33 33 37 46 63 65 70 76 81 95 Chapter 2 NONLINEAR DYNAMICAL SYSTEMS 115 Joshua E S Socolar 1 Introduction 115 2 Dynamical Systems in General 118 xi xii 3 4 5 6 CONTENTS Linear Systems and Some Basic Vocabulary Nonlinear Effects... produce other subsystems that are goal-directed, self-regulating, or self-reproducing Cybernetics is concerned with understanding the self-organization of human, artificial, and natural systems including the understanding of its own functioning Importantly, cybernetic systems do not have the means to evolve from a lesser to a more differentiated state Cybernetics was part of the systems thinking movement . in the biomedical sciences that things are changing—clear signs. Indeed, most of the field involved in mapping the human genome in the 1990s is now engaged in functional genomics. Beginning. Swamy Laxminarayan Complex Systems Science in Biomedicine Edited by Thomas S. Deisboeck and J. Yasha Kresh A Continuation Order Plan is available for this series. A continuation order will bring delivery.