tiểu luận identifying mirna targets and functions

Identifying miRNA, targets and functions Thành viên Lê Văn Hiếu Trung Trương Văn Nam Nguyễn Văn Thắng Giới thiệu Khái niệm miRNA Các chức Vấn đề đặt tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions Nhiều thập kỷ trôi qua, y học giới có nỗ lực khơng ngừng đạt nhiều thành tựu vượt bậc chiến chống lại bệnh hiểm nghèo ung thư, bệnh truyền nhiễm, tim mạch…Tuy nhiên, ung thư mối đe doạ gây tử vong hàng đầu việc chẩn đoán điều trị chưa kịp thời hữu hiệu Việc phát phân tử microRNA chức chúng điều hoà biểu gen khám phá bật ngành di truyền học 38 năm qua tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions • Khái niệm miRNA Acid ribonucleic (ARN hay RNA) - Là phân tử polyme có nhiều vai trị sinh học mã hóa, dịch mã, điều hịa biểu gene - RNA DNA acid nucleic, với lipid, protein cacbohydrat, tạo thành bốn loại đại phân tử sở cho dạng sống Trái Đất MicroRNA - Là phân tử RNA khơng mã hố, độ dài khoảng 18-25 nucleotides (nts) có vai trị quan trọng việc điều hồ biểu gen sau phiên mã tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions Chức - Ức chế biểu nhiều gen đích cách tương tác với vùng không dịch mã (3’-UTR) RNA thông tin (mRNA) tương ứng miARN thực chức cách bắt cặp bổ sung với trình tự bên mARN làm câm gen đặc hiệu mARN thơng qua ba cách sau: • Phân cắt mạch mARN thành phần • Làm ngắn poly A mARN, gây tính bền vững mARN • Giảm hiệu dịch mã mARN thành protein miARN đóng vai trị quan trọng hầu hết q trình sinh lý, sai sót điều hòa miARN dẫn đến nhiều bệnh ung thư, hội chứng trao đổi chất rối loạn thoái hóa thần kinh Kể từ Victor Ambros phát miR giun, lin-4 vào năm 1993 , đến có 20.000 miR xác định động vật, thực vật virus, 2.000 miR người điều hồ đến 60% toàn hệ gen người tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions MicroRNA ung thư - Ung thư chiếm 34% tổng số bệnh liên quan đến rối loạn biểu miR người - Các bệnh miễn dịch nhiễm trùng (15%), tim mạch (7%) loại bệnh khác Thành tựu bật - Làm đích sinh học nghiên cứu ung thư: thử nghiệm lâm sàng MRX34 bệnh nhân ung thư gan tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions Vấn đề đặt - Trường hợp khơng có phương pháp tiếp cận sinh học thông lượng cao để xác định mục tiêu miRNA - Một số phương pháp tính tốn: • miRanda • mirSVR • PicTar • RNA22 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tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions Dự đoán mục tiêu miRNA - Thuật tốn: RNA22 - Lồi: - Mơ tả ngắn gọn phương pháp dự đoán: sử dụng mẫu phát từ miRNA trưởng thành biết để dự đốn vị trí mục tiêu miRNA theo trình tự - Tool: RNA22 visualization tool tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions RNA22 - RNA22 thuật toán dựa mẫu để phát vị trí đích microRNA cac gen phức tạp tương ứng - Ý tưởng: bổ sung ngược lại đặc điểm trình tự bật mà người ta xác định vị trí đích microRNA theo trình tự quan tâm: rna22 sử dụng thuật toán Teiresias để khám phá tính bật tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions Sự hình thành miR Add a main point Add a main point Briefly elaborate on what Briefly elaborate on what you want to discuss you want to discuss tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions Add a main point Add a main point Briefly elaborate on what you want to discuss Briefly elaborate on what you want to discuss tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions out of Elaborate on the featured statistic 100% Elaborate on the featured statistic million Elaborate on the featured statistic 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tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions Write your topic or idea Add a main point Add a main point Add a main point Add a main point Briefly elaborate on what Briefly elaborate on what Briefly elaborate on what Briefly elaborate on what you want to 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tieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functionstieu.luan.identifying.mirna.targets.and.functions Write your topic or idea Write a COLUMN NAME Write a COLUMN NAME Write a COLUMN NAME Write a COLUMN NAME Write a COLUMN NAME Double click to add text 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