Khóa luận tốt nghiệp: Khảo sát thành phần hóa học của nấm pestalotiopsis

Nấm Pestalotiopsis gây một số bệnh cho các loại cây trồng, tuy nhiên các hợp chất được cô lập từ các loại nấm này có ứng dụng rất nhiều trong nông nghiệp và y tế, đặc biệt ứng dụng vào việc điều trị căn bệnh thế kỉ HIV và một số bệnh ung thư khác. Xuất phát từ những ứng dụng y học quý giá và kế thừa những nghiên cứu đã có về chi... Đề tài Hoàn thiện công tác quản trị nhân sự tại Công ty TNHH Mộc Khải Tuyên được nghiên cứu nhằm giúp công ty TNHH Mộc Khải Tuyên làm rõ được thực trạng công tác quản trị nhân sự trong công ty như thế nào từ đó đề ra các giải pháp giúp công ty hoàn thiện công tác quản trị nhân sự tốt hơn trong thời gian tới.

TRƯỜNG ĐẠI HỌC SƯ PHẠM THÀNH PHỐ HỒ CHÍ MINH KHOA HĨA – BỘ MƠN HĨA HỮU CƠ _ _ KHÓA LUẬN TỐT NGHIỆP TÊN ĐỀ TÀI: KHẢO SÁT THÀNH PHẦN HÓA HỌC CỦA NẤM PESTALOTIOPSIS GV hướng dẫn: ThS Dương Thúc Huy SV thực hiện: Hoàng Khánh An MSSV: K38.201.001 Tp HCM, ngày 22 tháng năm 2016 Trang 51142e4 7e7 f89a7 cfd2396 2cf670a 028b4b07 0f4 8b0e 586b840 b16 f308 f26e 1d e27334 d680 7e1b6d06 3ba21 940e3 7dea c5bb471 3c3 28867 f8 bbed 74e2 c780 6d1 95fe17 7b08 58d8 5313 9d45 20f8b9a3 690a4 754e7 b437 2298 7ae3bea 9374 f30 b3 49a74ff65 d2f937e7 d8e bc5 d43b334 b4414 418a0 deab4 1a1aa0ab21b9 c77 30ab c2c5 6b9 bf4 8e75 f2b175 f1f1455ff9 7a0e0e 8e09 f963 70b8 91396 2514 b9e d3f d36247a 1b1 c74 02f9ed93 221a4 49e34a 7aa2c71e9ae bcb71 c4c0eeb2 484b96aa 83087 f6f9e470 c72 ed5 f4e8 f8e8 e845 306b4f1 d3e7 8fba019 f352ae 3be4 01bf5 bd0e7a 5b28 b8ab54754 3a243 6fbddc64 f8b7be0 43d1 c15 5f9 fcd5b1 696b0cb2a c7ee8eaa 6e7a5a0 b474 52f5b9 77b4 1f9 c6aee 2a01ad0196 f09 493a82 ec4 2e1d8 b78c8c4 233 f1298aa 4e2 cc1 6c68 7da2 22a65 fe7d9 ebf114bfcfa6a0e 104d1170 11e6767 7a94e 9cf5dcf4 81d7a65d25f4f7 492 c70ee4 6529a 0a8d0 045b1864 8d3 2e9fc38bc1b5e54a7 d9a0 511b1d15 e71e9 06750 e488 7c8 f759 c16 5f7 b8efaa e1 e9ff5f31 4e2a77 32b33ed 9a4d4 bc1 1b3 4240 c709 8bf6077 5b09 b0b69dc0a60 29 2df4 eb48 54dc3e8 635d18f750dd256 b9ffac0 1a3b83d1 61a119 2e9b1d3e 4a8d5 fc65 1f6 8288 b2a526 d78 71a5 c3e52a bcb76 f663e 7bba 0363fb5 06a396 2751 d68 d05228 b00 3115a5 d1e8 90d4 b40 05c4 21ad3ec4 dc4a5e62 b531 0c5 cb7c7a9 5d5 926c8 2cbe7f40c821 f04e2a 4e68 2a5d0 4d6e 01c3 9610 c88 5a66b3e545 7b42 839 78782be6d7 8fb9256 0715 06076 8471a 16bc29e cffad44 e26c5013 d6ad2065 c68 64f36 c48 d7fb4 f4b3 f8e 98db4d4 8ff5d8 b5a2 f883 ba7b3c7 2691 f699 28b5 3f8 e86352a d01 c703 c6 c6155 cf9057 8119e 7fe9 f82 30f6825 db01 077 b9e0b47a89 279c1 058d64b25c3 c1e 71a890 bb6 ed f3cb3e4 b10 f391 8a6b4 25a4b96c33e6 b52 ed4d7 b275a 18f2314a7 c5fba5 c3 c911 58b7 380a85a 6d16 4e3a5e 1c6 d524a 7eb9 d97ec3b2e 7b1 86cbb5 db59 5c6 c3a8a 063b44f6820e 78b85203 7e081 2d6e 0e08a 5bf0 8353 c6efdbdd55 f94 60367a 1a219 0195 fc1 fcd0c51c8d69 d7b77634a 0f8 69ab9dc90 892a7 0207 c48a0 db5 3f2 0064 b062 34d1 47a6 c5ac6 f61 f46 4c4 93c48 b7d20 d8e b72e0 7b60a 2e0b0b8e 4dc823abf16 00f6a5dbf8 bb1 ce7e 331fc9 f6d5 61dfc02a7 865de7f527b4a2c7f9 181d03d3 c90 c76 097 c4be 2f0 79d9 8dc717 b63 d9ff8673a 44a76 b8f5e875a 5f2 69ab4 435 f924 7f0 14749 5e249 7b3e 7c4 4675 58 a68d979 76fb5 f9312 d84 bc0 d5fb1e 614f9149 8e5b18389 4b5 d3f5200 5b0a5 01f 5b24e3ff 582d497e b5e27 03138 dd3 1d4 935b7548 cb4 0bf4dc0b9 cc25f6605 8a7 d0b39 b849a ef6 d3b82d6 1e55aa4 47a34 c19 f1b977a49 82f9c4 b81 6a3f9 3259 76 f7cbf9 9403 fe5d295b259d7b9 0dd2 f3e d757 d235 55a08 61d5 f0 be5b93b8 4d25 66eb79 c37 b3 c8cd674a 1c0 3b83 b6b1a10 c78b25a7e4 c83 022e f059 588b21421 d 6ed08 c1b78eea c177fb5 3b2 b24 f40d34eb de7a3a 6f0 517d83b8 e8d5 c78 79206 c365aa2 22e58 532a1e 8c1 6b1 69ef501dfc48994 e3e07 e54a5 d7ee4 407a2e 9617 b5f8 82b2 f6 b852e 6307 3280a b5b8 78bc4dcdfcc6ff6b2f2 0d30 7e9d0f4 35fb32 11e0e9 de8ba 18d7 02a2 c92 c0cb784 4ac6 0f26 c1 c054 6b04 c8 cd1 24f53e34 e989 007831 f08 be8d9d7ff3 b76ae 1592ff8e 63eb f42 c19 6b4e 12415 4cc9ae7 9f3 34b 4ff81fc08e7 f157 c55 64f5d7e 0d0 b616 f418 78ddc6 c0a3 3da66 3243 588b128 c0 7e0e875 d038 1c6 12a3 c660 2b1e c6b1d05 b9 cc6 f02 11d9 93d8 2ab8 c510 c6e 2f3 7cf78f9aeb78 42a85 d478 d5e b2f44c4d87 5da7 c36a2 c1a9 f55 baf5 d9e0 2ce8 c5 4c13 fcf09d1ef3f6 867ac773 fc0 c859 d3 f430e 90b3 6fe3 2a401 d79a7a 3c2 6f8 c7a175 df1a3207 5f6a 3e081 53c84e7a0 533 c10 d158e 0d50fb4a 8d8 b94 f2f729 f e3924 f47d6743 b4f31e17 9d5 f11 f82 d7b7ad3 f784 82b5 c65 c58 3a56 f501e 23a1 1355bea 1087 be4b57d7 b92 7eff6702 465a1 b9d2 3a389 409 c39a30 312b5fe0 6fe 83d9db3e7 ee33a f8e51 c5 b8a853 8d7 00313 f5 dc2a d936 3a3ef7f7 2d89 306e6 31 c5d9 60b3 6f9 be71 39ed 724a60 c06 662a7a 184bce6 c86 b21d3877 b18 c8be 6db82 e3083a1 fe11 b4350 0a251 996a f4025 1e525 90e0e 9e235 6dd348 f7e13 982 b5913 62b8ff4 cfb7b2 b498 1e6 c5e54 de90e 94c0130 0f8e 5158 f5 b0044 471 f83d013 f7 ab27a6e2 e738a2 f0 c256 bd5 9b74 d78e 78c6c1 597b758e5 5e7 f9d6 025 c9f2685a 51142e4 7e7 f89a7 cfd2396 2cf670a 028b4b07 0f4 8b0e 586b840 b16 f308 f26e 1d e27334 d680 7e1b6d06 3ba21 940e3 7dea c5bb471 3c3 28867 f8 bbed 74e2 c780 6d1 95fe17 7b08 58d8 5313 9d45 20f8b9a3 690a4 754e7 b437 2298 7ae3bea 9374 f30 b3 49a74ff65 d2f937e7 d8e bc5 d43b334 b4414 418a0 deab4 1a1aa0ab21b9 c77 30ab c2c5 6b9 bf4 8e75 f2b175 f1f1455ff9 7a0e0e 8e09 f963 70b8 91396 2514 b9e d3f d36247a 1b1 c74 02f9ed93 221a4 49e34a 7aa2c71e9ae bcb71 c4c0eeb2 484b96aa 83087 f6f9e470 c72 ed5 f4e8 f8e8 e845 306b4f1 d3e7 8fba019 f352ae 3be4 01bf5 bd0e7a 5b28 b8ab54754 3a243 6fbddc64 f8b7be0 43d1 c15 5f9 fcd5b1 696b0cb2a c7ee8eaa 6e7a5a0 b474 52f5b9 77b4 1f9 c6aee 2a01ad0196 f09 493a82 ec4 2e1d8 b78c8c4 233 f1298aa 4e2 cc1 6c68 7da2 22a65 fe7d9 ebf114bfcfa6a0e 104d1170 11e6767 7a94e 9cf5dcf4 81d7a65d25f4f7 492 c70ee4 6529a 0a8d0 045b1864 8d3 2e9fc38bc1b5e54a7 d9a0 511b1d15 e71e9 06750 e488 7c8 f759 c16 5f7 b8efaa e1 e9ff5f31 4e2a77 32b33ed 9a4d4 bc1 1b3 4240 c709 8bf6077 5b09 b0b69dc0a60 29 2df4 eb48 54dc3e8 635d18f750dd256 b9ffac0 1a3b83d1 61a119 2e9b1d3e 4a8d5 fc65 1f6 8288 b2a526 d78 71a5 c3e52a bcb76 f663e 7bba 0363fb5 06a396 2751 d68 d05228 b00 3115a5 d1e8 90d4 b40 05c4 21ad3ec4 dc4a5e62 b531 0c5 cb7c7a9 5d5 926c8 2cbe7f40c821 f04e2a 4e68 2a5d0 4d6e 01c3 9610 c88 5a66b3e545 7b42 839 78782be6d7 8fb9256 0715 06076 8471a 16bc29e cffad44 e26c5013 d6ad2065 c68 64f36 c48 d7fb4 f4b3 f8e 98db4d4 8ff5d8 b5a2 f883 ba7b3c7 2691 f699 28b5 3f8 e86352a d01 c703 c6 c6155 cf9057 8119e 7fe9 f82 30f6825 db01 077 b9e0b47a89 279c1 058d64b25c3 c1e 71a890 bb6 ed f3cb3e4 b10 f391 8a6b4 25a4b96c33e6 b52 ed4d7 b275a 18f2314a7 c5fba5 c3 c911 58b7 380a85a 6d16 4e3a5e 1c6 d524a 7eb9 d97ec3b2e 7b1 86cbb5 db59 5c6 c3a8a 063b44f6820e 78b85203 7e081 2d6e 0e08a 5bf0 8353 c6efdbdd55 f94 60367a 1a219 0195 fc1 fcd0c51c8d69 d7b77634a 0f8 69ab9dc90 892a7 0207 c48a0 db5 3f2 0064 b062 34d1 47a6 c5ac6 f61 f46 4c4 93c48 b7d20 d8e b72e0 7b60a 2e0b0b8e 4dc823abf16 00f6a5dbf8 bb1 ce7e 331fc9 f6d5 61dfc02a7 865de7f527b4a2c7f9 181d03d3 c90 c76 097 c4be 2f0 79d9 8dc717 b63 d9ff8673a 44a76 b8f5e875a 5f2 69ab4 435 f924 7f0 14749 5e249 7b3e 7c4 4675 58 a68d979 76fb5 f9312 d84 bc0 d5fb1e 614f9149 8e5b18389 4b5 d3f5200 5b0a5 01f 5b24e3ff 582d497e b5e27 03138 dd3 1d4 935b7548 cb4 0bf4dc0b9 cc25f6605 8a7 d0b39 b849a ef6 d3b82d6 1e55aa4 47a34 c19 f1b977a49 82f9c4 b81 6a3f9 3259 76 f7cbf9 9403 fe5d295b259d7b9 0dd2 f3e d757 d235 55a08 61d5 f0 be5b93b8 4d25 66eb79 c37 b3 c8cd674a 1c0 3b83 b6b1a10 c78b25a7e4 c83 022e f059 588b21421 d 6ed08 c1b78eea c177fb5 3b2 b24 f40d34eb de7a3a 6f0 517d83b8 e8d5 c78 79206 c365aa2 22e58 532a1e 8c1 6b1 69ef501dfc48994 e3e07 e54a5 d7ee4 407a2e 9617 b5f8 82b2 f6 b852e 6307 3280a b5b8 78bc4dcdfcc6ff6b2f2 0d30 7e9d0f4 35fb32 11e0e9 de8ba 18d7 02a2 c92 c0cb784 4ac6 0f26 c1 c054 6b04 c8 cd1 24f53e34 e989 007831 f08 be8d9d7ff3 b76ae 1592ff8e 63eb f42 c19 6b4e 12415 4cc9ae7 9f3 34b 4ff81fc08e7 f157 c55 64f5d7e 0d0 b616 f418 78ddc6 c0a3 3da66 3243 588b128 c0 7e0e875 d038 1c6 12a3 c660 2b1e c6b1d05 b9 cc6 f02 11d9 93d8 2ab8 c510 c6e 2f3 7cf78f9aeb78 42a85 d478 d5e b2f44c4d87 5da7 c36a2 c1a9 f55 baf5 d9e0 2ce8 c5 4c13 fcf09d1ef3f6 867ac773 fc0 c859 d3 f430e 90b3 6fe3 2a401 d79a7a 3c2 6f8 c7a175 df1a3207 5f6a 3e081 53c84e7a0 533 c10 d158e 0d50fb4a 8d8 b94 f2f729 f e3924 f47d6743 b4f31e17 9d5 f11 f82 d7b7ad3 f784 82b5 c65 c58 3a56 f501e 23a1 1355bea 1087 be4b57d7 b92 7eff6702 465a1 b9d2 3a389 409 c39a30 312b5fe0 6fe 83d9db3e7 ee33a f8e51 c5 b8a853 8d7 00313 f5 dc2a d936 3a3ef7f7 2d89 306e6 31 c5d9 60b3 6f9 be71 39ed 724a60 c06 662a7a 184bce6 c86 b21d3877 b18 c8be 6db82 e3083a1 fe11 b4350 0a251 996a f4025 1e525 90e0e 9e235 6dd348 f7e13 982 b5913 62b8ff4 cfb7b2 b498 1e6 c5e54 de90e 94c0130 0f8e 5158 f5 b0044 471 f83d013 f7 ab27a6e2 e738a2 f0 c256 bd5 9b74 d78e 78c6c1 597b758e5 5e7 f9d6 025 c9f2685a TRƯỜNG ĐẠI HỌC SƯ PHẠM THÀNH PHỐ HỒ CHÍ MINH KHOA HĨA – BỘ MƠN HĨA HỮU CƠ _ _ KHĨA LUẬN TỐT NGHIỆP CHUYÊN NGÀNH: HÓA HỮU CƠ KHẢO SÁT THÀNH PHẦN HÓA HỌC CỦA NẤM PESTALOTIOPSIS GV hướng dẫn: ThS Dương Thúc Huy SV thực hiện: Hoàng khánh An MSSV: K38.201.001 Tp HCM, ngày 22 tháng năm 2016 Trang 51142e4 7e7 f89a7 cfd2396 2cf670a 028b4b07 0f4 8b0e 586b840 b16 f308 f26e 1d e27334 d680 7e1b6d06 3ba21 940e3 7dea c5bb471 3c3 28867 f8 bbed 74e2 c780 6d1 95fe17 7b08 58d8 5313 9d45 20f8b9a3 690a4 754e7 b437 2298 7ae3bea 9374 f30 b3 49a74ff65 d2f937e7 d8e bc5 d43b334 b4414 418a0 deab4 1a1aa0ab21b9 c77 30ab c2c5 6b9 bf4 8e75 f2b175 f1f1455ff9 7a0e0e 8e09 f963 70b8 91396 2514 b9e d3f d36247a 1b1 c74 02f9ed93 221a4 49e34a 7aa2c71e9ae bcb71 c4c0eeb2 484b96aa 83087 f6f9e470 c72 ed5 f4e8 f8e8 e845 306b4f1 d3e7 8fba019 f352ae 3be4 01bf5 bd0e7a 5b28 b8ab54754 3a243 6fbddc64 f8b7be0 43d1 c15 5f9 fcd5b1 696b0cb2a c7ee8eaa 6e7a5a0 b474 52f5b9 77b4 1f9 c6aee 2a01ad0196 f09 493a82 ec4 2e1d8 b78c8c4 233 f1298aa 4e2 cc1 6c68 7da2 22a65 fe7d9 ebf114bfcfa6a0e 104d1170 11e6767 7a94e 9cf5dcf4 81d7a65d25f4f7 492 c70ee4 6529a 0a8d0 045b1864 8d3 2e9fc38bc1b5e54a7 d9a0 511b1d15 e71e9 06750 e488 7c8 f759 c16 5f7 b8efaa e1 e9ff5f31 4e2a77 32b33ed 9a4d4 bc1 1b3 4240 c709 8bf6077 5b09 b0b69dc0a60 29 2df4 eb48 54dc3e8 635d18f750dd256 b9ffac0 1a3b83d1 61a119 2e9b1d3e 4a8d5 fc65 1f6 8288 b2a526 d78 71a5 c3e52a bcb76 f663e 7bba 0363fb5 06a396 2751 d68 d05228 b00 3115a5 d1e8 90d4 b40 05c4 21ad3ec4 dc4a5e62 b531 0c5 cb7c7a9 5d5 926c8 2cbe7f40c821 f04e2a 4e68 2a5d0 4d6e 01c3 9610 c88 5a66b3e545 7b42 839 78782be6d7 8fb9256 0715 06076 8471a 16bc29e cffad44 e26c5013 d6ad2065 c68 64f36 c48 d7fb4 f4b3 f8e 98db4d4 8ff5d8 b5a2 f883 ba7b3c7 2691 f699 28b5 3f8 e86352a d01 c703 c6 c6155 cf9057 8119e 7fe9 f82 30f6825 db01 077 b9e0b47a89 279c1 058d64b25c3 c1e 71a890 bb6 ed f3cb3e4 b10 f391 8a6b4 25a4b96c33e6 b52 ed4d7 b275a 18f2314a7 c5fba5 c3 c911 58b7 380a85a 6d16 4e3a5e 1c6 d524a 7eb9 d97ec3b2e 7b1 86cbb5 db59 5c6 c3a8a 063b44f6820e 78b85203 7e081 2d6e 0e08a 5bf0 8353 c6efdbdd55 f94 60367a 1a219 0195 fc1 fcd0c51c8d69 d7b77634a 0f8 69ab9dc90 892a7 0207 c48a0 db5 3f2 0064 b062 34d1 47a6 c5ac6 f61 f46 4c4 93c48 b7d20 d8e b72e0 7b60a 2e0b0b8e 4dc823abf16 00f6a5dbf8 bb1 ce7e 331fc9 f6d5 61dfc02a7 865de7f527b4a2c7f9 181d03d3 c90 c76 097 c4be 2f0 79d9 8dc717 b63 d9ff8673a 44a76 b8f5e875a 5f2 69ab4 435 f924 7f0 14749 5e249 7b3e 7c4 4675 58 a68d979 76fb5 f9312 d84 bc0 d5fb1e 614f9149 8e5b18389 4b5 d3f5200 5b0a5 01f 5b24e3ff 582d497e b5e27 03138 dd3 1d4 935b7548 cb4 0bf4dc0b9 cc25f6605 8a7 d0b39 b849a ef6 d3b82d6 1e55aa4 47a34 c19 f1b977a49 82f9c4 b81 6a3f9 3259 76 f7cbf9 9403 fe5d295b259d7b9 0dd2 f3e d757 d235 55a08 61d5 f0 be5b93b8 4d25 66eb79 c37 b3 c8cd674a 1c0 3b83 b6b1a10 c78b25a7e4 c83 022e f059 588b21421 d 6ed08 c1b78eea c177fb5 3b2 b24 f40d34eb de7a3a 6f0 517d83b8 e8d5 c78 79206 c365aa2 22e58 532a1e 8c1 6b1 69ef501dfc48994 e3e07 e54a5 d7ee4 407a2e 9617 b5f8 82b2 f6 b852e 6307 3280a b5b8 78bc4dcdfcc6ff6b2f2 0d30 7e9d0f4 35fb32 11e0e9 de8ba 18d7 02a2 c92 c0cb784 4ac6 0f26 c1 c054 6b04 c8 cd1 24f53e34 e989 007831 f08 be8d9d7ff3 b76ae 1592ff8e 63eb f42 c19 6b4e 12415 4cc9ae7 9f3 34b 4ff81fc08e7 f157 c55 64f5d7e 0d0 b616 f418 78ddc6 c0a3 3da66 3243 588b128 c0 7e0e875 d038 1c6 12a3 c660 2b1e c6b1d05 b9 cc6 f02 11d9 93d8 2ab8 c510 c6e 2f3 7cf78f9aeb78 42a85 d478 d5e b2f44c4d87 5da7 c36a2 c1a9 f55 baf5 d9e0 2ce8 c5 4c13 fcf09d1ef3f6 867ac773 fc0 c859 d3 f430e 90b3 6fe3 2a401 d79a7a 3c2 6f8 c7a175 df1a3207 5f6a 3e081 53c84e7a0 533 c10 d158e 0d50fb4a 8d8 b94 f2f729 f e3924 f47d6743 b4f31e17 9d5 f11 f82 d7b7ad3 f784 82b5 c65 c58 3a56 f501e 23a1 1355bea 1087 be4b57d7 b92 7eff6702 465a1 b9d2 3a389 409 c39a30 312b5fe0 6fe 83d9db3e7 ee33a f8e51 c5 b8a853 8d7 00313 f5 dc2a d936 3a3ef7f7 2d89 306e6 31 c5d9 60b3 6f9 be71 39ed 724a60 c06 662a7a 184bce6 c86 b21d3877 b18 c8be 6db82 e3083a1 fe11 b4350 0a251 996a f4025 1e525 90e0e 9e235 6dd348 f7e13 982 b5913 62b8ff4 cfb7b2 b498 1e6 c5e54 de90e 94c0130 0f8e 5158 f5 b0044 471 f83d013 f7 ab27a6e2 e738a2 f0 c256 bd5 9b74 d78e 78c6c1 597b758e5 5e7 f9d6 025 c9f2685a NHẬN XÉT CỦA HỘI ĐỒNG Trang 51142e4 7e7 f89a7 cfd2396 2cf670a 028b4b07 0f4 8b0e 586b840 b16 f308 f26e 1d e27334 d680 7e1b6d06 3ba21 940e3 7dea c5bb471 3c3 28867 f8 bbed 74e2 c780 6d1 95fe17 7b08 58d8 5313 9d45 20f8b9a3 690a4 754e7 b437 2298 7ae3bea 9374 f30 b3 49a74ff65 d2f937e7 d8e bc5 d43b334 b4414 418a0 deab4 1a1aa0ab21b9 c77 30ab c2c5 6b9 bf4 8e75 f2b175 f1f1455ff9 7a0e0e 8e09 f963 70b8 91396 2514 b9e d3f d36247a 1b1 c74 02f9ed93 221a4 49e34a 7aa2c71e9ae bcb71 c4c0eeb2 484b96aa 83087 f6f9e470 c72 ed5 f4e8 f8e8 e845 306b4f1 d3e7 8fba019 f352ae 3be4 01bf5 bd0e7a 5b28 b8ab54754 3a243 6fbddc64 f8b7be0 43d1 c15 5f9 fcd5b1 696b0cb2a c7ee8eaa 6e7a5a0 b474 52f5b9 77b4 1f9 c6aee 2a01ad0196 f09 493a82 ec4 2e1d8 b78c8c4 233 f1298aa 4e2 cc1 6c68 7da2 22a65 fe7d9 ebf114bfcfa6a0e 104d1170 11e6767 7a94e 9cf5dcf4 81d7a65d25f4f7 492 c70ee4 6529a 0a8d0 045b1864 8d3 2e9fc38bc1b5e54a7 d9a0 511b1d15 e71e9 06750 e488 7c8 f759 c16 5f7 b8efaa e1 e9ff5f31 4e2a77 32b33ed 9a4d4 bc1 1b3 4240 c709 8bf6077 5b09 b0b69dc0a60 29 2df4 eb48 54dc3e8 635d18f750dd256 b9ffac0 1a3b83d1 61a119 2e9b1d3e 4a8d5 fc65 1f6 8288 b2a526 d78 71a5 c3e52a bcb76 f663e 7bba 0363fb5 06a396 2751 d68 d05228 b00 3115a5 d1e8 90d4 b40 05c4 21ad3ec4 dc4a5e62 b531 0c5 cb7c7a9 5d5 926c8 2cbe7f40c821 f04e2a 4e68 2a5d0 4d6e 01c3 9610 c88 5a66b3e545 7b42 839 78782be6d7 8fb9256 0715 06076 8471a 16bc29e cffad44 e26c5013 d6ad2065 c68 64f36 c48 d7fb4 f4b3 f8e 98db4d4 8ff5d8 b5a2 f883 ba7b3c7 2691 f699 28b5 3f8 e86352a d01 c703 c6 c6155 cf9057 8119e 7fe9 f82 30f6825 db01 077 b9e0b47a89 279c1 058d64b25c3 c1e 71a890 bb6 ed f3cb3e4 b10 f391 8a6b4 25a4b96c33e6 b52 ed4d7 b275a 18f2314a7 c5fba5 c3 c911 58b7 380a85a 6d16 4e3a5e 1c6 d524a 7eb9 d97ec3b2e 7b1 86cbb5 db59 5c6 c3a8a 063b44f6820e 78b85203 7e081 2d6e 0e08a 5bf0 8353 c6efdbdd55 f94 60367a 1a219 0195 fc1 fcd0c51c8d69 d7b77634a 0f8 69ab9dc90 892a7 0207 c48a0 db5 3f2 0064 b062 34d1 47a6 c5ac6 f61 f46 4c4 93c48 b7d20 d8e b72e0 7b60a 2e0b0b8e 4dc823abf16 00f6a5dbf8 bb1 ce7e 331fc9 f6d5 61dfc02a7 865de7f527b4a2c7f9 181d03d3 c90 c76 097 c4be 2f0 79d9 8dc717 b63 d9ff8673a 44a76 b8f5e875a 5f2 69ab4 435 f924 7f0 14749 5e249 7b3e 7c4 4675 58 a68d979 76fb5 f9312 d84 bc0 d5fb1e 614f9149 8e5b18389 4b5 d3f5200 5b0a5 01f 5b24e3ff 582d497e b5e27 03138 dd3 1d4 935b7548 cb4 0bf4dc0b9 cc25f6605 8a7 d0b39 b849a ef6 d3b82d6 1e55aa4 47a34 c19 f1b977a49 82f9c4 b81 6a3f9 3259 76 f7cbf9 9403 fe5d295b259d7b9 0dd2 f3e d757 d235 55a08 61d5 f0 be5b93b8 4d25 66eb79 c37 b3 c8cd674a 1c0 3b83 b6b1a10 c78b25a7e4 c83 022e f059 588b21421 d 6ed08 c1b78eea c177fb5 3b2 b24 f40d34eb de7a3a 6f0 517d83b8 e8d5 c78 79206 c365aa2 22e58 532a1e 8c1 6b1 69ef501dfc48994 e3e07 e54a5 d7ee4 407a2e 9617 b5f8 82b2 f6 b852e 6307 3280a b5b8 78bc4dcdfcc6ff6b2f2 0d30 7e9d0f4 35fb32 11e0e9 de8ba 18d7 02a2 c92 c0cb784 4ac6 0f26 c1 c054 6b04 c8 cd1 24f53e34 e989 007831 f08 be8d9d7ff3 b76ae 1592ff8e 63eb f42 c19 6b4e 12415 4cc9ae7 9f3 34b 4ff81fc08e7 f157 c55 64f5d7e 0d0 b616 f418 78ddc6 c0a3 3da66 3243 588b128 c0 7e0e875 d038 1c6 12a3 c660 2b1e c6b1d05 b9 cc6 f02 11d9 93d8 2ab8 c510 c6e 2f3 7cf78f9aeb78 42a85 d478 d5e b2f44c4d87 5da7 c36a2 c1a9 f55 baf5 d9e0 2ce8 c5 4c13 fcf09d1ef3f6 867ac773 fc0 c859 d3 f430e 90b3 6fe3 2a401 d79a7a 3c2 6f8 c7a175 df1a3207 5f6a 3e081 53c84e7a0 533 c10 d158e 0d50fb4a 8d8 b94 f2f729 f e3924 f47d6743 b4f31e17 9d5 f11 f82 d7b7ad3 f784 82b5 c65 c58 3a56 f501e 23a1 1355bea 1087 be4b57d7 b92 7eff6702 465a1 b9d2 3a389 409 c39a30 312b5fe0 6fe 83d9db3e7 ee33a f8e51 c5 b8a853 8d7 00313 f5 dc2a d936 3a3ef7f7 2d89 306e6 31 c5d9 60b3 6f9 be71 39ed 724a60 c06 662a7a 184bce6 c86 b21d3877 b18 c8be 6db82 e3083a1 fe11 b4350 0a251 996a f4025 1e525 90e0e 9e235 6dd348 f7e13 982 b5913 62b8ff4 cfb7b2 b498 1e6 c5e54 de90e 94c0130 0f8e 5158 f5 b0044 471 f83d013 f7 ab27a6e2 e738a2 f0 c256 bd5 9b74 d78e 78c6c1 597b758e5 5e7 f9d6 025 c9f2685a LỜI CẢM ƠN Với lòng trân trọng biết ơn sâu sắc, em xin gởi lời cảm ơn chân thành đến: Thầy Dương Thúc Huy, người Thầy tận tình hướng dẫn, bảo, tài trợ cho em suốt thời gian thực khóa luận Thầy nhiệt tâm giảng dạy, hướng dẫn, quan tâm giúp đỡ em trình học tập trường Các Thầy/ Cơ khoa Hóa, đặc biệt Thầy/ Cơ mơn Hóa hữu tận tình giảng dạy, bảo tạo điều kiện để em hồn thành luận văn Thầy/ Cơ mơn Hóa Hữu Cơ trường Đại Học Sư Phạm Tp.HCM, nhận lời phản biện, đóng góp nhiều ý kiến giúp em hiểu rõ thêm nội dung mà thực Các bạn Lê Thị Kim Dung, Trần Thị Ngọc Nhung, Hạng Tái Xuân Hòa bạn, em sinh viên lớp K38, K39, Khoa Hóa trường ĐHSP Tp.HCM cộng tác, bảo tận tình giúp đỡ em trình nghiên cứu Cuối cùng, em xin bày tỏ lòng biết ơn sâu sắc đến ba mẹ em tạo điều kiện vật chất, điểm dựa tinh thần cho em trình học tập nghiên cứu trường Trang 51142e4 7e7 f89a7 cfd2396 2cf670a 028b4b07 0f4 8b0e 586b840 b16 f308 f26e 1d e27334 d680 7e1b6d06 3ba21 940e3 7dea c5bb471 3c3 28867 f8 bbed 74e2 c780 6d1 95fe17 7b08 58d8 5313 9d45 20f8b9a3 690a4 754e7 b437 2298 7ae3bea 9374 f30 b3 49a74ff65 d2f937e7 d8e bc5 d43b334 b4414 418a0 deab4 1a1aa0ab21b9 c77 30ab c2c5 6b9 bf4 8e75 f2b175 f1f1455ff9 7a0e0e 8e09 f963 70b8 91396 2514 b9e d3f d36247a 1b1 c74 02f9ed93 221a4 49e34a 7aa2c71e9ae bcb71 c4c0eeb2 484b96aa 83087 f6f9e470 c72 ed5 f4e8 f8e8 e845 306b4f1 d3e7 8fba019 f352ae 3be4 01bf5 bd0e7a 5b28 b8ab54754 3a243 6fbddc64 f8b7be0 43d1 c15 5f9 fcd5b1 696b0cb2a c7ee8eaa 6e7a5a0 b474 52f5b9 77b4 1f9 c6aee 2a01ad0196 f09 493a82 ec4 2e1d8 b78c8c4 233 f1298aa 4e2 cc1 6c68 7da2 22a65 fe7d9 ebf114bfcfa6a0e 104d1170 11e6767 7a94e 9cf5dcf4 81d7a65d25f4f7 492 c70ee4 6529a 0a8d0 045b1864 8d3 2e9fc38bc1b5e54a7 d9a0 511b1d15 e71e9 06750 e488 7c8 f759 c16 5f7 b8efaa e1 e9ff5f31 4e2a77 32b33ed 9a4d4 bc1 1b3 4240 c709 8bf6077 5b09 b0b69dc0a60 29 2df4 eb48 54dc3e8 635d18f750dd256 b9ffac0 1a3b83d1 61a119 2e9b1d3e 4a8d5 fc65 1f6 8288 b2a526 d78 71a5 c3e52a bcb76 f663e 7bba 0363fb5 06a396 2751 d68 d05228 b00 3115a5 d1e8 90d4 b40 05c4 21ad3ec4 dc4a5e62 b531 0c5 cb7c7a9 5d5 926c8 2cbe7f40c821 f04e2a 4e68 2a5d0 4d6e 01c3 9610 c88 5a66b3e545 7b42 839 78782be6d7 8fb9256 0715 06076 8471a 16bc29e cffad44 e26c5013 d6ad2065 c68 64f36 c48 d7fb4 f4b3 f8e 98db4d4 8ff5d8 b5a2 f883 ba7b3c7 2691 f699 28b5 3f8 e86352a d01 c703 c6 c6155 cf9057 8119e 7fe9 f82 30f6825 db01 077 b9e0b47a89 279c1 058d64b25c3 c1e 71a890 bb6 ed f3cb3e4 b10 f391 8a6b4 25a4b96c33e6 b52 ed4d7 b275a 18f2314a7 c5fba5 c3 c911 58b7 380a85a 6d16 4e3a5e 1c6 d524a 7eb9 d97ec3b2e 7b1 86cbb5 db59 5c6 c3a8a 063b44f6820e 78b85203 7e081 2d6e 0e08a 5bf0 8353 c6efdbdd55 f94 60367a 1a219 0195 fc1 fcd0c51c8d69 d7b77634a 0f8 69ab9dc90 892a7 0207 c48a0 db5 3f2 0064 b062 34d1 47a6 c5ac6 f61 f46 4c4 93c48 b7d20 d8e b72e0 7b60a 2e0b0b8e 4dc823abf16 00f6a5dbf8 bb1 ce7e 331fc9 f6d5 61dfc02a7 865de7f527b4a2c7f9 181d03d3 c90 c76 097 c4be 2f0 79d9 8dc717 b63 d9ff8673a 44a76 b8f5e875a 5f2 69ab4 435 f924 7f0 14749 5e249 7b3e 7c4 4675 58 a68d979 76fb5 f9312 d84 bc0 d5fb1e 614f9149 8e5b18389 4b5 d3f5200 5b0a5 01f 5b24e3ff 582d497e b5e27 03138 dd3 1d4 935b7548 cb4 0bf4dc0b9 cc25f6605 8a7 d0b39 b849a ef6 d3b82d6 1e55aa4 47a34 c19 f1b977a49 82f9c4 b81 6a3f9 3259 76 f7cbf9 9403 fe5d295b259d7b9 0dd2 f3e d757 d235 55a08 61d5 f0 be5b93b8 4d25 66eb79 c37 b3 c8cd674a 1c0 3b83 b6b1a10 c78b25a7e4 c83 022e f059 588b21421 d 6ed08 c1b78eea c177fb5 3b2 b24 f40d34eb de7a3a 6f0 517d83b8 e8d5 c78 79206 c365aa2 22e58 532a1e 8c1 6b1 69ef501dfc48994 e3e07 e54a5 d7ee4 407a2e 9617 b5f8 82b2 f6 b852e 6307 3280a b5b8 78bc4dcdfcc6ff6b2f2 0d30 7e9d0f4 35fb32 11e0e9 de8ba 18d7 02a2 c92 c0cb784 4ac6 0f26 c1 c054 6b04 c8 cd1 24f53e34 e989 007831 f08 be8d9d7ff3 b76ae 1592ff8e 63eb f42 c19 6b4e 12415 4cc9ae7 9f3 34b 4ff81fc08e7 f157 c55 64f5d7e 0d0 b616 f418 78ddc6 c0a3 3da66 3243 588b128 c0 7e0e875 d038 1c6 12a3 c660 2b1e c6b1d05 b9 cc6 f02 11d9 93d8 2ab8 c510 c6e 2f3 7cf78f9aeb78 42a85 d478 d5e b2f44c4d87 5da7 c36a2 c1a9 f55 baf5 d9e0 2ce8 c5 4c13 fcf09d1ef3f6 867ac773 fc0 c859 d3 f430e 90b3 6fe3 2a401 d79a7a 3c2 6f8 c7a175 df1a3207 5f6a 3e081 53c84e7a0 533 c10 d158e 0d50fb4a 8d8 b94 f2f729 f e3924 f47d6743 b4f31e17 9d5 f11 f82 d7b7ad3 f784 82b5 c65 c58 3a56 f501e 23a1 1355bea 1087 be4b57d7 b92 7eff6702 465a1 b9d2 3a389 409 c39a30 312b5fe0 6fe 83d9db3e7 ee33a f8e51 c5 b8a853 8d7 00313 f5 dc2a d936 3a3ef7f7 2d89 306e6 31 c5d9 60b3 6f9 be71 39ed 724a60 c06 662a7a 184bce6 c86 b21d3877 b18 c8be 6db82 e3083a1 fe11 b4350 0a251 996a f4025 1e525 90e0e 9e235 6dd348 f7e13 982 b5913 62b8ff4 cfb7b2 b498 1e6 c5e54 de90e 94c0130 0f8e 5158 f5 b0044 471 f83d013 f7 ab27a6e2 e738a2 f0 c256 bd5 9b74 d78e 78c6c1 597b758e5 5e7 f9d6 025 c9f2685a MỤC LỤC LỜI CẢM ƠN MỤC LỤC Trang DANH MỤC CÁC KÝ HIỆU, CÁC CHỮ VIẾT TẮT DANH MỤC CÁC BẢNG DANH MỤC CÁC HÌNH VẼ, SƠ ĐỒ DANH MỤC CÁC PHỤ LỤC PHỔ PHẦN MỞ ĐẦU CHƯƠNG 1: TỔNG QUAN 1.1 Vài nét chi Pestalotiopsis sp 1.2 Các nghiên cứu hóa sinh loài nấm Pestalotiopsis 1.2.1 Cây chưa xác định loài Trung Quốc 1.2.2 Cây đặc hữu vùng, khơng có Việt Nam 1.2.2.1 Melaleuca quinquenervia (Tràm gió) 1.2.2.2 Virola mechelii (Myristicaceae) Brazil 1.2.3 Cây vùng rừng ngập mặn 1.2.3.1 Cây Đưng Rhizophora mucronata 1.2.3.2 Cây Sấu Dracontomelon duperreanum 1.2.3.3 Cây Bần chua Sonneratica caseolaris 1.2.3.4 Cây Trang Kandelia candel (L.) Druce 1.2.3.5 Cây Sú biển Aegiceras corniculatum 1.2.4 Các loài khác 1.2.4.1 Cây trà Trung Quốc Camellia sinensis 1.2.4.2 Thông la hán Podocarpus macrophyllus 1.2.4.3 Cây cau vua Roystonea regia 1.2.4.4 Thông trắng Pinus armandii CHƯƠNG 2: THỰC NGHIỆM 19 Trang 2.1 Hóa chất, thiết bị, dụng cụ 19 2.1.1 Hóa chất 19 2.1.2 Thiết bị, dụng cụ 19 2.2 Nguyên liệu 19 2.3 Quy trình thực nghiệm 20 2.3.1 Sắc ký cột cao Et3 20 2.3.2 Sắc ký mỏng W1 20 CHƯƠNG 3: KẾT QUẢ VÀ THẢO LUẬN 3.1 Khảo sát cấu trúc hợp chất Et35 22 22 3.1.1 Đặc điểm hợp chất Et35 22 3.1.2 Biện luận cấu trúc hợp chất Et35 22 3.2 Khảo sát cấu trúc hợp chất EtA 25 3.2.1 Đặc điểm hợp chất EtA 25 3.2.2 Biện luận cấu trúc hợp chất EtA 25 CHƯƠNG 4: KẾT LUẬN- ĐỀ XUẤT 27 TÀI LIỆU THAM KHẢO 28 PHỤ LỤC Trang 51142e4 7e7 f89a7 cfd2396 2cf670a 028b4b07 0f4 8b0e 586b840 b16 f308 f26e 1d e27334 d680 7e1b6d06 3ba21 940e3 7dea c5bb471 3c3 28867 f8 bbed 74e2 c780 6d1 95fe17 7b08 58d8 5313 9d45 20f8b9a3 690a4 754e7 b437 2298 7ae3bea 9374 f30 b3 49a74ff65 d2f937e7 d8e bc5 d43b334 b4414 418a0 deab4 1a1aa0ab21b9 c77 30ab c2c5 6b9 bf4 8e75 f2b175 f1f1455ff9 7a0e0e 8e09 f963 70b8 91396 2514 b9e d3f d36247a 1b1 c74 02f9ed93 221a4 49e34a 7aa2c71e9ae bcb71 c4c0eeb2 484b96aa 83087 f6f9e470 c72 ed5 f4e8 f8e8 e845 306b4f1 d3e7 8fba019 f352ae 3be4 01bf5 bd0e7a 5b28 b8ab54754 3a243 6fbddc64 f8b7be0 43d1 c15 5f9 fcd5b1 696b0cb2a c7ee8eaa 6e7a5a0 b474 52f5b9 77b4 1f9 c6aee 2a01ad0196 f09 493a82 ec4 2e1d8 b78c8c4 233 f1298aa 4e2 cc1 6c68 7da2 22a65 fe7d9 ebf114bfcfa6a0e 104d1170 11e6767 7a94e 9cf5dcf4 81d7a65d25f4f7 492 c70ee4 6529a 0a8d0 045b1864 8d3 2e9fc38bc1b5e54a7 d9a0 511b1d15 e71e9 06750 e488 7c8 f759 c16 5f7 b8efaa e1 e9ff5f31 4e2a77 32b33ed 9a4d4 bc1 1b3 4240 c709 8bf6077 5b09 b0b69dc0a60 29 2df4 eb48 54dc3e8 635d18f750dd256 b9ffac0 1a3b83d1 61a119 2e9b1d3e 4a8d5 fc65 1f6 8288 b2a526 d78 71a5 c3e52a bcb76 f663e 7bba 0363fb5 06a396 2751 d68 d05228 b00 3115a5 d1e8 90d4 b40 05c4 21ad3ec4 dc4a5e62 b531 0c5 cb7c7a9 5d5 926c8 2cbe7f40c821 f04e2a 4e68 2a5d0 4d6e 01c3 9610 c88 5a66b3e545 7b42 839 78782be6d7 8fb9256 0715 06076 8471a 16bc29e cffad44 e26c5013 d6ad2065 c68 64f36 c48 d7fb4 f4b3 f8e 98db4d4 8ff5d8 b5a2 f883 ba7b3c7 2691 f699 28b5 3f8 e86352a d01 c703 c6 c6155 cf9057 8119e 7fe9 f82 30f6825 db01 077 b9e0b47a89 279c1 058d64b25c3 c1e 71a890 bb6 ed f3cb3e4 b10 f391 8a6b4 25a4b96c33e6 b52 ed4d7 b275a 18f2314a7 c5fba5 c3 c911 58b7 380a85a 6d16 4e3a5e 1c6 d524a 7eb9 d97ec3b2e 7b1 86cbb5 db59 5c6 c3a8a 063b44f6820e 78b85203 7e081 2d6e 0e08a 5bf0 8353 c6efdbdd55 f94 60367a 1a219 0195 fc1 fcd0c51c8d69 d7b77634a 0f8 69ab9dc90 892a7 0207 c48a0 db5 3f2 0064 b062 34d1 47a6 c5ac6 f61 f46 4c4 93c48 b7d20 d8e b72e0 7b60a 2e0b0b8e 4dc823abf16 00f6a5dbf8 bb1 ce7e 331fc9 f6d5 61dfc02a7 865de7f527b4a2c7f9 181d03d3 c90 c76 097 c4be 2f0 79d9 8dc717 b63 d9ff8673a 44a76 b8f5e875a 5f2 69ab4 435 f924 7f0 14749 5e249 7b3e 7c4 4675 58 a68d979 76fb5 f9312 d84 bc0 d5fb1e 614f9149 8e5b18389 4b5 d3f5200 5b0a5 01f 5b24e3ff 582d497e b5e27 03138 dd3 1d4 935b7548 cb4 0bf4dc0b9 cc25f6605 8a7 d0b39 b849a ef6 d3b82d6 1e55aa4 47a34 c19 f1b977a49 82f9c4 b81 6a3f9 3259 76 f7cbf9 9403 fe5d295b259d7b9 0dd2 f3e d757 d235 55a08 61d5 f0 be5b93b8 4d25 66eb79 c37 b3 c8cd674a 1c0 3b83 b6b1a10 c78b25a7e4 c83 022e f059 588b21421 d 6ed08 c1b78eea c177fb5 3b2 b24 f40d34eb de7a3a 6f0 517d83b8 e8d5 c78 79206 c365aa2 22e58 532a1e 8c1 6b1 69ef501dfc48994 e3e07 e54a5 d7ee4 407a2e 9617 b5f8 82b2 f6 b852e 6307 3280a b5b8 78bc4dcdfcc6ff6b2f2 0d30 7e9d0f4 35fb32 11e0e9 de8ba 18d7 02a2 c92 c0cb784 4ac6 0f26 c1 c054 6b04 c8 cd1 24f53e34 e989 007831 f08 be8d9d7ff3 b76ae 1592ff8e 63eb f42 c19 6b4e 12415 4cc9ae7 9f3 34b 4ff81fc08e7 f157 c55 64f5d7e 0d0 b616 f418 78ddc6 c0a3 3da66 3243 588b128 c0 7e0e875 d038 1c6 12a3 c660 2b1e c6b1d05 b9 cc6 f02 11d9 93d8 2ab8 c510 c6e 2f3 7cf78f9aeb78 42a85 d478 d5e b2f44c4d87 5da7 c36a2 c1a9 f55 baf5 d9e0 2ce8 c5 4c13 fcf09d1ef3f6 867ac773 fc0 c859 d3 f430e 90b3 6fe3 2a401 d79a7a 3c2 6f8 c7a175 df1a3207 5f6a 3e081 53c84e7a0 533 c10 d158e 0d50fb4a 8d8 b94 f2f729 f e3924 f47d6743 b4f31e17 9d5 f11 f82 d7b7ad3 f784 82b5 c65 c58 3a56 f501e 23a1 1355bea 1087 be4b57d7 b92 7eff6702 465a1 b9d2 3a389 409 c39a30 312b5fe0 6fe 83d9db3e7 ee33a f8e51 c5 b8a853 8d7 00313 f5 dc2a d936 3a3ef7f7 2d89 306e6 31 c5d9 60b3 6f9 be71 39ed 724a60 c06 662a7a 184bce6 c86 b21d3877 b18 c8be 6db82 e3083a1 fe11 b4350 0a251 996a f4025 1e525 90e0e 9e235 6dd348 f7e13 982 b5913 62b8ff4 cfb7b2 b498 1e6 c5e54 de90e 94c0130 0f8e 5158 f5 b0044 471 f83d013 f7 ab27a6e2 e738a2 f0 c256 bd5 9b74 d78e 78c6c1 597b758e5 5e7 f9d6 025 c9f2685a 51142e4 7e7 f89a7 cfd2396 2cf670a 028b4b07 0f4 8b0e 586b840 b16 f308 f26e 1d e27334 d680 7e1b6d06 3ba21 940e3 7dea c5bb471 3c3 28867 f8 bbed 74e2 c780 6d1 95fe17 7b08 58d8 5313 9d45 20f8b9a3 690a4 754e7 b437 2298 7ae3bea 9374 f30 b3 49a74ff65 d2f937e7 d8e bc5 d43b334 b4414 418a0 deab4 1a1aa0ab21b9 c77 30ab c2c5 6b9 bf4 8e75 f2b175 f1f1455ff9 7a0e0e 8e09 f963 70b8 91396 2514 b9e d3f d36247a 1b1 c74 02f9ed93 221a4 49e34a 7aa2c71e9ae bcb71 c4c0eeb2 484b96aa 83087 f6f9e470 c72 ed5 f4e8 f8e8 e845 306b4f1 d3e7 8fba019 f352ae 3be4 01bf5 bd0e7a 5b28 b8ab54754 3a243 6fbddc64 f8b7be0 43d1 c15 5f9 fcd5b1 696b0cb2a c7ee8eaa 6e7a5a0 b474 52f5b9 77b4 1f9 c6aee 2a01ad0196 f09 493a82 ec4 2e1d8 b78c8c4 233 f1298aa 4e2 cc1 6c68 7da2 22a65 fe7d9 ebf114bfcfa6a0e 104d1170 11e6767 7a94e 9cf5dcf4 81d7a65d25f4f7 492 c70ee4 6529a 0a8d0 045b1864 8d3 2e9fc38bc1b5e54a7 d9a0 511b1d15 e71e9 06750 e488 7c8 f759 c16 5f7 b8efaa e1 e9ff5f31 4e2a77 32b33ed 9a4d4 bc1 1b3 4240 c709 8bf6077 5b09 b0b69dc0a60 29 2df4 eb48 54dc3e8 635d18f750dd256 b9ffac0 1a3b83d1 61a119 2e9b1d3e 4a8d5 fc65 1f6 8288 b2a526 d78 71a5 c3e52a bcb76 f663e 7bba 0363fb5 06a396 2751 d68 d05228 b00 3115a5 d1e8 90d4 b40 05c4 21ad3ec4 dc4a5e62 b531 0c5 cb7c7a9 5d5 926c8 2cbe7f40c821 f04e2a 4e68 2a5d0 4d6e 01c3 9610 c88 5a66b3e545 7b42 839 78782be6d7 8fb9256 0715 06076 8471a 16bc29e cffad44 e26c5013 d6ad2065 c68 64f36 c48 d7fb4 f4b3 f8e 98db4d4 8ff5d8 b5a2 f883 ba7b3c7 2691 f699 28b5 3f8 e86352a d01 c703 c6 c6155 cf9057 8119e 7fe9 f82 30f6825 db01 077 b9e0b47a89 279c1 058d64b25c3 c1e 71a890 bb6 ed f3cb3e4 b10 f391 8a6b4 25a4b96c33e6 b52 ed4d7 b275a 18f2314a7 c5fba5 c3 c911 58b7 380a85a 6d16 4e3a5e 1c6 d524a 7eb9 d97ec3b2e 7b1 86cbb5 db59 5c6 c3a8a 063b44f6820e 78b85203 7e081 2d6e 0e08a 5bf0 8353 c6efdbdd55 f94 60367a 1a219 0195 fc1 fcd0c51c8d69 d7b77634a 0f8 69ab9dc90 892a7 0207 c48a0 db5 3f2 0064 b062 34d1 47a6 c5ac6 f61 f46 4c4 93c48 b7d20 d8e b72e0 7b60a 2e0b0b8e 4dc823abf16 00f6a5dbf8 bb1 ce7e 331fc9 f6d5 61dfc02a7 865de7f527b4a2c7f9 181d03d3 c90 c76 097 c4be 2f0 79d9 8dc717 b63 d9ff8673a 44a76 b8f5e875a 5f2 69ab4 435 f924 7f0 14749 5e249 7b3e 7c4 4675 58 a68d979 76fb5 f9312 d84 bc0 d5fb1e 614f9149 8e5b18389 4b5 d3f5200 5b0a5 01f 5b24e3ff 582d497e b5e27 03138 dd3 1d4 935b7548 cb4 0bf4dc0b9 cc25f6605 8a7 d0b39 b849a ef6 d3b82d6 1e55aa4 47a34 c19 f1b977a49 82f9c4 b81 6a3f9 3259 76 f7cbf9 9403 fe5d295b259d7b9 0dd2 f3e d757 d235 55a08 61d5 f0 be5b93b8 4d25 66eb79 c37 b3 c8cd674a 1c0 3b83 b6b1a10 c78b25a7e4 c83 022e f059 588b21421 d 6ed08 c1b78eea c177fb5 3b2 b24 f40d34eb de7a3a 6f0 517d83b8 e8d5 c78 79206 c365aa2 22e58 532a1e 8c1 6b1 69ef501dfc48994 e3e07 e54a5 d7ee4 407a2e 9617 b5f8 82b2 f6 b852e 6307 3280a b5b8 78bc4dcdfcc6ff6b2f2 0d30 7e9d0f4 35fb32 11e0e9 de8ba 18d7 02a2 c92 c0cb784 4ac6 0f26 c1 c054 6b04 c8 cd1 24f53e34 e989 007831 f08 be8d9d7ff3 b76ae 1592ff8e 63eb f42 c19 6b4e 12415 4cc9ae7 9f3 34b 4ff81fc08e7 f157 c55 64f5d7e 0d0 b616 f418 78ddc6 c0a3 3da66 3243 588b128 c0 7e0e875 d038 1c6 12a3 c660 2b1e c6b1d05 b9 cc6 f02 11d9 93d8 2ab8 c510 c6e 2f3 7cf78f9aeb78 42a85 d478 d5e b2f44c4d87 5da7 c36a2 c1a9 f55 baf5 d9e0 2ce8 c5 4c13 fcf09d1ef3f6 867ac773 fc0 c859 d3 f430e 90b3 6fe3 2a401 d79a7a 3c2 6f8 c7a175 df1a3207 5f6a 3e081 53c84e7a0 533 c10 d158e 0d50fb4a 8d8 b94 f2f729 f e3924 f47d6743 b4f31e17 9d5 f11 f82 d7b7ad3 f784 82b5 c65 c58 3a56 f501e 23a1 1355bea 1087 be4b57d7 b92 7eff6702 465a1 b9d2 3a389 409 c39a30 312b5fe0 6fe 83d9db3e7 ee33a f8e51 c5 b8a853 8d7 00313 f5 dc2a d936 3a3ef7f7 2d89 306e6 31 c5d9 60b3 6f9 be71 39ed 724a60 c06 662a7a 184bce6 c86 b21d3877 b18 c8be 6db82 e3083a1 fe11 b4350 0a251 996a f4025 1e525 90e0e 9e235 6dd348 f7e13 982 b5913 62b8ff4 cfb7b2 b498 1e6 c5e54 de90e 94c0130 0f8e 5158 f5 b0044 471 f83d013 f7 ab27a6e2 e738a2 f0 c256 bd5 9b74 d78e 78c6c1 597b758e5 5e7 f9d6 025 c9f2685a DANH MỤC CÁC CHỮ VIẾT TẮT VÀ KÝ HIỆU DMSO : DiMethyl SulfOxide NMR : Phổ cộng hưởng từ hạt nhân (Nuclear Magnetic Resonance Spectroscopy) HMBC : Tương quan 1H-13C qua 2,3 nối (Heteronuclear Multiple Bond Coherence) HSQC : Tương quan 1H-13C qua 01 nối (Heteronuclear Single Quantum Correlation) pTLC : Sắc Chromatography) CC : H-NMR: 13 C-NMR: ký lớp mỏng điều - Layer Carbon Nuclear Magnetic Resonance m/z: mass to charge ratio Transfer ppm: part per million Dung môi Acetone AcOH : Acetic Acid EA Ethyl Acetate : Thin Proton Nuclear Magnetic Resonance Hằng số tương tác spin – spin : (preparative Sắc ký cột (Chromotogrophy Column) J: Ac chế EtOH : Ethanol Me : Methanol H : Hexane Trang 51142e4 7e7 f89a7 cfd2396 2cf670a 028b4b07 0f4 8b0e 586b840 b16 f308 f26e 1d e27334 d680 7e1b6d06 3ba21 940e3 7dea c5bb471 3c3 28867 f8 bbed 74e2 c780 6d1 95fe17 7b08 58d8 5313 9d45 20f8b9a3 690a4 754e7 b437 2298 7ae3bea 9374 f30 b3 49a74ff65 d2f937e7 d8e bc5 d43b334 b4414 418a0 deab4 1a1aa0ab21b9 c77 30ab c2c5 6b9 bf4 8e75 f2b175 f1f1455ff9 7a0e0e 8e09 f963 70b8 91396 2514 b9e d3f d36247a 1b1 c74 02f9ed93 221a4 49e34a 7aa2c71e9ae bcb71 c4c0eeb2 484b96aa 83087 f6f9e470 c72 ed5 f4e8 f8e8 e845 306b4f1 d3e7 8fba019 f352ae 3be4 01bf5 bd0e7a 5b28 b8ab54754 3a243 6fbddc64 f8b7be0 43d1 c15 5f9 fcd5b1 696b0cb2a c7ee8eaa 6e7a5a0 b474 52f5b9 77b4 1f9 c6aee 2a01ad0196 f09 493a82 ec4 2e1d8 b78c8c4 233 f1298aa 4e2 cc1 6c68 7da2 22a65 fe7d9 ebf114bfcfa6a0e 104d1170 11e6767 7a94e 9cf5dcf4 81d7a65d25f4f7 492 c70ee4 6529a 0a8d0 045b1864 8d3 2e9fc38bc1b5e54a7 d9a0 511b1d15 e71e9 06750 e488 7c8 f759 c16 5f7 b8efaa e1 e9ff5f31 4e2a77 32b33ed 9a4d4 bc1 1b3 4240 c709 8bf6077 5b09 b0b69dc0a60 29 2df4 eb48 54dc3e8 635d18f750dd256 b9ffac0 1a3b83d1 61a119 2e9b1d3e 4a8d5 fc65 1f6 8288 b2a526 d78 71a5 c3e52a bcb76 f663e 7bba 0363fb5 06a396 2751 d68 d05228 b00 3115a5 d1e8 90d4 b40 05c4 21ad3ec4 dc4a5e62 b531 0c5 cb7c7a9 5d5 926c8 2cbe7f40c821 f04e2a 4e68 2a5d0 4d6e 01c3 9610 c88 5a66b3e545 7b42 839 78782be6d7 8fb9256 0715 06076 8471a 16bc29e cffad44 e26c5013 d6ad2065 c68 64f36 c48 d7fb4 f4b3 f8e 98db4d4 8ff5d8 b5a2 f883 ba7b3c7 2691 f699 28b5 3f8 e86352a d01 c703 c6 c6155 cf9057 8119e 7fe9 f82 30f6825 db01 077 b9e0b47a89 279c1 058d64b25c3 c1e 71a890 bb6 ed f3cb3e4 b10 f391 8a6b4 25a4b96c33e6 b52 ed4d7 b275a 18f2314a7 c5fba5 c3 c911 58b7 380a85a 6d16 4e3a5e 1c6 d524a 7eb9 d97ec3b2e 7b1 86cbb5 db59 5c6 c3a8a 063b44f6820e 78b85203 7e081 2d6e 0e08a 5bf0 8353 c6efdbdd55 f94 60367a 1a219 0195 fc1 fcd0c51c8d69 d7b77634a 0f8 69ab9dc90 892a7 0207 c48a0 db5 3f2 0064 b062 34d1 47a6 c5ac6 f61 f46 4c4 93c48 b7d20 d8e b72e0 7b60a 2e0b0b8e 4dc823abf16 00f6a5dbf8 bb1 ce7e 331fc9 f6d5 61dfc02a7 865de7f527b4a2c7f9 181d03d3 c90 c76 097 c4be 2f0 79d9 8dc717 b63 d9ff8673a 44a76 b8f5e875a 5f2 69ab4 435 f924 7f0 14749 5e249 7b3e 7c4 4675 58 a68d979 76fb5 f9312 d84 bc0 d5fb1e 614f9149 8e5b18389 4b5 d3f5200 5b0a5 01f 5b24e3ff 582d497e b5e27 03138 dd3 1d4 935b7548 cb4 0bf4dc0b9 cc25f6605 8a7 d0b39 b849a ef6 d3b82d6 1e55aa4 47a34 c19 f1b977a49 82f9c4 b81 6a3f9 3259 76 f7cbf9 9403 fe5d295b259d7b9 0dd2 f3e d757 d235 55a08 61d5 f0 be5b93b8 4d25 66eb79 c37 b3 c8cd674a 1c0 3b83 b6b1a10 c78b25a7e4 c83 022e f059 588b21421 d 6ed08 c1b78eea c177fb5 3b2 b24 f40d34eb de7a3a 6f0 517d83b8 e8d5 c78 79206 c365aa2 22e58 532a1e 8c1 6b1 69ef501dfc48994 e3e07 e54a5 d7ee4 407a2e 9617 b5f8 82b2 f6 b852e 6307 3280a b5b8 78bc4dcdfcc6ff6b2f2 0d30 7e9d0f4 35fb32 11e0e9 de8ba 18d7 02a2 c92 c0cb784 4ac6 0f26 c1 c054 6b04 c8 cd1 24f53e34 e989 007831 f08 be8d9d7ff3 b76ae 1592ff8e 63eb f42 c19 6b4e 12415 4cc9ae7 9f3 34b 4ff81fc08e7 f157 c55 64f5d7e 0d0 b616 f418 78ddc6 c0a3 3da66 3243 588b128 c0 7e0e875 d038 1c6 12a3 c660 2b1e c6b1d05 b9 cc6 f02 11d9 93d8 2ab8 c510 c6e 2f3 7cf78f9aeb78 42a85 d478 d5e b2f44c4d87 5da7 c36a2 c1a9 f55 baf5 d9e0 2ce8 c5 4c13 fcf09d1ef3f6 867ac773 fc0 c859 d3 f430e 90b3 6fe3 2a401 d79a7a 3c2 6f8 c7a175 df1a3207 5f6a 3e081 53c84e7a0 533 c10 d158e 0d50fb4a 8d8 b94 f2f729 f e3924 f47d6743 b4f31e17 9d5 f11 f82 d7b7ad3 f784 82b5 c65 c58 3a56 f501e 23a1 1355bea 1087 be4b57d7 b92 7eff6702 465a1 b9d2 3a389 409 c39a30 312b5fe0 6fe 83d9db3e7 ee33a f8e51 c5 b8a853 8d7 00313 f5 dc2a d936 3a3ef7f7 2d89 306e6 31 c5d9 60b3 6f9 be71 39ed 724a60 c06 662a7a 184bce6 c86 b21d3877 b18 c8be 6db82 e3083a1 fe11 b4350 0a251 996a f4025 1e525 90e0e 9e235 6dd348 f7e13 982 b5913 62b8ff4 cfb7b2 b498 1e6 c5e54 de90e 94c0130 0f8e 5158 f5 b0044 471 f83d013 f7 ab27a6e2 e738a2 f0 c256 bd5 9b74 d78e 78c6c1 597b758e5 5e7 f9d6 025 c9f2685a DANH MỤC CÁC BẢNG Trang Bảng 1.1: Hoạt tính kháng khuẩn, kháng nấm Bảng 1.2: Hoạt tính kháng virus Bảng 1.3: Hoạt tính gây độc tế bào 10 Bảng 3.1: Dữ liệu phổ NMR (R)-(-)-5-Ethoxycarbonyl-6-methyl- 24 4-phenyl-3,4-dihydropyrimidin-2(1H)-one Et35 DMSO-d Bảng 3.2: Dữ liệu phổ NMR Uracil EtA DMSO-d 26 DANH MỤC CÁC HÌNH VẼ, SƠ ĐỒ Trang Hình 1.1: Các hợp chất lập từ nấm Pestalotiopsis 11 Hình 3.1: Một số tương quan HMBC hợp chất Et35 23 Hình 3.2: Cấu trúc đề nghị hợp chất EtA 25 Hình 4.1: Hai hợp chất lập nấm Pestalotiopsis 27 Sơ đồ 1: Quá trình ly trích lập hợp chất 21 Trang 51142e4 7e7 f89a7 cfd2396 2cf670a 028b4b07 0f4 8b0e 586b840 b16 f308 f26e 1d e27334 d680 7e1b6d06 3ba21 940e3 7dea c5bb471 3c3 28867 f8 bbed 74e2 c780 6d1 95fe17 7b08 58d8 5313 9d45 20f8b9a3 690a4 754e7 b437 2298 7ae3bea 9374 f30 b3 49a74ff65 d2f937e7 d8e bc5 d43b334 b4414 418a0 deab4 1a1aa0ab21b9 c77 30ab c2c5 6b9 bf4 8e75 f2b175 f1f1455ff9 7a0e0e 8e09 f963 70b8 91396 2514 b9e d3f d36247a 1b1 c74 02f9ed93 221a4 49e34a 7aa2c71e9ae bcb71 c4c0eeb2 484b96aa 83087 f6f9e470 c72 ed5 f4e8 f8e8 e845 306b4f1 d3e7 8fba019 f352ae 3be4 01bf5 bd0e7a 5b28 b8ab54754 3a243 6fbddc64 f8b7be0 43d1 c15 5f9 fcd5b1 696b0cb2a c7ee8eaa 6e7a5a0 b474 52f5b9 77b4 1f9 c6aee 2a01ad0196 f09 493a82 ec4 2e1d8 b78c8c4 233 f1298aa 4e2 cc1 6c68 7da2 22a65 fe7d9 ebf114bfcfa6a0e 104d1170 11e6767 7a94e 9cf5dcf4 81d7a65d25f4f7 492 c70ee4 6529a 0a8d0 045b1864 8d3 2e9fc38bc1b5e54a7 d9a0 511b1d15 e71e9 06750 e488 7c8 f759 c16 5f7 b8efaa e1 e9ff5f31 4e2a77 32b33ed 9a4d4 bc1 1b3 4240 c709 8bf6077 5b09 b0b69dc0a60 29 2df4 eb48 54dc3e8 635d18f750dd256 b9ffac0 1a3b83d1 61a119 2e9b1d3e 4a8d5 fc65 1f6 8288 b2a526 d78 71a5 c3e52a bcb76 f663e 7bba 0363fb5 06a396 2751 d68 d05228 b00 3115a5 d1e8 90d4 b40 05c4 21ad3ec4 dc4a5e62 b531 0c5 cb7c7a9 5d5 926c8 2cbe7f40c821 f04e2a 4e68 2a5d0 4d6e 01c3 9610 c88 5a66b3e545 7b42 839 78782be6d7 8fb9256 0715 06076 8471a 16bc29e cffad44 e26c5013 d6ad2065 c68 64f36 c48 d7fb4 f4b3 f8e 98db4d4 8ff5d8 b5a2 f883 ba7b3c7 2691 f699 28b5 3f8 e86352a d01 c703 c6 c6155 cf9057 8119e 7fe9 f82 30f6825 db01 077 b9e0b47a89 279c1 058d64b25c3 c1e 71a890 bb6 ed f3cb3e4 b10 f391 8a6b4 25a4b96c33e6 b52 ed4d7 b275a 18f2314a7 c5fba5 c3 c911 58b7 380a85a 6d16 4e3a5e 1c6 d524a 7eb9 d97ec3b2e 7b1 86cbb5 db59 5c6 c3a8a 063b44f6820e 78b85203 7e081 2d6e 0e08a 5bf0 8353 c6efdbdd55 f94 60367a 1a219 0195 fc1 fcd0c51c8d69 d7b77634a 0f8 69ab9dc90 892a7 0207 c48a0 db5 3f2 0064 b062 34d1 47a6 c5ac6 f61 f46 4c4 93c48 b7d20 d8e b72e0 7b60a 2e0b0b8e 4dc823abf16 00f6a5dbf8 bb1 ce7e 331fc9 f6d5 61dfc02a7 865de7f527b4a2c7f9 181d03d3 c90 c76 097 c4be 2f0 79d9 8dc717 b63 d9ff8673a 44a76 b8f5e875a 5f2 69ab4 435 f924 7f0 14749 5e249 7b3e 7c4 4675 58 a68d979 76fb5 f9312 d84 bc0 d5fb1e 614f9149 8e5b18389 4b5 d3f5200 5b0a5 01f 5b24e3ff 582d497e b5e27 03138 dd3 1d4 935b7548 cb4 0bf4dc0b9 cc25f6605 8a7 d0b39 b849a ef6 d3b82d6 1e55aa4 47a34 c19 f1b977a49 82f9c4 b81 6a3f9 3259 76 f7cbf9 9403 fe5d295b259d7b9 0dd2 f3e d757 d235 55a08 61d5 f0 be5b93b8 4d25 66eb79 c37 b3 c8cd674a 1c0 3b83 b6b1a10 c78b25a7e4 c83 022e f059 588b21421 d 6ed08 c1b78eea c177fb5 3b2 b24 f40d34eb de7a3a 6f0 517d83b8 e8d5 c78 79206 c365aa2 22e58 532a1e 8c1 6b1 69ef501dfc48994 e3e07 e54a5 d7ee4 407a2e 9617 b5f8 82b2 f6 b852e 6307 3280a b5b8 78bc4dcdfcc6ff6b2f2 0d30 7e9d0f4 35fb32 11e0e9 de8ba 18d7 02a2 c92 c0cb784 4ac6 0f26 c1 c054 6b04 c8 cd1 24f53e34 e989 007831 f08 be8d9d7ff3 b76ae 1592ff8e 63eb f42 c19 6b4e 12415 4cc9ae7 9f3 34b 4ff81fc08e7 f157 c55 64f5d7e 0d0 b616 f418 78ddc6 c0a3 3da66 3243 588b128 c0 7e0e875 d038 1c6 12a3 c660 2b1e c6b1d05 b9 cc6 f02 11d9 93d8 2ab8 c510 c6e 2f3 7cf78f9aeb78 42a85 d478 d5e b2f44c4d87 5da7 c36a2 c1a9 f55 baf5 d9e0 2ce8 c5 4c13 fcf09d1ef3f6 867ac773 fc0 c859 d3 f430e 90b3 6fe3 2a401 d79a7a 3c2 6f8 c7a175 df1a3207 5f6a 3e081 53c84e7a0 533 c10 d158e 0d50fb4a 8d8 b94 f2f729 f e3924 f47d6743 b4f31e17 9d5 f11 f82 d7b7ad3 f784 82b5 c65 c58 3a56 f501e 23a1 1355bea 1087 be4b57d7 b92 7eff6702 465a1 b9d2 3a389 409 c39a30 312b5fe0 6fe 83d9db3e7 ee33a f8e51 c5 b8a853 8d7 00313 f5 dc2a d936 3a3ef7f7 2d89 306e6 31 c5d9 60b3 6f9 be71 39ed 724a60 c06 662a7a 184bce6 c86 b21d3877 b18 c8be 6db82 e3083a1 fe11 b4350 0a251 996a f4025 1e525 90e0e 9e235 6dd348 f7e13 982 b5913 62b8ff4 cfb7b2 b498 1e6 c5e54 de90e 94c0130 0f8e 5158 f5 b0044 471 f83d013 f7 ab27a6e2 e738a2 f0 c256 bd5 9b74 d78e 78c6c1 597b758e5 5e7 f9d6 025 c9f2685a DANH MỤC PHỤ LỤC PHỔ Phụ lục 1: Phổ 1H-NMR hợp chất Et35 Phụ lục 2: Phổ 13C-NMR hợp chất Et35 Phụ lục 3: Phổ HSQC hợp chất Et35 Phụ lục 4: Phổ HMBC hợp chất Et35 Phụ lục 5: Phổ HMBC dãn rộng hợp chất Et35 Phụ lục 6: Phổ 1H-NMR hợp chất EtA Phụ lục 7: Phổ 13C-NMR hợp chất EtA Trang HỒNG KHÁNH AN KHĨA LUẬN TỐT NGHIỆP LỜI NÓI ĐẦU Trong khoảng 10 năm trở lại đây, nghiên cứu hóa học sinh học chi Pestalotiopsis sp giới trở nên phổ biến Lồi nấm thuộc chi Pestalotiopsis sinh trưởng nhiều loài thực vật khác thực vật bậc thấp nấm lỗ, địa y hay san hô bậc cao Nấm Pestalotiopsis gây số bệnh cho loại trồng, nhiên hợp chất lập từ loại nấm có ứng dụng nhiều nông nghiệp y tế, đặc biệt ứng dụng vào việc điều trị bệnh kỉ HIV số bệnh ung thư khác Xuất phát từ ứng dụng y học quý giá kế thừa nghiên cứu có chi Pestalotiopsis sp., tiến hành nghiên cứu loài nấm Pestalotiopsis Th.S Trần Thị Minh Định – Khoa sinh học Đại học Sư phạm TP.HCM, ly trích từ Trang vùng rừng ngập mặn Cần Giờ ni cấy phịng thí nghiệm Trang 51142e4 7e7 f89a7 cfd2396 2cf670a 028b4b07 0f4 8b0e 586b840 b16 f308 f26e 1d e27334 d680 7e1b6d06 3ba21 940e3 7dea c5bb471 3c3 28867 f8 bbed 74e2 c780 6d1 95fe17 7b08 58d8 5313 9d45 20f8b9a3 690a4 754e7 b437 2298 7ae3bea 9374 f30 b3 49a74ff65 d2f937e7 d8e bc5 d43b334 b4414 418a0 deab4 1a1aa0ab21b9 c77 30ab c2c5 6b9 bf4 8e75 f2b175 f1f1455ff9 7a0e0e 8e09 f963 70b8 91396 2514 b9e d3f d36247a 1b1 c74 02f9ed93 221a4 49e34a 7aa2c71e9ae bcb71 c4c0eeb2 484b96aa 83087 f6f9e470 c72 ed5 f4e8 f8e8 e845 306b4f1 d3e7 8fba019 f352ae 3be4 01bf5 bd0e7a 5b28 b8ab54754 3a243 6fbddc64 f8b7be0 43d1 c15 5f9 fcd5b1 696b0cb2a c7ee8eaa 6e7a5a0 b474 52f5b9 77b4 1f9 c6aee 2a01ad0196 f09 493a82 ec4 2e1d8 b78c8c4 233 f1298aa 4e2 cc1 6c68 7da2 22a65 fe7d9 ebf114bfcfa6a0e 104d1170 11e6767 7a94e 9cf5dcf4 81d7a65d25f4f7 492 c70ee4 6529a 0a8d0 045b1864 8d3 2e9fc38bc1b5e54a7 d9a0 511b1d15 e71e9 06750 e488 7c8 f759 c16 5f7 b8efaa e1 e9ff5f31 4e2a77 32b33ed 9a4d4 bc1 1b3 4240 c709 8bf6077 5b09 b0b69dc0a60 29 2df4 eb48 54dc3e8 635d18f750dd256 b9ffac0 1a3b83d1 61a119 2e9b1d3e 4a8d5 fc65 1f6 8288 b2a526 d78 71a5 c3e52a bcb76 f663e 7bba 0363fb5 06a396 2751 d68 d05228 b00 3115a5 d1e8 90d4 b40 05c4 21ad3ec4 dc4a5e62 b531 0c5 cb7c7a9 5d5 926c8 2cbe7f40c821 f04e2a 4e68 2a5d0 4d6e 01c3 9610 c88 5a66b3e545 7b42 839 78782be6d7 8fb9256 0715 06076 8471a 16bc29e cffad44 e26c5013 d6ad2065 c68 64f36 c48 d7fb4 f4b3 f8e 98db4d4 8ff5d8 b5a2 f883 ba7b3c7 2691 f699 28b5 3f8 e86352a d01 c703 c6 c6155 cf9057 8119e 7fe9 f82 30f6825 db01 077 b9e0b47a89 279c1 058d64b25c3 c1e 71a890 bb6 ed f3cb3e4 b10 f391 8a6b4 25a4b96c33e6 b52 ed4d7 b275a 18f2314a7 c5fba5 c3 c911 58b7 380a85a 6d16 4e3a5e 1c6 d524a 7eb9 d97ec3b2e 7b1 86cbb5 db59 5c6 c3a8a 063b44f6820e 78b85203 7e081 2d6e 0e08a 5bf0 8353 c6efdbdd55 f94 60367a 1a219 0195 fc1 fcd0c51c8d69 d7b77634a 0f8 69ab9dc90 892a7 0207 c48a0 db5 3f2 0064 b062 34d1 47a6 c5ac6 f61 f46 4c4 93c48 b7d20 d8e b72e0 7b60a 2e0b0b8e 4dc823abf16 00f6a5dbf8 bb1 ce7e 331fc9 f6d5 61dfc02a7 865de7f527b4a2c7f9 181d03d3 c90 c76 097 c4be 2f0 79d9 8dc717 b63 d9ff8673a 44a76 b8f5e875a 5f2 69ab4 435 f924 7f0 14749 5e249 7b3e 7c4 4675 58 a68d979 76fb5 f9312 d84 bc0 d5fb1e 614f9149 8e5b18389 4b5 d3f5200 5b0a5 01f 5b24e3ff 582d497e b5e27 03138 dd3 1d4 935b7548 cb4 0bf4dc0b9 cc25f6605 8a7 d0b39 b849a ef6 d3b82d6 1e55aa4 47a34 c19 f1b977a49 82f9c4 b81 6a3f9 3259 76 f7cbf9 9403 fe5d295b259d7b9 0dd2 f3e d757 d235 55a08 61d5 f0 be5b93b8 4d25 66eb79 c37 b3 c8cd674a 1c0 3b83 b6b1a10 c78b25a7e4 c83 022e f059 588b21421 d 6ed08 c1b78eea c177fb5 3b2 b24 f40d34eb de7a3a 6f0 517d83b8 e8d5 c78 79206 c365aa2 22e58 532a1e 8c1 6b1 69ef501dfc48994 e3e07 e54a5 d7ee4 407a2e 9617 b5f8 82b2 f6 b852e 6307 3280a b5b8 78bc4dcdfcc6ff6b2f2 0d30 7e9d0f4 35fb32 11e0e9 de8ba 18d7 02a2 c92 c0cb784 4ac6 0f26 c1 c054 6b04 c8 cd1 24f53e34 e989 007831 f08 be8d9d7ff3 b76ae 1592ff8e 63eb f42 c19 6b4e 12415 4cc9ae7 9f3 34b 4ff81fc08e7 f157 c55 64f5d7e 0d0 b616 f418 78ddc6 c0a3 3da66 3243 588b128 c0 7e0e875 d038 1c6 12a3 c660 2b1e c6b1d05 b9 cc6 f02 11d9 93d8 2ab8 c510 c6e 2f3 7cf78f9aeb78 42a85 d478 d5e b2f44c4d87 5da7 c36a2 c1a9 f55 baf5 d9e0 2ce8 c5 4c13 fcf09d1ef3f6 867ac773 fc0 c859 d3 f430e 90b3 6fe3 2a401 d79a7a 3c2 6f8 c7a175 df1a3207 5f6a 3e081 53c84e7a0 533 c10 d158e 0d50fb4a 8d8 b94 f2f729 f e3924 f47d6743 b4f31e17 9d5 f11 f82 d7b7ad3 f784 82b5 c65 c58 3a56 f501e 23a1 1355bea 1087 be4b57d7 b92 7eff6702 465a1 b9d2 3a389 409 c39a30 312b5fe0 6fe 83d9db3e7 ee33a f8e51 c5 b8a853 8d7 00313 f5 dc2a d936 3a3ef7f7 2d89 306e6 31 c5d9 60b3 6f9 be71 39ed 724a60 c06 662a7a 184bce6 c86 b21d3877 b18 c8be 6db82 e3083a1 fe11 b4350 0a251 996a f4025 1e525 90e0e 9e235 6dd348 f7e13 982 b5913 62b8ff4 cfb7b2 b498 1e6 c5e54 de90e 94c0130 0f8e 5158 f5 b0044 471 f83d013 f7 ab27a6e2 e738a2 f0 c256 bd5 9b74 d78e 78c6c1 597b758e5 5e7 f9d6 025 c9f2685a HỒNG KHÁNH AN 3.2 KHĨA LUẬN TỐT NGHIỆP KHẢO SÁT CẤU TRÚC HỢP CHẤT EtA 3.2.1 Đặc điểm hợp chất EtA • Chất bột màu trắng, hấp thụ UV (γ= 254 µm), lập từ phân đoạn W1 • Dữ liệu phổ 1H-NMR (500 MHz, DMSO-d ) (Phụ lục 6) 13C-NMR (100 MHz, DMSO-d ) (Phụ lục 7) trình bày bảng 3.2 3.3.2 Biện luận cấu trúc hợp chất EtA Phổ 1H-NMR cho thấy có tín hiệu bao gồm: hai proton gắn với dị tố δ 10.98, hai proton nhân thơm δ 7.39 (1H, d, J=7.5Hz) δ 5.44 (1H, d, J=7.5Hz) Phổ 13C-NMR cho thấy tín hiệu carbon, bao gồm hai carbon liên kết với oxygen δ 164.7 δ 151.4, hai carbon nhân thơm δ 142.2 δ 100.2 Từ kiện phổ trên, kết hợp với so sánh liệu phổ uracil[9], thấy liệu phổ uracil EtA có tương đồng, nên cấu trúc hợp chất EtA xác định uracil hình vẽ 3.2 OH H N H N OH Hình 3.2: Cấu trúc đề nghị hợp chất EtA Trang 25 51142e4 7e7 f89a7 cfd2396 2cf670a 028b4b07 0f4 8b0e 586b840 b16 f308 f26e 1d e27334 d680 7e1b6d06 3ba21 940e3 7dea c5bb471 3c3 28867 f8 bbed 74e2 c780 6d1 95fe17 7b08 58d8 5313 9d45 20f8b9a3 690a4 754e7 b437 2298 7ae3bea 9374 f30 b3 49a74ff65 d2f937e7 d8e bc5 d43b334 b4414 418a0 deab4 1a1aa0ab21b9 c77 30ab c2c5 6b9 bf4 8e75 f2b175 f1f1455ff9 7a0e0e 8e09 f963 70b8 91396 2514 b9e d3f d36247a 1b1 c74 02f9ed93 221a4 49e34a 7aa2c71e9ae bcb71 c4c0eeb2 484b96aa 83087 f6f9e470 c72 ed5 f4e8 f8e8 e845 306b4f1 d3e7 8fba019 f352ae 3be4 01bf5 bd0e7a 5b28 b8ab54754 3a243 6fbddc64 f8b7be0 43d1 c15 5f9 fcd5b1 696b0cb2a c7ee8eaa 6e7a5a0 b474 52f5b9 77b4 1f9 c6aee 2a01ad0196 f09 493a82 ec4 2e1d8 b78c8c4 233 f1298aa 4e2 cc1 6c68 7da2 22a65 fe7d9 ebf114bfcfa6a0e 104d1170 11e6767 7a94e 9cf5dcf4 81d7a65d25f4f7 492 c70ee4 6529a 0a8d0 045b1864 8d3 2e9fc38bc1b5e54a7 d9a0 511b1d15 e71e9 06750 e488 7c8 f759 c16 5f7 b8efaa e1 e9ff5f31 4e2a77 32b33ed 9a4d4 bc1 1b3 4240 c709 8bf6077 5b09 b0b69dc0a60 29 2df4 eb48 54dc3e8 635d18f750dd256 b9ffac0 1a3b83d1 61a119 2e9b1d3e 4a8d5 fc65 1f6 8288 b2a526 d78 71a5 c3e52a bcb76 f663e 7bba 0363fb5 06a396 2751 d68 d05228 b00 3115a5 d1e8 90d4 b40 05c4 21ad3ec4 dc4a5e62 b531 0c5 cb7c7a9 5d5 926c8 2cbe7f40c821 f04e2a 4e68 2a5d0 4d6e 01c3 9610 c88 5a66b3e545 7b42 839 78782be6d7 8fb9256 0715 06076 8471a 16bc29e cffad44 e26c5013 d6ad2065 c68 64f36 c48 d7fb4 f4b3 f8e 98db4d4 8ff5d8 b5a2 f883 ba7b3c7 2691 f699 28b5 3f8 e86352a d01 c703 c6 c6155 cf9057 8119e 7fe9 f82 30f6825 db01 077 b9e0b47a89 279c1 058d64b25c3 c1e 71a890 bb6 ed f3cb3e4 b10 f391 8a6b4 25a4b96c33e6 b52 ed4d7 b275a 18f2314a7 c5fba5 c3 c911 58b7 380a85a 6d16 4e3a5e 1c6 d524a 7eb9 d97ec3b2e 7b1 86cbb5 db59 5c6 c3a8a 063b44f6820e 78b85203 7e081 2d6e 0e08a 5bf0 8353 c6efdbdd55 f94 60367a 1a219 0195 fc1 fcd0c51c8d69 d7b77634a 0f8 69ab9dc90 892a7 0207 c48a0 db5 3f2 0064 b062 34d1 47a6 c5ac6 f61 f46 4c4 93c48 b7d20 d8e b72e0 7b60a 2e0b0b8e 4dc823abf16 00f6a5dbf8 bb1 ce7e 331fc9 f6d5 61dfc02a7 865de7f527b4a2c7f9 181d03d3 c90 c76 097 c4be 2f0 79d9 8dc717 b63 d9ff8673a 44a76 b8f5e875a 5f2 69ab4 435 f924 7f0 14749 5e249 7b3e 7c4 4675 58 a68d979 76fb5 f9312 d84 bc0 d5fb1e 614f9149 8e5b18389 4b5 d3f5200 5b0a5 01f 5b24e3ff 582d497e b5e27 03138 dd3 1d4 935b7548 cb4 0bf4dc0b9 cc25f6605 8a7 d0b39 b849a ef6 d3b82d6 1e55aa4 47a34 c19 f1b977a49 82f9c4 b81 6a3f9 3259 76 f7cbf9 9403 fe5d295b259d7b9 0dd2 f3e d757 d235 55a08 61d5 f0 be5b93b8 4d25 66eb79 c37 b3 c8cd674a 1c0 3b83 b6b1a10 c78b25a7e4 c83 022e f059 588b21421 d 6ed08 c1b78eea c177fb5 3b2 b24 f40d34eb de7a3a 6f0 517d83b8 e8d5 c78 79206 c365aa2 22e58 532a1e 8c1 6b1 69ef501dfc48994 e3e07 e54a5 d7ee4 407a2e 9617 b5f8 82b2 f6 b852e 6307 3280a b5b8 78bc4dcdfcc6ff6b2f2 0d30 7e9d0f4 35fb32 11e0e9 de8ba 18d7 02a2 c92 c0cb784 4ac6 0f26 c1 c054 6b04 c8 cd1 24f53e34 e989 007831 f08 be8d9d7ff3 b76ae 1592ff8e 63eb f42 c19 6b4e 12415 4cc9ae7 9f3 34b 4ff81fc08e7 f157 c55 64f5d7e 0d0 b616 f418 78ddc6 c0a3 3da66 3243 588b128 c0 7e0e875 d038 1c6 12a3 c660 2b1e c6b1d05 b9 cc6 f02 11d9 93d8 2ab8 c510 c6e 2f3 7cf78f9aeb78 42a85 d478 d5e b2f44c4d87 5da7 c36a2 c1a9 f55 baf5 d9e0 2ce8 c5 4c13 fcf09d1ef3f6 867ac773 fc0 c859 d3 f430e 90b3 6fe3 2a401 d79a7a 3c2 6f8 c7a175 df1a3207 5f6a 3e081 53c84e7a0 533 c10 d158e 0d50fb4a 8d8 b94 f2f729 f e3924 f47d6743 b4f31e17 9d5 f11 f82 d7b7ad3 f784 82b5 c65 c58 3a56 f501e 23a1 1355bea 1087 be4b57d7 b92 7eff6702 465a1 b9d2 3a389 409 c39a30 312b5fe0 6fe 83d9db3e7 ee33a f8e51 c5 b8a853 8d7 00313 f5 dc2a d936 3a3ef7f7 2d89 306e6 31 c5d9 60b3 6f9 be71 39ed 724a60 c06 662a7a 184bce6 c86 b21d3877 b18 c8be 6db82 e3083a1 fe11 b4350 0a251 996a f4025 1e525 90e0e 9e235 6dd348 f7e13 982 b5913 62b8ff4 cfb7b2 b498 1e6 c5e54 de90e 94c0130 0f8e 5158 f5 b0044 471 f83d013 f7 ab27a6e2 e738a2 f0 c256 bd5 9b74 d78e 78c6c1 597b758e5 5e7 f9d6 025 c9f2685a HỒNG KHÁNH AN KHĨA LUẬN TỐT NGHIỆP Bảng 3.2: Dữ liệu phổ NMR Uracil EtA Uracil (DMSO-d ) N δH 10.82 EtA (DMSO-d ) δC δH δC 152.3 11.02 N 151.4 165.1 164.7 5.47 (d, 7.5Hz) 101.0 5.44 (d, 7.5Hz) 100.2 7.41 (dd,7.5Hz, 142.9 7.39 (d, 7.5Hz) 142.2 5.7 Hz) Trang 26 51142e4 7e7 f89a7 cfd2396 2cf670a 028b4b07 0f4 8b0e 586b840 b16 f308 f26e 1d e27334 d680 7e1b6d06 3ba21 940e3 7dea c5bb471 3c3 28867 f8 bbed 74e2 c780 6d1 95fe17 7b08 58d8 5313 9d45 20f8b9a3 690a4 754e7 b437 2298 7ae3bea 9374 f30 b3 49a74ff65 d2f937e7 d8e bc5 d43b334 b4414 418a0 deab4 1a1aa0ab21b9 c77 30ab c2c5 6b9 bf4 8e75 f2b175 f1f1455ff9 7a0e0e 8e09 f963 70b8 91396 2514 b9e d3f d36247a 1b1 c74 02f9ed93 221a4 49e34a 7aa2c71e9ae bcb71 c4c0eeb2 484b96aa 83087 f6f9e470 c72 ed5 f4e8 f8e8 e845 306b4f1 d3e7 8fba019 f352ae 3be4 01bf5 bd0e7a 5b28 b8ab54754 3a243 6fbddc64 f8b7be0 43d1 c15 5f9 fcd5b1 696b0cb2a c7ee8eaa 6e7a5a0 b474 52f5b9 77b4 1f9 c6aee 2a01ad0196 f09 493a82 ec4 2e1d8 b78c8c4 233 f1298aa 4e2 cc1 6c68 7da2 22a65 fe7d9 ebf114bfcfa6a0e 104d1170 11e6767 7a94e 9cf5dcf4 81d7a65d25f4f7 492 c70ee4 6529a 0a8d0 045b1864 8d3 2e9fc38bc1b5e54a7 d9a0 511b1d15 e71e9 06750 e488 7c8 f759 c16 5f7 b8efaa e1 e9ff5f31 4e2a77 32b33ed 9a4d4 bc1 1b3 4240 c709 8bf6077 5b09 b0b69dc0a60 29 2df4 eb48 54dc3e8 635d18f750dd256 b9ffac0 1a3b83d1 61a119 2e9b1d3e 4a8d5 fc65 1f6 8288 b2a526 d78 71a5 c3e52a bcb76 f663e 7bba 0363fb5 06a396 2751 d68 d05228 b00 3115a5 d1e8 90d4 b40 05c4 21ad3ec4 dc4a5e62 b531 0c5 cb7c7a9 5d5 926c8 2cbe7f40c821 f04e2a 4e68 2a5d0 4d6e 01c3 9610 c88 5a66b3e545 7b42 839 78782be6d7 8fb9256 0715 06076 8471a 16bc29e cffad44 e26c5013 d6ad2065 c68 64f36 c48 d7fb4 f4b3 f8e 98db4d4 8ff5d8 b5a2 f883 ba7b3c7 2691 f699 28b5 3f8 e86352a d01 c703 c6 c6155 cf9057 8119e 7fe9 f82 30f6825 db01 077 b9e0b47a89 279c1 058d64b25c3 c1e 71a890 bb6 ed f3cb3e4 b10 f391 8a6b4 25a4b96c33e6 b52 ed4d7 b275a 18f2314a7 c5fba5 c3 c911 58b7 380a85a 6d16 4e3a5e 1c6 d524a 7eb9 d97ec3b2e 7b1 86cbb5 db59 5c6 c3a8a 063b44f6820e 78b85203 7e081 2d6e 0e08a 5bf0 8353 c6efdbdd55 f94 60367a 1a219 0195 fc1 fcd0c51c8d69 d7b77634a 0f8 69ab9dc90 892a7 0207 c48a0 db5 3f2 0064 b062 34d1 47a6 c5ac6 f61 f46 4c4 93c48 b7d20 d8e b72e0 7b60a 2e0b0b8e 4dc823abf16 00f6a5dbf8 bb1 ce7e 331fc9 f6d5 61dfc02a7 865de7f527b4a2c7f9 181d03d3 c90 c76 097 c4be 2f0 79d9 8dc717 b63 d9ff8673a 44a76 b8f5e875a 5f2 69ab4 435 f924 7f0 14749 5e249 7b3e 7c4 4675 58 a68d979 76fb5 f9312 d84 bc0 d5fb1e 614f9149 8e5b18389 4b5 d3f5200 5b0a5 01f 5b24e3ff 582d497e b5e27 03138 dd3 1d4 935b7548 cb4 0bf4dc0b9 cc25f6605 8a7 d0b39 b849a ef6 d3b82d6 1e55aa4 47a34 c19 f1b977a49 82f9c4 b81 6a3f9 3259 76 f7cbf9 9403 fe5d295b259d7b9 0dd2 f3e d757 d235 55a08 61d5 f0 be5b93b8 4d25 66eb79 c37 b3 c8cd674a 1c0 3b83 b6b1a10 c78b25a7e4 c83 022e f059 588b21421 d 6ed08 c1b78eea c177fb5 3b2 b24 f40d34eb de7a3a 6f0 517d83b8 e8d5 c78 79206 c365aa2 22e58 532a1e 8c1 6b1 69ef501dfc48994 e3e07 e54a5 d7ee4 407a2e 9617 b5f8 82b2 f6 b852e 6307 3280a b5b8 78bc4dcdfcc6ff6b2f2 0d30 7e9d0f4 35fb32 11e0e9 de8ba 18d7 02a2 c92 c0cb784 4ac6 0f26 c1 c054 6b04 c8 cd1 24f53e34 e989 007831 f08 be8d9d7ff3 b76ae 1592ff8e 63eb f42 c19 6b4e 12415 4cc9ae7 9f3 34b 4ff81fc08e7 f157 c55 64f5d7e 0d0 b616 f418 78ddc6 c0a3 3da66 3243 588b128 c0 7e0e875 d038 1c6 12a3 c660 2b1e c6b1d05 b9 cc6 f02 11d9 93d8 2ab8 c510 c6e 2f3 7cf78f9aeb78 42a85 d478 d5e b2f44c4d87 5da7 c36a2 c1a9 f55 baf5 d9e0 2ce8 c5 4c13 fcf09d1ef3f6 867ac773 fc0 c859 d3 f430e 90b3 6fe3 2a401 d79a7a 3c2 6f8 c7a175 df1a3207 5f6a 3e081 53c84e7a0 533 c10 d158e 0d50fb4a 8d8 b94 f2f729 f e3924 f47d6743 b4f31e17 9d5 f11 f82 d7b7ad3 f784 82b5 c65 c58 3a56 f501e 23a1 1355bea 1087 be4b57d7 b92 7eff6702 465a1 b9d2 3a389 409 c39a30 312b5fe0 6fe 83d9db3e7 ee33a f8e51 c5 b8a853 8d7 00313 f5 dc2a d936 3a3ef7f7 2d89 306e6 31 c5d9 60b3 6f9 be71 39ed 724a60 c06 662a7a 184bce6 c86 b21d3877 b18 c8be 6db82 e3083a1 fe11 b4350 0a251 996a f4025 1e525 90e0e 9e235 6dd348 f7e13 982 b5913 62b8ff4 cfb7b2 b498 1e6 c5e54 de90e 94c0130 0f8e 5158 f5 b0044 471 f83d013 f7 ab27a6e2 e738a2 f0 c256 bd5 9b74 d78e 78c6c1 597b758e5 5e7 f9d6 025 c9f2685a HOÀNG KHÁNH AN KHÓA LUẬN TỐT NGHIỆP CHƯƠNG 4: KẾT LUẬN – ĐỀ XUẤT 4.1 KẾT LUẬN Từ mẫu sinh khối nấm Pestalotiopsis tiến hành điều chế cao ethanol thô Cao ethanol thơ hịa tan vào dung dịch EtOH: H O (9: 1) thu hai phần: phần tan dung dịch DE phần tủa TE Thực phương pháp sắc kí phần DE TE thu hợp chất Et35 EtA Sử dụng phương pháp phổ nghiệm đại kết hợp với so sánh tài liệu tham khảo xác định cấu trúc hai hợp chất hữu Et35 EtA lập được, hợp chất Et35 sản phẩm tổng hợp, lần tìm thấy tự nhiên OH O H N O NH H N OH N H O (R)-(-)-5-ethoxycarbonyl-6-methyl-4-phenyl -3,4-dihydropyrimidin-2(1H)-one Uracil Hình 4.1: Hai hợp chất lập nấm Pestalotiopsis 4.2 ĐỀ XUẤT Vì điều kiện thời gian vật chất không cho phép, nên phạm vi đề tài này, khảo sát phân đoạn cao Et3 W1 Trong thời gian tới, có điều kiện tiến hành khảo sát phân đoạn cao cịn lại Đồng thời chúng tơi tiến hành thử nghiệm số hoạt tính sinh học loại cao hợp chất cô lập Trang 27 51142e4 7e7 f89a7 cfd2396 2cf670a 028b4b07 0f4 8b0e 586b840 b16 f308 f26e 1d e27334 d680 7e1b6d06 3ba21 940e3 7dea c5bb471 3c3 28867 f8 bbed 74e2 c780 6d1 95fe17 7b08 58d8 5313 9d45 20f8b9a3 690a4 754e7 b437 2298 7ae3bea 9374 f30 b3 49a74ff65 d2f937e7 d8e bc5 d43b334 b4414 418a0 deab4 1a1aa0ab21b9 c77 30ab c2c5 6b9 bf4 8e75 f2b175 f1f1455ff9 7a0e0e 8e09 f963 70b8 91396 2514 b9e d3f d36247a 1b1 c74 02f9ed93 221a4 49e34a 7aa2c71e9ae bcb71 c4c0eeb2 484b96aa 83087 f6f9e470 c72 ed5 f4e8 f8e8 e845 306b4f1 d3e7 8fba019 f352ae 3be4 01bf5 bd0e7a 5b28 b8ab54754 3a243 6fbddc64 f8b7be0 43d1 c15 5f9 fcd5b1 696b0cb2a c7ee8eaa 6e7a5a0 b474 52f5b9 77b4 1f9 c6aee 2a01ad0196 f09 493a82 ec4 2e1d8 b78c8c4 233 f1298aa 4e2 cc1 6c68 7da2 22a65 fe7d9 ebf114bfcfa6a0e 104d1170 11e6767 7a94e 9cf5dcf4 81d7a65d25f4f7 492 c70ee4 6529a 0a8d0 045b1864 8d3 2e9fc38bc1b5e54a7 d9a0 511b1d15 e71e9 06750 e488 7c8 f759 c16 5f7 b8efaa e1 e9ff5f31 4e2a77 32b33ed 9a4d4 bc1 1b3 4240 c709 8bf6077 5b09 b0b69dc0a60 29 2df4 eb48 54dc3e8 635d18f750dd256 b9ffac0 1a3b83d1 61a119 2e9b1d3e 4a8d5 fc65 1f6 8288 b2a526 d78 71a5 c3e52a bcb76 f663e 7bba 0363fb5 06a396 2751 d68 d05228 b00 3115a5 d1e8 90d4 b40 05c4 21ad3ec4 dc4a5e62 b531 0c5 cb7c7a9 5d5 926c8 2cbe7f40c821 f04e2a 4e68 2a5d0 4d6e 01c3 9610 c88 5a66b3e545 7b42 839 78782be6d7 8fb9256 0715 06076 8471a 16bc29e cffad44 e26c5013 d6ad2065 c68 64f36 c48 d7fb4 f4b3 f8e 98db4d4 8ff5d8 b5a2 f883 ba7b3c7 2691 f699 28b5 3f8 e86352a d01 c703 c6 c6155 cf9057 8119e 7fe9 f82 30f6825 db01 077 b9e0b47a89 279c1 058d64b25c3 c1e 71a890 bb6 ed f3cb3e4 b10 f391 8a6b4 25a4b96c33e6 b52 ed4d7 b275a 18f2314a7 c5fba5 c3 c911 58b7 380a85a 6d16 4e3a5e 1c6 d524a 7eb9 d97ec3b2e 7b1 86cbb5 db59 5c6 c3a8a 063b44f6820e 78b85203 7e081 2d6e 0e08a 5bf0 8353 c6efdbdd55 f94 60367a 1a219 0195 fc1 fcd0c51c8d69 d7b77634a 0f8 69ab9dc90 892a7 0207 c48a0 db5 3f2 0064 b062 34d1 47a6 c5ac6 f61 f46 4c4 93c48 b7d20 d8e b72e0 7b60a 2e0b0b8e 4dc823abf16 00f6a5dbf8 bb1 ce7e 331fc9 f6d5 61dfc02a7 865de7f527b4a2c7f9 181d03d3 c90 c76 097 c4be 2f0 79d9 8dc717 b63 d9ff8673a 44a76 b8f5e875a 5f2 69ab4 435 f924 7f0 14749 5e249 7b3e 7c4 4675 58 a68d979 76fb5 f9312 d84 bc0 d5fb1e 614f9149 8e5b18389 4b5 d3f5200 5b0a5 01f 5b24e3ff 582d497e b5e27 03138 dd3 1d4 935b7548 cb4 0bf4dc0b9 cc25f6605 8a7 d0b39 b849a ef6 d3b82d6 1e55aa4 47a34 c19 f1b977a49 82f9c4 b81 6a3f9 3259 76 f7cbf9 9403 fe5d295b259d7b9 0dd2 f3e d757 d235 55a08 61d5 f0 be5b93b8 4d25 66eb79 c37 b3 c8cd674a 1c0 3b83 b6b1a10 c78b25a7e4 c83 022e f059 588b21421 d 6ed08 c1b78eea c177fb5 3b2 b24 f40d34eb de7a3a 6f0 517d83b8 e8d5 c78 79206 c365aa2 22e58 532a1e 8c1 6b1 69ef501dfc48994 e3e07 e54a5 d7ee4 407a2e 9617 b5f8 82b2 f6 b852e 6307 3280a b5b8 78bc4dcdfcc6ff6b2f2 0d30 7e9d0f4 35fb32 11e0e9 de8ba 18d7 02a2 c92 c0cb784 4ac6 0f26 c1 c054 6b04 c8 cd1 24f53e34 e989 007831 f08 be8d9d7ff3 b76ae 1592ff8e 63eb f42 c19 6b4e 12415 4cc9ae7 9f3 34b 4ff81fc08e7 f157 c55 64f5d7e 0d0 b616 f418 78ddc6 c0a3 3da66 3243 588b128 c0 7e0e875 d038 1c6 12a3 c660 2b1e c6b1d05 b9 cc6 f02 11d9 93d8 2ab8 c510 c6e 2f3 7cf78f9aeb78 42a85 d478 d5e b2f44c4d87 5da7 c36a2 c1a9 f55 baf5 d9e0 2ce8 c5 4c13 fcf09d1ef3f6 867ac773 fc0 c859 d3 f430e 90b3 6fe3 2a401 d79a7a 3c2 6f8 c7a175 df1a3207 5f6a 3e081 53c84e7a0 533 c10 d158e 0d50fb4a 8d8 b94 f2f729 f e3924 f47d6743 b4f31e17 9d5 f11 f82 d7b7ad3 f784 82b5 c65 c58 3a56 f501e 23a1 1355bea 1087 be4b57d7 b92 7eff6702 465a1 b9d2 3a389 409 c39a30 312b5fe0 6fe 83d9db3e7 ee33a f8e51 c5 b8a853 8d7 00313 f5 dc2a d936 3a3ef7f7 2d89 306e6 31 c5d9 60b3 6f9 be71 39ed 724a60 c06 662a7a 184bce6 c86 b21d3877 b18 c8be 6db82 e3083a1 fe11 b4350 0a251 996a f4025 1e525 90e0e 9e235 6dd348 f7e13 982 b5913 62b8ff4 cfb7b2 b498 1e6 c5e54 de90e 94c0130 0f8e 5158 f5 b0044 471 f83d013 f7 ab27a6e2 e738a2 f0 c256 bd5 9b74 d78e 78c6c1 597b758e5 5e7 f9d6 025 c9f2685a HỒNG KHÁNH AN KHĨA LUẬN TỐT NGHIỆP DANH MỤC TÀI LIỆU THAM KHẢO [1] Akone S H., Amrani M E., Lin W., Lai D., Proksch P., Cytosporins F-K, new epoxyquinols from the endophytic fungus Pestalotiopsis theae, Tet Lett., 54, 6751-6754, 2013 [2] Beekman A M., Barrow R A., Stereochemical assignment of the fungal metabolites pestalotiopsones D and E through entiopure synthesis, J Nat Prod., 76, 2054-2059, 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Liu S., Zhang H., Guo L., Che Y., Photinides A-F, cytotoxic benzofuranone-derived γ-lactone from the plant endophytic fungus Pestalotiopsis photiniae, J Nat Prod., 72, 942-945, 2009 [9] Erno P., Martin B., Philippe B., Structure Determination of Organic Compounds, 4th, Springer-Verlag Berlin Heidelberg, 2009, 150 – 237 Trang 28 51142e4 7e7 f89a7 cfd2396 2cf670a 028b4b07 0f4 8b0e 586b840 b16 f308 f26e 1d e27334 d680 7e1b6d06 3ba21 940e3 7dea c5bb471 3c3 28867 f8 bbed 74e2 c780 6d1 95fe17 7b08 58d8 5313 9d45 20f8b9a3 690a4 754e7 b437 2298 7ae3bea 9374 f30 b3 49a74ff65 d2f937e7 d8e bc5 d43b334 b4414 418a0 deab4 1a1aa0ab21b9 c77 30ab c2c5 6b9 bf4 8e75 f2b175 f1f1455ff9 7a0e0e 8e09 f963 70b8 91396 2514 b9e d3f d36247a 1b1 c74 02f9ed93 221a4 49e34a 7aa2c71e9ae bcb71 c4c0eeb2 484b96aa 83087 f6f9e470 c72 ed5 f4e8 f8e8 e845 306b4f1 d3e7 8fba019 f352ae 3be4 01bf5 bd0e7a 5b28 b8ab54754 3a243 6fbddc64 f8b7be0 43d1 c15 5f9 fcd5b1 696b0cb2a c7ee8eaa 6e7a5a0 b474 52f5b9 77b4 1f9 c6aee 2a01ad0196 f09 493a82 ec4 2e1d8 b78c8c4 233 f1298aa 4e2 cc1 6c68 7da2 22a65 fe7d9 ebf114bfcfa6a0e 104d1170 11e6767 7a94e 9cf5dcf4 81d7a65d25f4f7 492 c70ee4 6529a 0a8d0 045b1864 8d3 2e9fc38bc1b5e54a7 d9a0 511b1d15 e71e9 06750 e488 7c8 f759 c16 5f7 b8efaa e1 e9ff5f31 4e2a77 32b33ed 9a4d4 bc1 1b3 4240 c709 8bf6077 5b09 b0b69dc0a60 29 2df4 eb48 54dc3e8 635d18f750dd256 b9ffac0 1a3b83d1 61a119 2e9b1d3e 4a8d5 fc65 1f6 8288 b2a526 d78 71a5 c3e52a bcb76 f663e 7bba 0363fb5 06a396 2751 d68 d05228 b00 3115a5 d1e8 90d4 b40 05c4 21ad3ec4 dc4a5e62 b531 0c5 cb7c7a9 5d5 926c8 2cbe7f40c821 f04e2a 4e68 2a5d0 4d6e 01c3 9610 c88 5a66b3e545 7b42 839 78782be6d7 8fb9256 0715 06076 8471a 16bc29e cffad44 e26c5013 d6ad2065 c68 64f36 c48 d7fb4 f4b3 f8e 98db4d4 8ff5d8 b5a2 f883 ba7b3c7 2691 f699 28b5 3f8 e86352a d01 c703 c6 c6155 cf9057 8119e 7fe9 f82 30f6825 db01 077 b9e0b47a89 279c1 058d64b25c3 c1e 71a890 bb6 ed f3cb3e4 b10 f391 8a6b4 25a4b96c33e6 b52 ed4d7 b275a 18f2314a7 c5fba5 c3 c911 58b7 380a85a 6d16 4e3a5e 1c6 d524a 7eb9 d97ec3b2e 7b1 86cbb5 db59 5c6 c3a8a 063b44f6820e 78b85203 7e081 2d6e 0e08a 5bf0 8353 c6efdbdd55 f94 60367a 1a219 0195 fc1 fcd0c51c8d69 d7b77634a 0f8 69ab9dc90 892a7 0207 c48a0 db5 3f2 0064 b062 34d1 47a6 c5ac6 f61 f46 4c4 93c48 b7d20 d8e b72e0 7b60a 2e0b0b8e 4dc823abf16 00f6a5dbf8 bb1 ce7e 331fc9 f6d5 61dfc02a7 865de7f527b4a2c7f9 181d03d3 c90 c76 097 c4be 2f0 79d9 8dc717 b63 d9ff8673a 44a76 b8f5e875a 5f2 69ab4 435 f924 7f0 14749 5e249 7b3e 7c4 4675 58 a68d979 76fb5 f9312 d84 bc0 d5fb1e 614f9149 8e5b18389 4b5 d3f5200 5b0a5 01f 5b24e3ff 582d497e b5e27 03138 dd3 1d4 935b7548 cb4 0bf4dc0b9 cc25f6605 8a7 d0b39 b849a ef6 d3b82d6 1e55aa4 47a34 c19 f1b977a49 82f9c4 b81 6a3f9 3259 76 f7cbf9 9403 fe5d295b259d7b9 0dd2 f3e d757 d235 55a08 61d5 f0 be5b93b8 4d25 66eb79 c37 b3 c8cd674a 1c0 3b83 b6b1a10 c78b25a7e4 c83 022e f059 588b21421 d 6ed08 c1b78eea c177fb5 3b2 b24 f40d34eb de7a3a 6f0 517d83b8 e8d5 c78 79206 c365aa2 22e58 532a1e 8c1 6b1 69ef501dfc48994 e3e07 e54a5 d7ee4 407a2e 9617 b5f8 82b2 f6 b852e 6307 3280a b5b8 78bc4dcdfcc6ff6b2f2 0d30 7e9d0f4 35fb32 11e0e9 de8ba 18d7 02a2 c92 c0cb784 4ac6 0f26 c1 c054 6b04 c8 cd1 24f53e34 e989 007831 f08 be8d9d7ff3 b76ae 1592ff8e 63eb f42 c19 6b4e 12415 4cc9ae7 9f3 34b 4ff81fc08e7 f157 c55 64f5d7e 0d0 b616 f418 78ddc6 c0a3 3da66 3243 588b128 c0 7e0e875 d038 1c6 12a3 c660 2b1e c6b1d05 b9 cc6 f02 11d9 93d8 2ab8 c510 c6e 2f3 7cf78f9aeb78 42a85 d478 d5e b2f44c4d87 5da7 c36a2 c1a9 f55 baf5 d9e0 2ce8 c5 4c13 fcf09d1ef3f6 867ac773 fc0 c859 d3 f430e 90b3 6fe3 2a401 d79a7a 3c2 6f8 c7a175 df1a3207 5f6a 3e081 53c84e7a0 533 c10 d158e 0d50fb4a 8d8 b94 f2f729 f e3924 f47d6743 b4f31e17 9d5 f11 f82 d7b7ad3 f784 82b5 c65 c58 3a56 f501e 23a1 1355bea 1087 be4b57d7 b92 7eff6702 465a1 b9d2 3a389 409 c39a30 312b5fe0 6fe 83d9db3e7 ee33a f8e51 c5 b8a853 8d7 00313 f5 dc2a d936 3a3ef7f7 2d89 306e6 31 c5d9 60b3 6f9 be71 39ed 724a60 c06 662a7a 184bce6 c86 b21d3877 b18 c8be 6db82 e3083a1 fe11 b4350 0a251 996a f4025 1e525 90e0e 9e235 6dd348 f7e13 982 b5913 62b8ff4 cfb7b2 b498 1e6 c5e54 de90e 94c0130 0f8e 5158 f5 b0044 471 f83d013 f7 ab27a6e2 e738a2 f0 c256 bd5 9b74 d78e 78c6c1 597b758e5 5e7 f9d6 025 c9f2685a HỒNG KHÁNH AN KHĨA LUẬN TỐT NGHIỆP [10] Huang Y., Yang F., Zhu C., Highly Enantioseletive Biginelli Reaction Using a New Chiral Ytterbium Catalyst: Asymmetric Synthesis of Dihydropyrimidines, 2005 [11] Hwang I H., Swenson D C., Gloer J B., Wicklow D T., Pestaloporonins: Caryophylllene-Derived sesquiterpenoids from a fungicolous isolate of Pestalotiopsis sp., Org Lett., 17, 4284-4287, 2015 [12] Jia Y.-L., Wei M.-Y., Chen H.-Y., Guan F.-F., Wang C.-Y., Shao C.-L., (+)- and (-)-Pestaloxazine A, a pair of antiviral enantiomeric alkaloid dimers with a symmetric spiro[oxazinane-piperazinedione] skeleton from Pestalotiopsis sp., Org Lett., 17, 42164219, 2015 [13] Klaiklay S., Rukachaisirikul V., Tadpetch K., Sukpondma Y., Phongpaichit S., Buatong J., Sakayaroj J., Chlorinated chromone and diphenyl ether derivatives from the mangrove-derived fungus 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2cf670a 028b4b07 0f4 8b0e 586b840 b16 f308 f26e 1d e27334 d680 7e1b6d06 3ba21 940e3 7dea c5bb471 3c3 28867 f8 bbed 74e2 c780 6d1 95fe17 7b08 58d8 5313 9d45 20f8b9a3 690a4 754e7 b437 2298 7ae3bea 9374 f30 b3 49a74ff65 d2f937e7 d8e bc5 d43b334 b4414 418a0 deab4 1a1aa0ab21b9 c77 30ab c2c5 6b9 bf4 8e75 f2b175 f1f1455ff9 7a0e0e 8e09 f963 70b8 91396 2514 b9e d3f d36247a 1b1 c74 02f9ed93 221a4 49e34a 7aa2c71e9ae bcb71 c4c0eeb2 484b96aa 83087 f6f9e470 c72 ed5 f4e8 f8e8 e845 306b4f1 d3e7 8fba019 f352ae 3be4 01bf5 bd0e7a 5b28 b8ab54754 3a243 6fbddc64 f8b7be0 43d1 c15 5f9 fcd5b1 696b0cb2a c7ee8eaa 6e7a5a0 b474 52f5b9 77b4 1f9 c6aee 2a01ad0196 f09 493a82 ec4 2e1d8 b78c8c4 233 f1298aa 4e2 cc1 6c68 7da2 22a65 fe7d9 ebf114bfcfa6a0e 104d1170 11e6767 7a94e 9cf5dcf4 81d7a65d25f4f7 492 c70ee4 6529a 0a8d0 045b1864 8d3 2e9fc38bc1b5e54a7 d9a0 511b1d15 e71e9 06750 e488 7c8 f759 c16 5f7 b8efaa e1 e9ff5f31 4e2a77 32b33ed 9a4d4 bc1 1b3 4240 c709 8bf6077 5b09 b0b69dc0a60 29 2df4 eb48 54dc3e8 635d18f750dd256 b9ffac0 1a3b83d1 61a119 2e9b1d3e 4a8d5 fc65 1f6 8288 b2a526 d78 71a5 c3e52a bcb76 f663e 7bba 0363fb5 06a396 2751 d68 d05228 b00 3115a5 d1e8 90d4 b40 05c4 21ad3ec4 dc4a5e62 b531 0c5 cb7c7a9 5d5 926c8 2cbe7f40c821 f04e2a 4e68 2a5d0 4d6e 01c3 9610 c88 5a66b3e545 7b42 839 78782be6d7 8fb9256 0715 06076 8471a 16bc29e cffad44 e26c5013 d6ad2065 c68 64f36 c48 d7fb4 f4b3 f8e 98db4d4 8ff5d8 b5a2 f883 ba7b3c7 2691 f699 28b5 3f8 e86352a d01 c703 c6 c6155 cf9057 8119e 7fe9 f82 30f6825 db01 077 b9e0b47a89 279c1 058d64b25c3 c1e 71a890 bb6 ed f3cb3e4 b10 f391 8a6b4 25a4b96c33e6 b52 ed4d7 b275a 18f2314a7 c5fba5 c3 c911 58b7 380a85a 6d16 4e3a5e 1c6 d524a 7eb9 d97ec3b2e 7b1 86cbb5 db59 5c6 c3a8a 063b44f6820e 78b85203 7e081 2d6e 0e08a 5bf0 8353 c6efdbdd55 f94 60367a 1a219 0195 fc1 fcd0c51c8d69 d7b77634a 0f8 69ab9dc90 892a7 0207 c48a0 db5 3f2 0064 b062 34d1 47a6 c5ac6 f61 f46 4c4 93c48 b7d20 d8e b72e0 7b60a 2e0b0b8e 4dc823abf16 00f6a5dbf8 bb1 ce7e 331fc9 f6d5 61dfc02a7 865de7f527b4a2c7f9 181d03d3 c90 c76 097 c4be 2f0 79d9 8dc717 b63 d9ff8673a 44a76 b8f5e875a 5f2 69ab4 435 f924 7f0 14749 5e249 7b3e 7c4 4675 58 a68d979 76fb5 f9312 d84 bc0 d5fb1e 614f9149 8e5b18389 4b5 d3f5200 5b0a5 01f 5b24e3ff 582d497e b5e27 03138 dd3 1d4 935b7548 cb4 0bf4dc0b9 cc25f6605 8a7 d0b39 b849a ef6 d3b82d6 1e55aa4 47a34 c19 f1b977a49 82f9c4 b81 6a3f9 3259 76 f7cbf9 9403 fe5d295b259d7b9 0dd2 f3e d757 d235 55a08 61d5 f0 be5b93b8 4d25 66eb79 c37 b3 c8cd674a 1c0 3b83 b6b1a10 c78b25a7e4 c83 022e f059 588b21421 d 6ed08 c1b78eea c177fb5 3b2 b24 f40d34eb de7a3a 6f0 517d83b8 e8d5 c78 79206 c365aa2 22e58 532a1e 8c1 6b1 69ef501dfc48994 e3e07 e54a5 d7ee4 407a2e 9617 b5f8 82b2 f6 b852e 6307 3280a b5b8 78bc4dcdfcc6ff6b2f2 0d30 7e9d0f4 35fb32 11e0e9 de8ba 18d7 02a2 c92 c0cb784 4ac6 0f26 c1 c054 6b04 c8 cd1 24f53e34 e989 007831 f08 be8d9d7ff3 b76ae 1592ff8e 63eb f42 c19 6b4e 12415 4cc9ae7 9f3 34b 4ff81fc08e7 f157 c55 64f5d7e 0d0 b616 f418 78ddc6 c0a3 3da66 3243 588b128 c0 7e0e875 d038 1c6 12a3 c660 2b1e c6b1d05 b9 cc6 f02 11d9 93d8 2ab8 c510 c6e 2f3 7cf78f9aeb78 42a85 d478 d5e b2f44c4d87 5da7 c36a2 c1a9 f55 baf5 d9e0 2ce8 c5 4c13 fcf09d1ef3f6 867ac773 fc0 c859 d3 f430e 90b3 6fe3 2a401 d79a7a 3c2 6f8 c7a175 df1a3207 5f6a 3e081 53c84e7a0 533 c10 d158e 0d50fb4a 8d8 b94 f2f729 f e3924 f47d6743 b4f31e17 9d5 f11 f82 d7b7ad3 f784 82b5 c65 c58 3a56 f501e 23a1 1355bea 1087 be4b57d7 b92 7eff6702 465a1 b9d2 3a389 409 c39a30 312b5fe0 6fe 83d9db3e7 ee33a f8e51 c5 b8a853 8d7 00313 f5 dc2a d936 3a3ef7f7 2d89 306e6 31 c5d9 60b3 6f9 be71 39ed 724a60 c06 662a7a 184bce6 c86 b21d3877 b18 c8be 6db82 e3083a1 fe11 b4350 0a251 996a f4025 1e525 90e0e 9e235 6dd348 f7e13 982 b5913 62b8ff4 cfb7b2 b498 1e6 c5e54 de90e 94c0130 0f8e 5158 f5 b0044 471 f83d013 f7 ab27a6e2 e738a2 f0 c256 bd5 9b74 d78e 78c6c1 597b758e5 5e7 f9d6 025 c9f2685a HỒNG KHÁNH AN [19] KHĨA LUẬN TỐT NGHIỆP Liu L., Tian R., Liu S., Chen X., Guo L., Che Y., Pestaloficiols A-E, bioactive cyclopropane derivatives from the plant endophytic fungus Pestalotiopsis fici, Bioorg 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b0044 471 f83d013 f7 ab27a6e2 e738a2 f0 c256 bd5 9b74 d78e 78c6c1 597b758e5 5e7 f9d6 025 c9f2685a PHỤ LỤC 4'' 3'' 5'' 6'' 2'' O 3' 1'' 2' O 1' 4’ NH N H 4' 3’ O 2’’-6’’ 2’ Phụ lục Phổ 1H-NMR hợp chất Et35 4'' 3'' 5'' 6'' 2'' O 3' 1'' 2' O 1' NH 2’ 4' N H 2’’-6’’ O 3’ 4’ 1’ 1’’ Phụ lục Phổ 13C-NMR hợp chất Et35 4’ 3’ 2’ 2’’-6’’ 3’ 4’ 2’ 4'' 2’’-6’’ 3'' 5'' 1’’ 6'' 2'' O 3' 1'' 1’ 2' O 1' NH 4' Phụ lục Phổ HSQC hợp chất Et35 N H O 4’ 3’ 2’’-6’’ 3’ 4’ 2’ 2’’-6’’ 4'' 1’’ 3'' 5'' 6'' 1’ 2'' O 3' 1'' 2' O 1' NH 4' N H O Phụ lục Phổ HMBC hợp chất Et35 2’ 4’ 3’ 2’ 2’’-6’’ 3’ 4’ 2’ 4'' 3'' 5'' 6'' 2’’-6’’ 2'' O 3' 1'' 2' O 1' NH 1’’ 6 4' 1’ Phụ lục Phổ HMBC dãn rộng hợp chất Et35 N H O ETA-DMSO-1H OH H N H 6 N1 OH Phụ lục Phổ 1H-NMR hợp chất EtA OH H N H 6 OH N1 Phụ lục Phổ 13C-NMR hợp chất EtA