(Luận văn) the effect of betel quid chewing on the absorption of cigarette smoke containing acrolein

THAI NGUYEN UNIVERSITY UNIVERSITY OF AGRICULTURE AND FORESTRY NGUYEN THI MAI CHI TOPIC TITLE: an lu THE EFFECT OF BETEL QUID CHEWING ON THE ABSORPTION OF CIGARETTE SMOKE CONTAINING ACROLEIN n va to p ie gh tn BARCHELOR THESIS d oa nl w Full-time Major: Environmental Science and Management 2013 - 2017 ll u nf Batch: International Programs Office a nv Faculty: a lu Study Mode: oi m tz a nh z Thai Nguyen, 20/11/2017 om l.c gm @ DOCUMENTATION PAGE WITH ABSTRACT Thai Nguyen University of Agriculture and Forestry Degree Program Bachelor of Environmental Science and Management Student name Nguyen Thi Mai Chi Student ID DTN1353070121 Thesis Title THE EFFECT OF BETEL QUID CHEWING ON THE ABSORPTION OF CIGARETTE SMOKE CONTAINING ACROLEIN Supervisors Prof Tsung - Yun Liu Dr Do Thi Ngoc Oanh Abstract: Acrolein, a highly reactive, unsaturated aldehyde and respiratory irritant, is formed during combustion (e.g., cigarette smoke), high-temperature cooking of foods, and in vivo as a product of oxidative stress and polyamine metabolism 3-Hydroxypropyl mercapturic acid (3-HPMA) is the main metabolite of lu an acrolein in urine Previous studies demonstrated that betel quid can enhance the va n alkalinity of oral cavity, and might enhance the additional absorption of This study is designed to describe some characteristics of cigarette smokers p ie gh tn to acrolein(pKa is about 9.0) However, this has not been shown in literature d oa nl w in Kaohsiung and test the hypothesis that chewing betel quid will facilitate the absorption of acrolein while smoking cigarette by comparing the level of a lu urinary 3-HPMA in cigarette-smokers with and without betel quid chewing a nv u nf Urine samples were obtained from healthy volunteers in Kaohsiung, which ll is located in the southern part of Taiwan Urinary 3-HPMA and creatinine were oi m a nh analyzed by LC-MS/MS and HPLC with UV detector, respectively tz The results showed that the level of 3-HPMA in cigarette-smokers who z om l.c gm @ chewing betel quid (1.97 ng/ g creatinine) was significant higher (p